Motixafortide/BKT140 (4-fluorobenzoyl)，是CXCR4的最佳拮抗剂
2022-12-16 23:01 作者:youngshe-Leslie | 我要投稿
Motixafortide (Synonyms: BKT140 (4-fluorobenzoyl); BL-8040; TF14016)
分子: 2159.52
分子式: C97H144FN33O19S2
CAS 番号: 664334-36-5
Motixafortide（以前称为BL-8040/BKT140）是CXCR4趋化因子受体的一种新型选择性抑制剂。CXCR4是一种经过充分验证的有效成分，它参与造血干细胞、免疫细胞和癌细胞从骨髓和淋巴结到外周血的动员和运输。Motixafortide的独特特性，包括高亲和力、长受体占有率和反向激动剂活性，使其成为CXCR4的最佳拮抗剂。
Motixafortide
(BKT140) displays selective toxicity toward AmL and MM cells.
Treatment with Motixafortide (BKT140) can overcome IL-6 dependent
proliferation and survival of ARH77 MM cells. Motixafortide (BKT140)
specifically triggers CXCR4-dependent cell death in leukemia and MM
cells. Motixafortide (BKT140) stimulates apoptotic cell death in
leukemia and MM cells.
