活性氧Ligustrazine (hydrochloride)，CAS No. 76494-51-4

产品名称：

活性氧Ligustrazine (hydrochloride)，CAS No. 76494-51-4

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

状态：固体/粉末

储藏条件：冷藏-20℃

温馨提示：仅用于科研，不能用于人体实验！

说明：提供使用说明，核磁图谱，包装，价格，产地，制备方法，应用，稳定性，溶解度，简单合成等各种信息　　

Ligustrazine is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.1,2,3 It inhibits hydrogen peroxide-induced decreases in cell viability and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 100 and 150 μg/ml.1 Ligustrazine (50 and 100 μM) inhibits prostaglandin E2 (PGE2) production induced by LPS and IFN-γ in primary rat glia.2 It reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion when administered at a dose of 20 mg/kg. Ligustrazine inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro and reduces tumor growth in an MG-63 mouse xenograft model when administered at a dose of 100 mg/kg every other day.

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编辑：XAQYBIO HAO，2023年4月23日。