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【热门产品推介】Anti-HRSV F/Fusion glycoprotein F0 Nanobody (SAA1036)

2023-08-09 11:17 作者:AtaGenix-普健生物  | 我要投稿

货号:RVV02822

产品链接:http://www.antibodysystem.com/product/14139.html

物种反应性:Human respiratory syncytial virus A (strain A2)

形式:Liquid

存储缓冲区:0.01M PBS, pH 7.4.

浓度:1 mg/ml

纯度:>95% by SDS-PAGE.

克隆性:Monoclonal

应用:ELISA

靶点:F/Fusion glycoprotein F0

储存:Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

参考文献:

Identification of subgroups of bovine respiratory syncytial virus. PMID: 1583108
Infectivity of a human respiratory syncytial virus lacking the SH, G, and F proteins is efficiently mediated by the vesicular stomatitis virus G protein. PMID: 12610153

Transmembrane Domain Dissociation Is Required for Hendra Virus F Protein Fusogenic Activity. PMID: 31462574
Development of liposomes and pseudovirions with fusion activity for efficient gene delivery. PMID: 22023472
Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain. PMID: 34061592
Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability. PMID: 24089572
The electrophysiological net response ('F-complex') to spatial fusion of speech elements forming an auditory object. PMID: 12738428
Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors. PMID: 21460213

呼吸道合胞病毒(respiratory syncytial virus)是一种单股负链RNA病毒,是引起婴幼儿急性下呼吸道感染最常见的病毒病原体,冬春季高发,在全球范围内均有流行。据估计,2005年呼吸道合胞病毒在全球造成69 000~199 000例儿童患者死亡,99%的病例发生在发展中国家。呼吸道合胞病毒疫苗研发十分困难,到目前为止,尚未有一种疫苗被批准上市。为有效控制该病毒的流行,世界卫生组织在全球流感监测项目的基础上,于2017年建立了全球呼吸道合胞病毒的监测网络,并将其疫苗列入全球优先研发的传染病疫苗之一。

呼吸道合胞病毒在<2岁儿童中感染风险很高,并且与患儿以后的喘息发作和哮喘关系密切;其在老年人和免疫功能低下的高危人群中也有较高发病率,可延长患者的住院时间并导致死亡率增高。研究提示,及时识别呼吸道合胞病毒感染的危险因素对临床治疗和预后判断具有重要价值。但到目前为止,与此相关的研究还十分有限,本研究依托北京市呼吸道病原监测系统(Respiratory Pathogen Surveillance System, RPSS),面向不同类型医院,收集全年龄组范围的呼吸道合胞病毒肺炎患者,以探索重症呼吸道合胞病毒肺炎的独立危险因素。



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