为华生物分享科研试剂MPEG-NH2 甲氧基聚乙二醇氨基的简介

品牌：为华生物

产地：中国广州

PEG分子量：2k、3.4k、5k

外观：白色固体或液体，取决于分子量

常用溶剂：溶于大部分有机溶剂，溶于水

mPEG-NH2 是一种含有氨基的单官能甲氧基聚乙二醇衍生物之一。氨基与羧酸、活性酯等反应，羧基和许多其他胺反应性官能团在水性缓冲液或有机溶剂中快速反应。氨基官能PEG可用于通过其游离的伯胺基团修饰蛋白质，多肽，抗体，颗粒和其他材料，降低多肽和蛋白质的免疫原性。

产品的氨基端，对于酰化试剂活性比羟基高，它很容易进行还原氨基化反应。应用氨基的反应活性，可以通过生成稳定的化学键(如酰胺键，氨基甲酸酯键，脲键和仲胺键)，把另一些分子和其连接。它们可用于:制备带有生物活性化合物的配体;多肽合成时的载体;制备高分子接枝物和PEG涂层;制备PEG糖蛋白配体。

Mpeg-nh2 is one of the monofunctional methoxy polyethylene glycol derivatives containing amino groups. The amino group reacts with carboxylic acid and active ester, and the carboxyl group and many other amine reactive functional groups react rapidly in aqueous buffer or organic solvent. Amino functional peg can be used to modify proteins, polypeptides, antibodies, particles and other materials through its free primary amine groups to reduce the immunogenicity of peptides and proteins.

The amino end of the product is more active than the hydroxyl group for acylation reagent, and it is easy to carry out reductive amination reaction. By using the reactive activity of amino groups, other molecules can be connected to them by generating stable chemical bonds (such as amide bond, carbamate bond, urea bond and secondary amine bond). They can be used to: prepare ligands with bioactive compounds; Carrier for polypeptide synthesis; Polymer grafts and PEG coatings were prepared; Peg glycoprotein ligands were prepared.

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