乙酰基八肽-3——有效祛除脸部静态纹、细纹
简介
皮肤老化的最主要特征是脸部皱纹的增加，这既是人类基因预选安排的程序，又存在环境的加速因素，比如脸部皮肤不断受到压迫（如睡觉时），经常性的脸部表情导致的肌肉收缩运动等等。从生理学上讲，皮肤的衰老表现在胶原蛋白和弹性蛋白的减少，皮肤油脂的无规则排列。近年来已有文献报道，为了有效避免这些情况产生可以通过以下两种方法：抑制SNARE组合体的合成；抑制儿茶酚胺的释放。
乙酰基八肽-3为阿基瑞林的延长类似物，为模仿 SNAP- 25 蛋白的 N 端并由八个氨基酸组成的寡肽。临床实验证实八胜肽是基于人体皮肤生化机制而科学合理设计的抗皱多肽活性原料, 现已成为风靡世界的用于抗皱的化妆品原料,其功效可以与 A 型肉毒素媲美, 但是又避开了肉毒素的必须注射和使用成本高昂的缺点。
Acetyl group octopeptide-3 is an elongated analogue of Akirelin, an oligopeptide consisting of eight amino acids that mimics the N-terminal of SNAP-25 protein. Clinical experiments have confirmed that octapeptide is a scientifically and reasonably designed anti wrinkle peptide active raw material based on the biochemical mechanism of human skin. It has become a popular cosmetic raw material for anti wrinkle use worldwide. Its efficacy can be comparable to that of type A botulinum toxin, but it avoids the drawbacks of botulinum toxin's mandatory injection and high cost of use.
INCI 乙酰基八肽-3
参考 SNAP-8
英文 Acetyl Octapeptide-3
CAS 号 868844-74-0
分子量 1075.16
分子式 C41H70N16O16S
多肽序列 Ac-EEMQRRAD-NH2
机理
肌肉在接受到神经递质时会发生收缩（摘自A.FerrerMontieletal，TheJournalofBiologicalChemistry，1997，272，2634-2638）。神经递质是在神经元胞体中合成的，并贮存在突触小泡内，当受到外界刺激时，一种对钙有依赖性的胞外分泌物（称为SNARE蛋白质组合体）使突触小泡释放出神经递质，并经突触缝隙到达突触后膜，与相应的受体结合而发生作用。SNARE是由三种蛋白质VAMP、Syntaxin和SNAP-25结合而成的。
Muscles contract when they receive neurotransmitters (excerpted from A. FerrerMontieltal, The Journal of Biological Chemistry, 19972722634-2638). Neurotransmitters are synthesized in the neuronal cell body and stored in the Synaptic vesicle. When stimulated by the outside world, a calcium dependent extracellular secretion (called SNARE protein complex) makes the Synaptic vesicle release neurotransmitters, and then reach the postsynaptic membrane through the synaptic gap to interact with the corresponding receptors. SNARE is composed of three proteins: VAMP, Syntaxin, and SNAP-25.
