活性氧MCB-613，296792-62-6，4-ethyl-2,6-bis(3-pyridinylmethylene)-cyc

产品名称：

活性氧MCB-613，296792-62-6，4-ethyl-2,6-bis(3-pyridinylmethylene)-cyclohexanone

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

状态：固体/粉末

储藏条件：冷藏-20℃

温馨提示：仅用于科研，不能用于人体实验！

说明：提供使用说明，核磁图谱，包装，价格，产地，制备方法，应用，稳定性，溶解度，简单合成等各种信息　　

The p160 steroid receptor coactivator (SRC) family, SRC-1/NCOA1, SRC-2/NCOA2/TIF2/GRIP1, and SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression and integrate growth signaling pathways on which cancer cells rely. MCB-613 is a small molecule stimulator of SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs.1 MCB-613 can increase the interaction of SRCs with the coactivators CBP and CARM1 and can induce ER stress coupled to the generation of reactive oxygen species.1 Overactivation of SRCs by 1-7 µM MCB-613 was shown to selectively and dose dependently induce paraptosis in a variety of cancer cells in vitro but not in normal cells.1 At 20 mg/kg, MCB-613 was also shown to inhibit tumor growth in an MCF-7 breast cancer xenograft model in mice.1

p160类固醇受体辅激活子（SRC）家族、SRC-1/NCOA1、SRC-2/NCOA2/TIF2/GRIP1和SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP与核受体和其他转录因子相互作用，以驱动靶基因表达并整合癌症细胞所依赖的生长信号通路。MCB-613是SRC-1、SRC-2和SRC-3的小分子刺激物，以及用于破坏癌症细胞对SRC的稳态依赖性的SRC-3。1 MCB-613可以增加SRC与辅活化剂CBP和CARM1的相互作用，并可以诱导内质网应激与活性氧物种的生成相耦合。1 1-7µM MCB-612过度激活SRC，在体外可选择性地和剂量依赖性地诱导多种癌症细胞的截瘫，但不是在正常细胞中。1在20 mg/kg的MCF-7乳腺癌小鼠异种移植瘤模型中，MCB-613也显示出抑制肿瘤生长。

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编辑：XAQYBIO HAO，2023年4月10日。