《急诊每日一题》正确计算组织纤溶酶原聚合物（TPA）剂量重要性2021年4月

Question 问题：

Dosing of alteplase (TPA) for Acute Ischemic Stroke is complex and has been associated with error resulting in an increased rate of hemorrhagic conversions. How often is TPA administered incorrectly?

组织纤溶酶原聚合物（TPA）剂量计算是复杂的，常出现错误，使出血率增加。不正确给予TPA频率是什么？

Answer 答案：

19.8% patients had an error associated with TPA administration. More patients who had an error with alteplase administration (12.7%) experienced a hemorrhagic conversion compared to those with no error in administration (7.2%).

19.8%患者出现与TPA给药相关的错误。与正确给予TPA相比（7.2%），更多TPA给药错误患者继发出血（12.7%）。

参考文献：

 Dancsecs KA, et al. Am J Emerg Med. 2021 Mar 15;47:90-94