【热门产品推荐】伊妥木单抗，Iratumumab， AntibodySystem Laboratories

伊妥木单抗，Iratumumab，CAS: 640735-09-7，AntibodySystem Laboratories

货号：DHD80902

产品链接：http://www.atagenix.com/product_detail-75445.html

别名：MDX-060, CAS: 640735-09-7

简介：

Iratumumab (MDX-060) 是一种人抗 CD30 的 IgG1κ 单克隆抗体。Iratumumab 抑制表达 CD30 的肿瘤细胞的生长。 Iratumumab 可用于霍奇金淋巴瘤 (HL) 和间变性大细胞淋巴瘤 (ALCL) 的研究。

货号：DHD80902

产品品牌：Antibodysystem

通用名：Iratumumab

纯度：>95% by SDS-PAGE.

浓度：1mg/ml

Formulationicon：0.01M PBS, pH 7.4.

内毒素：Please contact with the lab for this information.

别名：MDX-060

靶点;物种：Human CD30/TNFRSF8

种类：Homo sapiens

受体鉴定：IgG1-kappa

CAS: 640735-09-7

存储条件：

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Store at +4°C short term (1-2 weeks).

Store at -20 °C 12 months.

Store at -80°C long term.

参考文献：

Immunotherapy in indolent Non-Hodgkin's Lymphoma. PMID: 35663281
Gateways to clinical trials. PMID: 19088949
Invasive Fungal Diseases in Children with Hematological Malignancies Treated with Therapies That Target Cell Surface Antigens: Monoclonal Antibodies, Immune Checkpoint Inhibitors and CAR T-Cell Therapies. PMID: 33807678
Monoclonal antibodies in the treatment of non-Hodgkin's lymphoma. PMID: 17335294
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells. PMID: 29721369
MDX-060. Medarex. PMID: 16370393
Current treatment and immunotherapy of Hodgkin's lymphoma. PMID: 16330443
TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species. PMID: 19890373
Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma. PMID: 17515574