简介

    Cannabidiol (CBD) has been shown to inhibit pain in various rodent models, but the mechanism of this effect is unknown. We describe the ability of CBD to inhibit repetitive action potential firing in primary nociceptive neurons from mouse dorsal root ganglia and analyze the effects on voltage-dependent sodium channels. We find that CBD interacts with TTX-resistant sodium channels in a state-dependent manner suggesting particularly tight binding to slow inactivated states of NAV1.8 channels, which dominate the overall inactivation of NAV1.8 channels for small maintained depolarizations from the resting potential. The results suggest that CBD can exert analgesic effects in part by directly inhibiting repetitive firing of primary nociceptors and suggest a strategy of identifying compounds that bind selectively to slow inactivated states of NAV1.8 channels for developing effective analgesics.

    大麻二酚（Cannabidiol，CBD）是一种从工业大麻中提取的化合物，已在多种啮齿动物模型中被证明具有抑制疼痛的作用，但这种作用的机制尚不清楚。近期，来自哈佛医学院Bruce Bean课题组的张涵雄（Han-Xiong Bear Zhang）的工作表明，CBD可以通过直接抑制初级痛觉感受体的重复放电来部分发挥镇痛作用。与此同时，他们提出，通过筛选选择性结合相关NAV1.8离子通道慢失活状态（slow inactivated state）的化合物，有望开发有效的镇痛药物。

会议信息

主题：云端论脑32期-张涵雄博士生

时间：

北京7月4日，周日，9: 00AM

美西7月3日，周六，18: 00PM

美东7月3日，周六，21: 00PM

柏林7月4日，周日，3: 00AM

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https://ucsf.zoom.us/j/4229780613

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