Research Grade Anti-RSV F/Fusion glycoprotein F0 (R1.42)
RSV基因组大小约15~16 kb，编码11种蛋白，包括8种结构蛋白和3种非结构蛋白(NS1、NS2和M2-2)，结构蛋白包括3种跨膜表面蛋白(G、F、SH)、2种基质蛋白(M和M2-1)、3种核壳蛋白(L、N和P)。G蛋白介导病毒与宿主细胞的结合，F蛋白介导病毒与宿主细胞膜的融合，使病毒进入细胞内，二者对于病毒复制至关重要，且均含有B细胞和T细胞表位，是刺激机体产生体液和细胞免疫最重要的病毒抗原蛋白。G蛋白编码区变异大，基于其变异可分为A亚型和B亚型，G蛋白诱导的中和抗体具有亚型特异性；F蛋白编码区高度保守，A亚型和B亚型的F蛋白氨基酸序列至少有90%相同，故F蛋白诱导的中和抗体可以同时抑制A、B亚型RSV感染
货号：DVV02815
产品链接：http://www.antibodysystem.com/product/9568.html
物种反应性：Human respiratory syncytial virus A (strain A2)
形式：Liquid
存储缓冲区：0.01M PBS, pH 7.4.
浓度：1 mg/ml
纯度：>95% by SDS-PAGE.
克隆性：Monoclonal
应用Research Grade Biosimilar
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
参考文献：
Virus-like particle vaccine primes immune responses preventing inactivated-virus vaccine-enhanced disease against respiratory syncytial virus. PMID: 28846899
Respiratory Syncytial Virus Attachment Glycoprotein Contribution to Infection Depends on the Specific Fusion Protein. PMID: 26468535
Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis. PMID: 25339762
Replication-competent or attenuated, nonpropagating vesicular stomatitis viruses expressing respiratory syncytial virus (RSV) antigens protect mice against RSV challenge. PMID: 11602747
Meeting report VLPNPV: Session 3: Immune responses. PMID: 25529229
Mucosal Delivery of Recombinant Vesicular Stomatitis Virus Vectors Expressing Envelope Proteins of Respiratory Syncytial Virus Induces Protective Immunity in Cotton Rats. PMID: 33408176
Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. PMID: 9236194
Nonglycosylated G-Protein Vaccine Protects against Homologous and Heterologous Respiratory Syncytial Virus (RSV) Challenge, while Glycosylated G Enhances RSV Lung Pathology and Cytokine Levels. PMID: 26018164
Development of nested PCR assays for detection of bovine respiratory syncytial virus in clinical samples. PMID: 7814551
RSV感染对人类健康有严重的危害，疫苗和抗体制剂研发对预防RSV感染、减少重症和死亡病例具有重要意义。随着对RSV分子结构及机体对RSV免疫应答等方面认识的深入，RSV疫苗研发工作不断向前推进，目前已有30多种候选疫苗进入临床试验阶段。对不同的高危感染人群，应研发不同类型的RSV疫苗。目前在研发中的4大类RSV候选疫苗各有优势和局限性，保证疫苗的安全性和免疫原性是研发面临的主要挑战。其中已有一种疫苗进入Ⅲ期临床试验，但未达到预期结果，还须进一步评估。特定高危人群的被动免疫是另一种预防选择，尽管受益范围有限，目前帕利珠单抗已开始临床应用。比帕利珠单抗更具成本效益的长效单克隆抗体MEDI8897已进入Ⅲ期临床试验，且获得优先研发资格，具有更广阔的应用前景。多克隆免疫球蛋白RI-002已在免疫缺陷人群中显示出较好的预防效果，成本较低，也具有开发应用的现实意义。
