【标题速读】【nbe】【2023年】【1-4月】
声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。
1.Peritumoural immunomodulatory scaffolds. This issue highlights an anti-CD98 antibody with pH-dependent binding for antitumour therapy, cytotoxic CAR T cells derived from human induced pluripotent stem cells with enhanced proliferation and persistency in solid tumours, intragastrically delivered polymeric micelles releasing butyrate for the restoration of barrier-protective responses in mouse models of gut inflammation, peritumourally implanted immunomodulatory macroporous scaffolds providing systemic antitumour immunity, and pathogen-mimicking polymer nanoparticles inducing T-helper-17-cell-mediated antitum.
瘤周免疫调节支架。本期重点介绍了用于抗肿瘤治疗的具有 pH 依赖性结合的抗 CD98 抗体、源自人诱导多能干细胞的细胞毒性 CAR T 细胞（在实体瘤中具有增强的增殖和持久性）、胃内递送的聚合胶束释放丁酸盐以恢复屏障保护肠道炎症小鼠模型中的反应、瘤周植入的免疫调节大孔支架提供全身抗肿瘤免疫，以及诱导 T-helper-17 细胞介导的抗肿瘤的模拟病原体聚合物纳米颗粒。
2.An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice.
一种抗 CD98 抗体，在 CD98 人源化小鼠中表现出针对多种癌症的 pH 依赖性 Fc 介导的肿瘤特异性活性。
3.Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells.
源自人类诱导多能干细胞的 CAR T 细胞增殖和持久性的优化。
4.Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles.
通过聚合胶束在肠道中释放丁酸盐来治疗小鼠花生过敏和结肠炎。
5.Systemic enhancement of antitumour immunity by peritumourally implanted immunomodulatory macroporous scaffolds.
通过瘤周植入免疫调节大孔支架全身增强抗肿瘤免疫力。
6.Induction of T-helper-17-cell-mediated anti-tumour immunity by pathogen-mimicking polymer nanoparticles.
通过模仿病原体的聚合物纳米粒子诱导 T 辅助细胞 17 细胞介导的抗肿瘤免疫。
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1.A soft robotic ventilator for assisting inspiration. This issue highlights an intravascular infused biomaterial for treating inflammation, an implantable soft robotic ventilator, the intraoperative histology of bone tissue via photoacoustic microscopy and deep learning, neural organoids for spinal-cord regeneration, piezoelectric nanoparticles for deep brain stimulation, receptor agonists with enhanced pharmacokinetics, and alterations in chromatin organization in disease.
用于辅助吸气的软体机器人呼吸机。本期重点介绍用于治疗炎症的血管内灌注生物材料、植入式软机器人呼吸机、通过光声显微镜和深度学习进行骨组织的术中组织学、用于脊髓再生的神经类器官、用于深部脑刺激的压电纳米粒子、具有增强药代动力学的受体激动剂，以及疾病中染色质组织的改变。
2.Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues.
血管内注入细胞外基质作为生物材料，用于靶向和治疗发炎组织。
3.An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency.
植入式软机器人呼吸机可增强呼吸功能不全的猪模型的吸气能力。
4.Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy.
通过深度学习辅助紫外光声显微镜对骨组织进行无标记术中组织学分析。
5.A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples.
一种基于水凝胶的机械超材料，用于对患者样本中的细胞外囊泡进行干涉分析。
6.Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound.
通过跨越血脑屏障的压电纳米颗粒在聚焦超声下产生电流和一氧化氮来刺激深部脑部。
7.Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.
通过将大环肽移植到片段可结晶区域来设计具有增强药代动力学的受体激动剂。
8.Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues.
患病纤维结缔组织细胞中响应化学机械线索改变的异常染色质重组。
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1.Hepatocyte-targeting nanoparticles for enhanced hepatobiliary MRI. This issue highlights that hepatobiliary MRI can be enhanced by an ultrasmall nanoparticle targeting hepatocytes, that transmembrane water-efflux rate is a sensitive biomarker of the expression of aquaporin-4, a hydrogel-based metamaterial for profiling extracellular vesicles in patient samples, a near-infrared fluorophore for the imaging of aggregates of amyloid-β and tau through the skull of mice, nanoparticles producing ultrasound-induced afterglow luminescence, a library of renally cleared fluorescence probes for the tracking of tumour-infiltrating leukocytes, liposomal nanoparticles for spatially mapping light in deep tissue via MRI, and a tomographic method for the location of photon pairs produced from high-energy X-rays.
用于增强肝胆 MRI 的肝细胞靶向纳米颗粒。本期强调，肝胆 MRI 可以通过靶向肝细胞的超小纳米颗粒得到增强，跨膜水流出率是水通道蛋白 4 表达的敏感生物标志物，水通道蛋白 4 是一种基于水凝胶的超材料，用于分析患者样本中的细胞外囊泡，这是一种近乎用于通过小鼠头骨对淀粉样蛋白-β 和 tau 蛋白聚集体进行成像的红外荧光团、产生超声诱导余辉发光的纳米颗粒、用于跟踪肿瘤浸润白细胞的肾清除荧光探针库、用于在空间映射光的脂质体纳米颗粒通过 MRI 探测深层组织，以及用于定位高能 X 射线产生的光子对的断层扫描方法。
2.A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging.
用于增强肝胆磁共振成像的肝细胞靶向纳米颗粒。
3.Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas.
通过磁共振成像测量跨膜水流出率作为神经胶质瘤中 aquaporin-4 表达的生物标志物。
4.Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes.
通过人类星形胶质细胞的直接重编程生成用于脊髓再生的神经类器官。
5.Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice.
通过小鼠完整头骨对淀粉样蛋白-β 聚集体和 tau 纤维进行近红外荧光寿命成像。
6.Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine.
可激活的近红外探针，用于检测体内和尿液中特定肿瘤浸润白细胞群。
7.Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics.
具有超声诱导余辉发光的纳米颗粒，用于肿瘤特异性治疗诊断。
8.Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes.
使用 MRI 可检测的光敏脂质体绘制组织中的光分布图。
9.Tomographic detection of photon pairs produced from high-energy X-rays for the monitoring of radiotherapy dosing.
对高能 X 射线产生的光子对进行断层扫描检测，用于监测放射治疗剂量。
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1.Bioresorbable optoelectronic neural interfaces. This issue includes a focus on neurotechnologies for the treatment of conditions of the central and peripheral nervous systems, with emphasis on neural interfaces and on motor and visual neural.
生物可吸收光电神经接口。本期重点关注用于治疗中枢和周围神经系统疾病的神经技术，重点关注神经接口以及运动和视觉神经。
2.Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.
用于神经活动的光电激发和抑制的生物可吸收薄膜硅二极管。
3.A one-photon endoscope for simultaneous patterned optogenetic stimulation and calcium imaging in freely behaving mice.
一种单光子内窥镜，用于在自由行为的小鼠中同时进行图案化光遗传学刺激和钙成像。
4.A low-power stretchable neuromorphic nerve with proprioceptive feedback.
具有本体感觉反馈的低功率可拉伸神经形态神经。
5.Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents.
超灵活的电极阵列，可对啮齿类动物的数千个神经元进行长达数月的高密度电生理图绘制。
6.A prototype closed-loop brain–machine interface for the study and treatment of pain.
用于研究和治疗疼痛的闭环脑机接口原型。
7.Rapid adaptation of brain–computer interfaces to new neuronal ensembles or participants via generative modelling.
通过生成模型，脑机接口快速适应新的神经元集合或参与者。
8.Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.
非人类灵长类动物神经活动动力学的闭环光遗传学控制。
9.Closed-loop enhancement and neural decoding of cognitive control in humans.
人类认知控制的闭环增强和神经解码。
10.A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback.
柔软的神经假手可同时提供肌电控制和触觉反馈。
