五肽Boc-Met-Enkephalin、CAS号: 59481-77-5

阿片生长因子（OGF）及其受体形成一个生物轴，在稳态条件下或肿瘤形成中，通过延迟细胞周期的G1/S界面来调节细胞增殖。外源性OGF在培养和裸鼠中抑制人胰腺癌细胞的生长。OGF单独治疗或与标准化疗联合治疗可增强DNA合成和肿瘤生长的抑制。

Opioid growth factor (OGF) and its receptor form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia. Exogenous OGF represses growth of human pancreatic cancer cells in culture and in nude mice. OGF therapy alone or in combination with standard chemotherapies results in enhanced inhibition of DNA synthesis and tumor growth.

编号: 134290

中文名称: 五肽Boc-Met-Enkephalin

CAS号: 59481-77-5

单字母: Boc-YGGFM-OH

三字母: Boc-Tyr-Gly-Gly-Phe-Met-COOH

氨基酸个数: 5

分子式: C32H43O9N5S1

平均分子量: 673.78

精确分子量: 673.28

等电点(PI): 6.86

pH=7.0时的净电荷数: -

平均亲水性: -2.4

疏水性值: 0.6

来源: 人工化学合成，仅限科学研究使用，不得用于人体。

储存条件: 负80℃至负20℃

标签: 未分类肽

文献：

DOI 名称

10.1074/jbc.M809396200

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