184179-08-6 | Ac-DEVD-CHO | 半胱胺酸蛋白酶-10

Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC₅₀ = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC₅₀ = 10 to 100 nM).

Ac-DEVD-CHO是聚(adp -核糖)聚合酶(PARP)被caspase-3裂解的有效抑制剂(IC₅₀= 0.2 nM)。PARP的分裂发生在细胞凋亡的开始。肽醛能够在体外减弱凋亡事件(IC₅₀= 10至100 nM)。

编号:194344

中文名称:半胱胺酸蛋白酶-10：Ac-Asp-Glu-Val-Asp-CHO

英文名:PASE-3 Inhibitor I; Ac-Asp-Glu-Val-Asp-CHO

CAS号:184179-08-6

单字母:Ac-DEVD-CHO

三字母:Ac-Asp-Glu-Val-Asp-CHO

氨基酸个数:4

分子式:C20H30O11N4

平均分子量:502.47

精确分子量:502.19

等电点(PI):-

pH=7.0时的净电荷数:-3

平均亲水性:1.875

疏水性值:-1.58

来源:化学合成

盐体系:TFA盐

储存条件:-20摄氏度

标签:<span class="nolink">醛肽<span class="nolink">抑制剂相关肽

参考文献：

10.1080/10428190701385181The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines

10.1016/j.jdermsci.2007.06.008Flavonolignans from Silybum marianum moderate UVA-induced oxidative damage to HaCaT keratinocytes

10.1002/cbdv.200800354Antiproliferative and proapoptotic activities of a new class of pyrazole derivatives in HL-60 cells