活性氧2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine，CAS No. 10565

产品名称：

活性氧2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine，CAS No. 105650-23-5

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

状态：固体/粉末

储藏条件：冷藏-20℃

温馨提示：仅用于科研，不能用于人体实验！

说明：提供使用说明，核磁图谱，包装，价格，产地，制备方法，应用，稳定性，溶解度，简单合成等各种信息　

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-derived carcinogen that is found in high temperature-cooked fish and meat. In humans, PhIP is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts, which are directly correlated with increased risk of breast, colon, and prostate cancers. Chronic treatment (1 pM/L for 20 cycles) of MCF-10A cells with PhIP induces anchorage-independent cell growth and reduces cellular dependence on growth factors. It increases wild-type H-Ras gene and protein expression, which activates ERK signaling, MMP-2 and MMP-9 protein expression, and NOX1-driven production of reactive oxygen species (ROS) in vitro. In vivo, PhIP pre-treatment of MCF-10A cells increases tumor formation in a murine breast cancer xenograft model. In a CYP1A2 humanized rat model, PhIP induces formation of colon tumors with β-catenin gene mutations that hyperactivate the Wnt signaling pathway, mimicking the phenotype observed in human tumor isolates. In vivo administration of PhIP (400 ppm/week for 52 weeks) also increases the occurrence of atypical hyperplasias and carcinomas in the ventral prostate and seminal vesicles of rats.

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编辑：XAQYBIO HAO，2023年4月28日。