巴西里奥格兰德联邦大学María教授：纳米材料毒性评估的新挑战
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本
期
主
题
New challenges for
the evaluation of nanomaterials toxicity
纳米材料毒性评估的新挑战
本期主持：
何益得 副教授
EEH期刊青年编委
南京工业大学
特邀主讲：
José María Monserrat 教授
Universidade Federal do Rio Grande
FURG, Brazil
He graduated with honors in Biological Sciences from the University of Buenos Aires (UBA), Argentina in 1988. Master's degree in Biostatistics (UBA) in 1993. PhD in Biological Oceanography from the Federal University of Rio Grande - FURG in 1997. He has published 232 articles in specialized journals and 10 book chapters in the areas of Aquaculture, Oxidative Stress in Aquatic Organisms, Chemoprevention of Toxic Compounds and Nanotoxicology (6009 citations, h-index: 40; database: Scopus). Full Professor at the Federal University of Rio Grande - FURG, based at the Institute of Biological Sciences (ICB). Permanent professor in the graduate programs of Aquaculture and Physiological Sciences. He is an evaluator of scientific projects submitted to national and foreign agencies and a scientific reviewer for more than 50 international journals and a member of the editorial board of Marine Life Science & Technology (MLST) and Chemistry and Ecology journals.
报告摘要
The increment in the generation and industry applications of nanomaterials (NM) rise concerns about their potential impacts on human and environmental health. In this sense, the development of nanotoxicology with an eye towards the health of organisms and the environment is essential for the growth and use of sustainable nanotechnologies. In the recent past, several efforts have been done (i.e. the European initiative NanoReg) to intercallibrate toxicity assays in terms of animal models, preparation of NM suspensions, NM characterization and end point suitable to point NM toxicity. Also, methodological evaluations of the potential interferences of NM on the endpoints used in the assays stiil are not the norm. Some studies have estimated that 95% and 90% of published articles that use spectrophotometric or fluorometric methods, respectively, have not considered the use of controls to assess the possible interference induced by NM. These control quality measurements should be mandatory in nanotoxicity assays as well as comparative studies of responses of different biological models in terms of their sensitity and simplicity to run the assays. Recently, the use of in silico approaches (i.e.: molecular docking, molecular dynamics) have shown their aplicability as a screening method to search molecular and biochemical targets of -mainly- organic NM. These methodologies posses the potential of helping in filling the the gap between the development of new NM and the study of their potential toxicity. Last but not least, it is critical to conduct nanotoxicity assays utilizing realistic environmental concentrations of NM in order to conduct accurate risk assessments, even though there are few reports indicating and measuring the presence of NM in the environment.
