液相应用解决方案-UPLC液相压力波动异常（规律性）
ACQUITY BSM 的压力下降至零 - WKB12836
文章编号: 12836点击此处访问英文版本文章
故障描述
液流开启时，初级泵的压力有时会下降
压力从 8000 psi 下降到 0 psi，然后再次升高
一个或多个溶剂管路或泵无液流
在疑似泵渗漏时可能会出现此问题
环境
ACQUITYBSM
ACQUITY QSM
原因
流动相储液瓶中的流动相耗尽或流动相储液瓶中的溶剂不足，导致溶剂管路中进入了空气
解决方法
检查流动相储液瓶的所有溶剂管路。
确保流动相储液瓶已装满，足以完全浸没溶剂管路末端的过滤头/沉子。
如果使用缓冲液，请将管路置于 100％ 水中。
灌注各管路 5 min，确保缓冲液被冲洗出来。
将所有溶剂管路放在 100% 甲醇中。
灌注所有溶剂管路 5-10 min，或者直至所有气泡消失。
以 100％ 甲醇开启液流，并监测压力表以确认压力稳定。
切换为正在使用的流动相。
再次灌注各管路 5 min，以确保甲醇被冲洗出来。
开启液流并监测压力表，确认压力稳定。
Pressure drops to zero on ACQUITY BSM - WKB12836
Article number: 12836
SYMPTOMS
During flow, primary pump shows sporadic pressure drops
Pressure drops from 8000 psi to 0 psi, and then rises again
No flow from one or more solvent lines or pumps
May appear as if the pump is leaking
ENVIRONMENT
ACQUITY BSM
ACQUITY QSM
CAUSE
Air in the solvent lines as a result of empty mobile phase bottles, or there is not enough solvent in mobile phase bottle
FIX or WORKAROUND
Check the mobile phase bottles for all solvent lines.
Ensure that the mobile phase bottle is full enough to completely cover the filter/sinker at the end of the solvent line.
If buffer is used, place the lines in 100% water.
Prime each line for 5 minutes, to ensure that the buffer is washed out.
Place all solvent lines in 100% methanol.
Prime all solvent lines for 5-10 minutes, or until any air bubbles dissipate.
Start a flow with 100% methanol and monitor the pressure charts to confirm steady pressure.
Switch to the mobile phase in use.
Prime each line again for 5 minutes, to ensure that the methanol is washed out.
Start a flow and monitor the pressure charts to confirm steady pressure.
Alliance 2695 上的初级泵柱塞输送期间突然出现压力急剧下降 - WKB63811
故障描述
Alliance 2695 上的一台传动装置在柱塞输送期间出现压力急剧下降
下降 2 - 3 秒后，压力恢复到正常水平
环境
2695 分离单元
原因
初级泵柱塞和正面密封件上发生盐沉积
解决方法
拆下泵头，检查是否发生盐沉积。
用水冲洗柱塞和密封件以去除盐沉积，然后重新安装泵头。
附加信息
其他：
清洗单向阀门
Sudden, sharp pressure drop during primary plunger stroke on Alliance 2695 - WKB63811
Article number: 63811
SYMPTOMS
Sharp pressure drop during plunger stroke of one actuator on Alliance 2695
2-3 seconds after pressure drop, pressure rebuilds to normal level
ENVIRONMENT
2695 Separations Module
CAUSE
Salt buildup on the primary plunger and face seals
FIX or WORKAROUND
Remove the pump head and inspect for salt buildup.
Rinse the plunger and seals with water to remove salt, and then reinstall the pump head.
Replace the seals if necessary
ADDITIONAL INFORMATION
ACQUITY H-Class QSM 出现压力波动 - WKB19400
故障描述
蓄积泵和系统压力迹线出现压力波动
波动仍处于系统压力的 1% 范围内，但高于平时且不稳定
可能会增加 UV 检测器的基线噪音
动态渗漏测试通过
更换单向阀无法解决问题
环境
ACQUITY H-Class 四元溶剂管理器 (QSM)
原因
梯度比例阀 (GPV) 堵塞。
影响 A/B 溶剂管路或 C/D 溶剂管路
从 ACQUITY 控制台关闭 GPV 时，一些溶剂仍然流经受影响的管路
解决方法
更换受影响溶剂管路的双通道 GPV (700005161)。
附加信息
Pressure fluctuations on ACQUITY H-Class QSM - WKB19400
Article number: 19400
SYMPTOMS
Pressure fluctuates on both Accumulator and System pressure traces
Delta still within 1% of system pressure but higher than usual and unstable
Can increase baseline noise on UV detectors
Dynamic leak test passes
Replacing check valves doesn't solve the problem
ENVIRONMENT
ACQUITY H-Class Quaternary Solvent Manager (QSM)
CAUSE
Blockage in gradient proportioning valve (GPV).
Affects either A/B solvent lines or C/D solvent lines
When closing GPV from Acquity Console, some solvent is still flowing through the affected line
FIX or WORKAROUND
Replace the dual-channel GPV (700005161) for the affected solvent lines.
