【龙腾网】就像魔法一样：科学家们找到了让衰老的人类细胞再次年轻的方法

‘Like magic’: Scientists find way to make old human cells young again

就像魔法一样：科学家们找到了让衰老的人类细胞再次年轻的方法

 

Scientists have discovered how to make old human cells young again through rejuvenation. It’s an exciting discovery that could change the way humans age.

科学家们已经发现如何通过恢复活性使衰老的人体细胞再次年轻化。这是一个令人兴奋的发现，可以改变人类年龄的方式。

Researchers at the University of Exeter and University of Brighton found they could rejuvenate senescent cells, cells that had stopped their natural growth cycle,causing them to start to divide again. The experiment found they not only look younger, but also behave like younger cells.

埃克塞特大学和布莱顿大学的研究人员发现，他们可以恢复衰老细胞，这些细胞已经停止了自然生长周期，导致它们再次开始分裂。实验发现它们不仅看起来更年轻，而且表现得像年轻细胞。

“When I saw some of the cells in the culture dish rejuvenating I couldn't believe it. These old cells were looking like young cells. It was like magic,” researcher Dr. Eva Latorre said. “I repeated the experiments several times and in each case the cells rejuvenated. I am very excited by the implications and potential for this research.”

“当我看到培养皿中的一些细胞恢复活性时，我无法相信。这些老细胞看起来像年轻细胞。这就像魔术，“研究员Eva Latorre博士说。“我重复了几次实验，每次都让细胞恢复活性。我对这项研究的意义和潜力感到非常兴奋。”

 

The research builds on earlier findings that showed ‘splicing factor’ genes switch off as humans age. Scientists found a way to restart the splicing through chemicals.

这项研究建立在早期发现的基础上，发现“剪接因子”基因随着人类年龄的增长而关闭。科学家们发现了一种通过化学物质重新开始拼接的方法。

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According to the researchers, this could change the way we age, with the hope that humans will experience less of the degeneration that comes with aging. Older people are more likely to have strokes, heart disease and other illnesses, but with cell rejuvenation, this could be decreased.

根据研究人员的说法，这可能会改变我们的衰老方式，希望人类能够减少衰老带来的退化。老年人更容易患中风，心脏病和其他疾病，但随着细胞再生，这可能性会减少。

“This demonstrates that when you treat old cells with molecules that restore the levels of the splicing factors, the cells regain some features of youth,” team leader Professor Lorna Harries said.  They are able to grow, and their telomeres - the caps on the ends of the chromosomes that shorten as we age -  are now longer, as they are in young cells. Far more research is needed now, to establish the true potential for these sort [sic] of approaches to address the degenerative effects of ageing. ”

“ 这表明当你用能够恢复剪接因子水平的分子治疗旧细胞时，细胞会恢复青春的某些特征，”团队负责人Lorna Harries教授说。  
Harries说。它们能够生长，而且它们的端粒——染色体末端的帽随着年龄的增长而缩短——现在更长了，就像它们在年轻细胞中一样。现在还需要更多的研究，以确定这类，解决老龄化退化效应之方法的真正潜力。