【热门产品推介】Anti-HRSV F/Fusion glycoprotein F0 Nanobody (SAA1037)

货号：RVV02823

产品链接：http://www.antibodysystem.com/product/14140.html

物种反应性：Human respiratory syncytial virus A (strain A2)

形式：Liquid

存储缓冲区：0.01M PBS, pH 7.4.

浓度：1 mg/ml

纯度：>95% by SDS-PAGE.

克隆性：Monoclonal

应用：ELISA

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

参考文献：

Identification of subgroups of bovine respiratory syncytial virus. PMID: 1583108
Infectivity of a human respiratory syncytial virus lacking the SH, G, and F proteins is efficiently mediated by the vesicular stomatitis virus G protein. PMID: 12610153

Transmembrane Domain Dissociation Is Required for Hendra Virus F Protein Fusogenic Activity. PMID: 31462574
Development of liposomes and pseudovirions with fusion activity for efficient gene delivery. PMID: 22023472
Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain. PMID: 34061592
Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability. PMID: 24089572
The electrophysiological net response ('F-complex') to spatial fusion of speech elements forming an auditory object. PMID: 12738428

HRSV基因组全长约15.2 kb，按照3′到5′顺序含有10个基因，分别为3′ -leader-NS1-NS2-N-P-M-SH-G-F-M2-L-trailer-5′，共编码11种蛋白，包括2个非结构蛋白及9个结构蛋白。NS1、NS2是非结构蛋白，其主要功能是抑制干扰素的合成。核衣壳蛋白（N）与磷蛋白（P）为病毒核酸合成提供场所，多聚酶亚单位蛋白（L）是病毒核酸转录和复制的必需成分。基质蛋白（M）是内包膜蛋白，可以有效抑制宿主细胞转录。M2-1为核蛋白相关蛋白，所包含的转录因子与病毒转录有关。M2下游开放阅读框编码M2-2调控蛋白，负责病毒粒子组装过程中RNA合成；其中小疏水（SH）、附着（G）和融合（F）基因编码病毒的3种表面蛋白，其中G、F蛋白是HRSV两个重要膜表面糖蛋白，刺激机体产生中和抗体，G蛋白辅助病毒黏附于宿主细胞，F蛋白负责病毒融合和合胞体形成，而SH蛋白功能尚不清楚，可能与病毒感染有关。