1,2-distearoyl-sn-glycerol-3-phosphate ethanolamine (DSPE) conjugated polyethylene glycol, DSPE-PEG is a phospholipid PEG conjugate with both hydrophilicity and hydrophobicity. PEGylated phospholipid is an excellent liposome forming material, which can be used for drug delivery, gene transfection and vaccine delivery. DSPE-PEG-N3 products can be used to prepare polyethylene glycol liposomes using click chemistry. Azides react easily with alkynes or cyclocyanides in aqueous solutions with or without copper catalysts. The PEG of phospholipid improves the blood circulation time and stability of the capsule drug.
Azide (- N3) can react with copper catalyzed alkynes in aqueous solution and be reduced to amino groups. Polyethylene glycol can increase solubility and stability. Reduce the immunogenicity of peptides and proteins, and it can also inhibit the non-specific binding of charged molecules on the modified surfaces.
