活性氧CFTR Inhibitor-172，CAS No. 307510-92-5

产品名称：活性氧CFTR Inhibitor-172，CAS No. 307510-92-5

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

状态：固体/粉末

储藏条件：冷藏-20℃

温馨提示：仅用于科研，不能用于人体实验！

说明：提供使用说明，核磁图谱，包装，价格，产地，制备方法，应用，稳定性，溶解度，简单合成等各种信息　　

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR).CFTR inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner.It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels.In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection.It slows cyst growth in animal models of polycystic kidney disease.5 As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.

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编辑：XAQYBIO HAO，2023年4月20日。