【文献速递】【Nature】【2022年】【3月】
声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。
增强酶
Biaryl compounds, which contain two connected aromatic rings, are common throughout chemistry, medicine and materials science. Joining together the individual molecular components to form these compounds can be a challenge. In this week’s issue, Alison Narayan and her colleagues report the design and engineering of enzyme biocatalysts that help to connect the necessary building blocks through their carbon–hydrogen bonds. The researchers used engineered forms of cytochrome P450 enzymes as the catalyst, and as a result were able to transform a low-yielding, unselective reaction into one that efficiently joined phenols to form biaryl compounds with control over both which C–H bonds are coupled and the stereochemistry of the products.
含有两个相连芳环的联芳基化合物在化学、医学和材料科学中很常见。 将各个分子成分连接在一起以形成这些化合物可能是一项挑战。 在本周的期刊中，Alison Narayan 和她的同事报告了酶生物催化剂的设计和工程，这些酶生物催化剂有助于通过碳氢键连接必要的构建块。 研究人员使用工程形式的细胞色素 P450 酶作为催化剂，因此能够将低产率、非选择性的反应转化为有效连接酚类以形成联芳基化合物的反应，同时控制 C-H 键的偶联和 产物的立体化学。
预测过去
Inscriptions provide an invaluable insight into the ancient world. But over the centuries, many inscriptions have been damaged and exist in fragmented or semi-legible forms, making the job of reading and interpreting them extremely difficult. In this week’s issue, Yannis Assael, Thea Sommerschield and their team introduce Ithaca, a deep neural network designed to help historians restore and understand ancient Greek inscriptions. Working alone, Ithaca is able to restore damaged texts with a 62% accuracy, but when historians use Ithaca, their accuracy on the same task rises to 72%. Ithaca can also determine the original geographical location of inscriptions with 71% accuracy, and can date them to within 30 years from the date ranges proposed by historians. The researchers say that such cooperation between artificial intelligence and historians could help transform studies of the ancient world.
铭文提供了对古代世界的宝贵见解。 但几个世纪以来，许多铭文已被损坏，并以支离破碎或半清晰的形式存在，这使得阅读和解释它们的工作变得极其困难。 在本周的期刊中，Yannis Assael、Thea Sommerschield 和他们的团队介绍了 Ithaca，这是一种深度神经网络，旨在帮助历史学家修复和理解古希腊铭文。 单独工作时，Ithaca能够以 62% 的准确率恢复损坏的文本，但当历史学家使用Ithaca时，他们在同一任务上的准确率上升到 72%。 Ithaca还可以以 71% 的准确度确定铭文的原始地理位置，并且可以将它们追溯到历史学家提出的日期范围的 30 年以内。 研究人员表示，人工智能与历史学家之间的这种合作可能有助于改变对古代世界的研究。
基因精灵
For more than 50 years, scientists have been trying to understand the relationship between DNA sequence, gene-expression phenotype and fitness to decipher principles of gene regulatory evolution. In this week’s issue, Eeshit Dhaval Vaishnav, Carl de Boer, Aviv Regev and their colleagues present a framework for understanding and engineering regulatory DNA sequences that takes a step towards this goal. The researchers built this framework around an ‘oracle’ they developed using a deep neural network model that predicts gene expression given a promoter DNA sequence. The neural network was trained using the expression measurements for tens of millions of promoter sequences. The result was an AI oracle that predicts expression from sequence well enough to study the evolutionary history and future evolvability of regulatory DNA sequences, as well as to design regulatory DNA sequences for synthetic biology applications. The cover offers a visual representation of the evolutionary properties of sequences at the extremes of the evolvability spectrum.
50 多年来，科学家们一直试图了解 DNA 序列、基因表达表型和适应性之间的关系，以破译基因调控进化的原理。 在本周的期刊中，Eeshit Dhaval Vaishnav、Carl de Boer、Aviv Regev 及其同事提出了一个框架，用于理解和工程化调控 DNA 序列，朝着这一目标迈出了一步。 研究人员围绕他们使用深度神经网络模型开发的“oracle”构建了这个框架，该模型可以预测给定启动子 DNA 序列的基因表达。 使用数千万启动子序列的表达测量来训练神经网络。 其结果是一个 AI oracle，它可以很好地预测序列的表达，以研究调节 DNA 序列的进化历史和未来的进化能力，以及为合成生物学应用设计调节 DNA 序列。 封面提供了进化谱极端序列的进化特性的可视化表示。
星际约会者的银河系指南
The cover image shows a view of the Milky Way captured at Nambung National Park in Western Australia. To understand how the Galaxy formed requires precision age dating of the stars that it contains. In this week’s issue, Maosheng Xiang and Hans-Walter Rix of the Max Planck Institute for Astronomy in Heidelberg, Germany, present an analysis of the birth dates for nearly 250,000 stars in their subgiant evolutionary phase, when they can serve as precise stellar clocks. The researchers found that the individual ages of the stars ranged from about 1.5 billion to more than 13 billion years old. Tripling the age-dating precision for such a large stellar sample allowed the researchers to infer the sequence of events that initiated our Galaxy’s formation. Using this information, Xiang and Rix were able to determine that the oldest part of our Galaxy’s disk had already begun to form about 13 billion years ago, just 800 million years after the Big Bang, and that the formation of the inner Galactic halo was completed some 2 billion years later.
封面图片展示了在西澳大利亚州南邦国家公园拍摄的银河景观。 要了解银河系是如何形成的，需要对它所包含的恒星进行精确的年龄测定。 在本周的期刊中，德国海德堡马克斯普朗克天文学研究所的 Maosheng Xiang 和 Hans-Walter Rix 对近 250,000 颗处于亚巨星演化阶段的恒星的诞生日期进行了分析，当它们可以作为精确的恒星时钟时。 研究人员发现，恒星的个体年龄从大约 15 亿岁到超过 130 亿岁不等。 将如此大的恒星样本的年龄测定精度提高三倍，使研究人员能够推断出引发我们银河系形成的事件顺序。 利用这些信息，Xiang 和 Rix 能够确定我们银河系最古老的部分在大约 130 亿年前就已经开始形成，也就是大爆炸之后的 8 亿年，并且银河系内晕的形成已经完成 大约 20 亿年后。
电话连接
The cover shows Yournina Akinyi using her mobile phone at her produce stand in Matasia village, Kenya. In this week’s issue, Joshua Blumenstock and his colleagues show how big data derived from mobile phone networks can improve the targeting of humanitarian aid. Rapid identification of those in greatest need is a significant challenge during a crisis. Blumenstock and his team used conventional survey data to train machine-learning algorithms to recognize patterns of poverty in mobile phone data. Their method was then used in Togo to distribute millions of dollars in COVID-19 relief. The researchers found that compared with more conventional targeting methods, their machine-learning approach reduced the proportion of individuals in need who missed out on aid by 4–21%, suggesting that data sources such as phones could enhance aid distribution in times of crisis.
封面展示了 Yournina Akinyi 在肯尼亚 Matasia 村的农产品摊位上使用她的手机。 在本周的期刊中，约书亚·布卢门斯托克 (Joshua Blumenstock) 和他的同事们展示了来自移动电话网络的大数据如何提高人道主义援助的针对性。 快速识别最需要帮助的人是危机期间的一项重大挑战。 Blumenstock 和他的团队使用传统的调查数据来训练机器学习算法，以识别手机数据中的贫困模式。 他们的方法随后在Togo被用于分发数百万美元的 COVID-19 救济金。 研究人员发现，与更传统的定位方法相比，他们的机器学习方法将错过援助的有需要的人的比例降低了 4-21%，这表明电话等数据源可以在危机时期加强援助分配。
1.Mechanism underlying a risk gene in neurodegeneration
神经退行性中的潜在风险基因机制
2.Plasmas primed for rapid pulse production
等离子体用于快速脉冲产生
3.From the archive
来自档案
4.Isotopes tracked on a sub-nanometre scale using electron spectroscopy
使用电子光谱法以亚纳米量表跟踪的同位素
5.Light-dependent development is tailored in visual neurons
光依赖性发育是在视觉神经元中量身定制的
6.Lung microbes mediate spinal-cord autoimmunity
肺微生物介导脊柱自身免疫性
7.Progress and prospects in magnetic topological materials
磁拓扑材料的进度和前景
8.A persistent ultraviolet outflow from an accreting neutron star binary transient
从中子恒星二进制瞬变中持续的紫外线流出
9.Recovery time of a plasma-wakefield accelerator
等离子体效率加速器的恢复时间
10.High-density switchable skyrmion-like polar nanodomains integrated on silicon
集成在硅上的高密度可切换的类似skyrmion的极性纳米域
11.Imaging of isotope diffusion using atomic-scale vibrational spectroscopy
使用原子尺度振动光谱学对同位素扩散的成像
12.All-perovskite tandem solar cells with improved grain surface passivation
全绿化晶状体串联太阳能电池，具有改善的晶粒表面钝化
13.Biocatalytic oxidative cross-coupling reactions for biaryl bond formation
双芳香键形成的生物催化氧化交叉偶联反应
14.A wet heterogeneous mantle creates a habitable world in the Hadean
一个湿的异质地幔在哈迪恩创造了一个可居住的世界
15.The Mesozoic terminated in boreal spring
中生代在北方春季终止
16.Genetic associations of protein-coding variants in human disease
人类疾病中蛋白质编码变体的遗传关联
17.Determinants of emissions pathways in the coupled climate–social system
结合气候 - 社会系统中排放途径的决定因素
18.A global timing mechanism regulates cell-type-specific wiring programmes
全球定时机制调节细胞类型特定的接线程序
19.A biophysical account of multiplication by a single neuron
单个神经元繁殖的生物物理说明
20.TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
TDP-43抑制FTD – ALS基因UNC13A中的隐性外显子包含
21.TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
TDP-43损失和ALS风险SNP驱动UNC13A的错误拼接和耗尽
22.The lung microbiome regulates brain autoimmunity
肺微生物组调节脑自身免疫性
23.The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Covid-19中CGA-sting途径驱动I型IFN的免疫病理学
24.Twin study reveals non-heritable immune perturbations in multiple sclerosis
双胞胎研究揭示了多发性硬化症中无遗物的免疫扰动
25.Low-dose metformin targets the lysosomal AMPK pathway through PEN2
低剂量二甲双胍通过PEN2靶向AMPK途径溶菌酶
26.Effective drug combinations in breast, colon and pancreatic cancer cells
乳腺癌，结肠和胰腺癌细胞中的有效药物组合
27.Structure and receptor recognition by the Lassa virus spike complex
LASSA病毒尖峰复合物的结构和受体识别
28.Structural architecture of the human NALCN channelosome
人类NALCN通道体的结构
29.Self-assembly of molecules triggered by electricity
由电触发的分子的自组装
30.Epstein–Barr virus sparks brain autoimmunity in multiple sclerosis
Epstein–Barr病毒在多发性硬化症中激发脑自身免疫性
31.Light arrays measure up on a chip the size of a fingertip
光阵列在指尖大小的芯片上测量
32.Letters and cards telling people about local police reduce crime
信件和卡告诉人们当地警察的信息减少犯罪
33.AI minds the gap and fills in missing Greek inscriptions
AI注意到差距并填补了缺少的希腊铭文
34.AGN as potential factories for eccentric black hole mergers
AGN作为偏心黑洞合并的潜在工厂
35.Ultra-narrow optical linewidths in rare-earth molecular crystals
稀土分子晶体中的超窄光线宽度
36.Structure of the moiré exciton captured by imaging its electron and hole
通过成像其电子和孔捕获的Moiré激子的结构
37.A large-scale microelectromechanical-systems-based silicon photonics LiDAR
大规模微电机电系统基于硅光子剂激光雷达
38.Vertical MoS2 transistors with sub-1-nm gate lengths
垂直MOS2晶体管，具有亚1-nm栅极长度
39.Electron-catalysed molecular recognition
电子催化分子识别
40.Au–Pd separation enhances bimetallic catalysis of alcohol oxidation
Au – Pd分离增强了酒精氧化的双金属催化
41.Weak cubic CaSiO3 perovskite in the Earth’s mantle
地幔上的薄弱立方CaSiO3钙钛矿
42.Restoring and attributing ancient texts using deep neural networks
使用深神经网络恢复和归属古代文本
43.Innovative ochre processing and tool use in China 40,000 years ago
40，000年前，中国创新的Ocher加工和工具使用
44.Ancient DNA and deep population structure in sub-Saharan African foragers
撒哈拉以南非洲觅食者的古代DNA和深层人口结构
45.Knowledge about others reduces one’s own sense of anonymity
对他人的知识减少了自己的匿名感
46.Differential mechanisms underlie trace and delay conditioning in Drosophila
差异机制是果蝇中的痕量和延迟调节的基础
47.Molecular hallmarks of heterochronic parabiosis at single-cell resolution
单细胞分辨率的异核抛物线的分子标志
48.The bacterial toxin colibactin triggers prophage induction
细菌大肠菌素触发噬菌体诱导
49.Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM
多发性硬化症中的克隆膨胀的B细胞结合EBV EBNA1和GlialCAM
50.A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells
靶向HER2和T细胞的三抗抗体通过CD4细胞抑制乳腺癌的生长
51.Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers
无声突变揭示了RAS Q61癌症中的治疗脆弱性
52.Structural basis for mismatch surveillance by CRISPR–Cas9
CRISPR – CAS9的不匹配监视的结构基础
53.Aquaculture will continue to depend more on land than sea
水产养殖将继续更多地依赖土地而不是海洋
54.Savannahs store carbon despite frequent fires
尽管经常发生火灾，热带稀树草原仍然储存碳
55.Methane might be made by all living organisms
甲烷可能是所有生物体制造的
56.Superfluid confines exotic atoms without disrupting precision measurements
超流体限制外来原子而不会破坏精度测量
57.AI predicts the effectiveness and evolution of gene promoter sequences
AI预测基因启动子序列的有效性和演变
58.The land-to-ocean loops of the global carbon cycle
全球碳循环的土地到海洋循环
59.High-resolution laser resonances of antiprotonic helium in superfluid 4He
超氟4HE中抗磷酸氦的高分辨率激光共振
60.Unbiasing fermionic quantum Monte Carlo with a quantum computer
公正的费米量子蒙特卡洛与量子计算机
61.Steady Floquet–Andreev states in graphene Josephson junctions
石墨烯Josephson连接中的稳定的floquet -andreev状态
62.Wind dispersal of battery-free wireless devices
无电池无线设备的风散
63.Flat-surface-assisted and self-regulated oxidation resistance of Cu(111)
Cu（111）的平表面辅助和自调节的氧化抗性
64.A kinase-cGAS cascade to synthesize a therapeutic STING activator
激酶-cGAS级联反应，以合成治疗性STING激活剂
65.Limited increases in savanna carbon stocks over decades of fire suppression
数十年来的灭火，稀树草纳碳储备的增加有限
66.New land-use-change emissions indicate a declining CO2 airborne fraction
新的土地利用变化排放表明二氧化碳的空气降低分数下降
67.The evolution, evolvability and engineering of gene regulatory DNA
基因调节DNA的进化，发展性和工程化
68.Cortical processing of flexible and context-dependent sensorimotor sequences
柔性和上下文依赖的感觉运动序列的皮质处理
69.FSH blockade improves cognition in mice with Alzheimer’s disease
FSH封锁改善了阿尔茨海默氏病小鼠的认知
70.A non-canonical tricarboxylic acid cycle underlies cellular identity
非经典三羧酸周期是细胞身份的基础
71.Methane formation driven by reactive oxygen species across all living organisms
甲烷形成由所有生物体中的活性氧驱动
72.T cell responses to SARS-CoV-2 spike cross-recognize Omicron
T 细胞对 SARS-CoV-2 刺突的反应交叉识别 Omicron
73.Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron
疫苗对SARS-COV-2 Omicron产生高度保守的细胞免疫力
74.Establishment of fetomaternal tolerance through glycan-mediated B cell suppression
通过聚糖介导的B细胞抑制建立胎儿耐受性
75.Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria
核糖体碰撞诱导细菌中的mRNA裂解和核糖体救援
76.Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue
细菌核糖体通过MutS DNA修复ATP酶旁系同源物感测碰撞
77.Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
在细菌中发现Ni2+依赖性鸟嘌呤水解酶
78.Overcoming universal restrictions on metal selectivity by protein design
克服蛋白质设计对金属选择性的普遍限制
79.Structure determination of high-energy states in a dynamic protein ensemble
在动态蛋白质组装中的高能状态的结构测定
80.The size of the land carbon sink in China
中国土地碳汇的大小
81.Reply to: The size of the land carbon sink in China
回复：中国的土地碳汇的大小
82.On the role of atmospheric model transport uncertainty in estimating the Chinese land carbon sink
大气模型传输不确定性在估算中国陆地碳汇中的作用
83.Reply to: On the role of atmospheric model transport uncertainty in estimating the Chinese land carbon sink
回复：大气模型传输不确定性在估算中国陆地碳汇中的作用
84.Trade-offs between stability and manoeuvrability in bird flight
在鸟类飞行中的稳定性与可操作性之间的权衡
85.A stellar clock reveals the assembly history of the Milky Way
恒星时钟揭示了银河系的组装历史
86.Immune cells alter genetic decoding in cancer
免疫细胞改变癌症中的遗传解码
87.Promising reversible protein inhibitors kept on target
保持在靶标上的潜力可逆蛋白抑制剂
88.A smart sensor that can be woven into everyday life
可以编织到日常生活的智能传感器
89.Human genetic and immunological determinants of critical COVID-19 pneumonia
人类遗传和免疫决定covid-19肺炎的关键
90.A time-resolved picture of our Milky Way’s early formation history
我们银河系早期形成历史的时间分辨图片
91.Optimal metrology with programmable quantum sensors
具有可编程量子传感器的最佳计量器
92.Emergence of Fermi arcs due to magnetic splitting in an antiferromagnet
由于反铁磁体中的磁分裂引起的费米弧的出现
93.Single fibre enables acoustic fabrics via nanometre-scale vibrations
单光纤通过纳米尺度振动启用声学织物
94.High-brightness all-polymer stretchable LED with charge-trapping dilution
高亮度全聚合物可拉伸的带电荷陷阱稀释LED
95.Metastable hexagonal close-packed palladium hydride in liquid cell TEM
液池 TEM 中的亚稳态六方密排氢化钯
96.Boron clusters as broadband membrane carriers
硼簇作为宽带膜载体
97.Geophysical imaging of the Yellowstone hydrothermal plumbing system
黄石水热管系统的地球物理成像
98.Birds can transition between stable and unstable states via wing morphing
鸟可以通过机翼变形在稳定状态和不稳定状态之间过渡
99.Reproducible brain-wide association studies require thousands of individuals
可再现的脑范围协会研究需要数千个人
100.Frontal neurons driving competitive behaviour and ecology of social groups
额叶神经元推动社会群体的竞争行为和生态
101.Cortical ensembles orchestrate social competition through hypothalamic outputs
皮质组装通过下丘脑输出协调社会竞争
102.Immune regulation by fungal strain diversity in inflammatory bowel disease
通过真菌菌株多样性在炎症性肠病中的免疫调节
103.Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa
南部非洲SARS-COV-2 Omicron变体的快速流行病扩展
104.SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
SARS-COV-2 Omicron病毒导致小鼠和仓鼠衰弱疾病
105.Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron
SARS-COV-2 B.1.1.529 Omicron的衰减复制和致病性
106.Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant
SARS-COV-2 Omicron变体的减毒融合性和致病性
107.Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
SARS-COV-2 Omicron使用的TMPRSS2改变了感染力和融合性
108.SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo
SARS-COV-2 Omicron变体在人支气管和离体肺中的复制
109.Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
色氨酸耗竭会导致色氨酸作为苯丙氨酸取代基
110.A genome-scale screen for synthetic drivers of T cell proliferation
T细胞增殖的合成驱动因素的基因组规模筛选
111.Regulation of liver subcellular architecture controls metabolic homeostasis
肝脏亚细胞体系结构的调节控制代谢稳态
112.Activation mechanism of the class D fungal GPCR dimer Ste2
D类真菌GPCR二聚体Ste2的激活机制
113.[{Th(C8H8)Cl2}3]2− is stable but not aromatic
[{Th(C8H8)Cl2}3]2-是稳定但不是芳香的
114.Reply to: [{Th(C8H8)Cl2}3]2− is stable but not aromatic
回复：[{Th(C8H8)Cl2}3]2-是稳定但不是芳香的
115.Models of flow through sponges must consider the sponge tissue
海绵的流动模型必须考虑海绵组织
116.Reply to: Models of flow through sponges must consider the sponge tissue
回复：海绵的流动模型必须考虑海绵组织
117.Bacteria swim faster when obstacles keep them in line
当障碍使它们排队时，细菌游泳更快
118.Mobile mantle could explain volcanic hotspot locations
移动地幔可以解释火山热点位置
119.Mucus secretion blocked at its source in the lungs
粘液分泌在其肺部的来源阻塞
120.From the archive: fishy business in 1972 and 1922
来自档案：1972年和1922年的鱼腥生意
121.Constrained human genes under scrutiny
受到审查的受约束人基因
122.Critical advances and future opportunities in upcycling commodity polymers
升级再造商品聚合物的关键进展和未来机会
123.A highly magnified star at redshift 6.2
红移 6.2的高度放大恒星
124.The colloidal nature of complex fluids enhances bacterial motility
复合液的胶体性质增强了细菌运动能力
125.Catalogue of flat-band stoichiometric materials
平板化学计量材料目录
126.Orbital-resolved visualization of single-molecule photocurrent channels
单分子光电流通道的轨道分辨可视化
127.Observing polymerization in 2D dynamic covalent polymers
观察2D动态共价聚合物中的聚合
128.Trends in Europe storm surge extremes match the rate of sea-level rise
欧洲暴风雨极端的趋势与海平面上升的速度相匹配
129.Assembly of the basal mantle structure beneath Africa
非洲下基础地幔结构的组装
130.Subaqueous foraging among carnivorous dinosaurs
食肉恐龙中的水下觅食
131.Reduced reproductive success is associated with selective constraint on human genes
繁殖成功率降低与对人类基因的选择性约束有关
132.Machine learning and phone data can improve targeting of humanitarian aid
机器学习和电话数据可以改善人道主义援助的目标
133.The development and evolution of inhibitory neurons in primate cerebrum
灵长类动物大脑中抑制性神经元的发展和演变
134.A multidimensional coding architecture of the vagal interoceptive system
迷走神经内感受系统的多维编码体系结构
135.A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk
人类脑血管的地图集揭示了阿尔茨海默氏症风险的各种介体
136.Single-cell dissection of the human brain vasculature
人脑脉管系统的单细胞解剖
137.Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence
FAS介导的杀伤的细菌抑制可促进神经侵袭和持久性
138.Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
人肠道细菌产生ΤΗ17调节胆汁酸代谢物
139.ACE2 binding is an ancestral and evolvable trait of sarbecoviruses
ACE2结合是sarbecoviruses的祖先和可发展的特征
140.Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants
来自三重疫苗的记忆B细胞针对不同的SARS-CoV-2变体
141.A single-cell atlas of human and mouse white adipose tissue
人和小鼠白色脂肪组织的单细胞地图集
142.GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
H3K27M突变的弥漫性中线神经胶质瘤的GD2-CAR T细胞疗法
143.Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer
胃癌中Nivolumab加化学疗法或ipilimumab
144.Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
通过碳氢化合物肽抑制钙触发的分泌
