中英文说明丨艾美捷 LKT Labs 阿达格拉西布

Description

Adagrasib is a inhibitor of KRASG12C, which is a notoriously difficult to treat cancerous mutation.

 

Product Info

Cas No. 2326521-71-3

Purity ≥99%

Formula C32H35ClFN7O2

Formula Wt. 604.13

IUPAC Name 2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile

Synonym MRTX-849

Appearance White powder

 

Shipping and Storage

Store Temp  -20°C

Ship Temp  Ambient

 

艾美捷 LKT Labs 阿达格拉西布Adagrasib是KRASG12C的抑制剂，KRASG<>C是一种众所周知的难以治疗的癌性突变。

 

阿达格拉西布基础信息：

编号：A121008

cas：2326521-71-3

纯度：≥99%

公式：C32H35ClFN7O2

配方重量：604.13

IUPAC名称：2-[（2S）-4-[7-（8-氯萘-1-基）-2-[[（2S）-1-甲基吡咯烷-2-基]甲氧基]-6，8-二氢-5H-吡啶并[3，4-d]嘧啶-4-基]-1-（2-氟丙基-2-烯酰基）哌嗪-2-基]乙腈

同义词：MRTX-849

外观：白色粉末

 

阿达格拉西布文献参考：

Zhang Y, Li C, Xia C, et al. Adagrasib, a KRAS G12c inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo. Cell Commun Signal. 2022 Sep 14;20(1):142. PMID: 36104708

 

Sabari J, Velcheti V, Shimizu K, et al. Activity of adagrasib (MRTX849) in brain metastases: preclinical models and clinical data from patients with KRASG12c-mutant non-small cell lung cancer. Clin Cancer Res. 2022 Aug 2;28(15):3318-3328. PMID: 35404402

 

Koga T, Suda K, Fujino T, et al. KRAS secondary mutations that confer acquired resistance to KRAS G12c inhibitors, sotorasib and adagrasib, and overcoming strategies: insights form in vitro experiments. J Thorac Oncol. 2021 Aug;16(8):1321-1332. PMID: 33971321