【标题速读】【Ncomm】【biological-sciences】【2022年】【2月】
声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。
1.Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis.
由一个基因座编码的Kastor和Polluks多肽合作调节VDAC和精子生成。
2.Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA.
细菌的N4-甲基胞嘧啶作为真核生物DNA的表观遗传标记。
3.Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors.
利用多价p53肽-MdmX的相互作用来指导小分子抑制剂的改进。
4.HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources.
HPV感染通过下调乳酸菌作为氨基酸来源的宿主粘膜先天性肽而改变阴道微生物组。
5.LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer.
LKB1驱动停滞和C/EBP介导的重编程到肺癌中的肺泡II型命运。
6.Single-cell gene fusion detection by scFusion.
scFusion的单细胞基因融合检测。
7.SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase.
SIRT1选择性地发挥肝细胞烟酰胺磷酸核苷转移酶的代谢保护作用。
8.Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch.
带有碱基对错配的易位DNA合成聚合酶ζ的低温冷冻电镜结构。
9.Structure and assembly of the S-layer in C. difficile.
艰难梭菌中S层的结构和组装。
10.AP-4-mediated axonal transport controls endocannabinoid production in neurons.
AP-4介导的轴突运输控制着神经元中的内源性大麻素的产生。
11.Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp.
细菌报警素(p)ppGpp对SRP依赖性蛋白质分泌的抑制。
12.Natural variation in Glume Coverage 1 causes naked grains in sorghum.
Glume Coverage 1的自然变异导致高粱的裸露谷物。
13.Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Tirzepatide和肽20在GIP、GLP-1或胰高血糖素受体上的多重药理作用的结构见解。
14.A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
通过S.cerevisiae ORC-DNA-Cdc6的自抑制进行起源许可控制的机制。
15.Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer.
YAP对雌激素受体α的转录抑制揭示了Hippo途径作为ER+乳腺癌的治疗目标。
16.Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies.
T细胞急性淋巴细胞白血病的磷蛋白组学分析揭示了可靶向的激酶和联合治疗策略。
17.Understanding self-assembly at molecular level enables controlled design of DNA G-wires of different properties.
了解分子水平的自组装可以控制设计不同性质的DNA G线。
18.A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis.
一种推定的帽结合蛋白和甲基磷酸酯盖帽酶Bin3/MePCE在端粒酶生物生成中的功能。
19.Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
Formylpeptide受体FPR1和FPR2对formylpeptide和各种激动剂的分子识别。
20.Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex.
小鼠前额叶皮层化学遗传抑制后fMRI连接性增加。
21.Investigation of Cas9 antibodies in the human eye.
对人眼中Cas9抗体的调查。
22.Quantifying arousal and awareness in altered states of consciousness using interpretable deep learning.
利用可解释的深度学习量化意识改变状态下的唤醒和意识。
23.Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases.
不同的肠道微生物群落与阿苯达唑-伊维菌素对土壤传播蠕虫病的疗效相关。
24.Structural basis of adenylyl cyclase 9 activation.
腺苷酸环化酶9激活的结构基础。
25.Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming.
在患者来源的宫颈器官中建立衣原体和HPV共同感染的模型，揭示了不同的细胞重编程。
26.A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.
一个快速肌球蛋白超级增强子通过与肌球蛋白基因的竞争性相互作用决定了肌肉纤维的表型。
27.Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors.
人类脑室下区祖细胞的单细胞分析确定了SFRP1是重新激活祖细胞的目标。
28.Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes.
识别不同的细胞毒颗粒作为T淋巴细胞中超分子攻击颗粒的起源。
29.Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly.
使用小分子组装调节剂调整hIAPP聚集成淀粉样蛋白的速度。
30.Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits.
小鼠视觉皮层中相反的适应形式由不同的抑制性微电路控制。
31.Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo.
成骨细胞源性囊泡诱导体内从骨形成到骨吸收的转换。
32.Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes.
髓系恶性肿瘤患者的循环微生物含量与疾病亚型和患者预后有关。
33.Targeting ferroptosis protects against experimental (multi)organ dysfunction and death.
靶向铁蛋白酶可防止实验性（多）器官功能障碍和死亡。
34.Multilateral benefit-sharing from digital sequence information will support both science and biodiversity conservation.
数字序列信息的多边利益共享将支持科学和生物多样性保护。
35.Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.
尖锐湿疣的综合分子和临床分析将22q11.21的局域扩增与转移联系起来。
36.Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
非肺炎SARS-CoV-2感染的早期病毒遏制中的保护性免疫轨迹。
37.Uncovering interpretable potential confounders in electronic medical records.
揭示电子医疗记录中可解释的潜在混杂因素.
38.Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter.
质子依赖性脂质转运体中捕获和翻转机制的证据。
39.Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus.
生物合成基因簇分析预测了芽孢杆菌的拮抗作用和系统发育之间的正相关。
40.Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
蛋白质组学分析揭示CDK6上调是多发性骨髓瘤来那度胺的可靶向耐药机制。
41.Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission.
防止SARS-CoV-2输入和传播的检疫措施的基因组学评估。
42.Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PK.
小Cajal体相关RNA 2（scaRNA2）通过抑制DNA-PK调节DNA修复途径选择。
43.Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice.
Kindlin-2单倍体功能通过靶向小鼠的Foxo1保护脂肪肝。
44.Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications.
中性粒细胞外陷阱促进胃癌患者术后腹腔感染性并发症的转移。
45.Fine-scale heterogeneity in population density predicts wave dynamics in dengue epidemics.
人口密度的精细异质性预示着登革热疫情的波浪动态。
46.High-throughput identification and quantification of single bacterial cells in the microbiota.
微生物群中单个细菌细胞的高通量鉴定和量化.
47.Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2.
IV型干扰素的鉴定和建立以及干扰素-υ的特征，包括其II类细胞因子受体IFN-υR1和IL-10R2。
48.Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease.
乙酰胆碱的缺乏破坏了阿尔茨海默病小鼠模型中前额叶皮质的脑外投射神经元。
49.Multi-parameter photon-by-photon hidden Markov modeling.
多参数逐个光子的隐马尔可夫模型。
50.Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling.
Menin通过表观遗传学设置PTX3来平衡FGF和BMP信号，指导区域化蜕膜转化。
51.Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4.
Dicer通过溴域转录共激活物BRD4促进基因组稳定。
52.Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa.
南非城市和农村肠道微生物组的短读和长读元基因组学揭示了过渡性组成和未描述的分类群。
53.White matter myelination during early infancy is linked to spatial gradients and myelin content at birth.
婴儿早期的白质髓鞘化与出生时的空间梯度和髓鞘含量有关。
54.Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core.
合作的多价受体结合促进了SARS-CoV-2融合机制核心的暴露。
55.Virtual intracranial EEG signals reconstructed from MEG with potential for epilepsy surgery.
由脑电图重建的虚拟颅内脑电信号具有癫痫手术的潜力。
56.Randomized controlled trial for time-restricted eating in healthy volunteers without obesity.
无肥胖症的健康志愿者限时进食的随机对照试验。
57.Rad52 mediates class-switch DNA recombination to IgD.
Rad52介导类开关DNA重组到IgD。
58.Disentangling the recognition complexity of a protein hub using a nanopore.
利用纳米孔解读蛋白质枢纽的识别复杂性。
59.A hemimetabolous wing development suggests the wing origin from lateral tergum of a wingless ancestor.
翅膀的半代谢发育表明翅膀起源于无翼祖先的侧肢。
60.Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium.
致癌的人类血吸虫血吸虫的中间宿主Bulinus truncatus的核基因组。
61.Atmospheric dryness reduces photosynthesis along a large range of soil water deficits.
大气干燥在很大的土壤缺水范围内降低了光合作用。
62.Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation.
多通道光遗传学与层状记录相结合的超控神经元审讯。
63.Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response.
微生物驱动的早产涉及先天和适应性免疫反应之间的串扰。
64.Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins.
8-oxoG的全球和转录耦合修复是由核苷酸切除修复蛋白启动的。
65.Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation.
特定的长度和结构而非高热力学稳定性使调节性mRNA干环能够暂停翻译。
66.Effect of biannual azithromycin distribution on antibody responses to malaria, bacterial, and protozoan pathogens in Niger.
两年一次的阿奇霉素分配对尼日尔的疟疾、细菌和原生动物病原体的抗体反应的影响。
67.Genome binning of viral entities from bulk metagenomics data.
来自大宗元基因组学数据的病毒实体的基因组分级。
68.High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport.
EmrE的高pH结构揭示了质子偶联底物运输的机制。
69.The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response.
昆虫体液蛋白途径在生殖成熟和交配后的反应过程中对卵黄发生的进展进行把关。
70.PyUUL provides an interface between biological structures and deep learning algorithms.
PyUUL为生物结构和深度学习算法提供了一个接口。
71.ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1.
ATF-4和硫化氢信号介导对翻译或mTORC1抑制的长寿反应。
72.Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice.
Kansl1单倍体功能损害自噬体-溶酶体融合，并将自噬功能障碍与小鼠Koolen-de Vries综合征联系起来。
73.ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.
ASPP2在形态发生过程中维持机械压力下的假层状上皮的完整性。
74.Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites.
细胞粘附分子KIRREL1是Hippo信号的反馈调节器，将SAV1招募到细胞-细胞接触点。
75.A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
人类线粒体大亚基的一个后期组装检查点。
76.CPEB1 directs muscle stem cell activation by reprogramming the translational landscape.
CPEB1通过重塑翻译格局指导肌肉干细胞的激活。
77.Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium.
正常子宫内膜上皮细胞中克隆选择和多样化的时空动态。
78.Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific.
脊柱突触中谷氨酸受体组织的纳米级规则是亚单位特异的。
79.The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.
组蛋白去甲基化酶Kdm6b调控小鼠脊柱运动神经元发育过程中的亚型多样化。
80.Development and characterization of functional antibodies targeting NMDA receptors.
靶向NMDA受体的功能性抗体的开发和特征。
81.Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
异型相互作用驱动针对疟疾候选疫苗的抗体协同作用。
82.Genome-wide functional screens enable the prediction of high activity CRISPR-Cas9 and -Cas12a guides in Yarrowia lipolytica.
全基因组功能筛选使人们能够预测脂质体中的高活性CRISPR-Cas9和-Cas12a指南。
83.TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice.
TrkB激动剂抗体改善了老年和环磷酰胺诱导的卵巢早衰模型小鼠的生育障碍。
84.Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish.
成年斑马鱼慢性感染期间，脓肿分枝杆菌的粗糙和光滑变体受到宿主免疫力的不同控制。
85.T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.
胶质母细胞瘤微环境中的T细胞功能障碍是由释放白细胞介素-10的骨髓细胞介导的。
86.Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications.
基于严重COVID-19并发症患者血浆蛋白组学的预知工具和候选药物.
87.Forest fragmentation impacts the seasonality of Amazonian evergreen canopies.
森林破碎化影响亚马逊常绿树冠的季节性。
88.Recurrent chromosome reshuffling and the evolution of neo-sex chromosomes in parrots.
鹦鹉中反复出现的染色体重组和新性染色体的进化。
89.TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence.
TRPC3塑造了ER-mitochondria Ca2+转移的特点，促进了肿瘤的衰老。
90.CytofIn enables integrated analysis of public mass cytometry datasets using generalized anchors.
CytofIn利用广义锚对公共质谱数据集进行综合分析。
91.RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.
RIF1-ASF1介导的高阶染色质结构保障了基因组的完整性。
92.Protease-controlled secretion and display of intercellular signals.
蛋白酶控制的细胞间信号的分泌和显示。
93.Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning.
通过免疫表型和机器学习将住院的COVID-19患者分层为临床严重程度进展组。
94.Stroke induces disease-specific myeloid cells in the brain parenchyma and pia.
中风诱导脑实质和皮亚区的疾病特异性骨髓细胞。
95.A cattle graph genome incorporating global breed diversity.
纳入全球品种多样性的牛图基因组。
96.Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
新型胰岛素受体部分激动剂的功能选择性信号和广泛的代谢益处。
97.Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer.
低氧诱导的巨细胞增多症代表了肝癌的代谢途径。
98.Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology.
二氢甘油酰胺和神经酰胺分析提供了对人类心脏代谢疾病病因的深入了解。
99.Chemical reversible crosslinking enables measurement of RNA 3D distances and alternative conformations in cells.
化学可逆交联能够测量RNA的三维距离和细胞中的替代构象。
100.Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal.
原子揭示了生物大分子-金属-有机框架共生晶体的结构-活性关系。
101.Dual clathrin and integrin signaling systems regulate growth factor receptor activation.
双重凝集素和整合素信号系统调节生长因子受体的激活。
102.The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system.
AUTOTAC化学生物学平台，通过自噬-溶酶体系统定向降解蛋白质。
103.Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.
早期生活中的抗生素对发育中的婴儿肠道微生物组和抵抗组的影响：一项随机试验。
104.Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains.
早期肺泡巨噬细胞反应和IL-1R依赖的T细胞引物决定了结核分枝杆菌菌株的传播性。
105.Brain-wide visual habituation networks in wild type and fmr1 zebrafish.
野生型和fmr1斑马鱼的全脑视觉习惯网络。
106.CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an L-proline exporter for L-proline hyperproduction.
CRISPR辅助下的合理通量调控和阵列式CRISPRi筛选L-脯氨酸出口者的L-脯氨酸超生。
107.Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Lin28B高的乳腺癌细胞通过外泌体促进肺部转移前生态位的免疫抑制，并支持癌症的发展。
108.A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis.
Hexokinase 2的非催化性支架活动有助于EMT和转移。
109.Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines.
感染SHIVs或用不同HIV疫苗免疫的非人灵长类动物的差异性V2导向抗体反应。
110.Population antibody responses following COVID-19 vaccination in 212,102 individuals.
在212,102人中接种COVID-19疫苗后的群体抗体反应。
111.RETRACTED ARTICLE: Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection.
被撤回的文章： 药理扰乱CXCL1信号，缓解HEVA71感染模型中的神经发病机制。
112.Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes.
对存档乳腺癌临床标本的蛋白质组学分析确定了具有不同生存结果的生物亚型。
113.Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.
肌肉中与疾病相关的蛋白酶LONP1的损失损害了线粒体功能，导致骨骼肌质量和力量下降。
114.Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA.
Xrn1是一种调节线粒体NAD封顶RNA的去NADding酶。
115.Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
La Crosse病毒聚合酶的结构快照揭示了Peribunyaviridae复制和转录的机制。
116.An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease.
高效的尿液肽组学工作流程识别乳糜泻患者的化学定义饮食麸皮肽。
117.Disruption of the grid cell network in a mouse model of early Alzheimer’s disease.
早期阿尔茨海默病小鼠模型中网格细胞网络的破坏。
118.Cell specific peripheral immune responses predict survival in critical COVID-19 patients.
细胞特异性外周免疫反应预测危重症COVID-19患者的生存率。
119.Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice.
有机阴离子转运体1是HDAC4调控的小鼠痛觉超敏的媒介。
120.IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.
IL-22启动IL-18依赖性上皮反应回路，强制肠道宿主防御。
121.Global patterns in functional rarity of marine fish.
海洋鱼类功能稀有性的全球模式。
122.Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer.
过度表达环状二AMP的再造卡介苗增强了训练有素的免疫力，对膀胱癌表现出更好的疗效。
123.TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy.
TLR4是杜氏肌肉萎缩症小鼠模型中训练有素的免疫力的调节器。
124.The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.
口服蛋白酶抑制剂（PF-07321332）可保护叙利亚仓鼠免受SARS-CoV-2变体的感染，值得关注。
125.Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects.
癌症患者的生存期可以被参数化，以提高试验的精确性，并揭示与时间有关的治疗效果。
126.HSL1 and BAM1/2 impact epidermal cell development by sensing distinct signaling peptides.
HSL1和BAM1/2通过感知不同的信号肽影响表皮细胞的发育。
127.Using language in social media posts to study the network dynamics of depression longitudinally.
利用社交媒体帖子中的语言，纵向研究抑郁症的网络动态。
128.Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies.
SARS-CoV-2 Delta变体识别ACE2受体和广义中和抗体的结构基础。
129.Gut metagenome associations with extensive digital health data in a volunteer-based Estonian microbiome cohort.
基于志愿者的爱沙尼亚微生物群队列中，肠道元基因组与大量数字健康数据的关联。
130.AusTrakka: Fast-tracking nationalized genomics surveillance in response to the COVID-19 pandemic.
AusTrakka：为应对COVID-19大流行，快速跟踪国家化基因组学监测。
131.Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions.
两个Ndc80复合物通过CENP-T途径的招募对激振子功能是足够的。
132.Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity.
间质干细胞以HLA依赖性的方式将线粒体转移到异体Tregs，提高了其免疫抑制活性。
133.Local and global crosstalk among heterochromatin marks drives DNA methylome patterning in Arabidopsis.
异染色质标记之间的局部和整体串扰驱动拟南芥的DNA甲基组模式。
134.Structural basis of neuropeptide Y signaling through Y1 receptor.
神经肽Y通过Y1受体信号传导的结构基础。
135.Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.
对维纳斯捕蝇草机械敏感离子通道Flycatcher1的结构见解。
136.Humoral and cellular responses after a third dose of SARS-CoV-2 BNT162b2 vaccine in patients with lymphoid malignancies.
淋巴性恶性肿瘤患者第三剂SARS-CoV-2 BNT162b2疫苗后的体液和细胞反应。
137.EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1.
EBV miRNAs BART11和BART17-3p通过增强子介导的PD-L1转录促进免疫逃逸。
138.Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay.
由m6A修饰指示的动态FMR1颗粒相切换有助于母体RNA的衰变。
139.Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein.
合成病毒揭示了SARS-CoV-2穗状糖蛋白的脂肪酸偶联适应性免疫原性。
140.A deep-learning system bridging molecule structure and biomedical text with comprehension comparable to human professionals.
一个连接分子结构和生物医学文本的深度学习系统，其理解力堪比人类专业人士。
这里我们以水杨酸为例。 受人类在不同信息内和跨不同信息广泛学习元知识的启发，我们的机器阅读系统首先通过 BPE 在 SMILES 字符串上序列化分子结构，然后将子字符串插入到 c 中。 大规模语料库，通过d掩码语言建模学习b个不同语义单元之间的细粒度映射。 通过这种方式，系统可以执行知识丰富的通用阅读，在单信息下游任务和通用阅读任务上都取得了良好的性能。
141.Clinical and biomarker analyses of sintilimab versus chemotherapy as second-line therapy for advanced or metastatic esophageal squamous cell carcinoma: a randomized, open-label phase 2 study (ORIENT-2).
辛硫磷与化疗作为晚期或转移性食管鳞状细胞癌二线治疗的临床和生物标志物分析：一项随机、开放标签的2期研究（ORIENT-2）。
142.Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans.
与颈动脉内膜厚度有关的遗传关联与撒哈拉以南非洲人的动脉粥样硬化有性别上的影响。
143.Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates.
基于液滴的磷酸盐转移催化筛查揭示了外显性如何形成MAP激酶与底物的相互作用。
144.Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat.
影响同源基因表达剂量的基因组变异有助于异源多倍体小麦的农艺性状变化。
145.PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection.
PEBP平衡白粉虱感染虫媒病毒后的细胞凋亡和自噬。
146.Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
通过双向开关对Ubp6和蛋白酶体的异生控制。
147.Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer.
BRCA1/2突变的高级别浆液性卵巢癌的单细胞肿瘤-免疫微环境。
148.Rhizosphere bacteriome structure and functions.
根瘤菌群的结构和功能。
149.Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis.
利用序列控制的合成技术实现可调节功能和可编程自组装的蛋白质纳米线。
150.Development of a skin- and neuro-attenuated live vaccine for varicella.
水痘皮肤和神经强化活疫苗的开发.
151.Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe.
用无线双色光电探针对自由行为的小鼠进行同位、双向的光遗传学调控。
152.The spatial transcriptomic landscape of the healing mouse intestine following damage.
损伤后小鼠肠道愈合的空间转录组景观。
153.Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation.
协调的海马-丘脑-皮层交流对系统巩固下的恩格动态至关重要。
154.Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis.
土壤元基因组指导下的全化学合成发现的强效双拓扑异构酶I/II抑制剂Lapcin。
155.Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar.
异质复极化在愈合的心肌梗塞瘢痕中形成室性心动过速回路。
156.Micro-mechanical blood clot testing using smartphones.
利用智能手机进行微机械血凝块检测。
157.Small RNA pathways in the nematode Ascaris in the absence of piRNAs.
没有piRNA的情况下线虫Ascaris的小RNA途径。
158.Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain.
单细胞RNA测序揭示了小鼠脊髓小胶质细胞对周围神经损伤的时间和性别特异性反应，并将载脂蛋白与慢性疼痛联系起来。
159.Data-informed discovery of hydrolytic nanozymes.
基于数据信息的水解纳米酶的发现。
160.Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer.
基于机器学习的整合开发了一个免疫衍生的lncRNA签名，以改善结肠直肠癌的结果。
161.Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans.
Metaboseek的比较代谢组学揭示了优雅动物中一个保守的脂肪代谢途径的功能。
162.Pluripotency factors determine gene expression repertoire at zygotic genome activation.
多能性因子决定了子代基因组激活时的基因表达剧目。
163.Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies.
酵母中的全细胞模型预测了驱动代谢策略的区间特异性蛋白质组限制。
164.In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells.
体内CRISPR筛选显示HIF-1α-mTOR-网络调节T滤泡辅助细胞与Th1细胞。
165.Pervasive misannotation of microexons that are evolutionarily conserved and crucial for gene function in plants.
在植物中普遍存在的对基因功能具有进化保守性和关键性的微外显子的错误注解。
166.Overlooked and widespread pennate diatom-diazotroph symbioses in the sea.
海洋中被忽视的广泛的笔状硅藻-重氮菌共生体。
167.GLI transcriptional repression is inert prior to Hedgehog pathway activation.
GLI转录抑制在Hedgehog途径激活之前是惰性的。
168.Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor.
人类α7尼古丁乙酰胆碱受体的高度灵活的细胞内结构。
169.Defining molecular glues with a dual-nanobody cannabidiol sensor.
用双纳米体大麻酚传感器定义分子胶粘剂。
170.Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82.
脱发症患者的全外显子组测序确定了KRT82的罕见变异。
171.Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats.
精神分裂症相关的SAP97突变增加了大鼠齿状回的谷氨酸突触强度，损害了大鼠的情境性记忆。
172.A mammalian methylation array for profiling methylation levels at conserved sequences.
哺乳动物甲基化阵列用于分析保守序列的甲基化水平。
173.Cotranslational N-degron masking by acetylation promotes proteome stability in plants.
乙酰化对N-egron的共翻译掩蔽促进了植物的蛋白质组稳定性。
174.SM-Omics is an automated platform for high-throughput spatial multi-omics.
SM-Omics是一个用于高通量空间多组学的自动化平台。
175.Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis.
ENSA的拷贝数扩增通过胆固醇的生物合成促进三阴性乳腺癌的进展。
176.Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice.
上丘脑至VTA通路控制定向反应并影响小鼠的社会互动。
177.Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
小分子SWELL1复合物的诱导改善了小鼠2型糖尿病的血糖控制和非酒精性脂肪肝的病情。
178.Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes.
在布基纳法索进行的标记-释放-捕捉实验表明，经基因改造的不育疟疾蚊子的健身性和扩散性降低。
179.Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific manner.
谷胱甘肽1控制营养压力下的单核细胞重编程，并以性别特异的方式保护小鼠免受肥胖和动脉硬化的影响。
180.The microbiome of the buffalo digestive tract.
水牛消化道的微生物组。
181.Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma.
破译多发性骨髓瘤单细胞分辨率下的空间基因组异质性。
182.Hyperuniformity and phase enrichment in vortex and rotor assemblies.
涡旋和转子组件中的超均匀性和相位富集。
183.Engineering and exploiting synthetic allostery of NanoLuc luciferase.
设计和利用NanoLuc荧光素酶的合成异构体。
184.Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection.
对以前非Omicron感染的Omicron SARS-CoV-2的中和。
185.Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis in Drosophila.
调节性激酶的时空表达指导果蝇从有丝分裂到细胞形态发生的过渡。
186.Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles.
用化学诱导染色体相互作用（CICI）方法研究染色体动态及其生物学作用。
187.A platform for oncogenomic reporting and interpretation.
肿瘤基因组学报告和解释的平台。
188.The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression.
诱导胰腺外周训练的免疫力煽动抗肿瘤活性以控制胰腺癌的发展。
189.Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response.
转化的嗜肺军团菌小RNA模拟真核微RNA，针对宿主免疫反应。
190.Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target.
人类胶质瘤和免疫细胞的单细胞分析确定了S100A4为免疫疗法的目标。
191.A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution.
一种SIMPLI(从 MultiPLexed 图像中识别单细胞)方法用于单细胞分辨率的空间分辨组织表型。
a 原始图像是从 IMC 或 MIBI 数据中提取或直接从其他成像技术导入的。 在他们可选的归一化之后，这些图像被阈值化以去除背景噪声并产生组织隔室或标记掩模。 可以使用基于细胞或基于像素的方法分析生成的图像。 b 在基于细胞的分析中，单个细胞使用确定性或深度学习模型进行分割，并使用无监督或监督方法进行表型分析。 然后可以通过同型或异型聚集的空间分析来研究组织中细胞的分布。 c 在基于像素的方法中，对用户定义的标记组合呈阳性的区域进行测量，并在整个图像的区域或定义隔间的掩码区域或对某些标记呈阳性的区域进行归一化。
192.Versioning biological cells for trustworthy cell engineering.
为值得信赖的细胞工程提供生物细胞版本。
193.Human transcription factor protein interaction networks.
人类转录因子蛋白质相互作用网络。
194.Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling.
利用DNA甲基化增强外周血的细胞解构，用于高分辨率的免疫分析。
195.A diencephalic circuit in rats for opioid analgesia but not positive reinforcement.
大鼠脑膜回路对阿片类药物镇痛的作用，但不是正强化作用。
196.Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels.
利用外源性瞬时受体电位A1通道对哺乳动物细胞进行声学控制。
197.Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial.
化脓性链球菌人体挑战试验中急性咽喉炎的免疫特征。
198.Development and validation of a prognostic and predictive 32-gene signature for gastric cancer.
胃癌预后和预测的32个基因特征的开发和验证.
199.An optogenetic approach for regulating human parathyroid hormone secretion.
一种调节人类甲状旁腺激素分泌的光遗传学方法。
200.Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair.
在没有错配修复的情况下，主编辑的效率和保真度得到提高。
201.Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.
动态Runx1染色质边界影响造血发育中的基因表达。
202.Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans.
组蛋白H3K4me3修饰是优雅凯诺虫脂质代谢的跨代表观遗传信号。
203.UINMF performs mosaic integration of single-cell multi-omic datasets using nonnegative matrix factorization.
UINMF使用非负矩阵分解法对单细胞多组学数据集进行镶嵌式整合。
204.Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimoto’s thyroiditis.
淋巴细胞浸润和甲状腺细胞破坏是由桥本甲状腺炎的基质和免疫细胞成分驱动的。
205.Perspectives in machine learning for wildlife conservation.
机器学习在野生动物保护中的应用前景.
206.Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy.
将p53 mRNA纳米疗法与免疫检查点阻断相结合，重新规划免疫微环境，以实现有效的癌症治疗。
207.Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis.
硒磷酸酯合成酶1的缺失通过调节氧化还原平衡而加剧骨关节炎。
208.Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.
咖啡因阻断SREBP2诱导的肝脏PCSK9表达以增强LDLR介导的胆固醇清除。
209.Genomic epidemiology of SARS-CoV-2 under an elimination strategy in Hong Kong.
香港消除策略下SARS-CoV-2的基因组流行病学。
210.Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor.
TARP调控GluA1/2-γ8 AMPA受体的机制。
211.SMAP is a pipeline for sample matching in proteogenomics.
SMAP是一个用于蛋白质基因组学中样本匹配的管道。
212.Physiological synaptic activity and recognition memory require astroglial glutamine.
生理突触活动和识别记忆需要星形细胞的谷氨酰胺。
213.Giant sponge grounds of Central Arctic seamounts are associated with extinct seep life.
中北极海山的巨型海绵地与已灭绝的渗水生物有关。
214.Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.
内源性甲醛清除细胞谷胱甘肽，导致氧化还原破坏和细胞毒性。
215.Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
溶血磷脂酸和1-磷酸鞘氨醇对脂质GPCRs的不同激活机制。
216.Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
英国某大学SARS-CoV-2的基因组流行病学确定了传播的动态。
217.Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.
免疫猕猴体内诱导的中和抗体可识别闭塞开放的HIV-1包膜三聚体上的CD4结合位点。
218.Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
杂乱样激酶 2通过客户模仿锁定ASF1组蛋白伴侣。
219.Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice.
胰淀素-降钙素受体在内侧视前区的信号传递介导了雌性小鼠的附属社会行为。
220.In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.
通过腺相关病毒传递到小鼠有丝分裂后组织的体内线粒体碱基编辑。
221.Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change.
季节性可塑性中的替代剪接和对环境变化的适应潜力。
222.A Mediator-cohesin axis controls heterochromatin domain formation.
介体粘连蛋白轴控制异染色质域的形成。
223.Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.
海马集合体代表了非空间事件扩展序列中的顺序关系。
224.Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants.
δ型和卡帕型SARS-CoV-2变体中穗状蛋白适应性增强的结构和生物化学原理。
225.Protein sequence design with a learned potential.
具有学习潜力的蛋白质序列设计。
226.Cooperation in alternating interactions with memory constraints.
有记忆约束的交替相互作用中的合作。
227.Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
β细胞特异性Insr缺失促进胰岛素过度分泌，并在全球胰岛素抵抗之前改善葡萄糖耐量。
228.Enhanced germline stem cell longevity in Drosophila diapause.
果蝇绝育期中生殖干细胞寿命的增强。
229.Reconstituting the complete biosynthesis of D-lysergic acid in yeast.
在酵母中重建D-麦角酸的完整生物合成。
230.Cryo-EM structures of human bradykinin receptor-Gq proteins complexes.
人类缓激肽受体-Gq蛋白复合体的低温电镜结构。
231.Spatial-temporal dynamics of a microbial cooperative behavior resistant to cheating.
抵抗作弊的微生物合作行为的空间-时间动态。
232.Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling.
间质-上皮串扰通过Wnt和Shh信号塑造肠道区域化。
233.Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants.
坏死病毒的衣壳蛋白以14-3-3a为目标，颠覆植物中MAPKKKα介导的抗病毒免疫力。
234.Primate anterior insular cortex represents economic decision variables proposed by prospect theory.
灵长类前岛皮层代表前景理论提出的经济决策变量。
235.Live-dead assay on unlabeled cells using phase imaging with computational specificity.
使用具有计算特异性的相位成像技术对未标记的细胞进行活体死亡检测。
236.An archaellum filament composed of two alternating subunits.
一个由两个交替的亚单位组成的弓形丝。
237.Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain.
脊柱痛觉终端上的突触前NMDARs状态依赖性地调节突触传递和疼痛。
238.Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.
全基因组关联元分析发现29个新的痤疮易感位点。
239.Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy.
体内PMK-1/p38信号将环境压力与生殖细胞凋亡和遗传性优生性联系起来。
240.The olfactory gating of visual preferences to human skin and visible spectra in mosquitoes.
蚊子对人类皮肤和可见光谱的视觉偏好的嗅觉门控。
241.Placental genomics mediates genetic associations with complex health traits and disease.
胎盘基因组学介导了与复杂健康特征和疾病的基因关联。
242.Bacterial filamentation as a mechanism for cell-to-cell spread within an animal host.
细菌丝状物作为动物宿主内细胞间传播的机制。
243.Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer.
用DNA编码的HIV包膜原生型三聚体诱导小鼠的第2级中和抗体。
244.ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation.
由TEAD/YAP激活驱动的人类恶性肿瘤的ROCK1机械信号依赖性。
245.Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene.
群体水平的同源性缺失揭开了CPSF3作为智力障碍综合征基因的面纱。
246.The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress.
肠道激素尿囊素C/生长抑素调节营养压力下的食物摄入和代谢平衡。
247.A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder.
SP7中的一个新形态变体改变了序列特异性，导致了高周转的骨质紊乱。
248.Sculpting tissues by phase transitions.
通过相变雕塑组织。
249.Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation.
内皮细胞特异性表达丝氨酸/苏氨酸激酶11调控树突状细胞分化。
250.A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58.
ColV质粒在致病性大肠杆菌ST58进化中的作用。
251.Genetically stable CRISPR-based kill switches for engineered microbes.
基因稳定的基于CRISPR的工程微生物的杀伤开关。
252.A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis.
RNase MRP中与疾病相关的lncRNA突变抑制了核糖体的合成。
253.Genomic insights into the evolution of Echinochloa species as weed and orphan crop.
对稗草物种作为杂草和孤儿作物的进化的基因组见解。
254.Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth.
Gαi2诱导的conductin/axin2缩合体抑制Wnt/β-catenin信号传递并抑制癌症生长。
255.Graph-based pan-genome reveals structural and sequence variations related to agronomic traits and domestication in cucumber.
基于图形的泛基因组揭示了与黄瓜农艺性状和驯化有关的结构和序列变异。
256.The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loops.
拓扑异构酶IIIalpha-RMI1-RMI2复合物为人类布鲁姆综合症螺旋酶定向，以有效破坏D环。
257.TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.
TNF拮抗剂使胶原蛋白诱导的关节炎小鼠模型中的滑膜成纤维细胞对铁质细胞死亡敏感。
258.Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division.
Cyclin B/CDK1和Cyclin A/CDK2磷酸化DENR以促进有丝分裂蛋白翻译和忠实的细胞分裂。
259.Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis.
线粒体蛋白导入通过代谢重编程和新的丝氨酸生物合成决定了寿命的长短。
260.Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis.
受体交互蛋白激酶2（RIPK2）稳定c-Myc，是前列腺癌转移的一个治疗目标。
261.Multiple expansions of globally uncommon SARS-CoV-2 lineages in Nigeria.
尼日利亚全球不常见的SARS-CoV-2系的多重扩展。
262.An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia.
白细胞介素-7受体α在人类B细胞前体白血病发展中的指导性作用。
263.Arabidopsis guard cell chloroplasts import cytosolic ATP for starch turnover and stomatal opening.
拟南芥守护细胞叶绿体导入细胞膜ATP用于淀粉周转和气孔开放。
264.Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice.
许旺细胞内体CGRP信号引起小鼠眶周机械性痛觉。
265.Hemoglobin in the blood acts as a chemosensory signal via the mouse vomeronasal system.
血液中的血红蛋白通过小鼠回声系统充当化学感应信号。
266.Constructing neural network models from brain data reveals representational transformations linked to adaptive behavior.
从大脑数据中构建神经网络模型，揭示了与适应性行为有关的表征性转变。
267.Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis.
一种HIV抗体的吞噬作用与病毒的减少有关，而不考虑补体裂解的增强。
268.Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater.
追踪纽约市废水中检测到的隐性SARS-CoV-2系。
269.Temporal dynamics of the neural representation of hue and luminance polarity.
色调和亮度极性的神经表征的时间动态。
270.Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves.
利用流行病学和病毒基因组数据对两次大流行的SARS-CoV-2院内传播事件进行定性。
271.Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin.
昼夜脂质和肝脏蛋白节律的转变，其相位反应曲线与褪黑激素不同。
272.TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A.
TAZ通过线粒体转录因子A将运动与线粒体生物生成联系起来。
273.The selection force weakens with age because ageing evolves and not vice versa.
选择力随着年龄的增长而减弱，因为老化是进化的，而不是反过来。
274.Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks.
利用深度神经网络从mRNA推断阿尔茨海默氏症的蛋白质表达变化。
275.Assortative mating biases marker-based heritability estimators.
基于标记的遗传性估计器的同种交配偏差。
276.Direct-laser writing for subnanometer focusing and single-molecule imaging.
用于亚纳米聚焦和单分子成像的直接激光写入。
277.Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice.
树突自噬降解突触后蛋白，是小鼠长期突触抑制的必要条件。
278.Myeloid cell interferon responses correlate with clearance of SARS-CoV-2.
髓细胞干扰素反应与SARS-CoV-2的清除相关。
279.Deep phenotyping of Alzheimer’s disease leveraging electronic medical records identifies sex-specific clinical associations.
利用电子病历对阿尔茨海默病进行深度表型，确定了性别特异的临床关联。
280.The IGFBP3/TMEM219 pathway regulates beta cell homeostasis.
IGFBP3/TMEM219途径调控β细胞的平衡。
281.A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments.
哺乳动物细胞特异性的泛CRISPR分析确定了用于基因组规模实验的超紧凑sgRNA子集。
282.Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.
原发性肿瘤相关巨噬细胞激活了传播性肿瘤细胞的入侵和休眠程序。
283.Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells.
广义中和抗HIV-1抗体将病毒颗粒拴在受感染细胞的表面。
284.Buxus and Tetracentron genomes help resolve eudicot genome history.
Buxus和Tetracentron的基因组有助于解决eudicot基因组历史。
285.Molecular mechanism of Arp2/3 complex inhibition by Arpin.
Arp2/3复合物被Arpin抑制的分子机制。
286.Manipulation of RNA polymerase III by Herpes Simplex Virus-1.
单纯疱疹病毒-1对RNA聚合酶III的操纵。
287.A robust method for collider bias correction in conditional genome-wide association studies.
条件性全基因组关联研究中对撞机偏差校正的稳健方法。
288.CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations.
CRISPR-Cas9诱导体内靶点和非靶点的大型结构变异，并跨代分离。
289.Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.
常规Wnt信号的构成性激活破坏了脉络丛上皮的命运。
290.Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.
最大的活体啮齿动物的肠道微生物群拥有前所未有的降解植物多糖的酶系统。
291.Event boundaries shape temporal organization of memory by resetting temporal context.
事件边界通过重新设置时间背景来塑造记忆的时间组织。
292.A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
AT-527对SARS-CoV-2聚合酶的双重作用机制。
293.Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.
用于心脏基因治疗的细菌电压门控钠通道平台。
294.Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.
罕见的SLC13A1变体与椎间盘紊乱有关，突出了硫酸盐在椎间盘病变中的作用。
295.A population-based cohort study of obesity, ethnicity and COVID-19 mortality in 12.6 million adults in England.
英国1260万成年人的肥胖、种族和COVID-19死亡率的人群队列研究。
296.Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism.
Lima1介导了膜动态和细胞代谢的多能性控制。
297.PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.
PplD是链球菌鼠李多糖的细胞壁连接单元的去N-乙酰化酶。
298.Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma.
通过整合多能干细胞衍生的肾脏基质生成器官型肾脏结构。
299.Automatic mapping of multiplexed social receptive fields by deep learning and GPU-accelerated 3D videography.
通过深度学习和GPU加速的3D摄像技术自动绘制多路社会接收场图。
300.Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes.
环磷酸腺苷信号和葡萄糖代谢介导非洲锥虫的pH计。
301.Electron transfer-triggered imaging of EGFR signaling activity.
EGFR信号活动的电子转移触发成像。
302.A neural circuit linking learning and sleep in Drosophila long-term memory.
果蝇长期记忆中连接学习和睡眠的神经回路。
303.PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
PPM1D突变是新发弥漫性中线胶质瘤形成的致癌驱动因素。
304.Impacts of rapid mass vaccination against SARS-CoV2 in an early variant of concern hotspot.
快速大规模接种SARS-CoV2疫苗对早期变异关注热点的影响。
305.Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.
最小真核生物核糖体结构中对基因组衰变的适应性。
306.Inhibition of base editors with anti-deaminases derived from viruses.
用来自病毒的抗脱氨酶抑制碱基编辑。
307.Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain.
具有插入外聚酶结构域的二聚体非核糖体肽合成酶亚单位的催化轨迹。
308.Multiplexed nanomaterial-assisted laser desorption/ionization for pan-cancer diagnosis and classification.
用于泛癌诊断和分类的多重纳米材料辅助激光解吸/离子化。
309.ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.
ΔNp63调控非小细胞肺癌中增强子相关基因的共同景观。
310.SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load.
来自沙特阿拉伯的SARS-CoV-2基因组暗示核苷酸突变与宿主反应和病毒负荷增加有关。
311.Relative effects of land conversion and land-use intensity on terrestrial vertebrate diversity.
土地转换和土地使用强度对陆生脊椎动物多样性的相对影响。
312.Cost-effectiveness of routine adolescent vaccination with an M72/AS01E-like tuberculosis vaccine in South Africa and India.
南非和印度青少年常规接种M72/AS01E类结核病疫苗的成本效益。
313.The mouse metallomic landscape of aging and metabolism.
衰老和代谢的小鼠金属组学景观。
314.Nationally representative SARS-CoV-2 antibody prevalence estimates after the first epidemic wave in Mexico.
墨西哥第一波疫情后具有全国代表性的SARS-CoV-2抗体流行率的估计。
315.Matrix condition mediates the effects of habitat fragmentation on species extinction risk.
基质条件介导了栖息地破碎化对物种灭绝风险的影响。
316.The DNA methylome of cervical cells can predict the presence of ovarian cancer.
宫颈细胞的DNA甲基组可以预测卵巢癌的存在。
317.Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity.
药用IRE1/XBP1s激活促进肥胖症的系统适应性重塑。
