【热门产品推介】Anti-HMPV F/Fusion Protein Antibody (SAA0840)

人偏肺病毒感染是人体感染人偏肺病毒（humanmetapneumovirus，hMPV）后引起的一种急性呼吸道传染病，全年散发，多发生于冬末及春初。

货号：RVV22901

产品链接：http://www.antibodysystem.com/product/13692.html

寄主物种：Human

物种反应性：Human metapneumovirus

形式：Liquid

存储缓冲区：0.01M PBS, pH 7.4.

浓度：1 mg/ml

纯度：>95% by SDS-PAGE.

克隆性：Monoclonal

种型：IgG1

应用：Neut

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

参考文献：

Low-pH triggering of human metapneumovirus fusion: essential residues and importance in entry. PMID: 19036821
Genetic diversity and molecular evolution of the major human metapneumovirus surface glycoproteins over a decade. PMID: 24041471
Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years. PMID: 19740442
Phylogenetic analysis of human metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia. PMID: 25382484

Transmembrane Domain Dissociation Is Required for Hendra Virus F Protein Fusogenic Activity. PMID: 31462574
Development of liposomes and pseudovirions with fusion activity for efficient gene delivery. PMID: 22023472
Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain. PMID: 34061592
Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability. PMID: 24089572
The electrophysiological net response ('F-complex') to spatial fusion of speech elements forming an auditory object. PMID: 12738428
Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis. PMID: 25339762
Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors. PMID: 21460213
A Randomized Control Trial Comparing Local Autografts and Allografts in Single Level Anterior Cervical Discectomy and Fusion Using a Stand-Alone Cage. PMID: 33189111
The 'F-complex' and MMN tap different aspects of deviance. PMID: 15661112
Cytogenetic mapping of the Muller F element genes in Drosophila willistoni group. PMID: 25134938

hMPV属于肺炎病毒科，偏肺病毒属，为有包膜的单股负链RNA病毒，平均直径大约200nm。hMPV包括A和B两个基因型，可分为A1、A2、B1、B2四个亚型，这些亚型常常同时流行，各亚型病毒传播力和致病性未见明显差别。

hMPV对热敏感，60℃ 30分钟可灭活；对乙醚、氯仿等有机溶剂敏感；1%次氯酸钠等含氯消毒剂、5%福尔马林、2%戊二醛、1%碘伏等常用消毒剂可灭活病毒；对0.1%脱氧胆酸钠、十二烷基硫酸钠（SDS）和曲拉通X-100（TritonX-100）等去污剂敏感。

HMPV属于肺病毒科，偏肺病毒属，有包膜的单股负链RNA病毒。2001年，由荷兰学者首次从未知病原体引起呼吸道感染患儿的鼻咽抽吸物样本中检出。血清学研究表明其存在至少60年，在世界各地均有分布，是常见呼吸道病原体之一。

HMPV主要通过咳嗽和打喷嚏产生的飞沫或气溶胶传播，与感染者密切接触和接触病毒污染的环境也可能造成传播。一般来说，感染后潜伏期约3-5天，HMPV诱发的免疫保护较弱，反复感染常见。HMPV全年均有检出，但以冬春季检出率最高。此外，HMPV感染也可以引起暴发流行。