【标题速读】【nature】【2023年】【3月】

声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。

1.Root and branch. Trees in dryland ecosystems play an important part in carbon cycling, but extensive data on their number and distribution have been lacking. In this week’s issue, Compton Tucker and his colleagues present an inventory of nearly 10 billion trees in sub-Saharan Africa. The researchers used machine learning to scan high-resolution satellite images to cover an area of nearly 10 million square kilometres. This allowed them to map individual trees and estimate the amount of carbon stored in the foliage, wood and roots of each tree. They divided the drylands into four zones, depending on the annual rainfall, and found that individual trees stored 51 kilograms of carbon in the driest regions, rising to 98 kilograms where the rainfall was greatest. The team has made a database of wood mass, foliage mass, root mass and carbon stock for each tree freely available (see go.nature.com/3ys6nhu).

根与枝。旱地生态系统中的树木在碳循环中发挥着重要作用，但缺乏关于其数量和分布的广泛数据。在本周的期刊中，康普顿·塔克 (Compton Tucker) 和他的同事介绍了撒哈拉以南非洲地区近 100 亿棵树木的清单。研究人员利用机器学习扫描高分辨率卫星图像，覆盖了近1000万平方公里的区域。这使得他们能够绘制每棵树的地图，并估计每棵树的叶子、木材和根部储存的碳量。他们根据年降雨量将旱地分为四个区域，发现在最干旱的地区，每棵树储存的碳量为 51 公斤，在降雨量最大的地区，每棵树的碳储存量为 98 公斤。该团队免费提供了每棵树的木材质量、叶子质量、根质量和碳储量的数据库（参见 go.nature.com/3ys6nhu）。

2.Murky waters. The cover image shows an algal bloom off the coast of Alaska in 2017. Phytoplankton blooms are accumulations of microscopic algae in the surface layer of water systems. Although they can provide food and nutrients for other organisms, they can also cause serious environmental problems. In this week’s issue, Lian Feng and colleagues present a comprehensive map of bloom distribution and trends in coastal waters. The researchers assessed 760,000 images captured by NASA’s Aqua satellite between 2003 and 2020, and identified blooms on the coast of 126 of the 153 ocean-bordering countries they examined. They found that the area of water affected by blooms expanded by 13.6% between 2003 and 2020, and that this increased bloom frequency correlated with changing ocean circulations and rising sea-surface temperatures.

浑浊的水域。封面图片显示了 2017 年阿拉斯加海岸的藻华。浮游植物华是水系统表层微观藻类的积累。尽管它们可以为其他生物提供食物和营养，但它们也会造成严重的环境问题。在本周的期刊中，连峰和同事展示了沿海水域水华分布和趋势的综合地图。研究人员评估了 NASA Aqua 卫星在 2003 年至 2020 年间拍摄的 76 万张图像，并在他们检查的 153 个临海国家中的 126 个国家的海岸发现了水华。他们发现，2003年至2020年间，受水华影响的水域面积扩大了13.6%，这种水华频率的增加与海洋环流的变化和海面温度的上升有关。

3.Twist factor. Chiral molecules are structures that have the same composition but are mirror images of each other. In this week’s issue, Nicholas Kotov and his colleagues use self-assembling nanosheets that form bow-tie-like microparticles to examine whether it is practical to use geometrical measures of chirality for chemical structures. The nanosheets hierarchically assemble into nanoribbons that stack together and twist to look like bow ties (as pictured on the cover), with the direction of twist depending on the chirality of the molecules used to form the nanosheets. Crucially, the twist angle of the bow ties is highly controllable. The team found that the various bow-tie particles interacted differently with circularly polarized light depending on their chirality measure. The researchers also printed their bow-tie particles onto fabric, creating photonically active metasurfaces that they suggest could form the basis for fiducial markers for lidars.

扭转系数。手性分子是具有相同组成但互为镜像的结构。在本周的期刊中，尼古拉斯·科托夫（Nicholas Kotov）和他的同事使用自组装纳米片来形成领结状微粒，以检查使用手性几何测量来测量化学结构是否实用。纳米片分层组装成纳米带，纳米带堆叠在一起并扭曲，看起来像领结（如封面所示），扭曲的方向取决于用于形成纳米片的分子的手性。至关重要的是，领结的扭转角度是高度可控的。研究小组发现，各种领结粒子与圆偏振光的相互作用不同，具体取决于其手性测量。研究人员还将他们的领结颗粒打印到织物上，创建光子活性超表面，他们认为这可以构成激光雷达基准标记的基础。

4.Driving test. One of the main hurdles to putting autonomous cars on the road is how to ensure the reliability of the artificial intelligence that replaces the human driver. Evaluating the safety of an AI driver to the level of a human in a naturalistic environment would require testing across hundreds of millions of miles — something that is clearly impractical. In this week’s issue, Henry Liu and his colleagues tackle this problem by training an AI to help test the AI in the driving seat. The researchers used dense deep reinforcement learning to train the AI tester, which allowed the tester to ignore safe scenarios and instead build a testing environment that focused on potentially dangerous situations. The team then successfully tested a real car using augmented reality — while the autonomous vehicle drove round a track it had to cope with virtual dangers set by the tester. The researchers say the system can speed up safety evaluations by several orders of magnitude.

驾驶测试。自动驾驶汽车上路的主要障碍之一是如何确保取代人类驾驶员的人工智能的可靠性。在自然环境中将人工智能驾驶员的安全性评估为人类水平需要进行数亿英里的测试——这显然是不切实际的。在本周的期刊中，Henry Liu 和他的同事通过训练人工智能来帮助测试驾驶座上的人工智能来解决这个问题。研究人员使用密集的深度强化学习来训练人工智能测试人员，这使得测试人员可以忽略安全场景，而是构建一个专注于潜在危险情况的测试环境。然后，该团队成功地使用增强现实技术测试了一辆真实的汽车——自动驾驶汽车在赛道上行驶时，它必须应对测试人员设置的虚拟危险。研究人员表示，该系统可以将安全评估速度提高几个数量级。

5.Swahili ancestry. Medieval people on the Swahili coast of East Africa were among the first sub-Saharan people to practise Islam. David Reich, Chapurukha Kusimba and colleagues sequenced DNA from 80 individuals buried in six medieval and early modern coastal Swahili stone towns, dating between 1250 and 1800. Their analysis shows that African women and Asian men began mixing along the East African coast before the year 1000, and that the earliest Asian migrants were of largely Persian origin. These findings match the Kilwa Chronicle, the oldest story told by the people of the Swahili coast. About one-tenth of the ancestry of the earliest Asian migrants came from India. The cover image is adapted from a photograph of a Swahili woman in Zanzibar taken in 1896. The textile patterns of the garment have been redrawn to reflect themes in the paper, including DNA, medieval dhows to signify trade, and symbols from Islam to represent cultural influence.

斯瓦希里血统。东非斯瓦希里海岸的中世纪人民是撒哈拉以南地区最早信奉伊斯兰教的人民之一。 David Reich、Chapurukha Kusimba 及其同事对 80 个人的 DNA 进行了测序，这些人埋藏在 6 个中世纪和早期现代沿海斯瓦希里石头城镇中，年代可追溯至 1250 年至 1800 年。他们的分析表明，非洲女性和亚洲男性在 1000 年之前就开始在东非海岸混合生活，最早的亚洲移民主要是波斯裔。这些发现与斯瓦希里海岸人民讲述的最古老的故事《基尔瓦编年史》相符。最早的亚洲移民的祖先中约有十分之一来自印度。封面图片改编自 1896 年在桑给巴尔拍摄的斯瓦希里妇女的照片。服装的纺织图案经过重新绘制，以反映报纸中的主题，包括 DNA、代表贸易的中世纪单桅帆船以及代表文化的伊斯兰教符号影响。

6.Carbon stocks of billions of individual African dryland trees estimated.

估算了数十亿非洲旱地树木的碳储量。

7.A gut reaction can tune tumour fate during chemotherapy.

肠道反应可以在化疗期间调节肿瘤的命运。

8.Black holes and neutron stars beat alike when bright.

黑洞和中子星在明亮时的跳动是相似的。

9.Rainfall affects interactions between plant neighbours.

降雨影响植物邻居之间的相互作用。

10.The genomic history of ice-age Europeans.

冰河时代欧洲人的基因组历史。

11.Drug trial for Alzheimer’s disease is a game changer.

阿尔茨海默病的药物试验改变了游戏规则。

12.A shared accretion instability for black holes and neutron stars.

黑洞和中子星共有的吸积不稳定性。

13.Critical role of hydrogen for superconductivity in nickelates.

氢对于镍酸盐超导性的关键作用。

14.Disorder-tuned conductivity in amorphous monolayer carbon.

无定形单层碳的无序调节电导率。

15.Ladderphane copolymers for high-temperature capacitive energy storage.

用于高温电容储能的梯烷共聚物。

16.Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations.

电化学反应器决定了 N-杂芳烃羧化的位点选择性。

17.Optimal nitrogen rate strategy for sustainable rice production in China.

中国水稻可持续生产的最优施氮策略

18.Sub-continental-scale carbon stocks of individual trees in African drylands.

非洲旱地次大陆范围内个别树木的碳储量。

19.Oceanic climate changes threaten the sustainability of Asia’s water tower.

海洋气候变化威胁着亚洲水塔的可持续性。

20.Primary N2–He gas field formation in intracratonic sedimentary basins.

克拉通内沉积盆地原生 N2-He 气田的形成。

21.Effects of moisture and density-dependent interactions on tropical tree diversity.

水分和密度依赖性相互作用对热带树木多样性的影响。

22.Annelid functional genomics reveal the origins of bilaterian life cycles.

环节动物功能基因组学揭示了两侧对称动物生命周期的起源。

23.Essential elements of radical pair magnetosensitivity in Drosophila.

果蝇自由基对磁敏感性的基本要素。

24.Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers.

旧石器时代晚期到新石器时代欧洲狩猎采集者的古基因组学。

25.Chemically defined cytokine-free expansion of human haematopoietic stem cells.

化学定义的人类造血干细胞的无细胞因子扩增。

26.FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

FXR 抑制可通过减少 ACE2 来防止 SARS-CoV-2 感染。

27.Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.

Spike 和 nsp6 是 SARS-CoV-2 Omicron BA.1 衰减的关键决定因素。

28.Active eosinophils regulate host defence and immune responses in colitis.

活跃的嗜酸性粒细胞调节结肠炎中的宿主防御和免疫反应。

29.Targeting TBK1 to overcome resistance to cancer immunotherapy.

靶向 TBK1 克服癌症免疫疗法的耐药性。

30.Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.

微生物群衍生的 3-IAA 影响胰腺癌的化疗效果。

31.Chemistry governs water organization at a graphene electrode.

化学控制着石墨烯电极上的水组织。

32.How an anxious heart talks to the brain.

焦虑的心如何与大脑对话。

33.MicroRNA uses a gym to get fit for cuts by Dicer enzyme.

MicroRNA 使用健身房来通过 Dicer 酶进行切割。

34.How wildfires deplete ozone in the stratosphere.

野火如何消耗平流层中的臭氧。

35.Hopes raised for room-temperature superconductivity, but doubts remain.

人们对室温超导性抱有希望，但疑虑依然存在。

36.Path unveiled for protein entry into chloroplasts.

蛋白质进入叶绿体的路径揭晓。

37.Fatty acids prime the lung as a site for tumour spread.

脂肪酸使肺部成为肿瘤扩散的场所。

38.Deuterium-enriched water ties planet-forming disks to comets and protostars.

富含氘的水将行星形成盘与彗星和原恒星联系在一起。

39.Atomic Bose–Einstein condensate in twisted-bilayer optical lattices.

扭曲双层光学晶格中的原子玻色-爱因斯坦凝聚态。

40.Geometric frustration of Jahn–Teller order in the infinite-layer lattice.

无限层晶格中 Jahn-Teller 序的几何挫败。

41.Evidence of near-ambient superconductivity in a N-doped lutetium hydride.

N 掺杂氢化镥具有近环境超导性的证据。

42.Population-based heteropolymer design to mimic protein mixtures.

基于群体的杂聚物设计来模拟蛋白质混合物。

43.Chlorine activation and enhanced ozone depletion induced by wildfire aerosol.

野火气溶胶引起的氯活化和臭氧消耗加剧。

44.The evolution of the marine carbonate factory.

海洋碳酸盐工厂的演变。

45.Tropical deforestation causes large reductions in observed precipitation.

热带森林砍伐导致观测到的降水量大幅减少。

46.Valley formation aridifies East Africa and elevates Congo Basin rainfall.

山谷的形成使东非干旱并增加了刚果盆地的降雨量。

47.Coastal phytoplankton blooms expand and intensify in the 21st century.

21 世纪沿海浮游植物大量繁殖并加剧。

48.Evolution of the germline mutation rate across vertebrates.

脊椎动物种系突变率的演变。

49.Cardiogenic control of affective behavioural state.

情感行为状态的心源性控制。

50.Coordination of bacterial cell wall and outer membrane biosynthesis.

细菌细胞壁和外膜生物合成的协调。

51.Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells.

唐氏综合症中通过细胞因子、CD4 T 细胞和 CD11c+ B 细胞产生的自身免疫。

52.TET2 guards against unchecked BATF3-induced CAR T cell expansion.

TET2 可防止不受控制的 BATF3 诱导的 CAR T 细胞扩增。

53.Sequence determinant of small RNA production by DICER.

DICER 产生小 RNA 的序列决定因素。

54.Structure of the human DICER–pre-miRNA complex in a dicing state.

处于切割状态的人类 DICER-pre-miRNA 复合物的结构。

55.H3K4me3 regulates RNA polymerase II promoter-proximal pause-release.

H3K4me3 调节 RNA 聚合酶 II 启动子近端暂停释放。

56.Architecture of chloroplast TOC–TIC translocon supercomplex.

叶绿体 TOC-TIC 易位子超级复合体的结构。

57.Multivariate BWAS can be replicable with moderate sample sizes.

多变量 BWAS 可以通过适度的样本量进行复制。

58.Reply to: Multivariate BWAS can be replicable with moderate sample sizes.

回复：多元 BWAS 可以通过中等样本量进行复制。

59.Bow-tie particles boast a tunable twist.

领结粒子拥有可调节的扭曲。

60.Bacterial meningitis hits an immunosuppressive nerve.

细菌性脑膜炎攻击免疫抑制神经。

61.Regrowing tropical forests absorb megatonnes of carbon.

重新生长的热带森林吸收了数百万吨的碳。

62.How loss of social status affects the brain.

社会地位的丧失如何影响大脑。

63.From the archive: Saturn, and Charles Darwin shares animal stories.

来自档案馆：土星和查尔斯·达尔文分享动物故事。

64.Mitochondrial molecule controls inflammation.

线粒体分子控制炎症。

65.Bleb protrusions help cancer cells to cheat death.

泡状突起有助于癌细胞逃避死亡。

66.Topological spin texture in the pseudogap phase of a high-Tc superconductor.

高温超导体赝能隙相中的拓扑自旋织构。

67.Ultrafast tunable lasers using lithium niobate integrated photonics.

使用铌酸锂集成光子学的超快可调谐激光器。

68.Photonically active bowtie nanoassemblies with chirality continuum.

具有手性连续体的光子活性领结纳米组件。

69.Tunnelling measured in a very slow ion–molecule reaction.

在非常慢的离子-分子反应中测量隧道效应。

70.Control of stereogenic oxygen in a helically chiral oxonium ion.

螺旋手性氧鎓离子中立体氧的控制。

71.The carbon sink of secondary and degraded humid tropical forests.

次生和退化湿润热带森林的碳汇。

72.Regime shift in Arctic Ocean sea ice thickness.

北冰洋海冰厚度的变化。

73.Deep, ultra-hot-melting residues as cradles of mantle diamond.

深层超热熔残渣是地幔金刚石的摇篮。

74.Weak upper-mantle base revealed by postseismic deformation of a deep earthquake.

深部地震的震后变形揭示了薄弱的上地幔基底。

75.Future temperature extremes threaten land vertebrates.

未来的极端温度将威胁陆地脊椎动物。

76.Protomelission is an early dasyclad alga and not a Cambrian bryozoan.

Protomelission 是一种早期的藻类，而不是寒武纪苔藓虫。

77.Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.

细菌劫持脑膜神经免疫轴以促进大脑入侵。

78.Molecular fate-mapping of serum antibody responses to repeat immunization.

重复免疫的血清抗体反应的分子命运图谱。

79.Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.

巨噬细胞富马酸水合酶抑制 mtRNA 介导的干扰素产生。

80.Fumarate induces vesicular release of mtDNA to drive innate immunity.

富马酸盐诱导线粒体 DNA 的囊泡释放，以驱动先天免疫。

81.Co-opting signalling molecules enables logic-gated control of CAR T cells.

增选信号分子可实现 CAR T 细胞的逻辑门控控制。

82.Blebs promote cell survival by assembling oncogenic signalling hubs.

气泡通过组装致癌信号中枢来促进细胞存活。

83.Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance.

核仁 URB1 确保 3' ETS rRNA 去除，以防止外泌体监视。

84.Phototrophy by antenna-containing rhodopsin pumps in aquatic environments.

水生环境中含有天线的视紫红质泵的光养作用。

85.Structural basis for bacterial energy extraction from atmospheric hydrogen.

从大气氢中提取细菌能量的结构基础。

86.Common orthopaedic trauma may explain 31,000-year-old remains.

常见的骨科创伤可以解释 31,000 年前的遗骸。

87.Reply to: Common orthopaedic trauma may explain 31,000-year-old remains.

回复：常见的骨科创伤可以解释31000年前的遗骸。

88.Huge broad-bean genome could improve yields of an underused crop.

巨大的蚕豆基因组可以提高未充分利用的作物的产量。

89.Activated immune cells drive neurodegeneration in an Alzheimer’s model.

激活的免疫细胞会导致阿尔茨海默病模型中的神经退行性变。

90.Political endorsements can affect scientific credibility.

政治认可会影响科学可信度。

91.A compelling explanation for the enigmatic small object ‘Oumuamua.

对神秘小物体“Oumuamua”的令人信服的解释。

92.Synthetic bacterial genome upgraded for viral defence and biocontainment.

合成细菌基因组升级用于病毒防御和生物遏制。

93.From the archive: the cell cycle and Antarctic exploration.

来自档案：细胞周期和南极探险。

94.Hazards help autonomous cars to drive safely.

危险有助于自动驾驶汽车安全驾驶。

95.Black holes up close.

近距离观察黑洞。

96.A helium-burning white dwarf binary as a supersoft X-ray source.

作为超软 X 射线源的氦燃烧白矮星双星。

97.Acceleration of 1I/‘Oumuamua from radiolytically produced H2 in H2O ice.

H2O 冰中辐射分解产生的 H2 对 1I/'Oumuamua 的加速。

98.Quantum-enabled millimetre wave to optical transduction using neutral atoms.

使用中性原子实现量子毫米波到光转换。

99.Dense reinforcement learning for safety validation of autonomous vehicles.

用于自动驾驶车辆安全验证的密集强化学习。

100.Diode effect in Josephson junctions with a single magnetic atom.

具有单个磁性原子的约瑟夫森结中的二极管效应。

101.Catalytic asymmetric synthesis of cannabinoids and menthol from neral.

从橙花醛催化不对称合成大麻素和薄荷醇。

102.Basin-scale reconstruction of euxinia and Late Devonian mass extinctions.

盆地尺度重建euxinia和晚泥盆世大规模灭绝。

103.Core origin of seismic velocity anomalies at Earth’s core–mantle boundary.

地球核心-地幔边界地震速度异常的核心起源。

104.The giant diploid faba genome unlocks variation in a global protein crop.

巨大的二倍体蚕豆基因组解锁了全球蛋白质作物的变异。

105.An airway-to-brain sensory pathway mediates influenza-induced sickness.

气道到大脑的感觉通路介导流感引起的疾病。

106.Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.

小胶质细胞介导的 T 细胞浸润会导致 tau 蛋白病的神经变性。

107.Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates.

阻断 NS3-NS4B 相互作用可抑制非人类灵长类动物中的登革热病毒。

108.Non-viral precision T cell receptor replacement for personalized cell therapy.

用于个性化细胞治疗的非病毒精准 T 细胞受体替代。

109.Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy.

PD-1 阻断疗法的新抗原靶向 CD8+ T 细胞反应。

110.The dietary sweetener sucralose is a negative modulator of T cell-mediated responses.

膳食甜味剂三氯蔗糖是 T 细胞介导反应的负调节剂。

111.Spatial mapping of mitochondrial networks and bioenergetics in lung cancer.

肺癌线粒体网络和生物能学的空间绘图。

112.A swapped genetic code prevents viral infections and gene transfer.

交换的遗传密码可以防止病毒感染和基因转移。

113.The structural basis for HIV-1 Vif antagonism of human APOBEC3G.

HIV-1 Vif 拮抗人类 APOBEC3G 的结构基础。

114.Autoregulation of GPCR signalling through the third intracellular loop.

通过第三个细胞内环路自动调节 GPCR 信号传导。

115.Structural basis of odorant recognition by a human odorant receptor.

人类气味受体识别气味的结构基础。

116.Southern Ocean heat sink hindered by melting ice.

南大洋散热器因冰融化而受阻。

117.Inheritance of epigenetic DNA marks studied in new mouse model.

在新的小鼠模型中研究表观遗传 DNA 标记的遗传。

118.Earliest molecular events of vision revealed.

揭示了最早的视觉分子事件。

119.Eggs made from male mouse stem cells using error-prone culture.

使用易错培养法由雄性小鼠干细胞制成的卵子。

120.A glimpse at the inner structure of the proton.

质子内部结构一瞥。

121.Fastest-ever calcium sensors broaden the potential of neuronal imaging.

有史以来最快的钙传感器拓宽了神经元成像的潜力。

122.Forming intracluster gas in a galaxy protocluster at a redshift of 2.16.

在红移为 2.16 的星系原星系团中形成星系团内气体。

123.Determining the gluonic gravitational form factors of the proton.

确定质子的胶子引力形状因子。

124.Universal logic with encoded spin qubits in silicon.

硅中具有编码自旋量子位的通用逻辑。

125.Thousands of conductance levels in memristors integrated on CMOS.

CMOS 上集成的忆阻器具有数千个电导级别。

126.Bright and stable perovskite light-emitting diodes in the near-infrared range.

在近红外范围内明亮且稳定的钙钛矿发光二极管。

127.Photosynthesis re-wired on the pico-second timescale.

光合作用在皮秒时间尺度上重新布线。

128.Abyssal ocean overturning slowdown and warming driven by Antarctic meltwater.

南极融水驱动的深海海洋速度减慢和变暖。

129.Diagnosing destabilization risk in global land carbon sinks.

诊断全球陆地碳汇的不稳定风险。

130.Degassing of early-formed planetesimals restricted water delivery to Earth.

早期形成的星子的脱气限制了向地球输送水。

131.Continent-wide declines in shallow reef life over a decade of ocean warming.

十年来海洋变暖导致整个大陆浅层珊瑚礁生命减少。

132.Entwined African and Asian genetic roots of medieval peoples of the Swahili coast.

斯瓦希里海岸中世纪民族的非洲和亚洲遗传根源交织在一起。

133.Diminishing benefits of urban living for children and adolescents’ growth and development.

城市生活对儿童和青少年成长和发展的好处正在减少。

134.Fast and sensitive GCaMP calcium indicators for imaging neural populations.

用于神经群体成像的快速、灵敏的 GCaMP 钙指示剂。

135.Population dynamics of head-direction neurons during drift and reorientation.

漂移和重新定向过程中头部方向神经元的群体动态。

136.Generation of functional oocytes from male mice in vitro.

体外雄性小鼠功能性卵母细胞的产生。

137.Immunoglobulin M perception by FcμR.

FcμR 感知免疫球蛋白 M。

138.MEN1 mutations mediate clinical resistance to menin inhibition.

MEN1 突变介导对 menin 抑制的临床抵抗。

139.The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.

menin 抑制剂 revumenib 用于治疗 KMT2A 重排或 NPM1 突变白血病。

140.Whole-genome doubling drives oncogenic loss of chromatin segregation.

全基因组加倍导致染色质分离的致癌损失。

141.Structural basis of mitochondrial membrane bending by the I–II–III2–IV2 supercomplex.

I–II–III2–IV2 超复合物导致线粒体膜弯曲的结构基础。

142.Ultrafast structural changes direct the first molecular events of vision.

超快的结构变化指导了视觉的第一个分子事件。

143.Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation.

机械力和配体依赖性粘附 GPCR 解离的分子传感。