新型注射剂的国内外研发进展

[ 摘要 ] 注射剂作为一种特殊的药物剂型，具有起效快、定位准等优点，因而被广泛应用于临床。随着临床应用需求的增多，在传统注射剂的
基础上，许多新型注射剂应运而生。脂质体、混悬剂、纳米粒、微球和包合物等注射给药系统的出现，不仅减少了药物在体内外的降解，还具
有缓释、控释的优点，受到研究人员密切关注。重点介绍了几种新型注射剂的特点，并对国内外已上市和在研的新型注射剂进行简要介绍，旨
在为其深度开发提供参考。
[ 关键词 ] 新型注射剂；缓控释给药系统；脂质体；纳米粒

[Abstract] As a special pharmaceutical dosage form, injectable products have the advantages of quick onset of action and accurate positioning,
and  thus  have  been  widely  used  in  clinical  practice. With  increased  clinical  demand,  many  novel  injections  have  been  developed  on  the  basis  
of  traditional  injections. The  emergence  of  novel  injection  delivery  systems  such  as  liposomes,  suspensions,  nanoparticles,  microspheres  and  
inclusion  complexes  not  only  reduces  drug  degradation  in  vitro  and  in  vivo  but  also  achieves  sustained  and  controlled  release,  receiving  close  
attention from researchers. This article focuses on the characteristics of several novel injections and briefly introduces novel injections that have
been marketed or under clinical development at home and abroad, so as to provide reference for their further development.
[Key words] novel injection; sustained- and controlled-release drug delivery system; liposome; nanoparticle