【标题速读】【Ncomm】【biological-sciences】【2022年】【3月】
声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。
1.A natural timeless polymorphism allowing circadian clock synchronization in “white nights”.
一种天然的永恒的多态性允许在 "白夜 "的昼夜时钟同步。
2.Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles.
哺乳动物细胞中通过工程化的共价修饰周期进行的稳健和可调整的信号处理。
3.Fixational drift is driven by diffusive dynamics in central neural circuitry.
固定性漂移是由中央神经回路的扩散动力学驱动的。
4.Assembly mechanism of the pleomorphic immature poxvirus scaffold.
多形性未成熟痘病毒支架的组装机制。
5.A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response.
研究肿瘤异质性和药物反应的乳腺癌细胞系的单细胞分析。
6.Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary.
从匈牙利的Schreiber's bats中分离出传染性的Lloviu病毒。
7.cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies.
cyCombine允许在技术内部和跨技术之间对单细胞细胞仪数据集进行强有力的整合。
8.Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination.
COVID-19下的人类季节性流感以及流感血统消除的潜在后果。
9.Individual experience as a key to success for the cuckoo catfish brood parasitism.
个体经验是杜鹃猫科鱼雏形寄生成功的关键。
10.A probabilistic map of emotional experiences during competitive social interactions.
竞争性社会互动中情绪体验的概率图。
11.USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy.
抑制USP8重塑炎症肿瘤微环境，增强了免疫疗法的效果。
12.Protein-based SARS-CoV-2 spike vaccine booster increases cross-neutralization against SARS-CoV-2 variants of concern in non-human primates.
基于蛋白质的SARS-CoV-2尖峰疫苗增强剂提高了对非人灵长类动物所关注的SARS-CoV-2变种的交叉中和作用。
13.SHAPE-guided RNA structure homology search and motif discovery.
SHAPE引导的RNA结构同源搜索和动机发现。
14.Effects of cryo-EM cooling on structural ensembles.
低温电镜冷却对结构集合的影响。
15.Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
儿童急性淋巴细胞白血病细胞系的综合多组学和药物反应分析。
16.Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma.
Hand2划定了间皮细胞的祖先，并在间皮瘤中重新激活。
17.Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids.
组织细胞外基质水凝胶作为Matrigel的替代品用于培养胃肠道器官。
18.Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium.
嗜环蛋白anaCyp40调控蓝藻中的光系统组装和植物蛋白体的结合。
19.Donut-like organization of inhibition underlies categorical neural responses in the midbrain.
抑制的甜甜圈式组织是中脑分类神经反应的基础。
20.Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics.
整合中枢神经系统元组学和宿主反应，诊断结核性脑膜炎及其模拟物。
21.DLMM as a lossless one-shot algorithm for collaborative multi-site distributed linear mixed models.
DLMM作为协作式多站点分布式线性混合模型的无损单次算法。
22.Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion.
运动过程中啮齿动物高阶视觉皮层的神经活动减少但编码得到改善。
23.Comprehensive generation, visualization, and reporting of quality control metrics for single-cell RNA sequencing data.
单细胞RNA测序数据质量控制指标的全面生成、可视化和报告。
24.A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy.
用于癌症光动力治疗的硫化氢反应性和耗损性纳米平台。
25.Pervasive Transcription-coupled DNA repair in E. coli.
大肠杆菌中普遍存在的转录偶合DNA修复。
26.Structure of a tetrameric photosystem I from a glaucophyte alga Cyanophora paradoxa.
来自蓝藻的四聚体光系统I的结构。
27.Cumulative lifetime stressor exposure assessed by the STRAIN predicts economic ambiguity aversion.
STRAIN评估的终身累积压力源暴露可预测经济模糊性厌恶。
28.Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer.
基于知识图谱的推荐框架确定了表皮生长因子受体突变的非小细胞肺癌的抗性驱动因素。
29.Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection.
肺部II型肺泡上皮细胞与CCR2+炎症单核细胞在宿主防御痘病毒感染方面的协作。
30.A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis.
分层转录网络激活特定CDK抑制剂，调节G2以控制拟南芥的细胞大小和数量。
31.Crystal structure and cellular functions of uPAR dimer.
uPAR二聚体的晶体结构和细胞功能。
32.The phytochrome interacting proteins ERF55 and ERF58 repress light-induced seed germination in Arabidopsis thaliana.
植物色素相互作用蛋白ERF55和ERF58抑制拟南芥中光诱导的种子发芽。
33.Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization.
减少突变积累和增加分化承诺之间的权衡决定了组织结构。
34.Phage peptides mediate precision base editing with focused targeting window.
噬菌体肽介导的精确碱基编辑具有集中的靶向窗口。
35.Exploring a blue-light-sensing transcription factor to double the peak productivity of oil in Nannochloropsis oceanica.
探索蓝光感应转录因子，使海洋拟南芥的石油峰值生产力翻倍。
36.BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation.
BAF复合物介导的染色质松弛是建立X染色体失活的必要条件。
37.Rho-dependent transcription termination proceeds via three routes.
Rho依赖的转录终止通过三种途径进行。
38.Neural relational inference to learn long-range allosteric interactions in proteins from molecular dynamics simulations.
从分子动力学模拟中学习蛋白质中长程异生相互作用的神经关系推理。
39.Predictive models for the selection of thermally tolerant corals based on offspring survival.
基于子代存活率的耐高温珊瑚选择的预测模型。
40.Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure.
通过在pegRNA中引入同义突变或稳定其结构来实现高效的质粒编辑。
41.Empirical prediction of variant-activated cryptic splice donors using population-based RNA-Seq data.
利用基于群体的RNA-Seq数据对变异激活的隐性剪接供体进行经验性预测。
42.Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice.
脂肪细胞Gq信号是小鼠葡萄糖和脂质平衡的调节器。
43.Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
S9.6单克隆抗体识别R环的结构基础。
44.Single-cell transcriptomic analysis suggests two molecularly distinct subtypes of intrahepatic cholangiocarcinoma.
单细胞转录组分析表明肝内胆管癌有两种分子上不同的亚型。
45.Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.
对B.1.617保持效力的单特异性和双特异性单克隆SARS-CoV-2中和抗体。
46.Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors.
细胞死亡诱导的免疫原性通过将免疫排斥转化为T细胞炎症的膀胱肿瘤来增强化疗免疫治疗反应。
47.Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors.
SARS-CoV-2疫苗接种后免疫力减弱的模型分析及影响因素.
48.Genetic variation of macronutrient tolerance in Drosophila melanogaster.
黑腹果蝇对宏量营养素耐受性的遗传变异.
49.Machine learning reveals cryptic dialects that explain mate choice in a songbird.
机器学习揭示了解释一种鸣禽的配偶选择的隐性方言。
50.Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system.
灵活的听觉训练，心理物理学，以及用一个自动的、基于触摸屏的系统来丰富普通狨猴的内容。
51.Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification.
中国小儿急性骨髓性白血病的独特基因组景观影响临床风险分类。
52.Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.
芬兰男性代谢物的全基因组关联研究确定了与疾病相关的位点。
53.Filopodia rotate and coil by actively generating twist in their actin shaft.
丝状体通过主动在其肌动蛋白轴上产生扭曲而旋转和盘绕。
54.Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes.
相关网络指导发现未聚类的镧系肽蛋白酶编码基因。
55.Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology.
哮喘的鼻腔气道转录组关联研究揭示了基因驱动的粘液病理学。
56.Programmable design of isothermal nucleic acid diagnostic assays through abstraction-based models.
通过基于抽象的模型对等温核酸诊断测定进行可编程设计。
57.Windows of developmental sensitivity to social media.
对社交媒体的发展敏感性的窗口。
58.A computational model of neurodegeneration in Alzheimer’s disease.
阿尔茨海默病的神经变性的计算模型.
59.Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts.
整合深度学习和无偏见的自动高内容筛选以识别人类成纤维细胞中的复杂疾病特征.
60.Aegilops sharonensis genome-assisted identification of stem rust resistance gene Sr62.
Aegilops sharonensis基因组辅助鉴定抗茎锈病基因Sr62.
61.CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.
CRISPR激活筛选发现BCL-2蛋白和B3GNT2是癌症对T细胞介导的细胞毒性产生抗性的驱动因素。
62.A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.
一种针对最优先的多药耐药革兰氏阴性病原体的合成脂肽。
63.The landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective.
通过单细胞视角看受体介导的精准癌症联合治疗的前景。
64.Metabolic engineering strategies to produce medium-chain oleochemicals via acyl-ACP:CoA transacylase activity.
通过酰基-ACP:CoA转酰酶活性生产中链油类的代谢工程策略。
65.Membrane thickness, lipid phase and sterol type are determining factors in the permeability of membranes to small solutes.
膜厚度、脂相和甾醇类型是膜对小溶质渗透性的决定因素。
66.Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation.
ΔNp63α和GCM1之间的功能拮抗作用调节人类滋养细胞的干性和分化。
67.Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences.
含有通用碱基的引导RNA使Cas9/Cas12a能够识别多态序列。
68.MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity.
MERS-CoV ORF4b采用了一种不寻常的结合机制，以IMPα为目标，阻断先天免疫。
69.Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells.
原发性和免疫缺陷小鼠移植的急性骨髓性白血病细胞之间克隆结构的比较。
70.Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers.
34,129例结直肠癌中PTEN突变情况的综合特征。
71.Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium.
从超微结构上看SARS-CoV-2在人类呼吸道上皮细胞中的进入和出芽情况。
72.Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue.
Wolbachia CidA和CidB的晶体结构揭示了细菌引起的细胞质不相容和救援的决定因素。
73.Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine.
随机临床试验评估间日疟CS合成疫苗的保护效力。
74.PUMILIO proteins promote colorectal cancer growth via suppressing p21.
PUMILIO蛋白通过抑制p21促进结直肠癌生长。
75.Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria.
Clueless/CLUH通过促进Drp1招募到线粒体来调节线粒体裂变。
76.UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony.
UBR4/POE促进分泌物贩运以维持昼夜节律钟的同步。
77.A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome.
一项全基因组元分析确定了与腕管综合征相关的50个遗传位点。
78.Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay.
Pumilio保护Xbp1 mRNA免受Ire1依赖性衰变的调节。
79.BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
BMP前馈回路促进胃腺末端分化，并被幽门螺杆菌驱动的炎症打断。
80.Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression.
早期肺腺癌的整合网络分析确定了极光激酶抑制是入侵和进展的拦截器。
81.Acquiring new memories in neocortex of hippocampal-lesioned mice.
在海马神经元缺失的小鼠新皮层中获得新记忆。
82.Ultrasound-controllable engineered bacteria for cancer immunotherapy.
用于癌症免疫治疗的超声控制工程细菌。
83.The architecture of assisted colonisation in sea turtles: building new populations in a biodiversity crisis.
海龟的辅助殖民结构：在生物多样性危机中建立新的种群。
84.Biosynthesizing structurally diverse diols via a general route combining oxidative and reductive formations of OH-groups.
通过氧化和还原形成OH基团的一般途径生物合成结构多样的二元醇。
85.Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing.
利用DSB修复来促进高效的同源性和非同源性编辑。
86.Genetic regulation of post-translational modification of two distinct proteins.
两种不同蛋白质翻译后修饰的遗传调节。
87.Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors.
靶向骨髓源性抑制细胞可逆转免疫抑制并使BRAF突变的乳头状甲状腺癌对MAPK抑制剂敏感。
88.Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics.
利用综合单细胞转录组学设计支持造血干细胞发展的生态位。
89.Stripenn detects architectural stripes from chromatin conformation data using computer vision.
Stripenn利用计算机视觉从染色质构象数据中检测建筑条纹。
90.Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease.
豆荚细胞中CLDN5的缺失使WIF1失调以激活WNT信号并导致肾脏疾病。
91.Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 – PHR2 complex.
对水稻SPX2-PHR2复合物调控植物磷酸盐平衡的机理的深入研究。
92.A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.
Kv-like KcsA突变体E71V中C型失活的独特机制。
93.Assessment of global health risk of antibiotic resistance genes.
抗生素耐药基因的全球健康风险评估。
94.PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.
PCBP2通过拮抗cGAS的凝结调节其酶活性来维持抗病毒信号的平衡。
95.Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2.
同源双剂量ChAdOx1与异源疫苗接种ChAdOx1和BNT162b2的有效性和安全性比较。
96.Expanding biochemical knowledge and illuminating metabolic dark matter with ATLASx.
用ATLASx拓展生化知识，照亮代谢暗物质。
97.Design of stable and self-regulated microbial consortia for chemical synthesis.
用于化学合成的稳定和自我调节的微生物联合体的设计。
98.Paternal transmission of migration knowledge in a long-distance bird migrant.
长途迁徙鸟类的迁移知识的父系传播。
99.Measuring protected-area effectiveness using vertebrate distributions from leech iDNA.
利用水蛭iDNA的脊椎动物分布测量保护区的有效性。
100.A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.
Kv-like KcsA突变体E71V中C型失活的独特机制。
101.Assessment of global health risk of antibiotic resistance genes.
抗生素耐药基因的全球健康风险评估。
102.PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.
PCBP2通过拮抗cGAS的凝结来调节cGAS的酶活性，从而维持抗病毒信号的平衡状态。
103.Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2.
同源双剂量ChAdOx1与异源疫苗接种ChAdOx1和BNT162b2的有效性和安全性比较。
104.Expanding biochemical knowledge and illuminating metabolic dark matter with ATLASx.
用ATLASx拓展生化知识，照亮代谢暗物质。
105.Design of stable and self-regulated microbial consortia for chemical synthesis.
用于化学合成的稳定和自我调节的微生物联合体的设计。
106.Paternal transmission of migration knowledge in a long-distance bird migrant.
长途迁徙鸟类的迁移知识的父系传播。
107.Measuring protected-area effectiveness using vertebrate distributions from leech iDNA.
利用水蛭iDNA的脊椎动物分布测量保护区的有效性。
108.Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis.
抑制肺部微生物群衍生的促凋亡肽可改善肺纤维化的急性加重。
109.Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals.
与新奇事物相关的位置盘功能降低与临床健康人的Aβ相关认知能力下降有关。
110.Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin.
揭开RCOR1作为转录允许性染色质的流变器的面纱。
111.Reconstructing antibody dynamics to estimate the risk of influenza virus infection.
重建抗体动态以估计流感病毒感染的风险。
112.The Chengjiang Biota inhabited a deltaic environment.
澄江生物群栖息在三角洲环境中。
113.Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism.
脂质代谢遗传缺陷导致的肌肉萎缩症的作用机制和治疗途径。
114.eIF6 rebinding dynamically couples ribosome maturation and translation.
eIF6再结合动态地耦合核糖体成熟和翻译。
115.Brain-wide projection reconstruction of single functionally defined neurons.
单个功能定义的神经元的全脑投影重建。
116.Identification of a protein responsible for the synthesis of archaeal membrane-spanning GDGT lipids.
鉴定一种负责合成古细菌膜跨度GDGT脂质的蛋白质。
117.Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
基于RNA的治疗方法的mRNA结构、稳定性和翻译的组合优化。
118.Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors.
单细胞转录组学确定了MYC横纹肌瘤的潜在起源细胞。
119.Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors.
中脑投射到基底外侧杏仁核编码焦虑样行为，但不是抑郁样行为。
120.De novo design and directed folding of disulfide-bridged peptide heterodimers.
二硫桥肽异构体的从头设计和定向折叠。
121.A deep-learning approach for online cell identification and trace extraction in functional two-photon calcium imaging.
功能性双光子钙成像中在线细胞识别和痕迹提取的深度学习方法。
122.Decoding internally generated transitions of conscious contents in the prefrontal cortex without subjective reports.
在没有主观报告的情况下对前额叶皮层意识内容的内部产生的转换进行解码。
123.Transcription factors modulate RNA polymerase conformational equilibrium.
转录因子调控RNA聚合酶的构象平衡。
124.South-to-north migration preceded the advent of intensive farming in the Maya region.
玛雅地区集约化耕作出现之前的由南向北的迁移。
125.Deep-learning two-photon fiberscopy for video-rate brain imaging in freely-behaving mice.
深度学习的双光子纤维镜用于自由行为小鼠的视频速率大脑成像。
126.Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.
用小鼠成本-收益觅食任务检测纹状体-矩阵区块的多重行动-结果表示。
127.Structures of pseudorabies virus capsids.
伪狂犬病病毒外壳的结构。
128.GIT1 protects against breast cancer growth through negative regulation of Notch.
GIT1通过对Notch的负向调节保护乳腺癌的生长。
129.Phylotranscriptomic insights into a Mesoproterozoic–Neoproterozoic origin and early radiation of green seaweeds (Ulvophyceae).
系统转录组对中生代-新生代绿色海藻（Ulvophyceae）的起源和早期辐射的见解。
130.S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions.
S6K1介导的PDK1磷酸化损害AKT激酶活性和致癌功能。
131.Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training.
通过听觉神经反馈训练，在一个完全锁定的病人身上利用皮层内信号实现拼写界面。
132.RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin.
RUFY3和RUFY4是ARL8效应器，促进内溶酶体与dynein-dynactin的耦合。
133.Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.
分化细胞的时空重编程是肠道上皮细胞再生和肿瘤的基础。
134.New recognition specificity in a plant immune receptor by molecular engineering of its integrated domain.
通过整合结构域的分子工程在植物免疫受体中的新识别特异性。
135.Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation.
大规模并行报告扰动实验揭示了神经分化过程中的时间调控架构。
136.The induction of natural competence adapts staphylococcal metabolism to infection.
自然能力的诱导使葡萄球菌的代谢适应于感染。
137.Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains.
相分离的Nup98 FG结构域中内聚相互作用的原子分辨率动态。
138.An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis.
炭疽杆菌中一种RNA结合蛋白作为主要的转录后调节剂。
139.Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria.
不对称的肽聚糖编辑在捕食性细菌中产生细胞曲率。
140.Comparative effectiveness of the BNT162b2 and ChAdOx1 vaccines against Covid-19 in people over 50.
BNT162b2和ChAdOx1疫苗对50岁以上人群Covid-19的有效性比较。
141.cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors.
cAMP和c-di-GMP通过其效应器的直接互动，协同支持生物膜的维持。
142.Siwi cooperates with Par-1 kinase to resolve the autoinhibitory effect of Papi for Siwi-piRISC biogenesis.
Siwi与Par-1激酶合作，解决Papi对Siwi-piRISC生物生成的自抑制作用。
143.Using CRISPR-Kill for organ specific cell elimination by cleavage of tandem repeats.
利用CRISPR-Kill通过裂解串联重复序列来消除器官特定的细胞。
144.Rational design of hairpin RNA excited states reveals multi-step transitions.
发夹式RNA激发态的合理设计揭示了多步骤的转变。
145.ADARs act as potent regulators of circular transcriptome in cancer.
ADARs在癌症中作为循环转录组的有力调节者。
146.Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories.
1型糖尿病从潜伏期到症状性疾病的进展是由不同的自身免疫轨迹预测的。
147.A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
具有高丙酮酸脱氢酶活性的非分裂细胞群调节着肠道的代谢异质性和肿瘤发生。
148.Transposon insertional mutagenesis of diverse yeast strains suggests coordinated gene essentiality polymorphisms.
不同酵母菌株的转座子插入诱变表明基因本质多态性的协调。
149.RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning.
RUFY3连接Arl8b和JIP4-Dynein复合物以调节溶酶体大小和定位。
150.Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis.
斑马鱼成像显示TP53突变在原发性肿瘤发生中从抑制者转换为驱动者。
151.A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats.
HIV-1整合酶的一个点突变使前病毒整合重定向到中心体重复区。
152.S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.
BRCA1突变型乳腺癌中S100A9-CXCL12的激活促进了与免疫疗法抗性相关的免疫抑制微环境。
153.The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross.
二倍体酵母杂交中加性、优势和外显性的相互作用。
154.Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers.
使用二-邻苯二甲醛交联剂的快速交联质谱法对蛋白质展开的特征进行分析。
155.CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.
效应器T细胞中CD4的表达取决于发育过程中建立的刺激反应元件上的DNA去甲基化。
156.Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors.
通过合成的CRISPRa电路对转录因子的同时增减进行精确的肿瘤免疫重构。
157.Parallel reduction in flowering time from de novo mutations enable evolutionary rescue in colonizing lineages.
新生突变引起的开花时间的平行减少使殖民系的进化得到拯救。
158.Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion.
葡醛酸酯酶的机制和生物质关联：一种具有生物质转化潜力的α/β水解酶。
159.Large field-of-view non-invasive imaging through scattering layers using fluctuating random illumination.
利用波动随机照明通过散射层的大视场非侵入性成像。
160.Evolutionary transition from a single RNA replicator to a multiple replicator network.
从单一RNA复制器到多复制器网络的进化过渡。
161.Structures of a deltacoronavirus spike protein bound to porcine and human receptors.
与猪和人类受体结合的德尔塔科罗纳病毒尖峰蛋白的结构。
162.p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases.
p16INK4A缺陷预测HER2+乳腺癌脑转移患者对联合HER2和CDK4/6抑制的反应。
163.Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy.
释放一氧化氮供体和抗CTLA-4胶束的热敏水凝胶用于抗肿瘤免疫治疗。
164.The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.
RET抑制剂耐药性在RET驱动的肺癌和甲状腺癌中的演变。
165.Extracellular vesiculo-tubular structures associated with suberin deposition in plant cell walls.
与植物细胞壁中亚精蛋白沉积有关的细胞外囊管结构。
166.DNA-based platform for efficient and precisely targeted bioorthogonal catalysis in living systems.
基于DNA的平台，用于在生命系统中进行高效和精确定向的生物正交催化。
167.Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains.
全基因组的核仁相互作用图显示了压抑性染色质域的不同层次。
168.N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.
N7-甲基鸟苷tRNA修饰通过RPTOR/ULK1/自噬轴促进食管鳞状细胞癌的肿瘤发生。
169.Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids.
生物仿生水凝胶支持患者来源的乳腺肿瘤器官的启动和生长。
170.Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo.
识别刚果民主共和国加强控制伽马氏昏睡病的区域。
171.Extra kinetic dimensions for label discrimination.
标签识别的额外动力学维度。
172.Structural basis for activation and gating of IP3 receptors.
IP3受体的激活和门控的结构基础。
173.Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication.
人类鼻病毒促进STING贩运到复制细胞器以促进病毒复制。
174.De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report.
在治疗免疫力低下的SARS-CoV-2持续感染期间，重新出现了remdesivir耐药性突变：一个案例报告。
175.RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection.
TMPRSS2中的RNA G-四联体降低了SARS-CoV-2感染。
176.Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia.
ASXL1突变型慢性粒细胞白血病的致癌基因表达和顺式调控元素的表观遗传重塑。
177.Single-molecule imaging of microRNA-mediated gene silencing in cells.
细胞中microRNA介导的基因沉默的单分子成像。
178.Trajectory of immune evasion and cancer progression in hepatocellular carcinoma.
肝细胞癌免疫规避和癌症进展的轨迹。
179.Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity.
恶性肿瘤前期巴雷特食道的多组学交叉队列研究揭示了早期结构变异和逆转录基因的活性。
180.Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel.
结构指导下的NaX解锁揭示了一个非选择性的河豚毒素敏感阳离子通道。
181.Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency.
Gpr125是多种乳腺祖细胞与肿瘤潜伏期相联系的统一标志。
182.FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity.
FrCas9是一个具有高编辑效率和保真度的CRISPR/Cas9系统。
183.Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome.
从人类微生物组转移抗生素抗性的广泛宿主范围移动遗传元素的菌株水平特征。
184.The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.
寡头细胞转录因子2 OLIG2在啮齿动物的髓鞘生成过程中调节转录抑制。
185.Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging.
肌肉干细胞上的初级纤毛对于维持再生能力至关重要，并在衰老过程中丧失。
186.Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23.
肝脏CD11c+细胞的自噬功能障碍通过产生IL-23促进非酒精性脂肪肝的发生。
187.Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.
鞭毛蛋白外域二聚体调控粘稠环境中致病菌和土壤细菌的运动能力。
188.Structure and function of the soil microbiome underlying N2O emissions from global wetlands.
全球湿地N2O排放背后的土壤微生物组的结构和功能。
189.Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival.
稳态血清IgE由胸腺中的浆细胞分泌并增强肥大细胞的生存能力。
190.Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor.
中脑多巴胺能神经元线粒体完整性的维持受一个保守的发育转录因子的支配。
191.LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy.
LC3B是一种RNA结合蛋白，可在自噬过程中引发mRNA的快速降解。
192.Agent-based modelling of reactive vaccination of workplaces and schools against COVID-19.
基于代理的工作场所和学校针对COVID-19的反应性疫苗接种的模型。
193.All-fiber high-speed image detection enabled by deep learning.
通过深度学习实现的全纤维高速图像检测。
194.Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy.
基于微藻的口服微载体用于癌症放疗中的肠道微生物群稳态和肠道保护。
195.Global profiling of regulatory elements in the histone benzoylation pathway.
组蛋白苯甲酰化途径中调控元素的全球剖析。
196.CEP128 is involved in spermatogenesis in humans and mice.
CEP128参与人类和小鼠的精子生成。
197.Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis.
癌症干细胞调控的表型可塑性保护转移的癌细胞不受铁锈病影响。
198.Machine learning discovery of missing links that mediate alternative branches to plant alkaloids.
机器学习发现介导植物生物碱替代分支的缺失环节。
199.Intralocus conflicts associated with a supergene.
与一个超级基因有关的焦点内冲突。
200.Tertiary lymphoid structures critical for prognosis in endometrial cancer patients.
对子宫内膜癌患者预后至关重要的三级淋巴结结构。
201.Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab.
炎症性肠病患者接受英夫利昔单抗和维多利珠单抗治疗后的抗体衰减、T细胞免疫和突破性感染。
202.Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior.
中间神经元和少突胶质细胞前体细胞之间的双向交流受损，影响社会认知行为。
203.Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma.
因迪苏兰针对RNA剪接和代谢，作为高危神经母细胞瘤的治疗策略。
204.Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase.
Dbf4-Cdc7激酶对MCM双六聚体激活的结构洞察。
205.Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma.
针对肝癌的组织驻留伽马δT细胞的特征和诱导。
206.Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity.
内侧前额叶皮层和前内侧丘脑的相互作用调控目标导向行为和多巴胺能神经元的活动。
207.The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.
通过SRSF10对包含10号外显子的SREK1进行异常上调，成为人类肝细胞癌的致癌驱动因素。
208.Dynamics of plasmid-mediated niche invasion, immunity to invasion, and pheromone-inducible conjugation in the murine gastrointestinal tract.
小鼠胃肠道中质粒介导的生态位入侵、入侵免疫和信息素诱导的结合的动态变化。
209.Spinal cord injury impairs cardiac function due to impaired bulbospinal sympathetic control.
脊髓损伤因球囊交感神经控制受损而损害心脏功能。
210.Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma.
靶向SOX10缺陷细胞以减少黑色素瘤的休眠侵袭表型状态。
211.Myosin VI regulates the spatial organisation of mammalian transcription initiation.
肌球蛋白VI调控哺乳动物转录起始的空间组织。
212.Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers.
绘制异型淀粉样物质相互作用的序列特异性，能够识别聚集修饰物。
213.Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2.
本质上无序的细胞内结构域控制着机械门控离子通道PIEZO2的关键特征。
214.A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity.
一个动力学模型预测了SpCas9的活性，改善了脱靶分类，并揭示了靶向保真度的物理基础。
215.Electrical modulation of transplanted stem cells improves functional recovery in a rodent model of stroke.
移植干细胞的电调控改善了啮齿类中风模型的功能恢复。
216.A microphysiological model of human trophoblast invasion during implantation.
植入过程中人类滋养细胞入侵的微观生理学模型。
217.A peroxisomal heterodimeric enzyme is involved in benzaldehyde synthesis in plants.
一种过氧化物酶异构体参与植物中苯甲醛的合成。
218.Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes.
非裔美国人前列腺癌患者的DNA损伤修复基因的种系突变情况突出了潜在的可靶向RAD基因。
219.Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate.
载体和手术方法的选择使非人类灵长类动物的耳蜗基因转移变得高效。
220.DIAMetAlyzer allows automated false-discovery rate-controlled analysis for data-independent acquisition in metabolomics.
DIAMetAlyzer允许对代谢组学中的数据独立采集进行自动假发现率控制的分析。
221.Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors.
伽蓝素受体的异生激动和G蛋白亚型选择性的分子基础。
222.Comprehensive evaluation of deconvolution methods for human brain gene expression.
人脑基因表达的去卷积方法的综合评价。
223.Numerosity tuning in human association cortices and local image contrast representations in early visual cortex.
人类联想皮层的数字调谐和早期视觉皮层的局部图像对比表征。
224.Tau deposition patterns are associated with functional connectivity in primary tauopathies.
Tau沉积模式与原发性tauopathies的功能连接有关。
225.Measuring mechanical anisotropy of the cornea with Brillouin microscopy.
用布里渊显微镜测量角膜的机械各向异性。
226.Mixotrophic plankton foraging behaviour linked to carbon export.
混合营养型浮游生物的觅食行为与碳输出有关。
227.A specialized bone marrow microenvironment for fetal haematopoiesis.
胎儿造血的专门骨髓微环境。
228.βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling.
βIV-spectrin作为VEGF信号传导的柄状细胞内在调节器。
229.Phylogenomic analyses highlight innovation and introgression in the continental radiations of Fagaceae across the Northern Hemisphere.
系统基因组分析突出了北半球山羊科植物大陆辐射中的创新和内收。
230.Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins.
基于结构的前融合稳定的人偏肺病毒融合蛋白的设计。
231.Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.
SpCas9变体的基准化使BRCA1和BCL2的基础编辑筛选更加深入。
232.The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
精氨酸甲基转移酶PRMT7促进单核细胞的外渗，导致COPD的组织损伤。
233.Quantifying and comparing radiation damage in the Protein Data Bank.
量化和比较蛋白质数据库中的辐射损伤。
234.Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica.
气道基底干细胞的功能障碍在气管支气管骨质增生症的病理生理学中起关键作用。
235.Rescuing low frequency variants within intra-host viral populations directly from Oxford Nanopore sequencing data.
直接从牛津纳米孔测序数据中抢救宿主内病毒种群中的低频变体。
236.DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development.
无DNA甲基化的拟南芥揭示了DNA甲基化在调控基因表达和发育中的关键作用。
237.Norway spruce postglacial recolonization of Fennoscandia.
挪威云杉冰川期后在芬诺斯卡迪亚的再殖民化。
238.Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage.
通过化学调控内质网保留信号的裂解来调节蛋白质的分泌。
239.Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas.
pembrolizumab在复发和残留的高等级脑膜瘤患者中的2期研究。
240.A systematic review and meta-analysis of gene therapy with hematopoietic stem and progenitor cells for monogenic disorders.
用造血干细胞和祖细胞治疗单基因疾病的系统回顾和荟萃分析.
241.Texture is encoded in precise temporal spiking patterns in primate somatosensory cortex.
纹理在灵长类动物体感皮层中被编码为精确的时间性尖峰模式。
242.Apoplastic class III peroxidases PRX62 and PRX69 promote Arabidopsis root hair growth at low temperature.
细胞膜III类过氧化物酶PRX62和PRX69促进拟南芥根毛在低温下生长。
243.Lysosomal Ca2+-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress.
溶酶体Ca2+介导的TFEB激活调控有丝分裂和胰岛β细胞对代谢压力的功能适应。
244.Oxidative metabolisms catalyzed Earth’s oxygenation.
氧化代谢催化了地球的氧合作用。
245.Mucospheres produced by a mixotrophic protist impact ocean carbon cycling.
一种混养原生动物产生的粘液球对海洋碳循环的影响。
246.CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT.
CrkII/Abl磷酸化级联对NLRC4炎症体活动至关重要，并被铜绿假单胞菌ExoT阻断。
247.Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition.
Bardet-Biedl蛋白Bbs1的缺失改变了光感受器外节蛋白和脂质的组成。
248.Structural basis for modulation of human NAV1.3 by clinical drug and selective antagonist.
临床药物和选择性拮抗剂调控人类NAV1.3的结构基础。
249.Recurring adaptive introgression of a supergene variant that determines social organization.
决定社会组织的超级基因变体的反复适应性引入。
250.Genotyping-by-sequencing-based identification of Arabidopsis pattern recognition receptor RLP32 recognizing proteobacterial translation initiation factor IF1.
基于基因分型-测序的拟南芥模式识别受体RLP32识别蛋白细菌翻译起始因子IF1的鉴定。
251.Secondary structure prediction for RNA sequences including N6-methyladenosine.
包括N6-甲基腺苷的RNA序列的二级结构预测。
252.The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.
磷酸甲酯封盖酶Bmc1/Bin3是裂殖酵母端粒酶全酶的一个稳定组成部分。
253.De novo inter-regional coactivations of preconfigured local ensembles support memory.
预先配置的局部组合的新的区域间协同激活支持记忆。
254.Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum.
胆碱能停顿、多巴胺能激活和棘突神经元去极化的巧合推动了纹状体的突触可塑性。
255.The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation.
谷胱甘肽转运体Ycf1被调节域磷酸化调节的结构基础。
256.Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum.
RAP蛋白的功能基因组学及其在恶性疟原虫中Mitoribosome调节中的作用。
257.Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution.
昆虫黄病毒中3'UTR的结构分析揭示了sfRNA生物生成的新决定因素，并为黄病毒的进化提供了新的见解。
258.Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice.
BLA副白蛋白中间神经元的Gq神经调控诱导突发射击并介导小鼠的恐惧相关网络和行为状态转换。
259.Inhibition allocates spikes during hippocampal ripples.
抑制在海马波纹期间分配尖峰。
260.Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity.
全面的三维表观基因组图谱定义了肢体干/祖细胞的功能和身份。
261.In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy.
肿瘤催化治疗的双酶驱动循环级联反应的体内三维多谱段光声成像。
262.Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array.
基于嵌段共聚物的三维多态人工细胞膜阵列的可调控和可扩展的制造。
263.The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages.
铜绿假单胞菌各系的核心和附属Hfq交互组。
264.A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing.
通过单细胞RNA测序揭示果蝇髓质神经细胞的综合时间模式基因网络。
265.An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
西格玛-1受体的开放样构象揭示了其配体进入途径。
266.Clinical and genomic features of Chinese lung cancer patients with germline mutations.
中国肺癌患者种系突变的临床和基因组特征.
267.iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2.
iRhom假蛋白酶通过IP3受体和BCL-2调节ER应激诱导的细胞死亡。
268.Divergent trajectories of antiviral memory after SARS-CoV-2 infection.
SARS-CoV-2感染后抗病毒记忆的不同轨迹。
269.Fully-automated and ultra-fast cell-type identification using specific marker combinations from single-cell transcriptomic data.
利用单细胞转录组数据的特定标志物组合进行全自动和超快速的细胞类型识别。
270.Improved prediction of protein-protein interactions using AlphaFold2.
使用AlphaFold2改进蛋白质-蛋白质相互作用的预测。
271.Synthetic glycans control gut microbiome structure and mitigate colitis in mice.
合成糖控制肠道微生物组结构并缓解小鼠结肠炎。
272.Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity.
主要的GII.4人类诺瓦克病毒外壳的原子结构揭示了新的稳定性和可塑性。
273.Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis.
核酸镰刀菌减少了METTL3介导的m6A修饰，有助于结直肠癌的转移。
274.Bacteria eat nanoprobes for aggregation-enhanced imaging and killing diverse microorganisms.
细菌食用纳米探针进行聚集增强成像并杀死不同的微生物。
a 示意图显示细菌吞噬金纳米颗粒以进行聚集增强成像和杀死细菌。 成像模型包括荧光成像（FI）和光声成像（PAI）。 治疗方法包括光热疗法（PTT）和光动力疗法（PDT）。 b 大肠杆菌中 ABC 转运蛋白的结构（左：侧视图；右：俯视图）。 大肠杆菌中ABC转运蛋白的序列来自http://www.rcsb.org/，结构通过PyMOL软件模拟。 c 经 1.0 mg mL−1 地氮丙啶和二氢卟酚 e6 (Ce6) 修饰的金纳米粒子 (AuNPs) (dAuNPs@Ce6) 或 GP（例如，poly [4-O-(α-D-吡喃葡萄糖基)-D-吡喃葡萄糖])、地氮丙啶和 Ce6 修饰的金纳米粒子 (AuNPs) (GP-dAuNPs@Ce6) 在 37°C 下保持 2小时。 孵育后，将处理过的细菌用 PBS 缓冲液漂洗数次。 GP-dAuNPs@Ce6 处理过的细菌接受或不接受激光照射（405nm，1.0W cm−2，25min）。 细菌细胞浓度约为 1.0 × 107 CFU。 比例尺，200nm。
275.Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control.
深度蛋白质组学分析揭示了丙烯硫酸酯酶A是一种非酒精性脂肪肝诱导性肝脏因子和血糖控制的调节剂。
276.Co-translational assembly orchestrates competing biogenesis pathways.
协同翻译组装协调了相互竞争的生物生成途径。
277.The YΦ motif defines the structure-activity relationships of human 20S proteasome activators.
YΦ motif定义了人类20S蛋白酶体激活剂的结构-活性关系。
278.Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.
Sirtuin-1敏感的赖氨酸-136乙酰化驱动TDP-43的相分离和病理性聚集。
279.Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections.
急性细菌性呼吸道感染治疗过程中抗生素耐药性突变的快速扩展和消亡。
280.A large and diverse autosomal haplotype is associated with sex-linked colour polymorphism in the guppy.
一个庞大而多样的常染色体单倍型与石首鱼的性联颜色多态性有关。
281.Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing.
恢复Sirtuin 2在少突胶质细胞祖细胞中的核进入，促进老化过程中的再髓化。
282.The flavonoid corylin exhibits lifespan extension properties in mouse.
黄酮类化合物冠醚在小鼠中表现出延长寿命的特性。
283.An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.
16q22.1的一个增强器变体通过调节PRMT7的表达易导致肝细胞癌。
284.Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.
靶向GPCRs和RAS相关分子的自身抗体与COVID-19的严重程度有关。
285.Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus.
阐明PROCR血管疾病位点的遗传性交叉疾病关联机制。
286.First-in-human immunoPET imaging of HIV-1 infection using 89Zr-labeled VRC01 broadly neutralizing antibody.
使用89Zr标记的VRC01广泛中和抗体对HIV-1感染进行首次人体免疫PET成像。
287.Mechanosensory trichome cells evoke a mechanical stimuli–induced immune response in Arabidopsis thaliana.
机械感觉毛细管细胞唤起拟南芥的机械刺激诱导的免疫反应。
288.Structural snapshots of V/A-ATPase reveal the rotary catalytic mechanism of rotary ATPases.
V/A-ATP酶的结构快照揭示了旋转ATP酶的旋转催化机制。
289.Fossil coleoid cephalopod from the Mississippian Bear Gulch Lagerstätte sheds light on early vampyropod evolution.
来自密西西比熊沟拉格斯塔特的头足类化石揭示了早期翼足类的进化。
290.Arabidopsis RBV is a conserved WD40 repeat protein that promotes microRNA biogenesis and ARGONAUTE1 loading.
拟南芥RBV是一个保守的WD40重复蛋白，可促进microRNA的生物生成和ARGONAUTE1的装载。
291.Bacterial F-type ATP synthases follow a well-choreographed assembly pathway.
细菌的F型ATP合成酶遵循一个精心编排的组装途径。
292.Ancient genomes from the Himalayas illuminate the genetic history of Tibetans and their Tibeto-Burman speaking neighbors.
来自喜马拉雅山的古老基因组阐明了藏族和他们的藏缅语邻居的遗传历史。
293.Differential recognition of canonical NF-κB dimers by Importin α3.
进口蛋白α3对经典NF-κB二聚体的不同识别。
294.MQuad enables clonal substructure discovery using single cell mitochondrial variants.
MQuad利用单细胞线粒体变体实现了克隆亚结构的发现。
295.Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling.
GPCR-G蛋白相互作用的动力学模型揭示了Allokairic对信号的调节。
296.CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses.
CMTr帽相邻2′-O-核糖mRNA甲基转移酶是奖励学习和mRNA定位到突触所需的。
297.Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing.
Cas9外切核酸酶在基因组编辑过程中消除了染色体易位。
298.A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning.
由内侧隔膜复合体中的体液蛋白神经元介导的自下而上的奖励途径，是食欲学习的基础。
299.Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer.
共同靶向BAX和BCL-XL蛋白广泛克服了癌症中对凋亡的抵抗。
300.Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination.
自我减毒的腺病毒使重组腺相关病毒的生产在无污染的情况下获得高产。
301.Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations.
接触前南美人类人口中地理上分散的人畜共患结核病。
302.Tropical extreme droughts drive long-term increase in atmospheric CO2 growth rate variability.
热带极端干旱推动了大气中二氧化碳增长率变化的长期增加。
303.Breeding future crops to feed the world through de novo domestication.
通过新的驯化培育未来的农作物以养活世界。
304.Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil.
巴西1,171名老年混血儿的全基因组测序。
305.Evolution of the SARS-CoV-2 spike protein in the human host.
SARS-CoV-2尖峰蛋白在人类宿主中的进化。
306.Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy.
低氧诱导的自噬需要ULK1的氧敏甲基化。
307.The molecular basis of FimT-mediated DNA uptake during bacterial natural transformation.
细菌自然转化过程中FimT介导的DNA摄取的分子基础。
308.Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C.
泛素和一个带电环调节Ark2C的泛素E3连接酶活性。
309.Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche.
细胞膜协调果蝇肌肉原基中的不对称信号传递和组织。
310.The indirect effect of mRNA-based COVID-19 vaccination on healthcare workers’ unvaccinated household members.
基于mRNA的COVID-19疫苗接种对医护人员未接种的家庭成员的间接影响。
311.Waning of SARS-CoV-2 booster viral-load reduction effectiveness.
SARS-CoV-2强化剂降低病毒量的效果减弱。
312.Hysteresis stabilizes dynamic control of self-assembled army ant constructions.
滞后性稳定了自组装军蚁结构的动态控制。
313.Neuronal activity in sensory cortex predicts the specificity of learning in mice.
感觉皮层的神经元活动预示着小鼠学习的特异性。
314.In vitro maturation of Toxoplasma gondii bradyzoites in human myotubes and their metabolomic characterization.
弓形虫布拉迪虫在人类肌管中的体外成熟及其代谢组学特征。
315.Landscape of adenosine-to-inosine RNA recoding across human tissues.
人体组织中腺苷-肌苷RNA重新编码的景观。
316.Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP.
Importin-7对核输入的机械控制受其主导货物YAP的调节。
317.Endothelial Unc5B controls blood-brain barrier integrity.
内皮细胞Uc5B控制血脑屏障的完整性。
318.Structural insight into Marburg virus nucleoprotein–RNA complex formation.
对马尔堡病毒核蛋白-RNA复合物形成的结构洞察。
319.White matter integrity in mice requires continuous myelin synthesis at the inner tongue.
小鼠的白质完整性需要内舌的持续髓鞘合成。
320.The control of transcriptional memory by stable mitotic bookmarking.
稳定的有丝分裂书签对转录记忆的控制。
321.Associations between alcohol consumption and gray and white matter volumes in the UK Biobank.
英国生物库中酒精消费与灰质和白质体积之间的关系。
322.Active label cleaning for improved dataset quality under resource constraints.
在资源限制下主动清理标签以提高数据集质量。
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