【标题速读】【Nm】【2022年】【2-6月】
声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。
Fowler et. al report their primary analysis of the ELARA phase 2 trial of tisagenlecleucel, an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy, that showed a robust response and manageable safety profile in heavily pre-treated patients with relapsed/refractory follicular lymphoma. Captured in a moment of suspense, the illustrated cover casts a retro space-age mood over the scene as a tisagenlecleucel CAR T cell recognizes and targets a CD19-expressing follicular lymphoma within the tumor microenvironment, highlighting the selective and specific mechanism of this novel cellular therapy.
Fowler等报告了他们对tisagenlecleucel（CAR T细胞药物）的ELARA 2期试验的初步分析，tisagenlecleucel是一种自体抗CD19嵌合抗原受体（CAR）T细胞疗法，该疗法在经过大量预处理的复发/难治性滤泡性淋巴瘤患者中显示出强烈的反应和可控的安全性。插图封面捕捉到一个悬念时刻，当tisagenlecleucel CAR T细胞识别并靶向肿瘤微环境中表达CD19的滤泡性淋巴瘤时，插图封面为场景投下了复古太空时代的气氛，突出了这种新型细胞疗法的选择性和特异性治疗机制。
1.AAV gene therapy for Tay-Sachs disease.
AAV基因疗法治疗Tay-Sachs病。
2.Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis.
依赖活动的脊髓神经调控在完全瘫痪后迅速恢复躯干和腿部运动功能。
3.Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates.
人类多能干细胞衍生的胰岛能改善非人类灵长类动物的糖尿病。
4.The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration.
针对糖类的抗体反应在生物假体心脏瓣膜钙化和恶化中的作用。
5.Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease.
代谢组和微生物组分析揭示了冠状动脉疾病的个性化风险因素。
6.Microbiome and metabolome features of the cardiometabolic disease spectrum.
心脏代谢性疾病谱的微生物组和代谢组特征。
7.Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer.
肠道Akkermansia muciniphila预测晚期非小细胞肺癌患者对PD-1阻断疗法的临床反应。
8.Tisagenlecleucel in adult relapsed or refractory follicular lymphoma: the phase 2 ELARA trial.
Tisagenlecleucel治疗成人复发或难治性滤泡性淋巴瘤：2期ELARA试验。
9.Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication.
抗GD2与CD47阻断协同作用，介导肿瘤的根除。
10.HLA-independent T cell receptors for targeting tumors with low antigen density.
靶向低抗原密度肿瘤的HLA无关的T细胞受体。
11.T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma.
与黑色素瘤患者免疫检查点阻断疗法的毒性有关的T细胞特征。
12.Influenza virus infection history shapes antibody responses to influenza vaccination.
流感病毒感染史影响了对流感疫苗接种的抗体反应。
13.A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination.
流感病毒H2血凝素中的一个单一残基增强了H2疫苗接种所引起的B细胞反应的广度。
14.Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial.
铁蛋白纳米颗粒H2流感疫苗在健康成人中的安全性和免疫原性：一项1期试验。
15.Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial.
IL-15超级拮抗剂N-803对HIV感染者的安全性和病毒学影响：1期试验。
16.Heterologous AD5-nCOV plus CoronaVac versus homologous CoronaVac vaccination: a randomized phase 4 trial.
异源AD5-nCOV加CoronaVac与同源CoronaVac疫苗接种：一项随机的4期试验。
17.Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.
与COVID-19疫苗接种或SARS-CoV-2感染有关的心肌炎、心包炎和心律失常的风险。
亚马逊的健康
Local communities protect the Amazon rainforest from illegal logging and mining, but this is threatened by a lack of local healthcare. Journalist Sofia Moutinho traveled with a medical team who delivered vaccines for COVID-19 and other supplies during a monthlong boat trip along the Amazon River.
当地社区保护亚马逊雨林免受非法伐木和采矿的侵害，但这受到当地医疗保健缺乏的威胁。记者索菲亚·穆蒂尼奥（Sofia Moutinho）与一支医疗队一起旅行，该医疗队在亚马逊河沿岸为期一个月的游船之旅中运送了COVID-19疫苗和其他物资。
1.An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies.
具有传染性的SARS-CoV-2 B.1.1.529 Omicron病毒能逃脱治疗性单克隆抗体的中和。
2.Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern.
通过感染或接种疫苗对SARS-CoV-2的尖峰蛋白进行三次接触，可对所有关注的变体产生卓越的中和免疫力。
3.SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland.
苏格兰孕妇的SARS-CoV-2感染和COVID-19疫苗接种率。
4.Whole-genome risk prediction of common diseases in human preimplantation embryos.
人类植入前胚胎中常见疾病的全基因组风险预测。
5.Hematopoietic stem cell transplantation chemotherapy causes microglia senescence and peripheral macrophage engraftment in the brain.
造血干细胞移植化疗导致小胶质细胞衰老和外周巨噬细胞在大脑中吞噬。
6.Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial.
口服小分子螯合剂对自闭症谱系障碍青少年的安全性和目标参与：一个开放标签的1b/2a期试验。
7.Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma.
肠道微生物组与免疫检查点抑制剂在晚期黑色素瘤中的反应的跨队列关联。
8.Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1.
抗PD-1治疗的黑色素瘤患者的临床反应和免疫相关不良事件的肠道微生物群特征。
9.Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.
干细胞结构驱动骨髓增生异常综合征进展并预测对基于venetoclax疗法的反应。
10.The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial.
SGLT2抑制剂empagliflozin在急性心衰住院患者中的应用：一项多国随机试验。
11.Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies.
基于深度学习的心内膜活检对心脏异体移植排斥的评估。
12.Long-term cardiovascular outcomes of COVID-19.
COVID-19的长期心血管结果。
癌症研究的未来
This special Focus issue presents an overview of the most promising developments in cancer research, with an eye toward delivering research and care that is innovative, equitable, sustainable and patient-focused. The cover presents an artistic rendition of the study by Seliger and colleagues, in this issue, showing an increased risk of death by suicide in patients with cancer and underscoring the need for comprehensive psycho-oncological therapy during routine clinical practice to improve the quality of life of such patients.
本期《焦点》特刊概述了癌症研究中最有前途的发展，着眼于提供创新、公平、可持续和以患者为中心的研究和护理。封面展示了Seliger及其同事在本期中的研究的艺术再现，显示癌症患者自杀死亡的风险增加，并强调在常规临床实践中需要综合心理肿瘤治疗以提高这类患者的生活质量。
1.Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial.
Nivolumab加ipilimumab，补充或不补充活细菌治疗转移性肾细胞癌：随机1期试验。
2.Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy.
抗CD19 CAR T细胞治疗后反应和毒性的肠道微生物组相关因素。
3.PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial.
PSMA靶向TGFβ不敏感的铠甲CAR T细胞治疗转移性耐阉割前列腺癌：1期试验。
4.Axicabtagene ciloleucel as first-line therapy in high-risk large B-cell lymphoma: the phase 2 ZUMA-12 trial.
Axicabtagene ciloleucel作为高危大B细胞淋巴瘤的一线治疗：2期ZUMA-12试验。
5.Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.
单细胞转录组学揭示了KMT2A重排的婴儿B细胞急性淋巴细胞白血病的独特发展状态。
6.Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism.
基于可操作的S100A9/RAGE抗性机制，对放射敏感的脑转移瘤进行分层。
7.Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.
溃疡性结肠炎的特点是与疾病活动相关的质粒偏斜的体液反应。
8.In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial.
体内局部基因治疗隐性萎缩性表皮松解症：1期和2期试验。
9.Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A.
腺相关病毒基因治疗血友病A后，转基因mRNA和蛋白质生产的个体间差异。
10.Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation.
通过玻璃化技术冷冻胰岛实现了高存活率、高功能、高恢复率和临床移植的可扩展性。
11.The SGLT2 inhibitor canagliflozin in heart failure: the CHIEF-HF remote, patient-centered randomized trial.
SGLT2抑制剂canagliflozin治疗心力衰竭：CHIEF-HF远程、以患者为中心的随机试验。
12.Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma.
代谢组分析显示哮喘病人吸入皮质类固醇治疗导致的广泛肾上腺抑制。
13.Initial analysis of viral dynamics and circulating viral variants during the mRNA-1273 Phase 3 COVE trial.
mRNA-1273三期COVE试验期间病毒动态和循环病毒变体的初步分析。
14.Effectiveness of COVID-19 booster vaccines against COVID-19-related symptoms, hospitalization and death in England.
英格兰COVID-19加强型疫苗对COVID-19相关症状、住院和死亡的有效性。
15.Vaccine effectiveness of heterologous CoronaVac plus BNT162b2 in Brazil.
巴西异源性CoronaVac加BNT162b2的疫苗有效性。
16.Increased global integration in the brain after psilocybin therapy for depression.
迷幻药治疗抑郁症后，大脑中的全局整合增加。
移植中的多基因风险评分
Shaked et al. applied a polygenic risk score for type 2 diabetes to liver and kidney transplant donors and recipients with the aim of identifying genetic associations with the development of post-transplantation diabetes mellitus. The cover is illustrative of genetic puzzle pieces in both the donor and the recipient, which can be leveraged to inform and develop personalized treatment strategies and to optimize donor–recipient matching.
Shaked等将2型糖尿病的多基因风险评分应用于肝肾移植供体和受体，目的是确定与移植后糖尿病发展的遗传关联。封面说明了捐赠者和接受者的基因拼图，可用于告知和制定个性化治疗策略并优化捐赠者与接受者的匹配。
1.Blood-based tumor mutational burden as a biomarker for atezolizumab in non-small cell lung cancer: the phase 2 B-F1RST trial.
基于血液的肿瘤突变负担作为非小细胞肺癌中阿特唑仑的生物标志物：2期B-F1RST试验。
2.Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.
来自突变的PIK3CA的公共新抗原的免疫原性和治疗目标。
3.Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial.
电子烟与尼古丁贴片在妊娠期戒烟中的比较：随机对照试验。
4.Dorzagliatin in drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial.
Dorzagliatin用于2型糖尿病患者的药物治疗：随机、双盲、安慰剂对照的3期试验。
5.Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial.
Dorzagliatin在2型糖尿病患者中作为二甲双胍的附加治疗：一项随机、双盲、安慰剂对照的3期试验。
6.Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes.
2型糖尿病的表型、疾病进展和药物反应的异质性。
7.The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation.
MHC I类MICA基因是肾脏移植的组织相容性抗原。
8.Donor and recipient polygenic risk scores influence the risk of post-transplant diabetes.
捐赠者和接受者的多基因风险评分影响移植后糖尿病的风险。
9.Development of a clinical polygenic risk score assay and reporting workflow.
开发临床多基因风险评分检测和报告工作流程。
10.Intravitreal antisense oligonucleotide sepofarsen in Leber congenital amaurosis type 10: a phase 1b/2 trial.
玻璃体内反义寡核苷酸sepofarsen治疗Leber先天性失明10型：1b/2期试验。
11.Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial.
AAV8传递广谱中和抗体在成人HIV感染者中的安全性和耐受性：一个1期的剂量递增试验。
12.Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults.
年轻成年人在SARS-CoV-2人体挑战中的安全性、耐受性和病毒动力学。
13.Immune response to SARS-CoV-2 after a booster of mRNA-1273: an open-label phase 2 trial.
强化mRNA-1273后对SARS-CoV-2的免疫反应：一个开放标签的2期试验。
14.Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19.
儿童多系统炎症综合征和小儿COVID-19中的免疫病理学特征。
15.Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants.
mRNA-1273对SARS-CoV-2 Omicron和Delta变体的疗效。
16.Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines.
普通人群在接种两剂ChAdOx1或BNT162b2疫苗后的抗体反应和保护的相关因素。
17.Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants.
基于CRISPR的微流控平台用于呼吸道病毒的临床测试和SARS-CoV-2变种的鉴定。
中和Omicron子系
In this issue, Bruel et al. demonstrate substantial differences in the sensitivity of the SARS-CoV-2 Delta variant and Omicron sublineages BA.1 and BA.2 to neutralization by nine therapeutic monoclonal antibodies. The cover combines an image of SARS-CoV-2-infected cells fusing with neighboring cells to form syncytia with a view of Earth, reflective of the ongoing global impact of the pandemic.
在这个问题上，Bruel等人表明SARS-CoV-2 Delta变体和Omicron亚系 BA.1 和 BA.2 对九种治疗性单克隆抗体中和的敏感性存在显着差异。封面结合了一张受SARS-CoV-2感染的细胞与邻近细胞融合形成合胞体的图像以及地球视角，反映了这一流行病对全球的持续影响。
1.Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial.
Sotigalimab和/或nivolumab与化疗用于一线转移性胰腺癌：随机2期PRINCE试验的临床和免疫学分析。
2.Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial.
高危III期黑色素瘤新辅助治疗ipilimumab和nivolumab后的个性化反应导向的手术和辅助治疗：PRADO试验。
3.Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results.
Claudin18.2特异性CAR T细胞治疗胃肠道癌症：1期试验中期结果。
4.Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort.
Pembrolizumab治疗具有三级淋巴结构的软组织肉瘤：2期PEMBROSARC试验队列。
5.In utero origin of myelofibrosis presenting in adult monozygotic twins.
呈现在成年单卵双胞胎中的骨髓纤维化的子宫内起源。
6.A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia.
用于理解异质性和预测急性髓性白血病药物反应的细胞层次框架。
7.Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial.
数字化远程监控加常规护理与口服抗癌药物治疗患者的常规护理：随机的3期CAPRI试验。
8.Swarm learning for decentralized artificial intelligence in cancer histopathology.
癌症组织病理学中分散式人工智能的蜂群学习.
9.Machine learning model to predict mental health crises from electronic health records.
从电子健康记录中预测心理健康危机的机器学习模型。
10.Brain lesions disrupting addiction map to a common human brain circuit.
扰乱成瘾的脑部病变映射到一个共同的人类大脑回路。
11.Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial.
利妥昔单抗与托西单抗治疗类风湿性关节炎：4期R4RA随机试验中基于滑膜活检的生物标志物分析。
12.Empagliflozin add-on therapy to closed-loop insulin delivery in type 1 diabetes: a 2 × 2 factorial randomized crossover trial.
Empagliflozin对1型糖尿病闭环胰岛素输送的附加治疗：一个2×2因子的随机交叉试验。
13.Noninvasive proteomic biomarkers for alcohol-related liver disease.
酒精相关肝病的非侵入性蛋白质组生物标志物。
14.Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial.
三合一广泛中和单克隆抗体治疗HIV-1的安全性和抗病毒活性：1期临床试验。
15.Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies.
接受单克隆抗体治疗的患者血清中和SARS-CoV-2 Omicron亚系BA.1和BA.2的情况。
16.A multisystem, cardio-renal investigation of post-COVID-19 illness.
对COVID-19后疾病的多系统、心肾功能的调查。
17.COVID-19 and resilience of healthcare systems in ten countries.
在十个国家，COVID-19和医疗系统的复原力。
