【热门产品推介】InVivoMAb Anti-HRSV F/F protein Antibody (AM16)

HRSV基因组全长约15.2 kb，按照3′到5′顺序含有10个基因，分别为3′ -leader-NS1-NS2-N-P-M-SH-G-F-M2-L-trailer-5′，共编码11种蛋白，包括2个非结构蛋白及9个结构蛋白。

货号：VVV02802

产品链接：http://www.antibodysystem.com/product/13699.html

寄主物种：Human

物种反应性：Human respiratory syncytial virus (HRSV)

形式：Liquid

存储缓冲区：0.01M PBS, pH 7.4.

浓度：1 mg/ml

纯度：>95% by SDS-PAGE.

克隆性：Monoclonal

应用：ELISA, In vivo Neutralization

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

参考文献：

Sequence elements of the fusion peptide of human respiratory syncytial virus fusion protein required for activity. PMID: 16690930
Gene junction sequences of bovine respiratory syncytial virus. PMID: 1626423

Rhizopus oryzae AM16; a new hyperactive L-asparaginase producer: Semi solid-state production and anticancer activity of the partially purified protein. PMID: 35222999
Genome Sequence Resource of an Avirulent Magnaporthe oryzae Field Strain AM16. PMID: 35728097
A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer. PMID: 25267700
Molecular architecture of bacteriophage T7 capsid. PMID: 6823742
Therapeutic effects of benznidazole in Swiss mice that are orally inoculated with Trypanosoma cruzi IV strains from the Western Brazilian Amazon. PMID: 34280400
Specificity and efficiency of editing of mismatches involved in the formation of base-substitution mutations by the 3'----5' exonuclease activity of phage T4 DNA polymerase. PMID: 3029763
Optimisation of synthetic vector systems for cancer gene therapy - the role of the excess of cationic dendrimer under physiological conditions. PMID: 24678705
DNA polymerase accuracy and spontaneous mutation rates: frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication. PMID: 6457301
Investigation of the In Vivo Metabolism of Sibirioside A and Angoroside C in Rats by HPLC-ESI-IT-TOF-MSn. PMID: 30347747
Ribosomal proteins L15 and L16 are mere late assembly proteins of the large ribosomal subunit. Analysis of an Escherichia coli mutant lacking L15. PMID: 2204629
Acidiphilamides A-E, Modified Peptides as Autophagy Inhibitors from an Acidophilic Actinobacterium, Streptacidiphilus rugosus. PMID: 30735389
Defined transversion mutations at a specific position in DNA using synthetic oligodeoxyribonucleotides as mutagens. PMID: 158749
呼吸道合胞病毒最早于1955年由美国沃尔特·里德陆军研究所在患有呼吸道疾病的黑猩猩体内发现，1957年Chanock和Finberg从儿童体内分离出，由于其特殊的细胞融合性病变，所以命名为人呼吸道合胞病毒（human respiratory syncytial virus，HRSV）。据报道，HRSV是世界范围内婴幼儿下呼吸道感染最重要的病原体之一，有些地区2岁以内的儿童至少发生过一次感染。近年来，研究发现HRSV也可引起成年人、老年人以及免疫抑制患者下呼吸道感染。2015年全球范围内由HRSV引起的呼吸道感染人数约3.31亿，导致约320万5岁以下儿童住院治疗，其中约6万名住院死亡，而老年人住院约33.6万，住院死亡约为1.4万，医院和社区每年因HRSV死亡人数约为10万～15万。HRSV占全球儿童急性下呼吸道感染的22%，中国HRSV感染率约为31/1000，占儿童急性下呼吸道感染的18.7%。HRSV触发宿主炎症免疫反应，虽然人体对HRSV免疫反应尚不完全，但会引起疾病进一步发展，且HRSV致病机制也尚不完善。HRSV临床尚无有效疫苗，开发有效疫苗和单克隆抗体，即是机遇，也是挑战。随着呼吸道合胞病毒多种基因型相继出现，并呈现交替流行以及共流行的现象，基因型的不断变异、变迁，所造成的疾病程度也有所不同。