活性氧Cu/Zn SOD Monoclonal Antibody，Cu/Zn Superoxide Dismutase，ROS小

产品名称：

活性氧Cu/Zn SOD Monoclonal Antibody，Cu/Zn Superoxide Dismutase

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

状态：固体/粉末

储藏条件：冷藏-20℃

温馨提示：仅用于科研，不能用于人体实验！

说明：提供使用说明，核磁图谱，包装，价格，产地，制备方法，应用，稳定性，溶解度，简单合成等各种信息　　

Cu/Zn Superoxide dismutase (Cu/Zn SOD) is an antioxidant enzyme that protects cells from oxidative stress by scavenging superoxide anions.1 It exists as a homodimer that is stabilized by a disulfide bond between the subunits. Each monomer is composed of a Greek key β-barrel and an active site channel made up of a β4/β5 loop, which interacts with the dimer interface and active site zinc, and an electrostatic loop, which facilitates superoxide entry into the copper-containing active site.2 Cu/Zn SOD is ubiquitously expressed and primarily localizes to the cytosol but has also been found in the nucleus, peroxisomes, lysosomes, and the intermembrane space of mitochondria.3,4 It catalyzes the dismutation of superoxide to hydrogen peroxide and oxygen by alternating reduction and reoxidation of copper at the enzyme active site.1 Overexpression of SOD1 protects against increases in reactive oxygen species (ROS) and apoptosis in an in vitro model of renal ischemia induced by ATP depletion.5 In vivo, transgenic mice expressing the destabilized Cu/Zn SODG93A mutation exhibit impaired spinal cord mitochondrial respiration.6,7 Mutations in SOD1 are associated with amyotrophic lateral sclerosis (ALS).8 Cayman’s Cu/Zn SOD Monoclonal Antibody can be used for flow cytometry (FC), immunoprecipitation (IP), and Western blot (WB) applications.

Cu/Zn超氧化物歧化酶（Cu/Zn SOD）是一种抗氧化酶，通过清除超氧化物阴离子来保护细胞免受氧化应激。1它以同源二聚体的形式存在，通过亚基之间的二硫键稳定。每个单体由希腊键β-桶和活性位点通道组成，活性位点通道由β4/β5环和静电环组成，β4/β5-环与二聚体界面和活性位点锌相互作用，静电环促进超氧化物进入含铜活性位点。2 Cu/Zn SOD普遍表达，主要定位于胞质溶胶，但也存在于细胞核、过氧化物酶体，溶酶体和线粒体的膜间空间。3，4它通过在酶活性位点交替还原和再氧化铜，催化超氧化物歧化为过氧化氢和氧气。1在ATP耗竭诱导的肾缺血体外模型中，SOD1的过度表达可防止活性氧（ROS）的增加和细胞凋亡。5在体内，表达不稳定的Cu/Zn SODG93A突变的转基因小鼠表现出脊髓线粒体呼吸受损。6,7 SOD1突变与肌萎缩侧索硬化症（ALS）有关。8开曼群岛的Cu/Zn-SOD单克隆抗体可用于流式细胞术（FC）、免疫沉淀（IP）和蛋白质印迹（WB）应用。

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编辑：XAQYBIO HAO，2023年4月10日。