基因编辑小鼠能成为新型冠状病毒疫苗与药物研发的助力
Modified mice could aid the quest for vaccines and drugs
Two teams have developed a short cut to generating COVID-19 mouse models: using a harmless virus to make the rodents cells susceptible to infection.
The SARS-CoV-2 virus invades a human cell by attaching to receptors, including one called ACE2, on its surface. Mice have a different version of ACE2, making them impervious to SARS-CoV-2 infection. Transgenic mice carrying the human version of ACE2 are susceptible to infection but are scarce.
To develop a more widely available mouse model, a team led by Michael Diamond at Washington University in St. Louis, Missouri, and another by Jincun Zhao at the First Affiliated Hospital of Guangzhou Medical University in China used adenoviruses — a workhorse of gene therapy — to deliver the human ACE2 gene to the lung cells of mice. After exposure to SARS-CoV-2, these mice lost weight and developed pneumonia.
Nature 2020-6-12
基因编辑小鼠能成为新型冠状病毒疫苗与药物研发的助力
两个研究团队开发了一种建立新型冠状病毒的小鼠感染模型的简单方法：使用无害的病毒使啮齿动物细胞更易受感染。
新型冠状病毒依靠与细胞表面的蛋白受体结合侵入人体细胞，蛋白受体包括一种叫ACE2*。小鼠有不同构型的ACE2受体，这使小鼠细胞更加难以被新型冠状病毒渗透与感染。带有人的转基因小鼠相较普通小鼠更易感染，但较为少见。
为了建立更广泛可得的的小鼠感染模型，一支由密苏里州，圣路易斯市，华盛顿大学的麦克•戴蒙德带领的团队与中国广州医科大学附属第一医院的赵金存教授的团队使用腺病毒—一种基因疗法的主力，用来将人的ACE2基因导入目标小鼠的肺部细胞。在暴露在有新型冠状病毒的环境下后，这种小鼠体重降低并表现出肺炎症状。
>impervious抗渗透的—previous 透水的，可通过的 adj.
>susceptible易受影响的，易感的 adj.
♦adenoviruses 腺病毒n.
>Affiliate 附属 v. [Affiliate with 与...产生关联（正式）近义：join up with、associate with]
>workhorse 主力，功臣 n.
*血管紧张素转化酶2，新型冠状病毒表面受体，与SARS病毒受体相同
-原文：https://www.nature.com/articles/d41586-020-00502-w
