【标题速读】【Ncomm】【biological-sciences】【2022年】【11月】

声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。

1.Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues.

小鼠组织中巨噬细胞的综合蛋白质组和转录组景观。

2.Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain.

解读小鼠大脑中Lyve1+血管周围巨噬细胞的异质性。

3.A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China.

一个具有广泛抗药性的志贺氏菌克隆与中国的水传播疾病爆发有关。

4.Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter.

A组链球菌对磺胺甲噁唑的依赖性抗性由水平获得的还原叶酸转运体介导。

5.Structures of the R-type human CAV2.3 channel reveal conformational crosstalk of the intracellular segments.

R型人类CAV2.3通道的结构显示了细胞内段的构象串联。

6.HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation.

HTLV-1感染供体来源的T细胞可能会促进肝移植后的急性移植物抗宿主疾病。

7.Spatially resolved proteomics via tissue expansion.

通过组织扩张的空间分辨率蛋白质组学。

8.Analysis of the first genetic engineering attribution challenge.

对第一个基因工程归属挑战的分析。

9.Cell type diversity in a developing octopus brain.

发育中的章鱼大脑的细胞类型多样性。

10.The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis.

E3泛素连接酶WWP2调控心脏纤维化中促纤维化单核细胞的浸润和活动。

11.Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo.

自裂导引RNA使体内精确基因编辑事件的药理选择成为可能。

12.Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.

原发性前列腺癌中广泛的雄性激素受体增强子异质性是转录多样性和转移潜力的基础。

13.Automated high-throughput genome editing platform with an AI learning in situ prediction model.

带有人工智能学习原位预测模型的自动化高通量基因组编辑平台。

14.Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma.

全外显子组测序研究确定了与眼内压和青光眼有关的罕见变体和基因。

15.Membrane-mediated protein interactions drive membrane protein organization.

膜介导的蛋白质相互作用驱动膜蛋白组织。

16.Time-resolved β-lactam cleavage by L1 metallo-β-lactamase.

L1金属β-内酰胺酶的时间分辨β-内酰胺裂解。

17.Perfluorodecalin-based oxygenated emulsion as a topical treatment for chemical burn to the eye.

以全氟萘烷为基础的含氧乳液作为眼部化学烧伤的局部治疗方法。

18.Global distribution and climate sensitivity of the tropical montane forest nitrogen cycle.

热带山地森林氮素循环的全球分布和气候敏感性.

19.A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance.

一种核酸酶模拟铂金纳米酶诱导同时进行的DNA排异和氧化裂解，以克服癌症药物抗性。

20.Post-covid medical complaints following infection with SARS-CoV-2 Omicron vs Delta variants.

感染SARS-CoV-2 Omicron与Delta变体后的医疗投诉。

21.Polymer nanoparticles pass the plant interface.

聚合物纳米颗粒通过植物界面。

22.Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity.

人类的视觉意识涉及大规模的皮质和皮质下网络，与任务报告和眼动活动无关。

23.HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.

HSP90-CDC37-PP5形成了一个激酶去磷酸化的结构平台。

24.Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.

四重基因工程的自然杀伤细胞使多抗原靶向对多发性骨髓瘤具有持久的抗肿瘤活性。

25.IL6 supports long-term expansion of hepatocytes in vitro.

IL6支持肝细胞在体外的长期扩张。

26.Evolutionary origins of the prolonged extant squamate radiation.

延长现存鱿鱼辐射的进化起源。

27.Genetically personalised organ-specific metabolic models in health and disease.

健康和疾病中的基因个性化器官特定代谢模型。

28.Engineering receptors in the secretory pathway for orthogonal signalling control.

分泌途径中用于正交信号控制的工程受体。

29.Shedding light on the base-pair opening dynamics of nucleic acids in living human cells.

揭示活人细胞中核酸的碱基对开放动态。

30.Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice.

慢性压力导致雄性小鼠SOM-中间神经元介导的纹状体抑制。

31.Acousto-holographic reconstruction of whole-cell stiffness maps.

全细胞刚度图的声学全息重建。

32.EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis.

EZH2-H3K27me3介导的KRT14上调促进TNBC腹膜转移。

33.A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents.

基于人群的儿童和青少年COVID后综合征患病率和风险因素的血清学研究。

34.Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing.

活性金属硼化物纳米颗粒捕集脂多糖和肽聚糖促进细菌感染的伤口愈合。

35.Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.

溶酶体损伤驱动线粒体蛋白质组重塑并重新规划巨噬细胞的免疫代谢。

36.Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis.

乳腺癌的可塑性受到LATS1-NCOR1压抑轴的限制。

37.Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins.

精氨酸的疏水性导致了富含精氨酸的蛋白质的返流性液-液相分离行为。

38.Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila.

tRNA加工的改变与嗜热四膜动物中一种独特的、不寻常的La蛋白有关。

39.Genomic basis of the giga-chromosomes and giga-genome of tree peony Paeonia ostii.

树状牡丹Paeonia ostii的千兆染色体和千兆基因组的基因组基础。

40.DNA methylation-based classification of sinonasal tumors.

基于DNA甲基化的鼻窦肿瘤分类。

41.SOTIP is a versatile method for microenvironment modeling with spatial omics data.

SOTIP是一种利用空间全息数据进行微环境建模的通用方法。

42.A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.

p38α-BLIMP1信号通路对浆细胞分化至关重要。

43.PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment.

PCGF1-PRC1在造血细胞系承诺期间将染色质压制与DNA复制联系起来。

44.Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury.

染色质可及性动态决定了肾小管上皮细胞对损伤的反应。

45.Gene activation guided by nascent RNA-bound transcription factors.

新生RNA结合的转录因子引导基因激活。

46.Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.

LATS1/2的失活驱动管腔-基底可塑性，启动基底样乳腺癌。

47.The fate of early perichondrial cells in developing bones.

发育中的骨骼中早期软骨周围细胞的命运。

48.Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.

低剂量IL-2降低IL-21+T细胞频率并诱导1型糖尿病的抗炎基因表达。

49.mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome.

mTORC1与斯蒂尔病和巨噬细胞激活综合征实验模型的病理联系。

50.Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer.

炎症促进高微卫星不稳定性结直肠癌对免疫检查点抑制剂的抵抗。

51.Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG.

通过HNF1B对TMPRSS2-ERG的共同控制，广泛的种系-体系相互作用有助于前列腺癌的进展。

52.Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation.

活跃的DNA损伤反应信号启动并维持减数分裂性染色体失活。

53.Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice.

分泌的EMC10在人类肥胖症中上调，其中和抗体可防止饮食诱导的小鼠肥胖症。

54.Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae.

大脑Aβ沉积和神经退行性后遗症的时间性不耦合的实验证据。

55.Plant genetic diversity affects multiple trophic levels and trophic interactions.

植物遗传多样性影响多种营养水平和营养相互作用。

56.Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly.

基因核和染色体驱动的微管成束的转变促进了纺锤体的组装。

57.Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment.

模块化刺激反应水凝胶密封剂用于早期胃肠道泄漏检测和遏制。

58.Predicting protein function and orientation on a gold nanoparticle surface using a residue-based affinity scale.

利用基于残基的亲和力尺度预测金纳米粒子表面的蛋白质功能和取向。

59.Greater genetic diversity is needed in human pluripotent stem cell models.

人类多能干细胞模型需要更大的遗传多样性。

60.CryoEM structure and assembly mechanism of a bacterial virus genome gatekeeper.

细菌病毒基因组守门员的低温EM结构和组装机制。

61.Structural basis for lipid and copper regulation of the ABC transporter MsbA.

脂质和铜对ABC转运体MsbA调节的结构基础。

62.Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase.

正交的糖酵解途径使非经典辅助因子氧化酶的定向进化。

63.Decoding molecular programs in melanoma brain metastases.

解码黑色素瘤脑转移的分子程序。

64.Creb5 coordinates synovial joint formation with the genesis of articular cartilage.

Creb5协调滑膜关节的形成与关节软骨的生成。

65.Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.

真核生物低聚糖转移酶的糖类识别和反应引物的分子基础。

66.Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.

RNA聚合酶II在含有连接物组蛋白H1的染色体上转录的结构基础。

67.Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus.

针对克里米亚-刚果出血热病毒的保护性非中和抗体的结构特征。

68.ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression.

ARID1A缺失诱导多形核髓源性抑制细胞趋化并促进前列腺癌的进展。

69.Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial.

AGILE IIa期临床试验中SARS-CoV-2基因组变异对莫尼帕韦治疗反应的特征。

70.Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.

母体先锋转录因子FoxH1的DNA识别的分子基础。

71.Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication.

Rad52的DNA退火活性驱动与重新启动的DNA复制有关的模板切换。

72.Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018.

2013-2018年中国南方儿童前瞻性队列研究中的肠道病毒A71感染血清流行病学。

73.Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins.

核糖体结合的HMGN蛋白对白色脂肪组织可塑性和能量代谢的表观遗传调节。

74.Increased fire activity under high atmospheric oxygen concentrations is compatible with the presence of forests.

高大气氧浓度下火灾活动的增加与森林的存在相适应。

75.Varying strength of selection contributes to the intragenomic diversity of rRNA genes.

不同强度的选择有助于rRNA基因的基因组内多样性。

76.Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples.

从恢复后的样本中推断出与随后的COVID-19严重程度有关的免疫表型。

77.Gating and ion selectivity of Channelrhodopsins are critical for photo-activated orientation of Chlamydomonas as shown by in vivo point mutation.

通过体内点突变显示Channelrhodopsins的门控和离子选择性对衣藻的光活化定向至关重要。

78.Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death.

肺泡巨噬细胞通过C型凝集素受体进行代谢编程，可防止脂质毒性和细胞死亡。

79.mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity.

mTORC1信号传导促进不同干细胞分化以塑造发育中的小鼠肺部，并与线粒体能力有关。

80.Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry.

通过捕获的离子移动性飞行时间质谱对单个人类细胞的蛋白质翻译后修饰景观的深入了解。

81.A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation.

一种源自海洋海绵的凝集素揭示了血小板生成素受体激活的隐藏途径。

82.PICH acts as a force-dependent nucleosome remodeler.

PICH作为力依赖的核糖体重塑者。

83.Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.

I型干扰素免疫的激活和调节缺陷与COVID-19严重程度的增加有关。

84.Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity.

神经元生长调节剂1的分泌减少有助于肥胖症中脂肪-神经元串扰的受损。

85.Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate.

一种经过处理的丙型肝炎病毒糖蛋白纳米颗粒候选疫苗诱导的交叉中和抗体。

86.A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma.

单细胞分析显示尖锐黑色素瘤的肿瘤异质性和免疫环境。

87.circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.

肉瘤中circCsnk1g3和circAnkib1调控的干扰素反应通过塑造免疫微环境促进肿瘤的发生。

88.Amyloid fibril structure from the vascular variant of systemic AA amyloidosis.

来自系统性AA淀粉样变的血管变体的淀粉样纤维结构。

89.A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly.

用于即时和无线探测心脏器官的柔软和超敏锐的力感应膜片。

90.GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages.

GPSM1通过控制巨噬细胞的促炎症途径损害代谢平衡。

91.Low-dose AAV-CRISPR-mediated liver-specific knock-in restored hemostasis in neonatal hemophilia B mice with subtle antibody response.

低剂量AAV-CRISPR介导的肝脏特异性基因敲入恢复了新生儿血友病B型小鼠的止血功能，并有细微的抗体反应。

92.The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane.

不同弯曲度的洞石的分子组织表明质膜上的可弯曲结构单元。

93.Evaluating cancer etiology and risk with a mathematical model of tumor evolution.

用肿瘤演变的数学模型评估癌症病因和风险。

94.AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics.

AlphaPeptDeep：一个模块化的深度学习框架，用于预测蛋白质组学的肽属性。

95.Resource sharing is sufficient for the emergence of division of labour.

资源共享对分工的出现是充分的。

96.Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets.

产后肠系膜淋巴结基质细胞向网状和CD34+基质细胞亚群的扩展。

97.Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium.

单细胞转录组和生物功能的整合揭示了骨髓内皮细胞的不同行为模式。

98.High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.

利用超分支的尾部纤维高分辨率重建感染胶囊细菌的巨型噬菌体。

99.Genomic disparities between cancers in adolescent and young adults and in older adults.

青少年和年轻人以及老年人的癌症之间的基因组差异。

100.Enhanced access to the human phosphoproteome with genetically encoded phosphothreonine.

用基因编码的磷酸苏氨酸加强对人类磷蛋白组的访问。

101.High-throughput screening of caterpillars as a platform to study host–microbe interactions and enteric immunity.

以毛虫的高通量筛选作为研究宿主-微生物相互作用和肠道免疫的平台。

102.Global landscape of replicative DNA polymerase usage in the human genome.

人类基因组中复制性DNA聚合酶使用的全球情况。

103.Critical Offset Magnetic PArticle SpectroScopy for rapid and highly sensitive medical point-of-care diagnostics.

用于快速和高度敏感的医疗点诊断的临界偏移磁悬浮粒子光谱仪。

104.CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease.

CXCL13是特发性多中心卡斯尔曼病的预测性生物标志物。

105.AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.

AMPK诱导转录抑制器PROX1的降解，损害支链氨基酸的代谢和肿瘤的发生。

106.Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment.

原药纳米组合中的混合黄铜键在肿瘤微环境中提供双重氧化还原反应。

107.Uptake mechanism of iron-phytosiderophore from the soil based on the structure of yellow stripe transporter.

基于黄色条纹转运体结构的土壤中铁-植物苷脂的吸收机制。

108.Primate-specific transposable elements shape transcriptional networks during human development.

灵长类特异性可转录元素在人类发育过程中塑造转录网络。

109.Spatially aware dimension reduction for spatial transcriptomics.

用于空间转录组学的空间感知降维。

110.A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry.

一个类错配的TCR通过一个非正统但功能齐全的结合几何学绕过了MHC的限制。

111.Phase separation modulates the assembly and dynamics of a polarity-related scaffold-signaling hub.

相分离调控极性相关支架-信号枢纽的组装和动态。

112.Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies.

种系BRCA1/2突变肿瘤的逆转突变揭示了非经典组织学中BRCA介导的表型。

113.Comparison of antibody responses to SARS-CoV-2 variants in Australian children.

澳大利亚儿童对SARS-CoV-2变种的抗体反应比较。

114.Kinetics of mRNA nuclear export regulate innate immune response gene expression.

mRNA核出口的动力学调节先天免疫反应基因的表达。

115.Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor.

基于合成方法的库的构建及其在鉴定GIT/PIX蛋白-蛋白相互作用抑制剂中的应用。

116.Smc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures.

Smc5/6的多方面DNA结合能力稳定了支链DNA结构。

117.Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.

成骨细胞/造血干细胞衍生的白细胞介素-11调控成骨和系统性脂肪生成。

118.Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo.

在体外和体内编辑线粒体或核DNA的紧凑型锌指基编辑。

119.RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway.

RNA控制的mRNA衰变因子的核细胞质穿梭调节mRNA的合成和一种新的mRNA衰变途径。

120.Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease.

阿尔茨海默病中骨髓细胞表型和对中枢神经系统反应的差异区划。

121.Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

阿尔茨海默病相关的蛋白激酶Cα变体的活性增强促使小鼠模型的认知能力下降。

122.Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound.

一个氧化酶的结构和计算辅助工程，从木质素衍生的化合物中产生异丁香酚。

123.GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies.

GhostKnockoff推断增强了全基因组关联研究中推定因果变体的识别能力。

124.Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment.

多组学分析确定了具有不同预后的骨肉瘤亚型，表明分层治疗。

125.Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models.

聚合物胶束有效地重塑了肿瘤微环境，增强了小鼠乳腺癌模型的纳米免疫疗法。

126.Genomic signatures of recent convergent transitions to social life in spiders.

蜘蛛近期向社会生活的趋同过渡的基因组特征。

127.High-precision estimation of emitter positions using Bayesian grouping of localizations.

利用贝叶斯定位分组对发射器位置进行高精度估计。

128.Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature.

基于显微镜的金黄色葡萄球菌临床分离物感染的表型分析揭示了细胞内生活方式是一个普遍的特征。

129.Sampling of structure and sequence space of small protein folds.

小型蛋白质褶皱的结构和序列空间的取样。

130.Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete.

莱姆病螺旋体的多倍体、基因组拷贝的规则模式化和DNA分区的异常控制。

131.A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes.

一个非编码的GWAS变体影响了人类iPSC衍生的心肌细胞中蒽环类药物诱导的心脏毒性表型。

132.CRISPR-Cas12a induced DNA double-strand breaks are repaired by multiple pathways with different mutation profiles in Magnaporthe oryzae.

CRISPR-Cas12a诱导的DNA双链断裂在木兰花菌中通过多种途径修复，其突变情况不同。

133.Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction.

功能整合型纳米颗粒缓解妊娠期深静脉血栓并挽救宫内生长受限。

134.Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy.

由生姜衍生的细胞外囊泡组成的生物仿生电动纳米颗粒用于协同抗感染治疗。

135.Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient.

肠道到肺部的转位和抗生素介导的选择塑造了ICU病人中铜绿假单胞菌的动态。

136.Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.

长非编码RNA DIO3OS诱导糖酵解主导的代谢重编程，促进乳腺癌中芳香化酶抑制剂的抗性。

137.Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis.

鞘氨醇1-磷酸介导对脂质平衡和胚胎发育至关重要的脂肪素受体信号传递。

138.SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.

SENP1通过抑制RIPK1驱动的细胞凋亡和炎症来预防脂肪性肝炎。

139.Ancient oral microbiomes support gradual Neolithic dietary shifts towards agriculture.

古代口腔微生物组支持新石器时代的饮食逐渐向农业转变。

140.Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS.

过早终止的保留内含子的mRNA在SFPQ无效驱动的神经变性中侵入轴突，是ALS的一个标志。

141.Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture.

绘制怀孕对静止状态大脑活动、白质微结构、神经代谢物浓度和灰质结构的影响。

142.Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity.

扩大交叉呈递的树突状细胞可增强溶瘤病毒治疗，对长期抗肿瘤免疫至关重要。

143.Wildflower phenological escape differs by continent and spring temperature.

野花的物候逃逸因大陆和春季温度而不同。

144.DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs.

DeepPROTACs是一个基于深度学习的PROTACs定向降解预测器。

145.Leveraging data-driven self-consistency for high-fidelity gene expression recovery.

利用数据驱动的自洽性进行高保真基因表达恢复。

146.Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB.

核受体REV-ERB的合成激动剂激活的结构基础。

147.Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling.

肺泡细胞的命运选择和FGF信号对AT2细胞的终身维护。

148.Renewal of planktonic foraminifera diversity after the Cretaceous Paleogene mass extinction by benthic colonizers.

白垩纪古生物大灭绝后底栖殖民者对浮游有孔虫多样性的更新。

149.Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase.

激活的星形胶质细胞通过驱动Na+-K+-ATP酶减弱啮齿动物模型中的新皮质发作。

150.Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability.

B型急性淋巴细胞白血病的调控组分析暴露了核心结合因子成瘾的治疗弱点。

151.Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin.

高度结晶的聚对苯二甲酸乙二醇酯的生物降解通过细菌PET酶和疏水性蛋白的细胞表面共同显示。

152.Structural basis for activation of DNMT1.

激活DNMT1的结构基础。

153.A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias.

一种CRISPR内切酶基因驱动揭示了不同的遗传偏向机制。

154.Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11.

染色体分离的保真度需要癌症下调酶TTLL11的微管聚谷氨酸化。

155.Biotechnologically produced chitosans with nonrandom acetylation patterns differ from conventional chitosans in properties and activities.

具有非随机乙酰化模式的生物技术生产的壳聚糖在特性和活性上与传统壳聚糖不同。

156.Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration.

CD206+M2类巨噬细胞的耗竭诱导纤维脂肪生成祖细胞的激活和肌肉再生。

157.Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4.

胆固醇诱导的LRP3下调通过靶向Syndecan-4促进骨关节炎的软骨变性。

158.Multi-omics signatures of the human early life exposome.

人类生命早期暴露组的多组学特征。

159.Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections.

野生型SARS-CoV-2疫苗的抗原罪在BA.2突破性感染中对BA.4/5/2.75亚变体的交叉中和作用不佳。

160.Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity.

机械敏感信号和主动力量之间的反馈制约着内皮细胞连接的完整性。

161.PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation.

PPARγ脂肪变异体揭示了增强子激活所需的分子间相互作用。

162.Structure of the human heparan sulfate polymerase complex EXT1-EXT2.

人类肝素硫酸盐聚合酶复合物EXT1-EXT2的结构。

163.How people wake up is associated with previous night’s sleep together with physical activity and food intake.

人们如何醒来与前一晚的睡眠连同身体活动和食物摄入有关。

164.Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling.

突变的RIG-I通过激活circRIG-I信号增强了癌症相关的炎症。

165.Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5α autoubiquitylation.

RING三聚体的结构和功能不对称性控制了TRIM5α自泛素化的引申和延伸事件。

166.How Carvedilol activates β2-adrenoceptors.

卡维地洛如何激活β2-肾上腺素受体.

167.Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers.

整合转录因子占用与全转录组关联分析，确定人类癌症的易感基因。

168.Transposable element-mediated rearrangements are prevalent in human genomes.

可转座元素介导的重排在人类基因组中普遍存在。

169.Deep learning to decompose macromolecules into independent Markovian domains.

深度学习将大分子分解为独立的马尔科夫域。

170.Consistent diel activity patterns of forest mammals among tropical regions.

热带地区森林哺乳动物一致的昼夜活动模式。

171.DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance.

DNA的机械灵活性控制着激活cGAS介导的免疫监视的DNA潜能。

172.PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis.

PEAR1调控肺纤维化中活化成纤维细胞的扩张和细胞外基质的沉积。

173.The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells.

DNA聚合酶epsilon在人类细胞复制启动中的非催化作用。

174.Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation.

药物抑制HDAC6可通过Smad3乙酰化下调TGF-β，改善肌营养不良小鼠的肌肉表型。

175.BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy.

新陈代谢压力激活BRAF促进糖酵解使NRASQ61突变的黑色素瘤对靶向治疗敏感。

176.Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population.

阿拉伯人口中2型糖尿病亚型的代谢和蛋白质组学特征。

177.Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.

与DNA寡核苷酸抑制剂结合的具有催化活性的APOBEC3G的结构显示了过渡态的四面体几何结构。

178.Phosphorylation disrupts long-distance electron transport in cytochrome c.

磷酸化破坏了细胞色素c的长距离电子运输。

179.A Myb enhancer-guided analysis of basophil and mast cell differentiation.

嗜碱细胞和肥大细胞分化的MYB增强器引导的分析。

180.A glutamine-based single α-helix scaffold to target globular proteins.

以谷氨酸为基础的单α螺旋支架瞄准球状蛋白。

181.Prioritizing autoimmunity risk variants for functional analyses by fine-mapping mutations under natural selection.

通过自然选择下的精细映射突变，优先考虑自身免疫风险变体的功能分析。

182.An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation.

淀粉样蛋白聚集图谱：替代、插入、缺失和截断对淀粉样蛋白β纤维核的影响。

183.A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome.

结核分枝杆菌H37Rv参考基因组的全面更新。

184.A widespread group of large plasmids in methanotrophic Methanoperedens archaea.

嗜甲烷的Methanoperedens古菌中广泛存在的一组大型质粒。

185.Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions.

G1中不定期的DNA复制导致了基因组的不稳定和表明复制碰撞的损伤特征。

186.Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.

疫苗病毒对细胞膜DNA感应失活的结构基础。

187.The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis.

异染色质蛋白1是溃疡性结肠炎中RNA剪接精确性缺乏的调节器。

188.Cancer cell survival depends on collagen uptake into tumor-associated stroma.

癌细胞的生存取决于对肿瘤相关基质的胶原蛋白摄取。

189.Biological effects of the loss of homochirality in a multicellular organism.

多细胞生物体中同源性丧失的生物学效应。

190.A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1.

一个氧化还原开关调控AcrIIC1的组装和抗CRISPR活性。

191.Pre-equilibrium biosensors as an approach towards rapid and continuous molecular measurements.

预平衡生物传感器是实现快速和连续分子测量的一种方法。

192.Donor-strand exchange drives assembly of the TasA scaffold in Bacillus subtilis biofilms.

供体链交换驱动TasA支架在枯草芽孢杆菌生物膜中的组装。

193.Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones.

ProQ/FinO域RNA伴侣识别转录终止器结构的结构基础。

194.Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense.

血液缺乏的新陈代谢和细胞分化受损，作为人类感染性的一种进化权衡，氏甘比亚锥虫。

195.Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis.

系统性硬化症中的中心粒缺陷、染色体不稳定和cGAS-STING激活。

196.Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.

偏重ELMO2的构象，揭示了可以利用肌细胞融合来改善肌肉再生。

197.Impact of pulmonary African trypanosomes on the immunology and function of the lung.

肺部非洲锥虫对肺部免疫学和功能的影响。

198.Developing medical imaging AI for emerging infectious diseases.

为新出现的传染病开发医学成像AI。

199.Global crop yields can be lifted by timely adaptation of growing periods to climate change.

通过及时调整生长期以适应气候变化，全球作物产量可得到提升。

200.Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models.

去甲肾上腺素转运体缺陷导致家族性自闭症模型中交感神经过度活跃。

201.Transposable elements maintain genome-wide heterozygosity in inbred populations.

可转座元素维持近交系种群的全基因组杂合性。

202.Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis.

骨髓瘤及其前体条件的单细胞特征显示了早期肿瘤发生的转录特征。

203.Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

肿瘤队列中的体细胞突变分布为癌症的正向选择提供了信号。

204.TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.

TOPOVIBL-REC114相互作用调控减数分裂期DNA双链断裂。

205.CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing.

CRY2与CIS1相互作用，通过FLM替代剪接调节热敏花。

206.Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity.

T细胞受体和CD4与肽-MHC的合作性结合增强了抗原敏感性。

207.CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids.

CHD7调控人类内耳器官中的听觉谱系规范和毛细胞分化。

208.Activation and signaling mechanism revealed by GPR119-Gs complex structures.

GPR119-Gs复合物结构所揭示的激活和信号传导机制。

209.Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.

鉴定嘌呤生物合成为NADH感应途径以介导能量压力。

210.mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters.

mTOR抑制通过诱导化疗耐药性持久性减弱化疗敏感性。

211.Patterned mechanical feedback establishes a global myosin gradient.

模式化的机械反馈建立了一个全球性的肌球蛋白梯度。

212.Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A.

中性粒细胞在透析过程中对血管周细胞层的突破需要肥大细胞派生的IL-17A。

213.Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas.

睫状神经营养因子介导的神经保护涉及变性小鼠视网膜的糖酵解和新陈代谢增强。

214.A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice.

Glb1-2A-mCherry报告器监测系统老化并预测中年小鼠的寿命。

215.The evolution of reproductive modes and life cycles in amphibians.

两栖动物的繁殖模式和生命周期的进化。

216.Host biology, ecology and the environment influence microbial biomass and diversity in 101 marine fish species.

宿主生物学、生态学和环境影响101种海洋鱼类的微生物生物量和多样性。

217.Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter.

与猫咪收容所中极端AA淀粉样变流行相关的体外纤维的低温电镜结构。

218.Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism.

从胚胎干细胞中产生的可移植的人类甲状腺器官以拯救甲状腺功能减退症。

219.Feedforward growth rate control mitigates gene activation burden.

前馈生长速率控制减轻了基因激活负担。

220.H2A.Z deposition by SWR1C involves multiple ATP-dependent steps.

SWR1C的H2A.Z沉积涉及多个ATP依赖性的步骤。

221.Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites.

蚊子叮咬人体模型中皮肤免疫反应的评价。

222.N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.

N6-甲基腺苷修饰通过稳定糖原合成酶2 mRNA来调控肝脏糖的生成。

223.Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.

五聚体配体门控离子通道的开放通道结构揭示了小叶特异性磷脂调节的机制。

224.A multicentre single arm phase 2 trial of neoadjuvant pyrotinib and letrozole plus dalpiciclib for triple-positive breast cancer.

新辅助Pyrotinib和letrozole加dalpiciclib治疗三阳性乳腺癌的多中心单臂2期试验。

225.The endocannabinoid anandamide is an airway relaxant in health and disease.

健康和疾病中的内源性安非他命是一种气道松弛剂。

226.XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection.

靶向SARS-CoV-2基因组的XNA酶可抑制病毒感染。

227.YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro.

YAP促进细胞自主免疫反应，以应对体外的细胞内金黄色葡萄球菌。

228.Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1.

在SARS-CoV-2 Omicron BA.1中，补偿性外显作用维持ACE2的亲和力。

229.CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.

CBP-HSF2在Rubinstein-Taybi神经发育障碍中的结构和功能相互作用。

230.Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.

激动剂结合的Hsp90-XAP2-AHR细胞膜复合物的低温EM结构。

231.Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.

对疟原虫传播至关重要的驱动蛋白马达的机械化学调控。

232.RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth.

RasGRP1促进急性炎症反应并限制炎症相关的癌细胞生长。

233.Understanding VPAC receptor family peptide binding and selectivity.

了解VPAC受体家族的肽结合和选择性。

234.Increased slow dynamics defines ligandability of BTB domains.

增加的慢速动力学定义了BTB结构域的配位性。

235.F-actin architecture determines constraints on myosin thick filament motion.

F-actin结构决定了对肌球蛋白粗丝运动的限制。

236.Global disparities in SARS-CoV-2 genomic surveillance.

SARS-CoV-2基因组监测的全球差异。

237.Ascertaining cells’ synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries.

用条形码狂犬病毒库同时确定细胞的突触连接和RNA表达。

238.Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity.

干扰素-λ治疗加速了SARS-CoV-2的清除，尽管与年龄有关的T细胞免疫的诱导延迟了。

239.Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores.

休眠孢子中由PI31样肽结合的还原小孢子虫蛋白体的结构。

240.Interruption of post-Golgi STING trafficking activates tonic interferon signaling.

高尔基体后STING贩运的中断激活了强直性干扰素信号。

241.Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny.

肌肉5：高精度的排列组合能够对序列同源性和系统发育进行无偏见的评估。

242.Ordovician opabiniid-like animals and the role of the proboscis in euarthropod head evolution.

奥陶纪类鸦片动物和长鼻器在欧亚大陆动物头部进化中的作用。

243.Two simple movement mechanisms for spatial division of labour in social insects.

社会性昆虫空间分工的两种简单运动机制。

244.Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice.

基于粘膜TLR2激活蛋白的疫苗接种诱导了小鼠强大的肺部免疫力和对SARS-CoV-2的保护。

245.Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid.

人类多系原心包/心肌器官支持心包/心肌器官的发展。

246.Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms.

帕金森病的元基因组学表明肠道微生物组与多种疾病机制有关。

247.Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster.

带状疱疹痊愈后皮肤中病毒特异性组织驻留T细胞的选择性保留。

248.Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination.

输送方式调节肠道微生物群并影响对疫苗接种的反应。

249.Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis.

拟南芥中通过microRNA协调的辅助信号对雌性生殖系统的规范。

250.Effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy: a national observational study in Israel.

怀孕期间第三次BNT162b2 mRNA COVID-19疫苗接种的有效性：以色列的一项国家观察研究。

251.Prediction of inter-chain distance maps of protein complexes with 2D attention-based deep neural networks.

用基于二维注意力的深度神经网络预测蛋白质复合体的链间距离图。

252.Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics.

对人类冈崎片段成熟的机制调查显示了缓慢的动力学。

308.IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection.

IL-33诱导胸腺内陷相关的幼稚T细胞老化并损害宿主对严重感染的控制。

309.Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food.

压力驱动的下丘脑外侧突触对腹侧被盖区多巴胺神经元的增效作用导致对适口食物的消费增加。

310.Prognostic and predictive value of a pathomics signature in gastric cancer.

胃癌病理组学特征的预后和预测价值。

311.The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria.

严重恶性疟疾患者的白细胞内疟原虫的预后和诊断价值。

312.The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration.

SOD1介导的ALS表型显示出症状发生的年龄与疾病持续时间之间的脱钩关系。

313.A flexible cross-platform single-cell data processing pipeline.

一个灵活的跨平台的单细胞数据处理管道。

314.Computationally designed GPCR quaternary structures bias signaling pathway activation.

计算设计的GPCR四元结构偏重于信号通路的激活。

315.Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans.

秀丽亚人机械感觉回路的性别二形结构和功能。

316.Glycolytic flux control by drugging phosphoglycolate phosphatase.

通过药物治疗磷酸甘油酯磷酸酶来控制糖酵解通量。

317.dcHiC detects differential compartments across multiple Hi-C datasets.

dcHiC检测跨多个Hi-C数据集的差异区间.

318.Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.

小鼠Pax6神经发育疾病模型中大脑突触组结构的发育破坏和恢复。

319.A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain.

第四剂SARS-CoV-2灭活疫苗将体液免疫力重新分配到N端域。

320.Programmable integrin and N-cadherin adhesive interactions modulate mechanosensing of mesenchymal stem cells by cofilin phosphorylation.

可编程的整合素和N-cadherin粘附作用通过cofilin磷酸化调节间充质干细胞的机械感应。

321.Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy.

无处不在的和肌肉的Dynamin 2异构体在肌肉生理学和核心肌病中的不同影响。

322.Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish.

显性ARF3变体破坏了高尔基体的完整性，并导致了在斑马鱼中再现的神经发育障碍。

323.An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice.

抑制小鼠奖励寻求的阿片门控丘脑回路。

324.Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology.

认知维度和精神病理学之间的集体基因组段具有不同的多态性。

325.pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.

pTINCR微蛋白通过CDC42 SUMOylation和激活促进上皮细胞分化并抑制肿瘤生长。

326.Influenza A virus reassortment in mammals gives rise to genetically distinct within-host subpopulations.

哺乳动物中的甲型流感病毒重配产生了遗传上不同的宿主亚群。

327.Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits.

血清IgA水平的遗传调控和对常见的免疫、感染、肾脏和心脑代谢特征的易感性。

328.Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations.

幽门螺旋杆菌在有害突变的替代作用下反复向非洲以外的地区扩展。

329.PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow.

PD-L1通过抑制中性粒细胞从骨髓中释放来负向调节抗真菌免疫力。

330.Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.

骨骼祖细胞的线粒体氧化代谢受损导致肌肉骨骼解体。

331.SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e.

SuperFi-Cas9表现出显著的保真度，但活性严重降低，却能与ABE8e有效配合。

332.A nascent peptide code for translational control of mRNA stability in human cells.

人类细胞中mRNA稳定性的翻译控制的新生肽代码。

333.A click chemistry amplified nanopore assay for ultrasensitive quantification of HIV-1 p24 antigen in clinical samples.

用于临床样本中HIV-1 p24抗原超灵敏定量的点击化学扩增纳米孔检测法。

334.Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.

支配小鼠不同肌肉群的本体感受器亚型的分子特征。

335.Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter.

人类SNAPc识别snRNA启动子近端序列元素的结构基础。

336.Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England.

英国1,542,510名成人研究中COVID-19的变体特异症状。

337.Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.

深度表型和终身轨迹显示长寿调节剂对C57BL/6J小鼠衰老过程的影响有限。

338.Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.

六种神经发育和精神疾病的协调性皮质厚度改变。

339.Design and directed evolution of noncanonical β-stereoselective metalloglycosidases.

非经典的β-立体选择性金属糖苷酶的设计和定向进化。

340.Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism.

双硫仑通过调节肠道微生物群和胆汁酸代谢改善非酒精性脂肪性肝炎。

341.Protein control of photochemistry and transient intermediates in phytochromes.

植物色素中光化学和瞬时中间产物的蛋白质控制。

342.Neural implementation of computational mechanisms underlying the continuous trade-off between cooperation and competition.

合作与竞争之间持续权衡的计算机制的神经实现。

343.Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma.

使肿瘤药物深入渗透的近红外可激活生物仿生纳米凝胶对正位胶质母细胞瘤的抑制。

344.Optical cavity-mediated exciton dynamics in photosynthetic light harvesting 2 complexes.

光合采光2复合物中光腔介导的激子动力学。

345.Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity.

基质FOXF2通过增强抗肿瘤免疫力抑制前列腺癌的进展和转移。

346.The 3D structure of lipidic fibrils of α-synuclein.

α-synuclein的脂质纤维的三维结构。

347.Integrase-mediated differentiation circuits improve evolutionary stability of burdensome and toxic functions in E. coli.

完整性介导的分化回路提高了大肠杆菌中负担性和毒性功能的进化稳定性。

348.Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations.

具有不同外显子19突变的EGFR的不同抑制剂敏感性的生物化学和结构基础。

349.Systematic characterization of cancer transcriptome at transcript resolution.

癌症转录组在转录本分辨率下的系统性特征。

350.Formation of synthetic RNA protein granules using engineered phage-coat-protein -RNA complexes.

利用工程化的噬菌体-衣壳-蛋白质-RNA复合物形成合成的RNA蛋白颗粒。

351.The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.

去泛素酶OTUD1调控多发性骨髓瘤中免疫球蛋白的产生和蛋白酶体抑制剂的敏感性。

352.Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis.

铁蛋白通过Msr1引发中性粒细胞胞外捕集器介导的细胞因子风暴，有助于成年发病的斯蒂尔病的发病机制。

353.An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss.

mTORC1介导的负反馈回路制约了TSC2缺失的肾细胞中氨基酸诱导的FLCN-Rag激活。

354.Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation.

与微管组装在一起的驱动蛋白-1运动域的魔角旋转核磁共振结构揭示了难以捉摸的颈部连接体方向。

355.A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience.

一个保守的基于巨蛋白的分子桥对脂质贩运和抗寒能力至关重要。

356.Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters.

合理减弱的SARS-CoV-2的鼻内递送对叙利亚仓鼠具有免疫原性和保护作用。

357.Fertilization mode differentially impacts the evolution of vertebrate sperm components.

受精模式对脊椎动物精子成分进化的影响不同。

358.Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice.

小鼠慢性脑缺血后血管内皮部署Caveolin-1以调节少突变。

359.De novo identification of microbial contaminants in low microbial biomass microbiomes with Squeegee.

用Squeegee对低微生物生物量微生物组中的微生物污染物进行从头识别。

360.Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.

选择性的PROTAC介导的SMARCA2降解对SMARCA4突变的癌症有效果。

361.An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons.

一种替代剪接调节剂减少了突变体HTT，改善了亨廷顿病患者神经元的分子指纹。

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