病毒学相关多肽HTLV-1 Tax (11-19)、141677-18-1

人类 T 淋巴细胞病毒 1 型 HTLV-1 Tax (11-1)，LLFGYPVYV，是一种免疫显性 HLA-A2 限制性表位。它被 HTLV-1 相关脊髓病/热带痉挛性下肢轻瘫 (HAM/TSP) 患者的大量 CD8⁺ 细胞毒性 T 淋巴细胞 (CTL) 识别，这是一种与 HTLV-1 感染相关的脱髓鞘炎性神经系统疾病。因此，LLFGYPVYV 是阐明抗原特异性 CD8⁺ CTL 在 HAM/TSP 中作用的有用工具。

Human T lymphotropic virus type 1 HTLV-1 Tax (11-1), LLFGYPVYV, is an immunodominant HLA-A2-restricted epitope. It is recognized by a high number of CD8⁺ cytotoxic T lymphocytes (CTLs) in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a demyelinating inflammatory neurologic disease associated with HTLV-1 infection. LLFGYPVYV therefore represents a useful tool to elucidate the role of antigen-specific CD8⁺ CTLs in HAM/TSP.

编号: 200168

中文名称: HTLV-1 Tax (11-19)

CAS号: 141677-18-1

单字母: H2N-LLFGYPVYV-OH

三字母: H2N-Leu-Leu-Phe-Gly-Tyr-Pro-Val-Tyr-Val-COOH

氨基酸个数: 9

分子式: C56H79N9O12

平均分子量: 1070.28

精确分子量: 1069.58

等电点(PI): 10.13

pH=7.0时的净电荷数: 1.97

平均亲水性: -2.2714285714286

疏水性值: 1.67

来源: 人工化学合成，仅限科学研究使用，不得用于人体。

储存条件: 负80℃至负20℃

标签: 病毒学

DOI 名称

10.1038/nm845 Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections 下载

10.1073/pnas.95.13.7568 Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients 下载

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