【标题速读】【Ncomm】【biological-sciences】【2022年】【9月】

声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。

1.Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection.

单细胞和空间转录组分析揭示了布氏锥虫感染期间大脑中的小胶质细胞-浆细胞串扰。

2.FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli.

FtsN通过与大肠杆菌中的隔膜特异性肽聚糖合成酶形成渐进式复合物来维持活跃的隔膜细胞壁合成。

3.A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma.

转录转移特征可预测透明细胞肾细胞癌的生存率。

4.Inositol hexakisphosphate is required for Integrator function.

肌醇六磷酸酯是整合者功能的必要条件。

5.ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing.

ANGEL2磷酸酶活性对非典范线粒体RNA加工是必需的。

6.Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy.

近红外磷光碳点用于声动力精准肿瘤治疗。

7.Effectiveness of COVID-19 vaccines against Omicron and Delta hospitalisation, a test negative case-control study.

COVID-19疫苗对Omicron和Delta住院的有效性，一项测试阴性的病例对照研究。

8.Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion.

AgRP-神经元中的脂质生物合成酶Agpat5是胰岛素诱导的低血糖感应和胰高血糖素分泌的必要条件。

9.Crowding results from optimal integration of visual targets with contextual information.

拥挤的结果是视觉目标与背景信息的最佳整合。

10.Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark.

丹麦SARS-CoV-2 Omicron变体关注亚变体BA.1和BA.2的家庭传播。

11.A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.

恶性疟原虫Na+泵PfATP4的G358S突变赋予了临床相关的对西帕卡明的抗性。

12.Climate change may outpace current wheat breeding yield improvements in North America.

气候变化可能超过目前北美地区小麦育种产量的提高。

13.Genomic analyses of rice bean landraces reveal adaptation and yield related loci to accelerate breeding.

稻豆陆地品种的基因组分析揭示了适应性和产量相关的位点，以加速育种。

14.A NAC-EXPANSIN module enhances maize kernel size by controlling nucellus elimination.

一个NAC-EXPANSIN模块通过控制核仁的消除来增强玉米核仁的大小。

15.Genome-wide association study identifies a gene responsible for temperature-dependent rice germination.

全基因组关联研究确定了一个负责温度依赖性水稻发芽的基因。

16.Regain flood adaptation in rice through a 14-3-3 protein OsGF14h.

通过一个14-3-3蛋白OsGF14h重新恢复水稻的水灾适应性。

17.Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer.

成本效益高的无细胞DNA甲基组测序用于准确检测和定位癌症。

18.Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells.

探索核体增强的苏木酰化，发现PML抑制胚胎干细胞的2细胞特征。

19.Deciphering microbial gene function using natural language processing.

利用自然语言处理破译微生物基因功能。

20.Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it.

蛋白质结构转换关键性地改变了RNA结合蛋白凝集体的网络连接和粘弹性，但RNA可以阻止它。

21.Adversarial attacks and adversarial robustness in computational pathology.

计算病理学中的对抗性攻击和对抗性稳健性。

22.Spatiotemporal organisation of protein processing in the kidney.

肾脏中蛋白质加工的时空组织。

23.MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.

MYPT1-PP1β磷酸酶同时负向调控染色质景观和共激活因子的招募以促进米色脂肪生成。

24.TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis.

TM9SF4是一种促进肿瘤进展和转移的F-肌动蛋白分解因子。

25.Systematic identification of intron retention associated variants from massive publicly available transcriptome sequencing data.

从大量公开的转录组测序数据中系统识别内含物保留相关变体。

26.Increased household transmission and immune escape of the SARS-CoV-2 Omicron compared to Delta variants.

与Delta变体相比，SARS-CoV-2 Omicron的家庭传播和免疫逃逸增加。

27.SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner.

SARS-CoV-2以一种依赖脂肪库和病毒系的方式感染脂肪组织。

28.Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals potential therapeutic strategies.

胃癌对化疗和靶向治疗反应的蛋白质组学特征揭示了潜在的治疗策略。

29.MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis.

MicroRNA-7调控参与哺乳动物能量平衡的黑色皮质素回路。

30.Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler.

噬菌体-抗生素联合疗法对抗广泛耐药的铜绿假单胞菌感染，让幼儿进行肝移植。

31.A deeper understanding of system interactions can explain contradictory field results on pesticide impact on honey bees.

深入了解系统的相互作用可以解释关于杀虫剂对蜜蜂影响的矛盾的现场结果。

32.Experimental validation that human microbiome phages use alternative genetic coding.

实验验证了人类微生物组噬菌体使用替代基因编码。

33.Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection.

干扰素调节因子1（IRF-1）在枸橼酸杆菌感染期间促进肠道第3组先天淋巴反应。

34.Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescence.

利用压力科学促进复原力并优化青少年时期的心理健康干预措施。

35.Multi-context genetic modeling of transcriptional regulation resolves novel disease loci.

转录调控的多背景遗传模型解决了新的疾病位点。

36.A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses.

一种基于蛋白质的cGAS-STING纳米拮抗剂增强了T细胞介导的抗肿瘤免疫反应。

37.Activation of the human insulin receptor by non-insulin-related peptides.

非胰岛素相关肽对人类胰岛素受体的激活作用。

38.The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors.

转录辅助因子RUVBL2调控Pol II与不同转录因子的聚集。

39.In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis.

体内自组装的siRNA作为溃疡性结肠炎联合治疗的模式。

40.Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice.

病变环境引导移植的神经祖细胞向小鼠伤口修复星形胶质表型发展。

41.Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression.

区域基因表达特征与抑郁症的性别特异性功能连接变化有关。

42.TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis.

TFEB调节硫氨基酸和辅酶A的代谢以支持肝脏代谢适应和氧化还原平衡。

43.Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.

拟南芥钾通道AKT1活性调节的结构基础。

44.Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy.

中和IgE和补充长双歧杆菌联合使用可降低食物过敏模型的过敏反应。

45.Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy.

Ras-cAMP-PKA(Tpk2)途径对Jhd2的磷酸化调节组蛋白修饰和自噬。

46.Gene expression based inference of cancer drug sensitivity.

基于基因表达的癌症药物敏感性推断。

47.Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance.

通过清除p16阳性的衰老细胞使小鼠大脑免疫细胞格局恢复活力。

48.The transcription factor Zfh1 acts as a wing-morph switch in planthoppers.

转录因子Zfh1作为翼形开关在刨花虫中的作用。

49.Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades.

预测未来几十年拉萨病毒流行区和高危人群的演变。

50.TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.

TP53突变和RNA结合蛋白MUSASHI-2驱动B细胞淋巴瘤对PRMT5靶向治疗的抗性。

51.Hardship at birth alters the impact of climate change on a long-lived predator.

出生时的困难改变了气候变化对一种长寿捕食者的影响。

52.Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity.

禁食期间的脂肪酸平衡预测了对化疗毒性的保护。

53.Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing.

光催化葡萄糖耗竭和氢气生成促进糖尿病伤口愈合。

54.In situ small-angle X-ray scattering reveals strong condensation of DNA origami during silicification.

原位小角X射线散射揭示了硅化过程中DNA折纸的强烈凝结。

55.Zymoseptoria tritici white-collar complex integrates light, temperature and plant cues to initiate dimorphism and pathogenesis.

Zymoseptoria tritici白领复合体整合光、温度和植物线索，启动二形性和致病机制。

56.Genetic analysis of seed traits in Sorghum bicolor that affect the human gut microbiome.

影响人类肠道微生物组的双色高粱种子性状的遗传分析。

57.The augmin complex architecture reveals structural insights into microtubule branching.

augmin复合体结构揭示了对微管分支的结构见解。

58.Circulating multimeric immune complexes contribute to immunopathology in COVID-19.

循环的多聚体免疫复合物有助于COVID-19的免疫病理学。

59.Modeling tissue-specific breakpoint proximity of structural variations from whole-genomes to identify cancer drivers.

从全基因组的结构变异中建立组织特异性断点接近的模型，以确定癌症驱动因素。

60.McaA and McaB control the dynamic positioning of a bacterial magnetic organelle.

McaA和McaB控制一个细菌磁性细胞器的动态定位。

61.High-throughput small molecule screen identifies inhibitors of microsporidia invasion and proliferation in C. elegans.

高通量小分子筛查确定了小孢子虫入侵和增殖的抑制剂。

62.Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.

经典的中心-周围感受区促进了视网膜双极细胞的新物体检测。

63.A Dilp8-dependent time window ensures tissue size adjustment in Drosophila.

依赖Dilp8的时间窗口确保果蝇的组织尺寸调整。

64.Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction.

基于Ihog-Glypicans相互作用的Hedgehog信号传导中的细胞膜引导预测模型。

65.β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells.

β-arrestin1和2在活细胞中与同一GPCR偶联时表现出不同的磷酸化依赖性构象。

66.Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.

中心-周围相互作用是小鼠视网膜双极细胞运动敏感性的基础。

67.A neuro-computational account of procrastination behavior.

拖延行为的神经-计算学解释。

68.TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy.

TraB家族蛋白是ER-mitochondrial接触点的组成部分，调节ER-mitochondrial的相互作用和mitophagy。

69.The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems.

细菌衍生的生物分子凝结物的材料特性在自然和合成系统中调控生物功能。

70.RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma.

RAS致癌活性可预测肺腺癌的化疗反应和结果。

71.Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4.

对MT-A70家族甲基转移酶METTL4的N6-腺苷甲基化的分子机制的结构见解。

72.Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis.

气道基底细胞显示出去分化的KRT17highPhenotype并促进特发性肺纤维化的纤维化。

73.Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.

小鼠脊髓损伤的单细胞图谱显示了脊髓小脑神经元的促再生特征。

74.Nocturnal plant respiration is under strong non-temperature control.

夜间植物的呼吸受到强烈的非温度控制。

75.Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells.

氧化石墨烯纳米片对DNMT3A突变型AML细胞显示出选择性的抗白血病功效。

76.Redβ177 annealase structure reveals details of oligomerization and λ Red-mediated homologous DNA recombination.

Redβ177退火酶结构揭示了低聚物化和λ红介导的同源DNA重组的细节。

77.USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer.

USP14通过稳定结直肠癌的IDO1促进色氨酸代谢和免疫抑制。

78.The comparison of cancer gene mutation frequencies in Chinese and U.S. patient populations.

中国和美国患者群体中癌症基因突变频率的比较.

79.Two modes of evolution shape bacterial strain diversity in the mammalian gut for thousands of generations.

两种进化模式塑造了哺乳动物肠道内数千代的细菌菌株多样性。

80.High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecological adaptation.

高分辨率的家蚕泛基因组为人工选择和生态适应提供了遗传学方面的见解。

81.Tail proteins of phage SU10 reorganize into the nozzle for genome delivery.

噬菌体SU10的尾部蛋白重组到用于基因组输送的喷嘴。

82.A miniaturized bionic ocean-battery mimicking the structure of marine microbial ecosystems.

模仿海洋微生物生态系统结构的小型仿生海洋电池。

83.Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models.

磷酰胆碱结合的金分子簇改善了临床前癌症模型中淋巴结NIR-II荧光成像的信号。

84.Experimental evidence for core-Merge in the vocal communication system of a wild passerine.

野生过山鸟发声通讯系统中核心合并的实验证据。

85.Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors.

融合基因作为EGFR抑制剂抗性机制的基因组学和生物学研究。

86.Human centromere repositioning activates transcription and opens chromatin fibre structure.

人类中心粒的重新定位激活了转录并打开了染色质纤维结构。

87.Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption.

用于基因破坏的微型CRISPR-Cas12f核酸酶的综合评估。

88.Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.

疟疾候选疫苗Pfs48/45的结构及其被传播阻断抗体的识别。

89.Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae.

乳酸菌支持梭状芽孢杆菌限制耐多药肠杆菌的肠道定植。

90.Synthetic neuromorphic computing in living cells.

活细胞中的合成神经形态计算。

91.DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types.

阿尔茨海默病神经病理学的DNA甲基化特征主要由非神经元细胞类型的变异驱动。

92.Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity.

γ干扰素介导了人类肥胖症中脂肪组织调节性T细胞的减少。

93.Revisiting life history and morphological proxies for early mammaliaform metabolic rates.

重新审视早期哺乳动物形态代谢率的生活史和形态学代用指标。

94.Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2.

使用内源性标记的斑马鱼sfGFP-Vangl2的活体成像和条件性破坏本地PCP活动。

95.The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases.

植物第3家族糖类外水解酶中芳香族钳的进化优势。

96.Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.

慢性SARS-CoV-2感染的B细胞耗竭型淋巴瘤患者的抗体和CD8 T细胞表位突变的积累。

97.Reply to: Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass.

Reply to： 循环恶性疟原虫生命周期阶段与循环寄生虫血症和寄生虫总生物量的关系。

98.Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules.

细胞内能量控制压力诱导的核糖核蛋白颗粒的动力学。

99.Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass.

恶性疟原虫生命周期阶段与循环寄生虫血症和总寄生虫生物量的关系。

100.Reply to: Revisiting life history and morphological proxies for early mammaliaform metabolic rates.

Reply to： 重新审视早期哺乳动物形态代谢率的生活史和形态学代用指标。

101.Using multiple sampling strategies to estimate SARS-CoV-2 epidemiological parameters from genomic sequencing data.

使用多种采样策略从基因组测序数据中估计SARS-CoV-2的流行病学参数。

102.Cytoplasmic organization promotes protein diffusion in Xenopus extracts.

细胞质组织促进蛋白质在Xenopus提取物中的扩散。

103.Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism.

细菌饮食通过宿主脂肪酸代谢调控他莫西芬诱导的死亡。

104.CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes.

中枢神经系统髓鞘化需要VAMP2/3介导的少突胶质细胞膜扩张。

105.Activation of the insulin receptor by an insulin mimetic peptide.

胰岛素模拟肽对胰岛素受体的激活.

106.Activation of stably silenced genes by recruitment of a synthetic de-methylating module.

通过招募合成去甲基化模块激活稳定沉默的基因。

107.Local features drive identity responses in macaque anterior face patches.

局部特征驱动猕猴前脸斑块的身份反应。

108.An online atlas of human plasma metabolite signatures of gut microbiome composition.

肠道微生物组组成的人类血浆代谢物特征的在线图谱。

109.Synaptic plasticity in self-powered artificial striate cortex for binocular orientation selectivity.

自力更生的人工纹状皮层的突触可塑性对双眼方向的选择性。

110.Household transmission of the SARS-CoV-2 Omicron variant in Denmark.

SARS-CoV-2 Omicron变体在丹麦的家庭传播。

111.Protein condensation diseases: therapeutic opportunities.

蛋白质凝结疾病：治疗机会。

112.A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action.

一种真菌耐受性特征和选择性抑制剂提供了HMG-CoA还原酶作为除草剂的作用方式。

113.Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.

将SARS-CoV-2特异性鸡尾酒抗体工程化为双特异性格式，提高中和效力和广度。

114.Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology.

用于实时可编程光遗传学和光药学的无线多侧光流体微系统。

115.IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis.

IL-23信号防止念珠菌病期间铁蛋白驱动的肾脏免疫病理学。

116.High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance.

高通量诱变确定了控制CD19剪接和CART-19疗法抗性的突变和RNA结合蛋白。

117.Endocytosis-like DNA uptake by cell wall-deficient bacteria.

细胞壁缺损的细菌对DNA的内吞作用。

118.Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers.

染色质组织者SATB1通过调控超级增强子的活性控制CD4+CD8+双阳性胸腺细胞的细胞身份。

119.Tracking changes in SARS-CoV-2 transmission with a novel outpatient sentinel surveillance system in Chicago, USA.

利用美国芝加哥的新型门诊哨点监测系统追踪SARS-CoV-2传播的变化。

120.Context-dependent selectivity to natural images in the retina.

视网膜中对自然图像的语境依赖性选择。

121.Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress.

CLIP-170家族蛋白的泛质化抑制了DNA复制压力下的极化生长。

122.Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis.

一种不可逆的小分子赖氨酸氧化酶抑制剂的局部应用可改善皮肤瘢痕和纤维化。

123.VAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin regulation at Arabidopsis FLC.

VAL1作为组装平台，协调拟南芥FLC的共转录抑制和染色质调节。

124.Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice.

通过双向无线给药和社会互动小鼠的电生理学，用于行为神经药理学的神经探测系统。

125.The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition.

SARS-CoV-2 Omicron BA.1穗状体G446S突变增强了抗病毒T细胞识别能力。

126.Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation.

WASH缺陷的中性粒细胞白细胞中颗粒亚群的差异性失调导致炎症的发生。

127.Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity.

静脉或毛细血管血源的SARS-CoV-2特异性T细胞反应的大小决定了COVID-19的免疫力。

128.Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency.

脊椎动物OCT4/POU5支持多能性功能的进化起源。

129.Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models.

猕猴母体肥胖模型中无细胞胎儿DNA甲基化的多组脑和行为相关性。

130.Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases.

利用I型顺式AT聚酮体合成酶的对接域进行代谢途径组装。

131.Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways.

岛状皮层回路作为执行通道，通过不同的皮层下途径破译威胁或消亡记忆。

132.Leaf water content contributes to global leaf trait relationships.

叶子含水量对全球叶子性状关系的贡献。

133.Transcriptomic architecture of nuclei in the marmoset CNS.

狨猴中枢神经系统核的转录组结构。

134.Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells.

基于反应的荧光探针用于检测活细胞中蛋白质半胱氨酸的氧化。

135.A de novo matrix for macroscopic living materials from bacteria.

来自细菌的宏观活体材料的脱胎换骨矩阵。

136.Intrinsic bias estimation for improved analysis of bulk and single-cell chromatin accessibility profiles using SELMA.

使用SELMA改进批量和单细胞染色质可及性分析的内在偏差估计。

137.Resolving molecular diffusion and aggregation of antibody proteins with megahertz X-ray free-electron laser pulses.

用兆赫X射线自由电子激光脉冲解析抗体蛋白的分子扩散和聚集。

138.Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration.

p38α激酶抑制剂neflamapimod治疗基底前脑胆碱能退化的临床前和随机临床评估。

139.Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish.

Adar 介导的 A-to-I 编辑是斑马鱼胚胎模式和先天免疫反应调节所必需的。

140.QuasAr Odyssey: the origin of fluorescence and its voltage sensitivity in microbial rhodopsins.

QuasAr Odyssey: 荧光的起源及其在微生物荷尔蒙蛋白中的电压敏感性。

141.Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow.

使用酵母生物传感器工作流程筛选微生物生产的Δ9-四氢大麻酚。

142.Learning enhances encoding of time and temporal surprise in mouse primary sensory cortex.

学习增强了小鼠初级感觉皮层中时间和时间性惊喜的编码。

143.Systematic profiling of conditional degron tag technologies for target validation studies.

用于目标验证研究的条件性degron标签技术的系统剖析。

144.Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors.

洞察临床补体抑制剂compstatin家族的作用方式和结构决定因素。

145.Deciphering multi-way interactions in the human genome.

解读人类基因组中的多向互动。

146.The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane.

AAA+ATP酶RavA及其结合伙伴ViaA通过与内膜的相互作用调节大肠杆菌氨基糖苷的敏感性。

147.Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease.

小的可溶性α-synuclein聚集物是帕金森病的毒性物种。

148.Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast.

单细胞图谱识别健康和恶性乳腺中的脂质处理和免疫调节内皮细胞。

149.Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition.

PAPP-ABP5复合物的结构揭示了底物识别的机制。

150.An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish.

斑马鱼组织损伤期间抗炎激活序列支配巨噬细胞的转录动态。

151.Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care.

用于青光眼护理中24小时连续监测眼压的智能软性隐形眼镜。

152.DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival.

DNA甲基化作为糖皮质激素反应和胶质瘤生存的药效学标志。

153.Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling.

粘附性GPCR GPR110被柄肽和G-蛋白质偶联激活的结构基础。

154.An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms.

一种EGFR/HER2靶向共轭物通过不同的SMAD4介导的机制使吉西他滨敏感和耐药的胰腺癌致敏。

155.Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals.

灵活的线索锚定策略使有视力和失明动物的头部方向编码稳定。

156.A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production.

核糖体异质性的干细胞路线图揭示了RPL10A在中胚层生产中的功能。

157.Structural characterization of a soil viral auxiliary metabolic gene product – a functional chitosanase.

土壤病毒辅助代谢基因产品的结构特征--一种功能性壳聚糖酶。

158.Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells.

血管内分泌胞外小泡对原神经胶质瘤干细胞施加间质重编程。

159.Extracellular fibrinogen-binding protein released by intracellular Staphylococcus aureus suppresses host immunity by targeting TRAF3.

细胞内金黄色葡萄球菌释放的细胞外纤维蛋白原结合蛋白通过靶向TRAF3抑制宿主免疫力。

160.Biosynthesis of plant hemostatic dencichine in Escherichia coli.

大肠杆菌中植物止血剂dencichine的生物合成。

161.Modeling human HSV infection via a vascularized immune-competent skin-on-chip platform.

通过一个血管化的免疫能力皮肤芯片平台模拟人类HSV感染。

162.Mutated processes predict immune checkpoint inhibitor therapy benefit in metastatic melanoma.

突变过程预测免疫检查点抑制剂治疗转移性黑色素瘤的益处。

163.Transformation of primary sensory cortical representations from layer 4 to layer 2.

初级感觉皮质表征从第4层到第2层的转变。

164.Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia.

小儿急性骨髓性白血病的综合干细胞特征和细胞分子风险判断。

165.Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm.

DNA甲基化超过H3K9me3对内胚层IAP沉默的主导作用。

166.Causal contribution of optic flow signal in Macaque extrastriate visual cortex for roll perception.

猕猴视外皮层中视流信号对滚动感知的因果贡献。

167.ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer.

ARID1A突变赋予结直肠癌对西妥昔单抗治疗的内在和获得性抵抗。

168.Stress induced TDP-43 mobility loss independent of stress granules.

应激诱导的TDP-43移动性丧失与应激颗粒无关。

169.Identification of spatially variable genes with graph cuts.

用图形切割识别空间可变基因。

170.The effect of carbon fertilization on naturally regenerated and planted US forests.

碳肥对美国自然再生林和人工林的影响.

171.Quantitative fragmentomics allow affinity mapping of interactomes.

定量片段组学允许亲和地绘制交互组图。

172.A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant.

一种自组装的三聚体蛋白疫苗诱导了对Omicron变体的保护性免疫力。

173.Phylogeographic analysis reveals an ancient East African origin of human herpes simplex virus 2 dispersal out-of-Africa.

系统地理学分析揭示了人类单纯疱疹病毒2在非洲以外地区传播的古老东非起源。

174.Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation.

tapasin介导的MHC-I肽在抗原表达中的结构机制。

175.Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones.

前列腺原位肿瘤的时空分析表明治疗抗性克隆的预先存在。

176.Mechanistic understanding of human SLFN11.

对人类SLFN11的机制理解。

177.The immune landscape of human thymic epithelial tumors.

人类胸腺上皮细胞肿瘤的免疫景观。

178.Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia.

单细胞转录组学揭示了主动脉瓣的细胞多样性和高脂血症时PPARγ的免疫调节作用。

179.A randomized controlled trial of heterologous ChAdOx1 nCoV-19 and recombinant subunit vaccine MVC-COV1901 against COVID-19.

异源ChAdOx1 nCoV-19和重组亚单位疫苗MVC-COV1901对抗COVID-19的随机对照试验。

180.Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma.

致癌性RAS征用氨基酸感应机制异常激活多发性骨髓瘤的mTORC1。

181.Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours.

下肢内侧前额叶皮层对后基底外侧杏仁核中calbindin 1阳性神经元的信号传递抑制了焦虑和抑郁样行为。

182.Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation.

小鼠iPSCs的印记保真度取决于供体细胞的性别和培养基配方。

183.A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission.

鞭毛顶端的多腺苷酸环化酶调节器控制非洲锥虫的传播。

184.A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.

SMN的一个小分子拮抗剂破坏了SMN和RNAP II之间的相互作用。

185.Molecular architecture of the augmin complex.

augmin复合物的分子结构。

186.Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.

对胰岛素和CD28信号中SHP2酪氨酸磷酸酶的pSer/pThr依赖性调控的结构见解。

187.Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro.

基于结构发现体外分解阿尔茨海默病组织衍生的tau纤维的小分子。

188.Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function.

静电和立体效应是乙酰化引起的泛素结构和功能变化的基础。

189.Clustering by measuring local direction centrality for data with heterogeneous density and weak connectivity.

通过测量具有异质密度和弱连接性的数据的局部方向中心性进行聚类。

190.Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C.

慢性丙型肝炎治愈后血清中和活性下降但记忆B细胞持续存在。

191.Unleashing the potential of noncanonical amino acid biosynthesis to create cells with precision tyrosine sulfation.

释放非经典氨基酸生物合成的潜力，创造具有精确酪氨酸硫酸化的细胞。

192.WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome.

Werner综合征中WRN通过其螺旋酶活性解开SHOX-G-四联体，促进骨骼发育和生长。

193.A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state.

丘脑活动的时间序列在行为唤醒状态的转换中展开。

194.Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase.

结构揭示了Rac1 GTP酶激活WAVE调节复合物的关键机制。

195.Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer.

TERT启动子复制的保守特征揭示了一种模仿癌症热点突变的激活机制。

196.Water regulates the residence time of Benzamidine in Trypsin.

水调控苯甲脒在胰蛋白酶中的停留时间。

197.Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks.

用于大规模生物库中全基因组生存关联分析的高效准确的虚弱度模型方法。

198.Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants.

使用平行级联策略和酪氨酸酶变体的苄基异喹啉生物碱的酶促合成。

199.Pangenomic analysis of Chinese gastric cancer.

中国胃癌的Pangenomic分析.

200.Batch effects removal for microbiome data via conditional quantile regression.

通过条件量化回归去除微生物组数据的批处理效应.

201.Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis.

肝脏第2组先天性淋巴细胞通过IL-13信号传导和抑制葡萄糖生成来调节血糖水平。

202.Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth.

小鼠胎儿骨髓在出生前不支持功能性造血干细胞和祖细胞。

203.Cryptococcal Hsf3 controls intramitochondrial ROS homeostasis by regulating the respiratory process.

隐球菌Hsf3通过调控呼吸过程控制线粒体内ROS平衡。

204.Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.

匹配患者活体组织的转录分析阐明了恩扎鲁胺诱导的血统可塑性的分子决定因素。

205.Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.

活跃的Gi偶联人类溶血磷脂酸受体1与强效激动剂复合的结构。

206.Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.

小鼠运动神经元在体内和体外成熟时的转录动态。

207.The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure.

补体C3-补体因子D-C3a受体信号轴调节右心室衰竭的心脏重塑。

208.Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling.

抑制Sirtuin 6通过调节IGF/PI3K/AKT信号来保护糖皮质激素引起的骨骼肌萎缩。

209.Reconstitution of microtubule into GTP-responsive nanocapsules.

将微管重组为GTP反应型纳米胶囊。

210.Inhibition of UBA6 by inosine augments tumour immunogenicity and responses.

肌苷对UBA6的抑制增强了肿瘤的免疫原性和反应。

211.Cancer co-opts differentiation of B-cell precursors into macrophage-like cells.

癌症共同决定了B细胞前体向巨噬细胞的分化。

212.Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy.

agalactiae链球菌cadD减轻金属压力，促进巨噬细胞的细胞内生存和怀孕期间的上升感染。

213.Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli.

大肠杆菌的膜结合型甲酸氢酶复合物的结构。

214.A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories.

从单分子FRET轨迹推断动力学速率常数的分析工具的盲测基准。

215.The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils.

临床候选药物anle138b在脂质α-synuclein纤维的空腔中结合。

216.Layered feedback control overcomes performance trade-off in synthetic biomolecular networks.

分层反馈控制克服了合成生物分子网络中的性能折衷问题。

217.Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues.

光遗传控制顶端收缩诱导了哺乳动物组织的合成形态发生。

218.Multiple parameters shape the 3D chromatin structure of single nuclei at the doc locus in Drosophila.

多个参数塑造了果蝇doc基因座上单个核的三维染色质结构。

219.Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity.

MHC I-tapasin-ERp57编辑复合物的结构确定了伴侣的杂乱性。

220.Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus.

模型霉菌病原体曲霉的端粒到端粒的基因组序列。

221.Structural basis for APE1 processing DNA damage in the nucleosome.

APE1处理核糖体中DNA损伤的结构基础。

222.Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia.

ZNF384融合对FLT3基因的表观遗传激活赋予急性淋巴细胞白血病的治疗易感性。

223.In situ analysis of nanoparticle soft corona and dynamic evolution.

纳米粒子软冕的原位分析和动态演变。

224.Assembly of transmembrane pores from mirror-image peptides.

镜像肽的跨膜孔的组装。

225.Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice.

生物性别错配对神经祖细胞移植治疗小鼠脊髓损伤的影响。

226.Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila.

Mettl3依赖的m6A修饰减弱了果蝇的大脑应激反应。

227.Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cells.

轻度血脂异常通过扩张Ly6Chi单核细胞和分化为促血管生成的骨髓细胞加速了肿瘤的发生。

228.Paternal imprinting of dosage-effect defective1 contributes to seed weight xenia in maize.

剂量效应缺陷1的父系印记有助于玉米的种子重量异位。

229.Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37.

侵袭性B细胞淋巴瘤中的脂肪酸代谢被四泛素CD37所抑制。

230.Diverse cell-specific patterns of alternative polyadenylation in Drosophila.

果蝇替代性聚腺苷酸化的不同细胞特异性模式。

231.Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm.

白细胞介素-1有助于JAK2V617F诱导的骨髓增生性肿瘤中的克隆扩展和骨髓纤维化的进展。

232.Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.

抑制白细胞介素-1β可以减少JAK2-V617F驱动的骨髓增生性肿瘤小鼠的骨髓纤维化和骨质硬化。

233.Machine-learning prediction of hosts of novel coronaviruses requires caution as it may affect wildlife conservation.

对新型冠状病毒宿主的机器学习预测需要谨慎，因为它可能影响野生动物的保护。

234.Reply to: Machine-learning prediction of hosts of novel coronaviruses requires caution as it may affect wildlife conservation.

回应： 机器学习预测新型冠状病毒的宿主需要谨慎，因为它可能会影响野生动物的保护。

235.The importance of antimicrobial resistance in medical mycology.

医学真菌学中抗菌素抗性的重要性。

236.Improved immunoassay sensitivity and specificity using single-molecule colocalization.

利用单分子共聚焦技术提高免疫测定的灵敏度和特异性。

237.GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.

GCAF(TMEM251)通过激活甘露糖-6-磷酸途径调控溶酶体生物生成。

238.Genomic insights into rapid speciation within the world’s largest tree genus Syzygium.

对世界上最大的树种Syzygium属的快速物种形成的基因组学见解。

239.SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus.

SREBP2依赖的脂质基因转录增强了寨卡病毒对人类树突状细胞的感染。

240.Robust data storage in DNA by de Bruijn graph-based de novo strand assembly.

基于de Bruijn图的新链组装在DNA中的稳健数据存储。

241.Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis.

鉴定可溶性RANKL上的一个结合位点，可作为抑制可溶性RANK-RANKL相互作用和治疗骨质疏松症的目标。

242.Kinetic compartmentalization by unnatural reaction for itaconate production.

通过非自然反应生产衣康酸的动力学区划。

243.Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate.

阐明乙烯基异腈和异氰基丙烯酸酯形成过程中不同的脱饱和途径。

244.Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear.

在重新巩固过程中重新激活海马介导的记忆以破坏恐惧。

245.Life at high temperature observed in vitro upon laser heating of gold nanoparticles.

激光加热金纳米粒子后在体外观察到的高温生命。

246.Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease.

不确定潜力的克隆造血，DNA甲基化和冠状动脉疾病的风险。

247.An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis.

一种结合组织清除技术和拓扑数据分析的血管结构分析模式。

248.A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging.

一种用于体内cAMP成像的高性能基因编码荧光指示剂。

249.Polyvinyl chloride degradation by a bacterium isolated from the gut of insect larvae.

从昆虫幼虫肠道中分离出的一种细菌对聚氯乙烯的降解。

363.Global patterns of vascular plant alpha diversity.

维管束植物阿尔法多样性的全球模式。

364.Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march.

TSLP和IL-1β在皮肤过敏性致敏和特应性行进中的情境依赖功能。

365.Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy.

细菌装载葡萄糖聚合物和光敏ICG硅纳米粒子用于胶质母细胞瘤光热免疫治疗。

366.Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli.

通过靶向转录组学解码嗅觉地图，将小鼠嗅觉受体与肾小球联系起来。

367.Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.

SUMOylation和泛素化之间的串联通过维持染色质上的MRE11平衡来控制DNA末端切除。

368.Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.

心电图QT间期及其组成部分的遗传分析确定了额外的位点和途径。

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