【标题速读】【Ncomm】【biological-sciences】【2022年】【10月】
声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。
1.Translation and natural selection of micropeptides from long non-canonical RNAs.
来自长的非经典RNA的微肽的翻译和自然选择。
2.A hierarchical transcription factor cascade regulates enteroendocrine cell diversity and plasticity in Drosophila.
层次分明的转录因子级联调控果蝇的肠道内分泌细胞多样性和可塑性。
3.MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia.
MIR逆转录子将急性骨髓性白血病的表观基因组和编码基因的转录组联系起来。
4.Multidimensional memory topography in the medial parietal cortex identified from neuroimaging of thousands of daily memory videos.
内侧顶叶皮层的多维记忆拓扑图从数千个日常记忆视频的神经影像学中识别出来。
5.Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis.
Syntaxin-2的质膜翻转调控其对胰岛素颗粒外渗的抑制作用。
6.BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.
BRCA突变状态塑造了胰腺癌的基质微环境，将癌症相关成纤维细胞中clusterin的表达与HSF1信号传导联系起来。
7.Unexpected assembly machinery for 4(3H)-quinazolinone scaffold synthesis.
4(3H)-喹唑啉酮支架合成的意想不到的组装机制。
8.Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair.
环状RNA circBNC2抑制上皮细胞G2-M停滞以防止纤维化的不良修复。
9.Deep transfer learning of cancer drug responses by integrating bulk and single-cell RNA-seq data.
通过整合大量和单细胞RNA-seq数据对癌症药物反应进行深度转移学习。
10.Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration.
骨骼干细胞中的雌性双态感应控制骨骼再生。
11.Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures.
胰岛素受体的功能选择性由诱导剂捕获的受体结构揭示。
12.De novo analysis of bulk RNA-seq data at spatially resolved single-cell resolution.
以空间分辨率的单细胞分辨率对大量RNA-seq数据进行从头分析。
13.Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context.
通过模拟巨噬细胞-成纤维细胞在免疫-代谢背景下的相互作用了解纤维化的发病机制。
14.Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology.
孟德尔随机化解释了复杂的相关水平多态性，同时阐释了共同的遗传病因学。
15.Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis.
通过多模态单细胞分析确定人类常染色体显性多囊肾病的细胞复杂性。
16.Inducing forgetting of unwanted memories through subliminal reactivation.
通过潜意识的重新激活诱导遗忘不需要的记忆。
17.Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation.
Gi/o蛋白偶联受体对β细胞电兴奋性和胰岛素分泌的抑制取决于Na+/K+ATP酶的激活。
18.Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation.
通过CD28与CTLA4的配体的不同贩运促进了细胞对共同刺激的集体控制。
19.Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection.
B3GAT1的细胞糖修饰广泛限制了流感病毒的感染。
20.Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.
神经元CaMKK2促进胶质母细胞瘤的免疫抑制和检查点阻断的抵抗。
21.Microfluidic space coding for multiplexed nucleic acid detection via CRISPR-Cas12a and recombinase polymerase amplification.
通过CRISPR-Cas12a和重组酶聚合酶扩增进行多重核酸检测的微流体空间编码。
a Brief overview of the steps involved in the subtyping process. The collected cervical cell specimen is first thermolyzed. Then, RPA is performed to amplify the nine HPV subtypes. The amplicons are subsequently tested via the CRISPR-Cas12a system on the microfluidic device, followed by fluorescence imaging to obtain the readout. b On-chip testing principles. A 30-plexed starburst-shaped chip (SS-Chip) with one central inlet connected to 30 outlets is used. The outlets are preloaded with various Cas12a/crRNAs that recognize the relevant target HPV subtype. After the on-chip assay, the fluorescent readout at specific outlets (i.e., space coding) indicates the presence of relevant HPV subtypes in the sample.
子类型化过程中涉及的步骤的简要概述。采集的宫颈细胞标本首先进行热解。然后，进行RPA 以扩增九种HPV 亚型。 随后通过微流体设备上的 CRISPR-Cas12a 系统测试扩增子，然后进行荧光成像以获得读数。 b 片上测试原则。 使用一个 30 重星爆型芯片（SS 芯片），其中一个中央入口连接到 30 个出口。 这些出口预装了识别相关目标 HPV 亚型的各种 Cas12a/crRNA。 片上检测后，特定出口处的荧光读数（即空间编码）表明样本中存在相关的 HPV 亚型。
22.Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications.
单细胞分析揭示了MDA5+皮肌炎中独特的适应性免疫标志，并具有治疗意义。
23.Automated identification of sequence-tailored Cas9 proteins using massive metagenomic data.
利用海量元基因组学数据自动识别序列定制的Cas9蛋白。
24.Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets.
病毒相关肝癌的蛋白质基因组学特征揭示了潜在的亚型和治疗目标。
25.Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes.
Hi-C与短线和长线基因组测序的整合揭示了种系重排基因组的结构。
26.Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling.
谷氨酰-脯氨酰-tRNA合成酶1协调早期内体抗炎的AKT信号传导。
27.CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.
CDK12在BRAF突变的黑色素瘤中被过度激活并成为合成致死目标。
28.Isotropic reconstruction for electron tomography with deep learning.
用深度学习进行电子断层扫描的各向异性重建。
29.Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1.
巨型病毒Paramecium bursaria chlorella virus 1的近原子、非二十面体平均结构。
30.Analysis of anti-SARS-CoV-2 Omicron-neutralizing antibody titers in different vaccinated and unvaccinated convalescent plasma sources.
不同接种疫苗和未接种疫苗的疗养院血浆来源中的抗SARS-CoV-2 Omicron中和抗体滴度分析。
31.Multiple sources of aerobic methane production in aquatic ecosystems include bacterial photosynthesis.
水生生态系统中好氧甲烷生产的多种来源包括细菌光合作用。
32.Genome-wide rare variant score associates with morphological subtypes of autism spectrum disorder.
全基因组的罕见变体得分与自闭症谱系障碍的形态亚型有关。
33.Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1.
自然场景采样揭示了人类V1的可靠的粗尺度方向调谐。
34.Tracing the international arrivals of SARS-CoV-2 Omicron variants after Aotearoa New Zealand reopened its border.
追踪新西兰奥特亚罗亚州重新开放边境后SARS-CoV-2 Omicron变体的国际到达情况。
35.Structural insights into light-driven anion pumping in cyanobacteria.
对蓝藻中光驱动的阴离子泵的结构见解。
36.The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors.
无细胞DNA甲基组捕捉到局部和转移性前列腺肿瘤之间的区别。
37.Flexible hyperspectral surface plasmon resonance microscopy.
灵活的高光谱表面等离子体共振显微镜。
38.Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity.
在抗逆转录病毒疗法开始时给予广泛中和的抗HIV-1抗体可维持长期的CD8+T细胞免疫。
39.Competing instabilities reveal how to rationally design and control active crosslinked gels.
竞争不稳定性揭示了如何合理地设计和控制活性交联凝胶。
40.Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors.
化学空间对接使得基于结构的大规模虚拟筛选能够发现ROCK1激酶抑制剂。
41.The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection.
免疫突触揭示了慢性HIV感染期间CD8 T细胞的反常功能。
42.Structural mechanism of SGLT1 inhibitors.
SGLT1抑制剂的结构机制。
43.A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma.
在晚期腺癌患者中传递MUC1/CD40配体融合蛋白的腺病毒载体的I期研究。
44.Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing.
带有集成参考控制的文库适配器提高了纳米孔测序的准确性和可靠性。
45.Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo.
多纤毛细胞利用丝状体探测体内上皮细胞整合过程中的组织力学。
46.Natural variation of Dt2 determines branching in soybean.
Dt2的自然变异决定了大豆的分枝。
47.A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing.
一种用于光遗传基因组编辑的多西环素和光诱导的Cre重组酶小鼠模型。
48.A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria.
革兰氏阳性菌的T7SS毒素-抗毒素系统中的毒素变形依赖性抑制机制。
49.Light activation of Orange Carotenoid Protein reveals bicycle-pedal single-bond isomerization.
橙色类胡萝卜素蛋白的光激活揭示了自行车踏板的单键异构化。
50.Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2.
营养物质通过NSP1和NSP2调控植物的脂溶性寡糖识别。
51.A slit-diaphragm-associated protein network for dynamic control of renal filtration.
用于动态控制肾脏滤过的狭缝-膈肌相关蛋白网络。
52.ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cancer.
ESRP1调节的LRRFIP2的异构体转换决定了胃癌的转移。
53.Strain level microbial detection and quantification with applications to single cell metagenomics.
应用于单细胞元基因组学的菌种级微生物检测和量化。
54.Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase.
人流感H3N2神经氨酸酶的普遍性和进化偶然性机制。
55.Structures of the CcmABCD heme release complex at multiple states.
CcmABCD血红素释放复合物在多种状态下的结构。
56.The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.
N6-甲基腺苷甲基转移酶METTL16通过保障基因组完整性实现红细胞生成。
57.The emergence and development of behavioral individuality in clonal fish.
克隆鱼行为个体性的出现和发展。
58.Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection.
雾化融合抑制肽保护猕猴免受麻疹病毒感染。
59.Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3.
SARS-CoV-2 Omicron变体BA.1、BA.2和BA.3中CD8+T细胞对免疫优势表位识别的消融。
60.Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack.
动态的HIV-1尖峰运动使其膜结合的三联体容易受到抗体的攻击。
61.Arctic introgression and chromatin regulation facilitated rapid Qinghai-Tibet Plateau colonization by an avian predator.
北极引入和染色质调控促进了青藏高原被一种鸟类捕食者快速殖民。
62.Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states.
靶向雄性激素受体无序转导域的小分子诱导形成塌陷的螺旋状态。
63.GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation.
GPR97通过PAR2激活的上游大分子复合物引发人类中性粒细胞的炎症过程。
64.Blue and green food webs respond differently to elevation and land use.
蓝色和绿色食物网对海拔高度和土地利用的反应不同。
65.Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
上皮细胞柯萨奇病毒腺病毒受体促进屋尘螨引起的肺部炎症。
66.Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans.
CDK相关激酶的泛素蛋白分解调控真菌病原体新隐球菌的泰坦细胞形成和毒力。
67.Endothelial alpha globin is a nitrite reductase.
内皮细胞α球蛋白是一种亚硝酸盐还原酶。
68.Cryo-EM structure of an ATTRwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis.
来自系统性非遗传性转甲状腺素淀粉样变性的ATTRwt淀粉样纤维的低温电镜结构。
69.Genomic signatures associated with maintenance of genome stability and venom turnover in two parasitoid wasps.
两种寄生蜂中与维持基因组稳定性和毒液周转有关的基因组特征。
70.Aversive memory formation in humans involves an amygdala-hippocampus phase code.
人类厌恶性记忆的形成涉及杏仁核-海马体相位代码。
71.A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
一个独特的哺乳动物disome碰撞界面包含了uS10的K63连接的多泛素化，以触发hRQT介导的亚单位解离。
72.Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control.
人类mtRF1终止了COX1的翻译，它的消减诱发了线粒体核糖体相关的质量控制。
73.The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma.
致癌性融合蛋白DNAJB1-PRKACA可被基于肽的免疫疗法特异性地靶向于纤维化肝细胞癌。
74.Distinct organization of two cortico-cortical feedback pathways.
两条皮层反馈通路的不同组织.
75.Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma.
靶向血管活性肠肽介导的信号传递增强了对胰腺导管腺癌免疫检查点疗法的反应。
76.Divergent regulation of basement membrane trafficking by human macrophages and cancer cells.
人类巨噬细胞和癌细胞对基底膜贩运的不同调节。
77.Molecular insights into DNA recognition and methylation by non-canonical type I restriction-modification systems.
对非经典I型限制性修饰系统的DNA识别和甲基化的分子见解。
78.Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells.
p53的短暂抑制增强了人类多能干细胞的原基编辑和胞嘧啶碱基编辑的效率。
79.Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism.
肝脏甲状腺激素信号通过胆汁酸介导的FXR拮抗作用调节GLP-1的产生来调节葡萄糖的稳态。
80.Human cooperation in changing groups in a large-scale public goods game.
大规模公共产品游戏中人类在变化群体中的合作。
81.Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium.
心肌内出血驱动梗塞心肌的脂肪变性。
82.Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor.
用基因编码的生物传感器揭示活细胞中β-TrCP的活动动态。
83.Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis.
细胞系之间的Eya控制的亲和力驱动果蝇卵生期间的组织自组织。
84.Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly.
在催化有丝分裂检查点复合体组装过程中，Bub1和Cdc20并列在磷酸化的Mad1上。
85.V1-bypassing suppression leads to direction-specific microsaccade modulation in visual coding and perception.
V1绕行抑制导致视觉编码和感知中的方向特异性微信调制。
86.Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer.
克隆体细胞拷贝数改变的驱动事件为高等级浆液性卵巢癌的药物敏感性提供了依据。
87.Crystal structure of the Na+/H+ antiporter NhaA at active pH reveals the mechanistic basis for pH sensing.
活性pH值下的Na+/H+抗体NhaA的晶体结构揭示了pH感应的机制基础。
88.Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids.
极病毒N端通读结构域结构揭示了减轻蚜虫传播病毒的分子策略。
89.Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy.
光遗传学控制的免疫治疗设计细胞用于外科手术后的癌症免疫治疗。
90.Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy.
自噬相关分子特征的多组学特征，用于自噬的治疗靶向。
91.ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning.
ΔFosB在海马颗粒细胞中的积累推动了空间学习中的cFos模式分离。
92.A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin.
一种真菌NRPS-PKS酶催化了黄酮类化合物柚皮苷的形成。
93.Drivers of global mangrove loss and gain in social-ecological systems.
社会生态系统中全球红树林损失和收益的驱动因素。
94.The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.
1型糖尿病基因TYK2调控β细胞发育及其对干扰素-α的反应。
95.Ultrafast one-minute electronic detection of SARS-CoV-2 infection by 3CLpro enzymatic activity in untreated saliva samples.
未经处理的唾液样本中3CLpro酶活性对SARS-CoV-2感染的超快速一分钟电子检测。
96.Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda.
乌干达北部恶性疟原虫对双氢青蒿素和鲁米凡特林的敏感性下降。
97.METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
METTL3乙酰化通过微调其核和细胞膜功能阻碍了癌症的转移。
98.Subcellular spatial transcriptomics identifies three mechanistically different classes of localizing RNAs.
亚细胞空间转录组学确定了三类机制上不同的定位RNAs。
99.Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor.
G蛋白偶联血小板活化因子受体的低聚物导致的偏向性信号传递。
100.Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.
唐氏综合征Ts65Dn小鼠模型中Brwd1拷贝数恢复对缺陷的拯救。
101.HiFi metagenomic sequencing enables assembly of accurate and complete genomes from human gut microbiota.
高保真元基因组测序能够从人类肠道微生物群中组装出准确和完整的基因组。
102.Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs.
成纤维细胞A20支配着纤维化的易感性，它被DREAM压制会促进多个器官的纤维化。
103.Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.
心肌TRPC6介导的Zn2+流入通过β-肾上腺素受体诱导有益的正性肌力。
104.Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis.
犬尿喹啉通过刺激心肌细胞增殖和心脏血管生成促进新生儿心脏再生。
105.Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes.
新发1型糖尿病患儿肠道微生物群的功能和代谢改变。
106.Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention.
未折叠蛋白反应的终止由ER压力诱导的HAC1 mRNA核保留引导。
107.SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identification.
SUMMIT： 更好的转录组数据归纳的综合方法改善了因果基因的识别。
108.Subcellular localization of type IV pili regulates bacterial multicellular development.
IV型纤毛的亚细胞定位调控细菌的多细胞发育。
109.Binary-FRET reveals transient excited-state structure associated with activity-dependent CaMKII - NR2B binding and adaptation.
Binary-FRET揭示了与活动依赖的CaMKII - NR2B结合和适应有关的瞬时兴奋态结构。
110.Common evolutionary origin of acoustic communication in choanate vertebrates.
舌尖上的脊椎动物声音交流的共同进化起源。
111.Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost.
肠道特异性去除DAF-2后，优雅动物的寿命几乎翻倍，而健身成本很小。
112.Salience memories formed by value, novelty and aversiveness jointly shape object responses in the prefrontal cortex and basal ganglia.
由价值、新颖性和厌恶性形成的显著性记忆共同塑造了前额叶皮层和基底神经节中的物体反应。
113.Cone opponent functional domains in primary visual cortex combine signals for color appearance mechanisms.
初级视觉皮层中的锥体对手功能域结合了颜色外观机制的信号。
114.Cell-specific bioorthogonal tagging of glycoproteins.
细胞特异性生物正交标签的糖蛋白。
115.E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice.
电子烟及其孤独成分诱发小鼠的心律失常和传导缺陷。
116.Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins.
计算药物基因组学筛选出能增强他汀类药物抗乳腺癌活性的药物。
117.A universal glycoenzyme biosynthesis pipeline that enables efficient cell-free remodeling of glycans.
一个通用的糖酶生物合成管道，使糖类的高效无细胞重塑。
118.Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice.
小鼠小胶质细胞碎片被星形胶质细胞通过C4b促进的吞噬作用清除，并通过RUBICON依赖的非典范自噬作用进行降解。
119.Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2.
转录因子Emx2在耳石器官中建立的双向敏感性的功能。
120.Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response.
通过阻止ESCRT依赖性细胞膜修复加强Gasdermin诱导的肿瘤热化，增强了抗肿瘤免疫反应。
121.Ribosome-mediated biosynthesis of pyridazinone oligomers in vitro.
体外核糖体介导的哒嗪酮低聚物的生物合成。
122.Purification and structural characterization of the Na+-translocating ferredoxin: NAD+ reductase (Rnf) complex of Clostridium tetanomorphum.
四面体梭菌的Na+转运递质毒素：NAD+还原酶（Rnf）复合物的纯化和结构特征。
123.Engineered helicase replaces thermocycler in DNA amplification while retaining desired PCR characteristics.
工程化的螺旋酶在DNA扩增中取代了热循环器，同时保留了理想的PCR特性。
124.Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion.
通过LAT2介导的氨基酸摄取对CD47表达的代谢控制促进肿瘤免疫规避。
125.A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis.
EIF4E的非经典功能限制了ALDH1B1的活性并增加了对铁中毒的易感性。
126.Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.
纳米颗粒疫苗诱导的SARS-CoV-2中和与保护的广度。
127.Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer.
视网膜母细胞瘤蛋白作为一种内在的BRD4抑制剂调节癌症中小分子BET抑制剂的敏感性。
128.Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer.
冷冻显微镜揭示了免疫球蛋白M五聚体中灵活铰链运动的结构基础。
129.Detection and prevalence of SARS-CoV-2 co-infections during the Omicron variant circulation in France.
法国Omicron变体循环期间SARS-CoV-2合并感染的检测和流行情况。
130.Contact tracing reveals community transmission of COVID-19 in New York City.
接触追踪揭示了纽约市COVID-19的社区传播。
131.Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
MRK-560对presenilin-1的同种型选择性抑制的分子基础。
132.Characterization of somatic structural variations in 528 Chinese individuals with Esophageal squamous cell carcinoma.
528名中国食道鳞状细胞癌患者的体细胞结构变异特征。
133.Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinoma.
单细胞转录组分析突出了人类子宫内膜癌的起源和病理过程。
134.Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability.
染色体相关lncRNA基因的表观遗传学控制对复制和稳定至关重要。
135.Protein language models trained on multiple sequence alignments learn phylogenetic relationships.
基于多序列排列训练的蛋白质语言模型学习系统发育关系。
136.REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation.
REDD1通过非典型的NF-κB激活促进肥胖诱导的代谢功能障碍。
137.PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer.
PD-L1导向的PlGF/VEGF阻断通过靶向胰腺癌中CD141+癌相关成纤维细胞与化疗协同作用。
138.Reward salience but not spatial attention dominates the value representation in the orbitofrontal cortex.
奖励显著性而非空间注意主导了眶额皮层的价值表征。
139.Layer-specific, retinotopically-diffuse modulation in human visual cortex in response to viewing emotionally expressive faces.
人类视觉皮层对观看情绪表达面孔的反应具有层特异性和视网膜扩散性的调制。
140.TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine.
TRPM8通过促进慢性偏头痛小鼠模型中正常敏感性的恢复而对性别二形性作出贡献。
141.Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm.
丝胶蛋白的异位表达使家蚕高效生产具有结构变化的古丝。
142.Seeing the unseen: High-resolution AFM imaging captures antibiotic action in bacterial membranes.
看不见的东西：高分辨率AFM成像捕捉到细菌膜中的抗生素作用。
143.Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane.
抗生素多粘菌素将脂多糖排列成结晶结构，使细菌膜凝固。
144.The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling.
流感病毒PB2蛋白通过抑制JAK1/STAT信号来逃避抗病毒的先天免疫。
145.Functional architecture of executive control and associated event-related potentials in macaques.
猕猴执行控制和相关事件相关电位的功能结构。
146.Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line.
形成组织的人类细胞系中GalNAc-T异构体特异性和O-糖基化位点占用的全球图谱。
147.Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses.
刺激条件决定了对沙贝科病毒的中和抗体反应的广度。
148.Population genomics of Puccinia graminis f.sp. tritici highlights the role of admixture in the origin of virulent wheat rust races.
小麦锈病菌（Puccinia graminis f.sp. tritici）的群体基因组学强调了混杂在有毒的小麦锈病种族起源中的作用。
149.Micro-scale functional modules in the human temporal lobe.
人类颞叶的微观尺度功能模块。
150.Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life.
应对累积压力的翻译重编程确保了Hsp90对哺乳动物生命的关键阈值水平。
151.Investigating lytic polysaccharide monooxygenase-assisted wood cell wall degradation with microsensors.
用微型传感器研究多糖单氧酶辅助的木材细胞壁降解。
152.Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice.
奖励和厌恶处理由输入定义的小鼠平行的阿肯色脑核回路进行。
153.Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation.
对肽诱导的PTH1R激活的不同信号时间的分子见解。
154.Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment.
嗜铬细胞瘤和副神经节瘤的单核和批量组织基因表达分析将疾病亚型与肿瘤微环境联系起来。
155.The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics.
胆固醇运输蛋白GRAMD1C调控自噬启动和线粒体生物能量学。
156.Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function.
Wnt4在成熟的β细胞中被异质性激活，控制钙信号、代谢和功能。
157.The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step.
保留的β-Kdo糖基转移酶WbbB使用一个具有中间加合物重排步骤的双置换机制。
158.Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model.
神经元-胃细胞集合体tauopathy模型的单细胞转录组分析。
159.Incorporating evolutionary and threat processes into crop wild relatives conservation.
将进化和威胁过程纳入农作物野生近缘植物保护中。
160.Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits.
全转录组和分层基因组结构方程模型确定了不同认知特征中共享的神经生物学途径。
161.Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12.
拼接因子BUD31通过维持抗凋亡性BCL2L12的表达促进卵巢癌的进展。
162.CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro.
CRISPR/Cas9介导的切除C9ORF72中导致ALS/FTD的六核苷酸重复扩增，在体内和体外挽救了主要疾病机制。
163.Sleep decreases neuronal activity control of microglial dynamics in mice.
睡眠降低了小鼠小胶质细胞动态的神经元活动控制。
164.WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition.
WASH的激活控制了肿瘤抑制细胞竞争过程中的内体回收和EGFR及Hippo信号的传递。
165.Long-term whole blood DNA preservation by cost-efficient cryosilicification.
通过具有成本效益的冷冻保存全血DNA。
166.DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon.
DNA甲基转移酶3A控制结肠上皮屏障功能和再生。
167.Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo.
内溶酶体系统的交联揭示了潜在的弗罗提林结构和货物。
168.Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma.
血液中单核细胞衍生的CD169+巨噬细胞对胶质母细胞瘤的抗肿瘤免疫有贡献。
169.Promiscuity of response regulators for thioredoxin steers bacterial virulence.
硫氧还蛋白反应调节器的普适性引导了细菌的毒力。
170.Combining mass spectrometry and machine learning to discover bioactive peptides.
结合质谱法和机器学习发现生物活性肽。
171.Rapid antibiotic susceptibility testing and species identification for mixed samples.
混合样品的快速抗生素药敏试验和物种鉴定。
172.Atomic resolution protein allostery from the multi-state structure of a PDZ domain.
从一个PDZ结构域的多态结构看原子分辨率的蛋白质异构。
173.Genomic insights into the physiology of Quinella, an iconic uncultured rumen bacterium.
从基因组学角度深入了解昆仑菌--一种标志性的未培养的瘤胃细菌的生理学。
174.Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.
肿瘤产生的和衰老相关的副代谢物甲基丙二酸促进了癌症相关的成纤维细胞的激活以推动转移性进展。
175.A BDNF-TrkB autocrine loop enhances senescent cell viability.
BDNF-TrkB自分泌回路增强了衰老细胞的活力。
176.Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor.
对芳烃受体配体结合机制的结构深入研究。
177.Central role of Prominin-1 in lipid rafts during liver regeneration.
肝脏再生过程中Prominin-1在脂质筏中的核心作用。
178.Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function.
类风湿性关节炎成纤维细胞样滑膜细胞的系统生物学分析暗示了细胞系特异性转录因子的功能。
179.Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility.
热稳定的prestin的低温电镜结构提供了关于外毛细胞电动性的机械学见解。
180.Hemisphere-specific spatial representation by hippocampal granule cells.
海马颗粒细胞的半球特异性空间表示。
181.Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3.
TET酶的急性缺失通过Khdc3的表达减少导致小鼠胚胎干细胞的非整倍体。
182.p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
正常食道中的p53突变会促进多个阶段的癌变，但会受到克隆竞争的制约。
183.Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy.
合成生物学结构的透皮微针贴片用于可追踪的光动力疗法。
184.RNA G-quadruplex structure contributes to cold adaptation in plants.
RNA G-四联体结构有助于植物的冷适应。
185.Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.
蛋白质基因组学完善了慢性淋巴细胞白血病的分子分类。
186.Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.
原发性人类淋巴瘤B细胞的病毒转导揭示了NOTCH介导的免疫逃避机制。
187.NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.
NIMA相关激酶9调节心脏中重要肌球蛋白轻链的磷酸化。
188.Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues.
低温造影剂增强的微型CT实现了软体生物组织的无损三维定量组织病理学研究。
189.Harnessing bioengineered microbes as a versatile platform for space nutrition.
利用生物工程微生物作为空间营养的多功能平台。
190.Sublinear scaling of the cellular proteome with ploidy.
细胞蛋白质组与倍体的亚线性比例。
191.The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5.
一种植物寄生线虫及其宿主的基因组和生命期特定的转录组揭示了参与维生素B5跨王国合成的易感基因。
192.CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.
催化活性酶丙酮酸羧化酶的低温EM结构探索。
193.Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor.
金属蛋白酶meprinα与小分子抑制剂复合物的螺旋状超微结构。
194.Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.
糖原承诺的PP1/PTG全能酶的分子结构。
195.Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb.
未成熟的嗅觉神经元向嗅球提供行为上相关的感觉输入。
196.The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans.
未折叠蛋白反应逆转了葡萄糖对化学灭菌的优雅动物寿命的影响。
197.Remodelling of tumour microenvironment by microwave ablation potentiates immunotherapy of AXL-specific CAR T cells against non-small cell lung cancer.
微波消融对肿瘤微环境的重塑增强了AXL特异性CAR T细胞对非小细胞肺癌的免疫治疗。
198.Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.
利用AAV基因递送抑制纤维发育不良骨质增生症的异位骨化。
199.Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts.
益生菌和交配酵母的工程化细胞分化和有性繁殖。
200.Brainstem networks construct threat probability and prediction error from neuronal building blocks.
脑干网络从神经元构建块中构建威胁概率和预测误差。
201.P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.
P300通过调节辐射诱导的胶质瘤干细胞向血管样细胞转化促进肿瘤复发。
202.Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
与先天免疫、环境感应和细胞功能有关的宿主遗传因子与人类皮肤微生物群有关。
203.Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
Runx2和Runx3在手术诱导的骨关节炎发展过程中对关节软骨细胞有不同的调节作用。
204.HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids.
HBEGF-TNF在人类器官中诱发复杂的外视网膜病变与光感受器细胞挤压。
205.Systematic design of cell membrane coating to improve tumor targeting of nanoparticles.
系统设计细胞膜涂层以提高纳米粒子的肿瘤靶向性.
206.Proteome effects of genome-wide single gene perturbations.
全基因组单基因扰动的蛋白质组效应。
207.Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Tmem65对小鼠心脏夹层盘的结构和功能至关重要。
208.A simple thermodynamic description of phase separation of Nup98 FG domains.
Nup98 FG结构域的相分离的简单热力学描述。
209.Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair.
Lys63连接的泛素链的选择性大环肽调节剂破坏了DNA损伤修复。
210.The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans.
低氧反应途径促进优雅动物的PEP羧基激酶和葡萄糖生成。
211.Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial.
来自芬兰随机SOLIDARITY试验的COVID-19感染住院后remdesivir的效果。
212.Structural insight into Tn3 family transposition mechanism.
对Tn3家族转座机制的结构洞察。
213.A synthetic transcription platform for programmable gene expression in mammalian cells.
用于哺乳动物细胞中可编程基因表达的合成转录平台。
214.Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
蛋白酶PAPP-A与内源性抑制剂stanniocalcin-2的结构揭示了其抑制机制。
215.Genome-wide functional screening of drug-resistance genes in Plasmodium falciparum.
恶性疟原虫耐药基因的全基因组功能筛选。
216.Perception and memory have distinct spatial tuning properties in human visual cortex.
人类视觉皮层中感知和记忆具有不同的空间调谐特性。
217.Rapid protein assignments and structures from raw NMR spectra with the deep learning technique ARTINA.
利用深度学习技术ARTINA从原始核磁共振光谱中快速分配蛋白质和结构。
218.Flexibility of functional neuronal assemblies supports human memory.
功能性神经元集合体的灵活性支持人类的记忆。
219.Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma.
非髓系甲状腺癌患者骨髓细胞及其祖细胞的重新编程。
220.Actin polymerization promotes invagination of flat clathrin-coated lattices in mammalian cells by pushing at lattice edges.
肌动蛋白聚合通过在晶格边缘的推动促进哺乳动物细胞中平坦的凝集素涂层晶格的内陷。
221.Online single-cell data integration through projecting heterogeneous datasets into a common cell-embedding space.
通过将异质数据集投射到一个共同的细胞嵌入空间实现在线单细胞数据整合。
222.Brain milieu induces early microglial maturation through the BAX-Notch axis.
脑环境通过BAX-Notch轴诱导早期小胶质细胞成熟。
223.Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis.
极化NHE1和SWELL1调节迁移方向、效率和转移。
224.HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design.
HIV-1 CD4结合位点种系抗体-Env结构为疫苗设计提供参考。
225.Mammalian N1-adenosine PARylation is a reversible DNA modification.
哺乳动物的N1-腺苷PARylation是一种可逆转的DNA修饰。
226.An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment.
c-JUN N端磷酸化的内在时间顺序通过协调辅助因子的招募来调节其活性。
227.Cryo-EM structures of the translocational binary toxin complex CDTa-bound CDTb-pore from Clostridioides difficile.
艰难梭菌的易位二元毒素复合物CDTa-结合CDTb-孔的低温电镜结构。
228.The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain.
人类TRPA1内在的冷和热敏感性涉及N-ARD结构域以外的独立通道结构。
229.Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements.
带有片段rRNA的线粒体核糖体与膜靶向元素复合的结构。
230.Anaerobic oxidation of propane coupled to nitrate reduction by a lineage within the class Symbiobacteriia.
丙烷的厌氧氧化与共生菌类中的一个系的硝酸盐还原相结合。
231.SARS-COV-2 antibody responses to AZD1222 vaccination in West Africa.
西非地区对AZD1222疫苗接种的SARS-COV-2抗体反应。
232.Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability.
Sirtuin5通过保持核苷酸的可用性保护结直肠癌免受DNA损伤。
233.Vesicular release probability sets the strength of individual Schaffer collateral synapses.
囊泡释放概率设定了单个沙弗尔侧枝突触的强度。
234.ChAd155-RSV vaccine is immunogenic and efficacious against bovine RSV infection-induced disease in young calves.
ChAd155-RSV疫苗对牛RSV感染引起的小牛疾病具有免疫原性和有效性。
235.Comprehensive and clinically accurate head and neck cancer organs-at-risk delineation on a multi-institutional study.
全面的、临床上准确的头颈部癌症风险器官划分对多机构研究的影响。
236.A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection.
基于人群的COVID-19疫苗接种和SARS-CoV-2感染后早期妊娠结果的匹配队列研究。
237.A scalable platform to discover antimicrobials of ribosomal origin.
发现核糖体来源的抗菌剂的可扩展平台。
238.A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.
局部肿瘤微环境获得性超级增强器诱导结直肠癌的致癌驱动因素。
239.Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke.
利用人类血浆蛋白组的系统性孟德尔随机化，发现潜在的中风治疗目标。
240.Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics.
通过早期内体蛋白组学研究淀粉样前体蛋白膜内加工的空间快照。
241.Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo.
体外工程人浆细胞表现出强大的蛋白质分泌和长期体内移植的能力。
242.ATF4-dependent fructolysis fuels growth of glioblastoma multiforme.
ATF4依赖的果实分解助长了多形性胶质母细胞瘤的生长。
243.Contrasting life-history responses to climate variability in eastern and western North Pacific sardine populations.
北太平洋东部和西部沙丁鱼种群对气候变异的生活史反应截然不同。
244.HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia.
HSF1是急性骨髓性白血病干细胞自我更新的驱动因素。
245.In vitro assembly, positioning and contraction of a division ring in minimal cells.
最小细胞中分裂环的体外组装、定位和收缩。
246.Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern.
针对SARS-CoV-2变体的多克隆IgG1反应中的鉴别交叉反应性值得关注。
247.Maintenance of neurotransmitter identity by Hox proteins through a homeostatic mechanism.
Hox蛋白通过同源机制维持神经递质的特性。
248.Structural basis for recognition of antihistamine drug by human histamine receptor.
人类组胺受体识别抗组胺药物的结构基础。
249.Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.
与精神疾病相关的遗传变体在淋巴细胞的表观遗传活性位点富集。
250.Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways.
TMPRSS2在SARS-CoV-2感染小鼠气道中的重要作用。
251.Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model.
活体斑马鱼胚胎中Nodal和Lefty的单分子追踪支持阻碍性扩散模型。
252.Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas.
TNF-α抑制剂certolizumab加化疗治疗IV期肺腺癌的I期试验。
253.Alignment of single-cell trajectory trees with CAPITAL.
用CAPITAL对准单细胞轨迹树。
254.Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
昼夜节律蛋白DBP和非典型E2F家族E2F8在抗肿瘤Th9细胞分化中的对立功能。
255.Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy.
基于纳米颗粒的CD4+T细胞效应和辅助功能的调控增强了采用性免疫疗法。
256.Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
酒精对肝脏芳烃受体的诱导通过PPP2R2D调控自噬和磷脂代谢。
257.Structure of the core human NADPH oxidase NOX2.
核心人类NADPH氧化酶NOX2的结构。
258.The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
IgG的Fab区在Fc参与后损害了FcRn的内化途径。
259.DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia.
小儿急性淋巴细胞白血病单卵双胞胎出生时的DNA甲基化问题。
260.Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes.
通过可视化活动复制体上CMG螺旋酶的支架来解决MCM悖论。
261.Genetic map of regional sulcal morphology in the human brain from UK biobank data.
来自英国生物库数据的人脑区域沟壑形态的遗传图。
262.Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations.
来自高分辨率低温电镜和分子动力学模拟的Mrp型反输送器的离子传输机制。
263.TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.
TLCD1和TLCD2调节细胞磷脂酰乙醇胺组成并促进非酒精性脂肪性肝炎的发展。
264.Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.
基于免疫肽组学的针对单核细胞增生李斯特菌的mRNA疫苗配方设计。
265.Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system.
纤维细胞通过内皮素系统促进肺癌龛内的肿瘤支持性表型转换。
266.The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis.
肠道时钟驱动微生物组以维持胃肠道平衡。
267.Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.
磷酸酶保护剂α4（α4）通过调节胰岛素信号参与脂肪细胞维持和线粒体稳态。
268.Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity.
Hemipiperazines作为肽衍生的分子光开关具有低纳摩尔的细胞毒性。
269.The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
肠道微生物Bacteroides fragilis改善了小鼠的肾脏纤维化状况。
270.Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis.
PD-L1特异性嵌合开关受体的共同表达通过CD70-CD27轴增强了CAR T细胞的效力和持久性。
271.The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.
Hippo途径将脂肪细胞的可塑性与脂肪组织的纤维化联系起来。
272.Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue.
慢性摄入高膳食蔗糖诱导小鼠肝脏和脂肪组织的性双态代谢适应。
273.TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine.
TGF-β依赖淋巴组织驻留的干性T细胞限制了对肿瘤疫苗的反应。
274.Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system.
定量蛋白质组学揭示了控制成人视觉系统再支配的指导性景观。
275.Genome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians.
以基因组为中心的短读和长读元基因组分析揭示了东南亚人未定性的微生物组多样性。
276.Continuous biomarker monitoring with single molecule resolution by measuring free particle motion.
通过测量自由粒子运动实现单分子分辨率的连续生物标记物监测。
