达夫奈肽/Davunetide/CAS211439-12-2，一种源于ADNP的生长因子
2022-09-29 15:41 作者:youngshe-Leslie | 我要投稿
达夫奈肽/Davunetide/CAS211439-12-2
是一种鼻内神经肽疗法，来源于活动依赖性神经保护蛋白 (ADNP)，ADNP
是神经胶质细胞在暴露于血管活性肠肽时释放的一种生长因子。其中包含八个氨基酸 Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln
的肽。该肽具有高效的神经保护活性。
Name: 达夫奈肽/Davunetide
Synonyms: NAP, AL-108
Chemical Name: NAPVSIPQ
达夫奈肽/Davunetide (AL-108, NAP) is an eightamino acid peptide that promotes microtubule stability and decreases tau phosphorylation in pre-clinical studies. Since PSP is tightly linked to tau pathology, davunetide could be an effective treatment for Progressive supranuclear palsy (PSP). The goals of this study were to evaluate the efficacy and safety of davunetide in PSP.
