Anti-HRSV-A F/Fusion glycoprotein F0 Antibody (Fab13)

人呼吸道合胞病毒（HRSV）属于肺炎病毒科，正肺病毒属，非节段性单股负链RNA病毒。HRSV主要引起呼吸道感染，已经成为婴幼儿和5岁以下儿童呼吸道感染住院的主要原因之一，也是成年人、老年人以及免疫缺陷患者严重呼吸道疾病的主要病原体之一。 目前，临床尚无有效的HRSV疫苗或治疗方法。 HRSV有A、B两个亚型及多个基因型，不同亚型及基因型流行病学特征不同。 本研究对HRSV病原学、分子流行病学、疫苗研究及HRSV检测分型技术等进行综述，为HRSV疫苗研究及相关呼吸道传染病的防治和监测预警提供重要的理论依据。

货号：RVV08405

产品链接：http://www.atagenix.com/product_detail-76503.html

产品购买联系方式：027-65279366

宿主：Mouse

反应种属：Human respiratory syncytial virus A (strain Long)

克隆性:Monoclonal

偶连物；Unconjugated

别名；F, Fusion glycoprotein F0, Protein F

参考文献：

Genotyping of Type A Human Respiratory Syncytial Virus Based on Direct F Gene Sequencing. PMID: 31137571

Chimeric bovine respiratory syncytial virus with glycoprotein gene substitutions from human respiratory syncytial virus (HRSV): effects on host range and evaluation as a live-attenuated HRSV vaccine. PMID: 10627529

Hospital outbreak of human respiratory syncytial virus (HRSV) illness in immunocompromised hospitalized children during summer. PMID: 24521518

Molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B. PMID: 28414106

Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV. PMID: 29057917

Syncytia Induction by Clinical Isolates of Human Respiratory Syncytial Virus A. PMID: 28869960

Gene sequence variability of the three surface proteins of human respiratory syncytial virus (HRSV) in Texas. PMID: 24625544

Development of TaqMan RT-qPCR for the detection of type A human respiratory syncytial virus. PMID: 28223170

Molecular evolution of the fusion protein gene in human respiratory syncytial virus subgroup A. PMID: 27291709

In silico analysis of amino acid variation in human respiratory syncytial virus: insights into immunodiagnostics. PMID: 28953993

Glycosylation is not necessary for recognition of the fusion glycoprotein domain of the human respiratory syncytial virus by a polyclonal antibody. PMID: 20822310

Molecular investigation of human metapneumovirus in children with acute respiratory infections in Chennai, South India, from 2016-2018. PMID: 35118597

Genetic variability in G2 and F2 region between biological clones of human respiratory syncytial virus with or without host immune selection pressure. PMID: 25742274

Amino acid changes in the attachment G glycoprotein of human respiratory syncytial viruses (subgroup A) isolated in Italy over several epidemics (1997-2006). PMID: 17935190

HRSV感染后，潜伏期通常为2-8天，临床表现以呼吸道感染症状为主，早期HRSV感染大部分局限于上呼吸道，临床表现如鼻塞、流涕、咳嗽和声音嘶哑等。HRSV感染患儿大多数症状会在1-2周内自行消失，少部分可以发展为下呼吸道感染，主要表现为毛细支气管炎或肺炎，多见于2岁以下婴幼儿，临床症状包括咳嗽、喘息，极少部分进一步加重出现呼吸急促和喂养困难等，严重者可发展为呼吸衰竭。

各年龄段人群均可感染HRSV，但HRSV感染的高危人群主要集中在儿童、老年人和免疫功能低下人群。

在传播途径方面，有症状的HRSV感染者和无症状的隐性感染者都可传播病毒，通常可通过以下途径传播：一是接触传播，如鼻咽黏膜或眼黏膜接触到含病毒的分泌物或污染物；二是近距离接触患者咳嗽或打喷嚏等。北京大学人民医院呼吸内科主任高占成表示，对于易感人群的预防，要注意勤洗手，避免不洁净的手触摸眼、口、鼻，养成良好的个人卫生习惯，及时佩戴口罩，减少出入人员密集场所。