LC Laboratories 环巴胺 / Cyclopamine 解决方案

环巴胺(Cyclopamine)从藜芦属植物内分离得到的一种异甾体类生物碱，主要存在百合科植物中北美山藜芦(Veratrum californicum)、印第安鹿食草(Corn lily)及毛叶藜芦(Veratrum grandiflorum)、伊贝(Fritillaria pallidiflora Schrenk)四种植物。

环巴胺对Hedgehog信号通路有抑制作用,在抗肿瘤方面表现出良好的活性。研究表明，环巴胺可以对Hedgehog信号通路的激活起到抑制作用，而后者参与原癌基因 Smoothened (Smo) 或灭活肿瘤抑制基因 Patched (Ptch) 的突变相关反应途径，并且这两种基因都能够编码多程跨膜蛋白。此外，已经证明环巴胺的抑制作用是由于其与Smo七螺旋蛋白束的直接结合有关。

艾美捷丨LC Laboratories 环巴胺 / Cyclopamine 目前已经应用到quan球4100个实验室，纯度非常高，当然价格也是十分友好的。

环巴胺 / Cyclopamine 其它基本参数：

cat# LCL-C-8700

规格 10mg/25mg/100mg/300mg

CAS号 4449-51-8

分子式 C27H41NO2

分子量 411.62

纯度 ＞99%

外观 白色结晶固体；或小瓶底部透明固体膜

溶解性 溶于乙醇或DMSO

运输与保存方法 常温运输；-20℃保存

Nature communications正文引用：

其他参考文献

[1]. Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog Signaling pathway. Bioorg Med Chem Lett, 2009, 19(2), 328-331.

[2]. Berman DM, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 2003, 425(6960), 846-851.

[3]. Thayer SP, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 2003, 425(6960), 851-856.

[4]. Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

[5]. Qi Wan, et al. Overexpression of Laminin α4 Facilitates Proliferation and Migration of Fibroblasts in Knee Arthrofibrosis by Targeting Canonical Shh/Gli1 Signaling. Connect Tissue Res. 2020 May 24.