Question 问题：

In recent years, tranexamic acid has been explored as a treatment for various causes of uncontrolled or coagulopathic bleeding in Emergency Medicine. What neurologic adverse effect has been reported after TXA administration? 

近年来，氨甲环酸在急诊医学领域被用来治疗多种难以控制或凝血障碍出血。已有报告显示，在使用TXA后会出现什么神经系统副作用？

Answer 答案：

TXA antagonizes the inhibitory neurotransmitter gamma-aminobutyric acid, which can increase seizure risk. High doses of TXA (> 100 mg/kg) are associated with an increased risk of seizure activity. 

TXA对抑制性神经介质胺基丁酸有抑制作用，增加癫痫危险。大剂量TXA（> 100 mg/kg）与增加癫痫风险有关。

参考文献：

Ann of EM, epub, 8/2/21