关键词

突变 细胞 线粒体 免疫检查点 中粒细胞 抗体 基因药物

 

#今日行业热点#

①Science：Oncogenic CDK13 mutations impede nuclear RNA surveillance

细胞周期蛋白依赖性激酶13（CDK13）突变通过抑制RNA监测通路促进癌症发生

DOI :10.1126/science.abn7625

②Advanced Drug Delivery Reviews：Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies

综述：基于细胞的药物载体及其临床转化的新进展、新技术和新策略

DOI :10.1016/j.addr.2023.114840

③Trends in Cancer：Fluorescence microscopic platforms imaging mitochondrial abnormalities in neurodegenerative diseases

神经退行性疾病中线粒体异常的荧光显微镜成像平台

DOI :10.1016/j.addr.2023.114841

④Frontiers in Immunology：Targeting immune checkpoints in anti-neutrophil cytoplasmic antibodies associated vasculitis: the potential therapeutic targets in the future

综述：潜在靶点——针对抗中性粒细胞胞质抗体相关血管炎的免疫检查点

DOI :10.3389/fimmu.2023.1156212

⑤Clinical Immunology：Blocking activation of CD4-CD8- T cells modulates their cytotoxic potential and decreases the expression of inflammatory and chemotactic receptors

阻断CD4-CD8-T细胞的激活可调节其细胞毒活性并减少炎症和趋化受体的表达

DOI :10.1016/j.clim.2023.109331

⑥Clinical Immunology：Crosstalk between microglia and neural stem cells influences the relapse of glioblastoma in GBM immunological microenvironment

在GBM免疫微环境中，小胶质细胞和神经干细胞之间的交互作用影响胶质母细胞瘤的复发

DOI :10.1016/j.clim.2023.109333

⑦创新CD47抗体来佐利单抗用于血液系统恶性肿瘤MDS（骨髓增生异常综合征）的中国Ⅲ期注册临床试验已完成首例患者给药

⑧国内首个获批进入临床试验的血友病B的腺相关病毒（AAV）基因药物BBM-H901顺利完成Ⅲ期注册临床试验受试者给药

⑨在研乙肝新药反义寡核苷酸（ASO）bepirovirsen（GSK3228836）在中国启动Ⅲ期临床

⑩用于甲型流感的ZSP1273片Ⅲ期临床研究已完成全部病例数入组

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