【标题速读】【Ncomm】【biological-sciences】【2022年】【1月】
声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。
1.Splicing is an alternate oncogenic pathway activation mechanism in glioma.
剪接是胶质瘤中另一种致癌途径的激活机制。
2.Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex.
双链DNA和BLM调节人类TopoIIIα-RMI1-RMI2复合物的开门。
3.Geminiviruses employ host DNA glycosylases to subvert DNA methylation-mediated defense.
Geminiviruses利用宿主的DNA糖基化酶来颠覆DNA甲基化介导的防御。
4.Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica.
去除番茄红素底物的抑制，使脂溶雅罗菌具有较高的类胡萝卜素生产率。
5.Cerebellar connectivity maps embody individual adaptive behavior in mice.
小脑连接图体现了小鼠的个体适应性行为。
6.CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells.
重定向到细胞表面GRP78的CAR T细胞显示出强大的抗急性骨髓性白血病活性，并且不针对造血祖细胞。
7.Heterogeneity within and among co-occurring foundation species increases biodiversity.
共同出现的基础物种内部和之间的异质性增加了生物多样性。
8.NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model.
NAc-VTA回路是三室代际社会失败压力小鼠模型中情绪压力诱导的焦虑样行为的基础。
9.Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults.
住院成人肠道微生物组中共生菌和致病菌的罕见传播。
10.Reply to: No specific relationship between hypnotic suggestibility and the rubber hand illusion.
答复： 催眠暗示性和橡皮手幻觉之间没有特定的关系。
11.Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing.
间质基质细胞衍生的隔膜细胞在发育期骨化和骨折愈合过程中吸收软骨。
12.Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis.
弧菌胶原酶VhaC的结构提供了对细菌胶原溶解机制的深入了解。
13.Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors.
水和蛋白质动力学在p38α MAP激酶抑制剂的停留时间中的决定性作用。
14.Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections.
宿主受体靶向治疗方法对抗新世界乳腺病毒感染的致病性。
15.Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk.
通过对人乳中的细胞进行单细胞测序揭示哺乳期乳腺的转录变化.
16.No specific relationship between hypnotic suggestibility and the rubber hand illusion.
催眠暗示性与橡胶手幻觉之间没有特定关系。
17.Phloem iron remodels root development in response to ammonium as the major nitrogen source.
韧皮部铁重塑根系发育对作为主要氮源的铵的反应。
18.Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice.
微生物DNA的积累促进了小鼠肥胖症中胰腺炎症和β细胞的异常。
19.Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.
线粒体蛋氨酸腺苷转移酶α1的耗竭引发酒精相关肝病的线粒体功能紊乱。
20.Divalent metal cations stimulate skeleton interoception for new bone formation in mouse injury models.
二价金属阳离子刺激小鼠损伤模型中的骨架互换，促进新骨形成。
21.Population structure analysis and laboratory monitoring of Shigella by core-genome multilocus sequence typing.
通过核心基因组多焦点序列分型对志贺菌进行种群结构分析和实验室监测。
22.A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice.
小鼠佐剂疫苗和减毒活疫苗先天免疫的分子图谱。
23.GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation.
GPCR激酶敲除细胞揭示了个别GRKs对逮捕素结合和GPCR调节的影响。
24.Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module.
尾随氧化酶与非核糖体肽合成酶模块复合的结构和功能。
25.Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis.
呼吸复合物I的突变通过改变细胞内酸度和蛋白质合成促进抗生素的持久性。
26.Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.
胆碱能信号在造血干细胞再生过程中保护造血干细胞的静止状态。
27.Machine learning-informed and synthetic biology-enabled semi-continuous algal cultivation to unleash renewable fuel productivity.
基于机器学习和合成生物学的半连续海藻培养，释放出可再生燃料的生产力。
28.Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins.
Galectin-9通过p62/SQSTM1介导的病毒核心蛋白的选择性自噬来限制乙肝病毒的复制。
29.Carbohydrate-aromatic interface and molecular architecture of lignocellulose.
木质纤维素的碳水化合物-芳香剂界面和分子结构。
30.Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis.
CLN7神经元类脂质变性症中糖酵解酶PFKFB3的异常上调。
31.Multiple conformations of trimeric spikes visualized on a non-enveloped virus.
非包膜病毒上可视化的三聚体尖峰的多种构象。
32.Circularly polarised luminescence laser scanning confocal microscopy to study live cell chiral molecular interactions.
圆偏振发光激光扫描共聚焦显微镜研究活细胞手性分子相互作用。
33.The neglected role of relative humidity in the interannual variability of urban malaria in Indian cities.
相对湿度在印度城市疟疾年际变化中被忽视的作用。
34.Structural basis for safe and efficient energy conversion in a respiratory supercomplex.
呼吸系统超级复合体中安全和高效的能量转换的结构基础。
35.Emerging experience-dependent dynamics in primary somatosensory cortex reflect behavioral adaptation.
初级体感皮层中新出现的经验依赖型动态反映了行为适应性。
36.Non-telecentric two-photon microscopy for 3D random access mesoscale imaging.
用于三维随机存取中尺度成像的非远程中心双光子显微镜。
37.Degradable mesoporous semimetal antimony nanospheres for near-infrared II multimodal theranostics.
可降解介孔半金属锑纳米球用于近红外II多模式治疗学。
38.Citrus Huanglongbing is a pathogen-triggered immune disease that can be mitigated with antioxidants and gibberellin.
柑橘黄龙冰是一种病原体引发的免疫性疾病，可以用抗氧化剂和赤霉素缓解。
39.Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins.
斯坦博霉素模块化多酮体合成酶的工程化产生了37元的迷你斯坦博霉素。
40.Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel.
体液免疫缺陷破坏了胆汁酸的平衡，促进了小肠的炎症性疾病。
41.Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens.
在HTT-polyQ和FUS聚集调节中的DNAJ异构体的不同作用被合剂筛选所揭示。
42.The pollen virome of wild plants and its association with variation in floral traits and land use.
野生植物的花粉病毒组及其与花的性状和土地利用的变化的关系。
43.Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings.
优化基因组学方法，识别医疗机构中耐万古霉素的粪肠球菌传播。
44.Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry.
低CCR5表达可保护精英控制者的HIV特异性CD4+T细胞免受病毒入侵。
45.Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism.
靶向激活中脑神经元可恢复帕金森症小鼠模型的运动功能。
46.The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes.
MuvB复合物结合并稳定细胞周期依赖基因转录起始位点下游的核糖体。
47.Hierarchical and nonhierarchical features of the mouse visual cortical network.
小鼠视觉皮层网络的层次性和非层次性特征。
48.Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities.
绘制乳腺癌脑转移的分子亚型特异性改变，确定临床相关的脆弱性。
49.Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1.
微观骨骼硬度通过Piezo1维持病态血管平滑肌细胞的机械感觉，促进主动脉瘤的发生。
50.Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2.
中性粒细胞胞外陷阱及其组蛋白通过TLR2直接促进Th17细胞的分化。
51.Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations.
绘制帕金森病视觉幻觉的大脑结构差异和神经受体的相关图。
52.A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
一种非催化性的疱疹病毒蛋白通过针对宿主的激酶对接系统重新配置ERK-RSK信号。
53.Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.
异三聚体Gq蛋白作为GRK5/6选择性的开关，是β-arrestin转导器偏向的基础。
54.Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens.
用碱基编辑筛选对人类内胚层分化中的m6A位点进行平行功能评估。
55.USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma.
USP44调控辐照诱导的DNA双链断裂修复并抑制鼻咽癌的肿瘤发生。
56.Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage.
改进的gRNA二级结构允许编辑抗CRISPR-Cas9裂解的目标位点。
57.Nitrogen nutrition contributes to plant fertility by affecting meiosis initiation.
氮素营养通过影响减数分裂的启动对植物的生育能力做出贡献。
58.Characterization of the COPD alveolar niche using single-cell RNA sequencing.
利用单细胞RNA测序对COPD肺泡龛的特征进行分析。
59.Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
对RAS结合所介导的BRAF单体到二聚体转变的结构见解。
60.A self-supervised domain-general learning framework for human ventral stream representation.
用于人类腹腔流表征的自监督领域通用学习框架。
61.Ion currents through Kir potassium channels are gated by anionic lipids.
通过Kir钾通道的离子电流被阴离子脂类所控制。
62.Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity.
管理CRISPR/Cas9特异性的序列决定因素的系统化分解。
63.A genome-wide association study of serum proteins reveals shared loci with common diseases.
血清蛋白的全基因组关联研究揭示了与常见疾病的共享位点。
64.Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification.
聚焦超声通过机械敏感的钙积累和离子通道放大来激发皮质神经元。
65.Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids.
Nodal是一种短程形态发生剂，其活性通过中继机制在人类胃肠道中传播。
66.PHOSPHATE STARVATION RESPONSE transcription factors enable arbuscular mycorrhiza symbiosis.
PHOSPHATE STARVATION RESPONSE转录因子使菌根共生得以进行。
67.Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.
表观遗传修饰物的选择性翻译影响神经干细胞的时间模式和分化。
68.High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.
嗜热真核生物80S核糖体的高分辨率结构揭示了转位的原子细节。
69.Modular assembly of the principal microtubule nucleator γ-TuRC.
主要微管核子γ-TuRC的模块化组装。
70.Coding and regulatory variants are associated with serum protein levels and disease.
编码和调节变体与血清蛋白水平和疾病有关。
71.The evolution of mechanisms to produce phenotypic heterogeneity in microorganisms.
微生物中产生表型异质性的机制的演变。
72.Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome.
免疫球蛋白特征预测急性COVID-19后综合征的风险。
73.Regional excess mortality during the 2020 COVID-19 pandemic in five European countries.
2020年欧洲五国COVID-19大流行期间的区域超额死亡率。
74.Rapid metabolism fosters microbial survival in the deep, hot subseafloor biosphere.
快速的新陈代谢促进了深层高温海底生物圈的微生物生存。
75.Misaligned sequencing reads from the GNAQ-pseudogene locus may yield GNAQ artefact variants.
来自GNAQ-假基因位点的错位测序读数可能产生GNAQ假象变体。
76.Breathing coordinates cortico-hippocampal dynamics in mice during offline states.
呼吸协调了小鼠离线状态下的皮质-海马动态。
77.Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development.
单细胞转录组和染色质地貌的整合揭示了驱动咽部器官发育的调控程序。
78.A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies.
一个由大流行促成的发现平台的比较表明，一个幼稚的抗体库可以匹配最好的免疫来源的抗体。
79.Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections.
人类的繁殖受到来自古代智人特异性病毒感染的逆转录子的调节。
80.Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.
超极化13C-MRI确定了中危人类前列腺癌中出现的糖酵解细胞群。
81.Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
褪黑激素受体配体结合和信号传导机制的结构基础。
82.Significance of gene variants for the functional biogeography of the near-surface Atlantic Ocean microbiome.
基因变异对大西洋近海微生物组功能生物地理学的意义。
83.Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis.
组蛋白去甲基化酶Lsd1是Nematostella vectensis神经细胞分化的必要条件。
84.Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase.
双环唑类药物通过抑制寄生虫的苯丙氨酸t-RNA合成酶而针对弓形虫的急性和慢性阶段。
85.Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant.
由SARS-CoV-2 Delta变体引起的大规模、有迹可循的爆发中的病毒感染和传播。
86.Pandemic preparedness: synthetic biology and publicly funded biofoundries can rapidly accelerate response time.
大流行病的准备：合成生物学和公共资助的生物工厂可以迅速加快反应时间。
87.Tissue-specific multi-omics analysis of atrial fibrillation.
心房颤动的组织特异性多组学分析。
88.Activation of the plant mevalonate pathway by extracellular ATP.
细胞外ATP对植物甲壳素途径的激活。
89.Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
单细胞多组学揭示了进展期COVID-19中先天和适应性免疫系统的不同步。
90.Adenosine receptor 2a agonists target mouse CD11c+T-bet+ B cells in infection and autoimmunity.
腺苷受体2a激动剂在感染和自身免疫中针对小鼠CD11c+T-bet+B细胞。
91.Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.
使用GUIDE-tag在体内检测CRISPR编辑的全基因组。
92.Massively parallel characterization of engineered transcript isoforms using direct RNA sequencing.
利用直接RNA测序技术对工程转录物异构体进行大规模平行表征。
93.Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis.
结核分枝杆菌的ATP结合盒F蛋白和核糖体之间的相互作用。
94.The combined DNA and RNA synthetic capabilities of archaeal DNA primase facilitate primer hand-off to the replicative DNA polymerase.
弓形虫DNA引物酶的DNA和RNA合成能力有助于引物移交给复制型DNA聚合酶。
95.A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling.
一种Klotho衍生的多肽通过靶向TGF-β信号传导保护肾脏纤维化。
96.Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids.
转录因子PU.1的表达诱导了人类皮质器官中小胶质细胞的产生。
97.Shared features and reciprocal complementation of the Chlamydomonas and Arabidopsis microbiota.
衣藻类和拟南芥微生物群的共同特征和互为补充。
98.A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family.
ZUFSP去泛素酶家族中不同连接特异性的结构基础。
99.Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors.
通过识别易感竞争者的肽聚糖来解决抗生素生产和快速生长之间的冲突。
100.A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging.
一种生物激活的体内组装纳米技术制造的近红外探针用于小胰腺肿瘤术中成像。
101.Neuroanatomy in a middle Cambrian mollisoniid and the ancestral nervous system organization of chelicerates.
寒武纪中期软体动物的神经解剖学和螯足动物的祖先神经系统组织。
102.Correction of a Factor VIII genomic inversion with designer-recombinases.
用特制的重组酶纠正因子VIII的基因组倒置。
103.In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins.
利用光活化肽类毒素对电压门离子通道的体内时空控制。
104.Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong.
香港的多发病和与Covid-19疫苗有关的特别关注的不良事件。
105.Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis.
附睾脂肪组织中的巨噬细胞分泌骨质素以调节骨的平衡。
106.Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2.
循环中表达ACE2的胞外囊泡阻断SARS-CoV-2的广泛菌株。
107.Stereoselective gold(I)-catalyzed approach to the synthesis of complex α-glycosyl phosphosaccharides.
立体选择性金（I）催化法合成复杂的α-糖基磷脂糖。
108.Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1.
骨骼肌中分泌蛋白STX4的富集补救了外周胰岛素抵抗，并通过Drp1改变了线粒体的动力学。
109.Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data.
混合细胞解卷的进展使空间转录组数据中的细胞类型得到量化。
110.Immune-related adverse events and the balancing act of immunotherapy.
免疫相关不良事件和免疫疗法的平衡行为。
111.Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids.
由多药耐药性F质粒编码的IV型分泌系统核心复合物的结构。
112.Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.
α1B-肾上腺素受体的晶体结构揭示了选择性配体识别的分子决定因素。
113.Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging.
用眼内比率成像法量化骨髓间的pH值和钙浓度。
114.The mitochondrial β-oxidation enzyme HADHA restrains hepatic glucagon response by promoting β-hydroxybutyrate production.
线粒体β-氧化酶HADHA通过促进β-羟丁酸的产生抑制肝脏的胰高血糖素反应。
115.Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases.
锌指脱氨酶在人类细胞中的核和线粒体DNA编辑。
116.Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens.
脂肪族卤化酶WelO5*的算法辅助工程，用于山梨醇的不对称后期功能化。
117.Deciphering the mechanism of processive ssDNA digestion by the Dna2-RPA ensemble.
破译Dna2-RPA组合对ssDNA的渐进式消化机制。
118.Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2.
感染SARS-CoV-2的孕妇的母体-胎儿免疫反应。
119.Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae.
预适应性噬菌体疗法与抗生素结合治疗耐潘多拉唑肺炎克雷伯菌引起的骨折相关感染。
120.Resolving the structure of phage–bacteria interactions in the context of natural diversity.
在自然多样性的背景下解析噬菌体-细菌相互作用的结构。
121.53BP1 regulates heterochromatin through liquid phase separation.
53BP1通过液相分离调控异染色质。
122.Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration.
视网膜色素上皮细胞特异性CLIC4突变体是干性年龄相关性黄斑变性的小鼠模型。
123.Microbiome differential abundance methods produce different results across 38 datasets.
微生物组差异丰度方法在38个数据集中产生不同的结果。
124.Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.
鉴定一种生产二元戊酸的聚酮体合成酶，揭示了琼浆玉液中2-(2-苯基乙基)色酮的一种不寻常的生物合成途径。
125.Synthetic DNA applications in information technology.
合成DNA在信息技术中的应用。
a The attributes of DNA make the biomolecule ideal for various computational applications. (i) Watson–Crick base pairing: to allow to predict the connectivity of molecules. (ii) Polymerase chain reaction (PCR) amplification: to copy a DNA molecule to an exponential multiple. PCR amplification is based on Watson–Crick base pairing. (iii) Strand displacement: to enable chemical signal processing. This attribute is also based on Watson–Crick base pairing. A single strand input molecule binds to the toehold of the double-strand gate complex and displaces one of the strands to release a single strand output. (iv) Sequencing: to read the information in DNA strands (v) Synthesis: to make new DNA molecules within minutes. b Applications of DNA in information technology and the amount of information described in research literature so far. The attributes of DNA (see a) that are dominant in the respective applications are color-coded. The purpose of each application is also shown.
a DNA 的属性使生物分子成为各种计算应用的理想选择。 (i) Watson-Crick 碱基配对：允许预测分子的连通性。 (ii) 聚合酶链式反应 (PCR) 扩增：将 DNA 分子复制成指数倍数。 PCR 扩增基于 Watson–Crick 碱基配对。 (iii) 链位移：使化学信号处理成为可能。 此属性也基于 Watson–Crick 碱基配对。 单链输入分子与双链门复合体的立足点结合并置换其中一条链以释放单链输出。 (iv) 测序：读取 DNA 链中的信息 (v) 合成：在几分钟内制造新的 DNA 分子。 b DNA 在信息技术中的应用以及迄今为止研究文献中描述的信息量。 在各自应用中占主导地位的 DNA 属性（见 a）用颜色编码。 还显示了每个应用程序的用途。
126.Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C.
短线底物图案与APC结合的特异性和多价性的单分子分析。
127.Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii.
泛酸生物合成对神经性寄生虫弓形虫的慢性感染至关重要。
128.Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos.
用组蛋白修饰预先配置染色质结构指导小鼠胚胎中造血干细胞的形成。
129.Obligate mutualistic cooperation limits evolvability.
义务性互助合作限制了进化性。
130.Epigenetic aging of the demographically non-aging naked mole-rat.
人口学上不衰老的裸鼹鼠的表观遗传学衰老。
131.Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction.
通过氟-硫醇置换反应实现无保护肽的大环化和装订。
132.A polytherapy based approach to combat antimicrobial resistance using cubosomes.
利用立方体对抗抗菌素耐药性的基于多元疗法的方法。
133.The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity.
Epstein-Barr病毒基因组的三维结构因潜伏期类型而异，并受PARP1酶活性调节。
134.Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure.
对111种恶性疟原虫蛋白的抗体的不同动力学，确定了近期接触疟疾的标志物。
135.Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour.
控制接近和回避行为的两条对立的海马到前额叶皮层的途径。
136.Premature commitment to uncertain decisions during human NMDA receptor hypofunction.
人类NMDA受体功能低下时对不确定决定的过早承诺。
137.Contribution of the medial eye field network to the voluntary deployment of visuospatial attention.
内侧眼域网络对视觉空间注意的自愿部署的贡献。
138.RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
RNF43/ZNRF3的缺失通过损害肝脏再生和改变肝脏脂质代谢基态而容易导致肝细胞癌。
139.Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.
调节神经元分化的转录程序在DLG2敲除的人类胚胎干细胞中被破坏，并富集了精神分裂症和相关疾病的风险变异。
140.Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
粘液蛋白3缺陷小鼠的肺气肿和巨噬细胞弹性蛋白酶清除功能受损。
141.Minimal genetically encoded tags for fluorescent protein labeling in living neurons.
在活体神经元中用于荧光蛋白标记的最小基因编码标签。
142.The genetic architecture underlying prey-dependent performance in a microbial predator.
微生物捕食者的猎物依赖性表现的遗传结构。
143.Structure and function of a family of tick-derived complement inhibitors targeting properdin.
蜱虫源性补体抑制剂家族的结构和功能，以profitdin为目标。
144.Model-based evaluation of alternative reactive class closure strategies against COVID-19.
基于模型评估针对COVID-19的替代反应性类封闭策略。
145.HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia.
HIF-1与TRIM28和DNA-PK相互作用，释放暂停的RNA聚合酶II并激活目标基因转录以应对缺氧。
146.Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome.
通过小鼠基因组的定向人源化建立独特的人类基因调控功能模型。
147.Molecular mechanism of agonism and inverse agonism in ghrelin receptor.
胃泌素受体的激动和反激动的分子机制。
148.An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes.
一个内含转座子的插入与Midas慈鲷鱼的跨物种颜色多态性有关。
149.Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy.
Tmem120a基因敲除小鼠的基因组位点错位产生了潜在的脂肪变性。
150.4polar-STORM polarized super-resolution imaging of actin filament organization in cells.
细胞内肌动蛋白丝组织的4polar-STORM极化超分辨率成像。
151.Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones.
通过组蛋白的丝氨酸ADP-核糖基化将DNA修复和细胞周期进展联系起来。
152.NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis.
NuA4和H2A.Z控制拟南芥的环境反应和自养生长。
153.Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation.
严重的COVID-19患者的死后高维免疫分析揭示了免疫抑制和免疫激活的不同模式。
154.Dynamic targeting enables domain-general inhibitory control over action and thought by the prefrontal cortex.
动态定位使前额叶皮层对行动和思维进行领域性的抑制控制。
155.The formation of avian montane diversity across barriers and along elevational gradients.
跨越障碍和沿着海拔梯度的鸟类山地多样性的形成。
156.Single particle cryo-EM structure of the outer hair cell motor protein prestin.
外毛细胞运动蛋白prestin的单颗粒低温电镜结构。
157.Genetic diversity in terrestrial subsurface ecosystems impacted by geological degassing.
受地质脱气影响的陆地次表层生态系统的遗传多样性。
158.Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.
与其他组织相比，哺乳动物的脑糖蛋白表现出较低的糖类复杂性。
159.Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
原核生物泛素样蛋白被霉菌Mpa-蛋白酶体复合体参与和转运的结构基础。
160.Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
SUMO异肽酶SENP6的遗传改变驱动弥漫性大B细胞淋巴瘤的淋巴发生和遗传不稳定性。
161.Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia.
耐受性纳米颗粒缓解了高尿酸血症患者对聚乙二醇尿酸酶的抗药性抗体的形成。
162.Reversing insecticide resistance with allelic-drive in Drosophila melanogaster.
用等位基因驱动逆转黑腹果蝇的杀虫剂抗性。
163.Coding strategy for surface luminance switches in the primary visual cortex of the awake monkey.
醒着的猴子初级视觉皮层中表面亮度开关的编码策略。
164.The rise of grasslands is linked to atmospheric CO2 decline in the late Palaeogene.
草原的兴起与古近代晚期大气中二氧化碳的减少有关。
165.Biosensor for branched-chain amino acid metabolism in yeast and applications in isobutanol and isopentanol production.
酵母中支链氨基酸代谢的生物传感器及在异丁醇和异戊醇生产中的应用。
166.Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
通过IRAK1/4抑制剂消除慢性骨髓性白血病干细胞。
167.Identification of a modular super-enhancer in murine retinal development.
小鼠视网膜发育中模块式超级增强器的鉴定。
168.Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin.
基质力学通过调整丝氨酸的动态定位来调节上皮细胞对癌症的防御。
169.Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system.
在无细胞翻译系统中为治疗相关的多肽和蛋白质建立通用的原型方法。
170.Signatures of selection in recently domesticated macadamia.
最近驯化的澳洲坚果中的选择特征。
171.Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding.
中子晶体学揭示了铜绿假单胞菌用于宿主细胞结合的机制。
172.Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging.
超分辨率定量透射和活性区成像揭示突触多样性的决定因素。
173.Design principles for site-selective hydroxylation by a Rieske oxygenase.
Rieske加氧酶的位点选择性羟基化的设计原则。
174.Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2.
对SARS-CoV-2宿主内多样性的细胞类型特异性进化的结构见解。
175.The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation.
RNA甲基转移酶METTL8在线粒体tRNAsThr/Ser(UCN)中安装m3C32以优化tRNA结构和线粒体翻译。
176.MyoD is a 3D genome structure organizer for muscle cell identity.
MyoD是肌肉细胞身份的三维基因组结构组织者。
177.BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1.
BRCA1缺失特异性碱基替换突变依赖于翻译合成并受53BP1调控。
178.Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells.
癌细胞表达的BTNL2通过与产生IL-17A的γδ T细胞接触促进肿瘤免疫逃逸。
179.Structural basis of BAK activation in mitochondrial apoptosis initiation.
线粒体细胞凋亡启动中BAK激活的结构基础。
180.Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer.
转谷氨酰胺酶3交联分泌的形成凝胶的粘液成分Mucin-2并稳定结肠粘液层。
181.The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage.
转录因子肝细胞核因子4A在肠道内作用，促进白色脂肪组织能量储存。
182.molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history.
molBV揭示了细菌性阴道病的免疫景观并预测了人类乳头瘤病毒感染的自然历史。
183.Distinct mechanisms orchestrate the contra-polarity of IRK and KOIN, two LRR-receptor-kinases controlling root cell division.
不同的机制协调了IRK和KOIN这两个控制根细胞分裂的LRR-受体激酶的反极性。
184.Robust differentiation of human enteroendocrine cells from intestinal stem cells.
从肠道干细胞分化出的人类肠道内分泌细胞的稳健性。
185.MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade.
MAPK4促进三阴性乳腺癌生长并降低肿瘤对PI3K阻断的敏感性。
186.The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis.
CLASSY家族控制拟南芥的组织特异性DNA甲基化模式。
187.Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures.
杀死细菌同时放过哺乳动物细胞的亲水纳米颗粒揭示了纳米结构的抗生素作用。
188.Age influences on the molecular presentation of tumours.
年龄对肿瘤的分子表现的影响。
189.Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes.
与颈部淋巴结相连的人脑淋巴网络的无创MR成像。
190.Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
利用纳米抗体绘制1918年大流行流感病毒RNA聚合酶上的抑制性位点。
191.MicroRNA-365 regulates human cardiac action potential duration.
MicroRNA-365调控人类心脏动作电位持续时间。
192.Zero-preserving imputation of single-cell RNA-seq data.
单细胞RNA-seq数据的保零归因。
193.A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control.
一种小RNA在一个口袋里合作感知两种堆积的代谢物，用于基因控制。
194.Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion.
肠道微生物群通过调节胆汁酸成分和胆汁胆固醇分泌促进胆固醇胆石的形成。
195.A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating.
顶叶后皮层的一个皮质细胞组合控制着过去经验依赖的记忆更新。
196.Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans.
磷酸甘油酯磷酸酯酶同源物作为甘油-3-磷酸酯磷酸酯酶控制优雅动物的压力和健康范围。
197.An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch.
阴离子配体锁住了镁折叠核糖开关中的长程相互作用。
198.A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.
一种基于BAFF配体的CAR-T细胞针对三种受体和多种B细胞癌症。
199.Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.
MYC的典范WNT信号依赖性门控需要远端结合点的非典范CTCF功能。
200.Berberine bridge enzyme-like oxidase-catalysed double bond isomerization acts as the pathway switch in cytochalasin synthesis.
小檗碱桥酶类氧化酶催化的双键异构化作为细胞色素合成的途径开关。
201.A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.
GATA4调节的分泌程序通过招募细胞毒性CD8 T细胞抑制肿瘤。
202.A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
一种蜂胶衍生的小分子通过靶向CREB/CRTC2转录复合物改善肥胖小鼠的代谢综合征。
203.Rapid antigen testing as a reactive response to surges in nosocomial SARS-CoV-2 outbreak risk.
快速抗原检测作为对鼻腔SARS-CoV-2疫情风险激增的反应性反应。
204.DeepNull models non-linear covariate effects to improve phenotypic prediction and association power.
DeepNull建立非线性协变量效应模型，以提高表型预测和关联能力。
205.C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.
C型凝集素受体CLEC4A2促进巨噬细胞的组织适应性并保护其免受动脉硬化的影响。
206.Lifelong single-cell profiling of cranial neural crest diversification in zebrafish.
斑马鱼颅骨神经嵴多样化的终身单细胞分析.
207.EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation.
EZH2耗竭增强MYC降解抑制神经母细胞瘤和小细胞癌肿瘤的形成。
208.The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1.
TCPTP的催化活性受其本征无序尾部的自动调控，并被整合素α-1激活。
209.Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension.
整合基因表达和临床数据，确定高脂血症和高血压的再利用候选药物。
210.Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis.
鸡卵泡生成过程中颗粒细胞的动态转录组和染色质结构。
211.Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry.
Gasdermin D孔是由局部磷脂酰亚胺电路动态调节的。
212.The need for improved methodology in protein corona analysis.
蛋白质电晕分析中需要改进方法。
213.Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.
Notch信号的温度敏感性是羊齿动物大脑中物种特异性发育可塑性和稳健性的基础。
214.Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
基于吡啶哌嗪的RND型多药排泄泵的异生抑制剂。
215.Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts.
交叉反应性记忆T细胞与COVID-19接触者对SARS-CoV-2感染的保护有关。
216.Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry.
通过集成微流控芯片和数据无关的采集质谱技术简化单细胞蛋白质组学。
a 集成蛋白质组学芯片 (iProChip) 的明场图像，其中包括细胞捕获室（青色）、反应容器（橙色）、片上 SPE 柱（绿色）、样品收集端口（深绿色）和控制层（ 棕色）显示。 b iProChip 操作的整个系统设置。 c 单个操作单元的特写视图。 比例尺：300μm。 d 安装在显微镜上的即用型 iProChip。 e 细胞捕获柱（左）和 SPE 柱中的 C18 过滤器（右）的 SEM 图像。 这些图像代表使用 SEM 观察到的两个芯片。 f iProChip 用于简化样品制备的操作程序，包括 (1) 细胞捕获、成像和计数，(2) 细胞裂解，(3) 蛋白质消化，(4) 脱盐和 (5) 肽收集。 g 使用基于数据采集的液相色谱-串联质谱 (LC-MS/MS) 和谱库搜索进行蛋白质组学分析。
217.Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.
细菌性炎症期间，氧化脂质代谢受线粒体β-氧化控制。
218.A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues.
基于近似生物素化的方法识别PROTACs和分子胶水诱导的蛋白-E3连接酶相互作用。
219.CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells.
CD4和CD8共同受体调控CD1b限制性T细胞的功能热度。
220.Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly.
内体贩运缺陷改变神经祖细胞的增殖并导致小头畸形。
221.Cortical state dynamics and selective attention define the spatial pattern of correlated variability in neocortex.
皮质状态动态和选择性注意确定了新皮层中相关变异的空间模式。
222.Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression.
Progranulin通过调节MHCI的表达介导了胰腺导管腺癌的免疫规避。
223.Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association.
利用全球基因网络关联预测抗PD-1免疫疗法的生物标志物和治疗组合。
224.Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
功能增益基因筛选确定了TMEM120A通过STING激活的抗病毒功能。
225.Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis.
利用组合荧光光谱和寿命编码、成像和分析的空间转录组学。
226.Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.
5-氟尿嘧啶治疗时核糖体功能的改变有利于癌细胞的耐药性。
227.The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans.
转录因子ZIP-1促进优雅动物对细胞内感染的抵抗。
228.Maximizing response to intratumoral immunotherapy in mice by tuning local retention.
通过调整局部滞留，使小鼠对瘤内免疫疗法的反应最大化。
229.Harnessing protein folding neural networks for peptide–protein docking.
利用蛋白质折叠神经网络进行肽-蛋白质对接。
230.Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives.
Hypocrates是一种基因编码的荧光生物传感器，用于检测（伪）次卤酸及其衍生物。
231.Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states.
人类原发性前列腺癌的单细胞分析揭示了肿瘤相关上皮细胞状态的异质性。
232.Mini-batch optimization enables training of ODE models on large-scale datasets.
小型批量优化使大规模数据集上的ODE模型得到训练。
233.The legacy of the extinct Neotropical megafauna on plants and biomes.
已灭绝的新热带巨型动物对植物和生物群落的影响。
234.Helical structure motifs made searchable for functional peptide design.
可用于功能肽设计的螺旋结构主题的搜索。
235.Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding.
Cryo-EM证明了体外淀粉样纤维形态的播种体外增殖。
236.A method to construct the dynamic landscape of a bio-membrane with experiment and simulation.
一种用实验和模拟构建生物膜动态景观的方法。
237.Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast.
乳腺转移性浸润性微乳头状癌的基因组改变和细胞集群的演变。
238.G-quadruplex DNA structures in human stem cells and differentiation.
人类干细胞和分化中的G-四联体DNA结构。
239.A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation.
一种质谱方法，用于深入分析磷脂酰肌醇 regioisomers 及其与疾病相关的调节。
240.Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling.
通过位点分辨蛋白质周转率分析将翻译后修饰和蛋白质周转率联系起来。
241.Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity.
胶质母细胞瘤蛋白质组的地形图显示了肿瘤内异质性的三轴模型。
242.Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.
反应性星形胶质细胞在应对Tau和Aß病理时获得了神经保护性以及有害性的特征。
243.Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.
Hcfc1和Ronin的突变导致钴胺代谢的先天性错误和核糖体病。
244.Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states.
Topoisomerase I (TOP1)的动态：从开放状态到封闭状态的构象转换。
245.Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome.
症状出现后Scn1a基因的重新激活可挽救Dravet综合征小鼠模型的病理表型。
246.GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models.
GPR182在小鼠黑色素瘤模型中通过趋化因子清除作用限制了抗肿瘤免疫力。
247.Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets.
雪貂SARS-CoV-2感染的年龄依赖性致病特征。
248.Crystal structure and functional implication of bacterial STING.
细菌STING的晶体结构和功能暗示。
249.SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration.
SYP72与机械敏感通道MSL8相互作用，保护花粉在水化过程中免受低渗透性冲击。
250.Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice.
前额叶皮层的神经元Yin Yang1调节小鼠慢性应激的转录和行为反应。
251.C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer.
C/EBPB依赖对棕榈酸的适应性促进激素受体阴性乳腺癌的肿瘤形成。
252.Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
GLP-1R肽激动剂参与的动态与G蛋白激活的动力学相关。
253.The role of methanotrophy in the microbial carbon metabolism of temperate lakes.
温带湖泊微生物碳代谢中甲烷营养的作用。
254.Hyphal compartmentalization and sporulation in Streptomyces require the conserved cell division protein SepX.
链霉菌的分层和孢子形成需要保守的细胞分裂蛋白SepX。
255.Functional dissection of inherited non-coding variation influencing multiple myeloma risk.
影响多发性骨髓瘤风险的遗传性非编码变异的功能剖析。
256.Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7.
骨髓细胞核分化抗原通过IRF7的转录调控人类单核细胞中病原体刺激的I型干扰素级联。
257.Transient neuronal suppression for exploitation of new sensory evidence.
瞬时神经元抑制对新感觉证据的利用。
258.Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia.
孤独感和社会隔离与精神分裂症关系的多基因贡献。
259.Resonator nanophotonic standing-wave array trap for single-molecule manipulation and measurement.
用于单分子操作和测量的共振器纳米光子驻波阵列陷阱.
260.Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
公共和私人T细胞受体识别的HLA-A2限制性SARS-CoV-2尖峰表位的结构评估。
261.TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
TASOR表观遗传抑制器与CNOT1 RNA降解途径合作，抑制艾滋病毒。
262.Polyply; a python suite for facilitating simulations of macromolecules and nanomaterials.
Polyply；一个用于促进大分子和纳米材料模拟的python套件。
263.DNA methylation aging and transcriptomic studies in horses.
马的DNA甲基化老化和转录组学研究。
264.Mechanism for inverted-repeat recombination induced by a replication fork barrier.
复制叉屏障诱导的倒置重复重组的机制。
265.A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.
一种双特异性单体纳米抗体诱导穗状三聚体二聚体并在体内中和SARS-CoV-2。
266.Single cell transcriptomic landscape of diabetic foot ulcers.
糖尿病足溃疡的单细胞转录组景观。
267.A de novo paradigm for male infertility.
男性不育症的新模式。
268.Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma.
肾脏中的单细胞染色质可及性景观确定了异源性乳头状肾细胞癌的额外起源细胞。
269.Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions.
突变特征效应过程与驱动基因和非编码区的突变热点的关联。
270.Cryo-EM structure of native human thyroglobulin.
原生人甲状腺球蛋白的低温电镜结构。
271.Phylogenetically and functionally diverse microorganisms reside under the Ross Ice Shelf.
罗斯冰架下居住着系统发育和功能多样的微生物。
272.Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase.
一个不寻常的非核糖体多肽合成酶中的II型硫酯酶域催化的氨基链转移。
273.An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes.
在非洲锥虫中，核体的集合体与活性VSG表达位点相联系。
274.Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells.
克伦特罗通过骨骼肌细胞的代谢重编程发挥抗糖尿病活性。
275.Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies.
靶向肌肉纤维的坏死组织可改善炎症性肌病。
276.Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants.
PRAF/RLD和GNOM在膜贩运中的连接功能控制了植物的内在细胞极性。
277.Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.
血管和血脑屏障相关的变化是雌性小鼠的应激反应和复原力以及人类组织的抑郁症的基础。
278.Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.
抗酒石酸磷酸酶5通过调控β-catenin信号传导促进肺纤维化。
279.Latency reversal plus natural killer cells diminish HIV reservoir in vivo.
潜伏期逆转加自然杀伤细胞减少体内的HIV储库。
280.Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment.
通过间歇性抗PI3Kα/β/δ治疗克服PTEN缺失的前列腺癌对免疫检查点疗法的耐药性。
281.Proximity labeling identifies a repertoire of site-specific R-loop modulators.
近似标记确定了一个位点特异性R环调节器的复制品。
282.Robust and durable serological response following pediatric SARS-CoV-2 infection.
小儿SARS-CoV-2感染后稳健而持久的血清学反应。
283.Imagined speech can be decoded from low- and cross-frequency intracranial EEG features.
想象中的语音可以从低频和跨频的颅内EEG特征中解码。
284.Context-independent encoding of passive and active self-motion in vestibular afferent fibers during locomotion in primates.
灵长类动物运动过程中前庭传入纤维的被动和主动自我运动的情境独立编码。
285.Nutrient supply controls the linkage between species abundance and ecological interactions in marine bacterial communities.
营养供应控制着海洋细菌群落中物种丰度和生态相互作用之间的联系。
286.The 2018 European heatwave led to stem dehydration but not to consistent growth reductions in forests.
2018年欧洲热浪导致茎干脱水，但没有导致森林一致的生长减退。
287.Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.
Grainyhead 1作为药物诱导的保守转录调节器与胰岛素信号传导和寿命有关。
288.Lipidomic profiling of human serum enables detection of pancreatic cancer.
人类血清的脂质组学分析能够检测胰腺癌。
289.Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease.
阿尔茨海默病中线粒体蛋白、APP和tau的琥珀酰化发生改变。
290.Focal neural perturbations reshape low-dimensional trajectories of brain activity supporting cognitive performance.
局部神经扰动重塑了支持认知性能的低维大脑活动轨迹。
291.Targeted editing and evolution of engineered ribosomes in vivo by filtered editing.
通过过滤式编辑对体内的工程核糖体进行定向编辑和进化。
292.Dynamics and mechanism of dimer dissociation of photoreceptor UVR8.
光感受器UVR8的二聚体解离的动力学和机制。
293.Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
多巴胺对酪氨酸羟化酶的抑制和Ser40磷酸化的重新激活的结构机制。
294.Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF.
对异常杂乱和催化多变的Fe(II)/α-酮戊二酸依赖性加氧酶SptF的分子深入研究。
295.The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice.
m6A甲基转移酶METTL3调节小鼠的肌肉维持和生长。
296.Prefrontal cortical plasticity during learning of cognitive tasks.
认知任务学习过程中的前额叶皮层可塑性。
297.Smart facemask for wireless CO2 monitoring.
用于无线二氧化碳监测的智能面罩。
298.Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges.
在所有成人年龄范围内，对COVID-19 BNT162b2/Comirnaty疫苗的抗体反应的群体同质性仅在第二剂后达到。
299.Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction.
抑制骨形态发生蛋白1.3可减少疤痕形成，支持心肌梗死后心肌细胞的存活。
300.Percolation in networks with local homeostatic plasticity.
具有局部稳态可塑性的网络中的渗滤作用。
301.Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires.
通过碳化硅半导电纳米线合成恢复心肌梗塞的脉冲传播.
302.Maternal regulation of biliary disease in neonates via gut microbial metabolites.
母体通过肠道微生物代谢物对新生儿胆道疾病的调节。
303.Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents.
SARS-CoV-2康复者长期随访和接种疫苗过程中尖峰和核衣壳特异性免疫力的动态变化。
304.Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth.
酵母衍生的纳米颗粒重塑肿瘤和肿瘤引流淋巴结的免疫抑制微环境，抑制肿瘤生长。
305.Chirality transmission in macromolecular domains.
大分子结构域中的手性传递。
306.Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition.
成人的总能量消耗是可重复的，但与身体成分的短期变化无关。
307.Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
微生物酶通过重新激活小鼠胃肠道中的三氯生而诱发结肠炎。
308.Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
植物甾醇的全基因组元分析揭示了五个新的基因位点和对冠状动脉硬化的不利影响。
309.Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
机械力促进二甲基精氨酸二甲氨基水解酶1介导的代谢物不对称二甲基精氨酸的水解以增强骨形成。
310.Guest-host doped strategy for constructing ultralong-lifetime near-infrared organic phosphorescence materials for bioimaging.
构建用于生物成像的超长寿命近红外有机磷光材料的客体掺杂策略。
311.PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis.
PPARα-ACOT12轴负责通过调节新的脂肪生成来维持软骨的稳态。
