乙酰四肽-40——改善不均匀肤色和皮肤暗沉
简介
在免疫系统自然应对潜在有害物质和环境的反应中，激肽释放酶和抗菌化合物如抗菌肽起着非常重要的作用。它们可以诱导白细胞介素(interleukins,IL)的释放，但是过量的白细胞介素可能导致面部皮肤发红和毛细血管扩张。红斑及血管扩张性皮肤病，如红斑痤疮，LL-37的表达都异常的高，它一旦被激活后大量的炎性反应会导致促炎性代谢物的增加，其中就包括IL-6和IL-8。细胞外基质如胶原蛋白被MMPs 水解后，真皮的连接组织会被破坏掉。因此皮肤发红的区域会变得更明显易见，毛细血管变得脆弱和通透性增强，发炎更容易导致血管扩大。乙酰四肽-40降低由于LL-37活化和白细胞介素释放引起的面部发红及相关皮肤问题。它还具有光保护的效应，降低细胞受损程度和皮肤发炎导致的不良反应。
INCI 乙酰四肽-40
机理
乙酰四肽-40可以降低由抗菌肽LL-37诱导的白细胞介素IL-6和IL-8的过度释放。它可以减少由于过度炎症引起的不良反应如皮肤发红，血管扩张，组织降解和发炎后色素过度沉积和皮肤暗淡。另外乙酰四肽-40还具有光保护的效应，降低细胞受损程度和皮肤发炎导致的不良反应。
Acetyltetrapeptide-40 can reduce the excessive release of IL-6 and IL-8 induced by Cathelicidin LL-37. It can reduce adverse reactions caused by excessive inflammation, such as skin redness, vascular dilation, tissue degradation, and excessive pigmentation and skin dullness after inflammation. In addition, acetyltetrapeptide-40 also has a photoprotective effect, reducing the degree of cell damage and adverse reactions caused by skin inflammation.
美容功效
乙酰四肽-40是一种新型四肽，它能降低LL-37诱导的IL-6和IL-8释放，减少体内外的胶原蛋白降解，改善肤质，在体内仅7天便能显著减少面部红斑和红血丝现象。同时，它具有细胞光保护作用，减少肌肤色素沉着（改善可能与炎症有关的post-inflammatory hyperpigmentation,PIH），改善肤色均匀性和暗沉外观。
Acetyltetrapeptide-40 is a new type of tetrapeptide that can reduce the release of IL-6 and IL-8 induced by LL-37, reduce collagen degradation in vitro and in vivo, improve skin quality, and significantly reduce facial erythema and redness in just 7 days in the body. At the same time, it has a cellular photoprotective effect, reducing skin pigmentation (improving post inflammatory hyperpigmentation (PIH) that may be related to inflammation), improving skin tone uniformity and dull appearance.
