关键词

 抗体 流感 肺炎 B细胞 基因 阿尔茨海默病

 

#今日行业热点#

①MABS ：Blueprint for antibody biologics developability

综述：抗体生物制剂可开发性的蓝图

DOI :10.1080/19420862.2023.2185924

②Journal of Medical Virology：The Clinical Predictors of and Vaccine Protection Against Severe Influenza Infection in Children

儿童抗严重流感感染的临床预测因素和疫苗保护作用

DOI :10.1002/jmv.28638

③Journal of Experimental Medicine：Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia

遗传性MyD88或IRAK-4缺乏有发生低氧性COVID-19肺炎的高风险

DOI :10.1084/jem.20220170

④Journal of Experimental Medicine：B cell receptor ligation induces IgE plasma cell elimination

B细胞受体连接诱导IgE浆细胞清除

DOI :10.1084/jem.20220964

⑤GeroScience：Proteomic basis of mortality resilience mediated by FOXO3 longevity genotype

FOXO3弹性基因型通过降低相关通路的死亡率来发挥作用

DOI :10.1007/s11357-023-00740-6

⑥Gut：Gnotobiotic mice housing conditions critically influence the phenotype associated with transfer of faecal microbiota in a context of obesity

肥胖条件下，居住条件严重影响与粪便微生物群转移相关的表型
DOI :10.1136/gutjnl-2021-326475

⑦德喜曲妥珠单抗（Trastuzumab Deruxtecan）Ⅱ期临床试验数据公布，在表达HER2晚期实体瘤中达到ORR终点

⑧用于早期阿尔茨海默病的Lecanemab基于IIb期概念验证性临床试验数据获FDA批准sBLA优先审评资格

⑨中国生物：采用新型抗原设计的新型冠状病毒mRNA疫苗I期临床试验启动

⑩FDA已接受度普利尤单抗（Dupixent）用于成人和青少年慢性自发性荨麻疹补充生物制品许可申请(sBLA)审查

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