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Thalamic reticular nucleus

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Thalamic reticular nucleus

 

Thalamus

Details

Part of

Thalamus

Identifiers

Latin

nucleus reticularis thalami

NeuroNames

365

NeuroLex ID

birnlex_1721

TA98

A14.1.08.638

TA2

5704

FMA

62026

Anatomical terms of neuroanatomy

[edit on Wikidata]

The thalamic reticular nucleus is part of the ventral thalamus 

（说明thalamic reticular nucleus很有可能只影响lateral ventral thalamus--VA, VL, VI, VPL, VPM。）

that forms a capsule around the thalamus laterally. However, recent evidence from mice and fish question this statement and define it as a dorsal thalamic structure.[1][2] It is separated from the thalamus by the external medullary lamina. Reticular cells are GABAergic, and have discoid dendritic arbors in the plane of the nucleus.

Thalamic Reticular Nucleus is variously abbreviated TRN, RTN, NRT, and RT.

Contents

· 1Input and output

· 2References

· 3Further reading

· 4External links

Input and output[edit]

The thalamic reticular nucleus receives input from the cerebral cortex and dorsal thalamic nuclei. Most input comes from collaterals of fibers passing through the thalamic reticular nucleus. Primary thalamic reticular nucleus efferent fibers project to dorsal thalamic nuclei, but never to the cerebral cortex. This is the only thalamic nucleus that does not project to the cerebral cortex, instead it modulates the information from other nuclei in the thalamus. Its function is modulatory on signals going through thalamus (and the reticular nucleus).

The thalamic reticular nucleus receives massive projections from the external segment of the Globus Pallidus

（这一句话就与basal ganglia扯上联系了，这样我就又可以研究thalamic reticular nucleus,事实上我也得到了一些与其相关的推理。这个词条中其他的内容基本都是表述模糊的废话。the external segment of the Globus Pallidus对thalamic reticular nucleus起到抑制作用，而serotonin在某种意义上也起到降低thalamic reticular nucleus敏感性的效果，而NE浓度高当然就是加强其敏感性，增强抑制丘脑的效果。在NE作用下，丘脑的输出减少，从而减少对amygdala的输入，从而拉低NE放大环路，降低NE浓度。这一推理所对应的行为效果十分重要，对应着回避行为，和一类特殊的不愿回忆的记忆类型。回避行为是下意识的，无事先计划的，而这种下意识回避行为可以被自己学到，因为发现逃跑的好处，从而回避行为的发生转移到basal ganglia，从而形成主动有计划的逃跑，二者产生的回避效果一样，但是basal ganglia主导的主动有计划的逃跑是在DA system状态下完成的，NE浓度很低，与thalamic reticular nucleus主导的高NE浓度状态下回避行为有本质区别，二者的的许多附带行为也不一样，也就是说你想装落荒逃跑的样子还是很容易被识破的。对了，thalamic reticular nucleus主导的高NE浓度状态下回避行为的持续时间很短，不会长时间维持，你所看到的动物受惊逃跑的距离其实都很短，长途转移逃跑那都是有目的的basal ganglia行为，毕竟离危险越来越远的过程也会感受到快乐，basal ganglia主导的持续行为就是好行为的不断重复，哈哈，别忘了external segment of the Globus Pallidus就是在caudate nucleus的控制之下，而caudate nucleus在DA system的直接控制之下，这样一来，basal ganglia主导的持续行为也对thalamic reticular nucleus进行抑制。对了，人的瞬间闪避行为就是高NE浓度下thalamic reticular nucleus活动的杰作。以上内容均超出现在科学家的认知，因为他们没有搞清楚serotonin和NE放大环路的规律，他们没有搞清楚basal ganglia的运作机制，所以就算他们搞清楚了thalamic reticular nucleus的结构和连接关系，他们依然认识不到“thalamic reticular nucleus是回避行为的本质”。既然与thalamic reticular nucleus功能相关的行为找到了，接下来我的任务就是要在thalamic reticular nucleus的结构和连接关系基础上，分析出回避行为的细胞层面的机制。）

, thought to play a part in disinhibition of thalamic cells, which is essential for initiation of movement (Parent and Hazrati, 1995)

It has been suggested that the reticular nucleus receives afferent input from the reticular formation[citation needed] and in turn projects to the other thalamic nuclei, regulating the flow of information through these to the cortex. There is debate over the presence of distinct sectors within the nucleus that each correspond to a different sensory or cognitive modality.

For original connectivity anatomy see Jones 1975.[3]

For discussion of mapping and cross modality pathways see Crabtree 2002.[4]