【标题速读】【Ncomm】【biological-sciences】【2022年】【8月】

声明:本专栏主要对生命科学领域的一些期刊文章标题进行翻译,所有内容均由本人手工整理翻译。由于本人专业为生物分析相关,其他领域如果出现翻译错误请谅解。
1.Structural and mechanistic basis for recognition of alternative tRNA precursor substrates by bacterial ribonuclease P.
细菌核糖核酸酶P识别替代tRNA前体底物的结构和机制基础。
2.Structural basis of ion uptake in copper-transporting P1B-type ATPases.
铜转运的P1B型ATP酶的离子吸收的结构基础。
3.PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability.
PD-L2通过维持代谢活性和Foxp3稳定性控制外周诱导的调节性T细胞。
4.OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling.
OXTR高基质成纤维细胞通过ERK5信号控制口腔鳞状细胞癌的侵袭模式。
5.Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer.
肿瘤免疫微环境的无创成像与胃癌免疫疗法的反应相关。
6.Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation.
单细胞转录组和翻译组双组学揭示了人类卵细胞成熟的潜在机制。
7.Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
形状选择性识别和氨基酰化的结构基础,一种D-armless人类线粒体tRNA。
8.Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
蚊子Aedes aegypti中Toll免疫受体激活的结构和动态。
9.Structural bases for aspartate recognition and polymerization efficiency of cyanobacterial cyanophycin synthetase.
天门冬氨酸识别的结构基础和蓝细菌蓝藻素合成酶的聚合效率。
10.Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling.
巨噬细胞对肥胖症的早期反应包含了干扰素调节因子5调节的线粒体结构重塑。
11.Controlling gene expression with deep generative design of regulatory DNA.
用调控DNA的深度生成设计控制基因表达。
12.Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy.
通过抗病毒单体疗法解决危重病中顽固的铜绿假单胞菌感染问题。
13.Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates.
法匹拉韦对非人灵长类动物的寨卡和SARS-CoV-2病毒的抗病毒效果。
14.Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy.
用于低剂量X射线诱导的光动力疗法的有机磷光纳米闪烁器。
15.Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
多组学分析定义了高度难治性RAS负担的婴儿急性淋巴细胞白血病未成熟亚组。
16.Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis.
结核分枝杆菌W148欧洲/俄罗斯支系的跨洲传播和向广泛耐药结核的进化。
17.Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3.
大肠杆菌CRISPR-Cas3干扰的动态机制。
18.Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity.
鼻咽部气道宿主反应和微生物组与支气管炎严重程度的综合关系。
19.Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy.
用多组学大流行追踪策略解构COVID-19严重性的复杂相关因素。
20.A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
MCM8/9螺旋酶复合物在复制压力下维持叉子完整性的多功能作用。
21.Comprehensive structural assignment of glycosaminoglycan oligo- and polysaccharides by protein nanopore.
通过蛋白质纳米孔对糖胺聚糖的寡糖和多糖进行综合结构分配。
22.Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes.
内生型效应大小支持单基因疾病易感基因的变体致病性。
23.Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
胆汁NIK促进小鼠的导管反应和肝脏损伤及纤维化。
24.Synthesizing theories of human language with Bayesian program induction.
用贝叶斯程序归纳法合成人类语言理论。
25.Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase.
脂肪细胞通过空泡型H+ATP酶控制食物摄入和体重恢复。
26.A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes.
一项试点随机试验,检查混合闭环胰岛素输送系统对1型糖尿病青少年的神经发育和认知结果的影响。
27.The automated Galaxy-SynBioCAD pipeline for synthetic biology design and engineering.
用于合成生物学设计和工程的自动化Galaxy-SynBioCAD管道。
28.Deep learning image segmentation reveals patterns of UV reflectance evolution in passerine birds.
深度学习图像分割揭示了鸟类紫外线反射率的演变模式。
29.Proteolytic processing induces a conformational switch required for antibacterial toxin delivery.
蛋白水解加工诱导抗菌毒素递送所需的构象转换。
30.Cytoplasmic forces functionally reorganize nuclear condensates in oocytes.
细胞质力在功能上重组了卵母细胞中的核凝集物
31.PIF7 is a master regulator of thermomorphogenesis in shade.
PIF7是阴影下热形态发生的主调控器。
32.Degenerate boundaries for multiple-alternative decisions.
多重选择决策的退行性界线。
33.Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling.
核糖体结合的MuvB转录因子复合物的结构显示了DNA重塑。
34.Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.
布氏锥虫的不变表面糖蛋白65是一种补体C3受体。
35.A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses.
驱动运动活动和交感神经心血管反应的脑干单突触兴奋性通路。
36.HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells.
HnRNPK通过控制哺乳动物细胞中的双链RNA维持单链RNA。
37.Subcortical-cortical dynamical states of the human brain and their breakdown in stroke.
人脑的皮层下-皮层动态状态及其在中风中的分解。
38.Divergent changes in particulate and mineral-associated organic carbon upon permafrost thaw.
冻土融化时颗粒和矿物相关有机碳的差异性变化.
39.NODULIN HOMEOBOX is required for heterochromatin homeostasis in Arabidopsis.
NODULIN HOMEOBOX是拟南芥异染色质平衡的必要条件。
40.Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques.
芬戈莫德治疗在SIV感染猕猴ART最初几周的有限影响。
41.Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes.
重新利用有丝分裂机制来驱动恶性疟原虫配子细胞的细胞伸长和染色质重组。
42.Organization of the gravity-sensing system in zebrafish.
斑马鱼重力感应系统的组织。
43.The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1.
KU-PARP14轴不同程度地调节MRE11和EXO1对停滞复制叉的DNA切除。
44.Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau.
Tauopathy模型中Retromer的缺乏增强了Tau的截断和毒性。
45.Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.
产后早期5-羟色胺调控通过突触转录重编程防止Arid1b缺陷小鼠成年阶段的缺陷。
46.Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression.
通过靶向持续的肾小管p21表达逆转糖尿病肾病中的肾脏高血糖记忆。
47.Fast DNA-PAINT imaging using a deep neural network.
使用深度神经网络的快速DNA-PAINT成像。
48.Paving the way to improve therapy for Myeloproliferative Neoplasms.
为改善骨髓增生性肿瘤的治疗铺平道路。
49.Call for a unified approach to Monkeypox infection in pregnancy: Lessons from the COVID-19 pandemic.
呼吁对怀孕期间的猴痘感染采取统一的方法:来自COVID-19大流行的教训。
50.Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse.
人类NK细胞NKR-P1:LLT1受体:配体复合物的结构揭示了免疫突触中的集群。
51.Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism.
穿孔蛋白-2顺时针手拉手前孔到孔的过渡机制。
52.The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation.
蛋白精氨酸甲基转移酶PRMT9通过精氨酸甲基化减弱了MAVS的激活。
53.Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment.
干性肿瘤细胞的Midkine表达推动了对mTOR抑制和免疫抑制微环境的持久性。
54.Spatially patterned hydrogen peroxide orchestrates stomatal development in Arabidopsis.
空间模式的过氧化氢协调了拟南芥的气孔发育。
55.Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities.
Hox成员Deformed的特异性由转录因子水平和结合点亲和力决定。
56.Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform.
亚磷酸酯脱氢酶的定向进化,通过通用生长选择平台循环非经典的氧化还原辅助因子。
57.Efficient DNA fluorescence labeling via base excision trapping.
通过碱基切除诱捕实现高效的DNA荧光标记。

a 在 DNA 合成过程中掺入脱氨基碱基,然后进行 DNA 修复和 UBER 标记。 b 碱基切除捕获机制 (BETr)。 c 在 dsDNA (DNA_dU/DNA, 400nM) 和 DNA/RNA 杂交体 (DNA_dU/RNA, 400nM) 中,BETr 标记后荧光强度发生变化。 d 使用 2 U/mL Klenow (exo-) 原位 DNA 合成和 BETr 过程的荧光强度变化。 e 使用 2 U/µL Revert Aid H 减去 RT 的原位逆转录和 BETr 标记的荧光强度变化。 f 通过缺口平移对 gDNA 进行原位 BETr 标记的图示。 g 切口平移和原位 BETr 标记期间的荧光增强取决于 dUTP 相对于 dTTP 的相对浓度。 h 荧光强度比较取决于原位标记 100 分钟后 dUTP 的相对浓度。 [CCVJ-1] = 20 µM,[UDG] = 10U/mL (c–e),20U/mL(g,h),[目标 ODN] = 1 µM (9dA),0.5 µM(RNA), [gDNA]⟩= 40 µg/mL,[引物] = 5 µM(引物),1 µM(RT 引物),[dNTP(A、C、G)]⟩= 50 µM,[dUTP] =⟩100 µM(c–e ). [dUTP+dTTP] = 100µM (g, h)。 在 c、d、g、h Fluoroskan Ascent 酶标仪(485nm/538nm)或 e Bio-Tek Synergy HT 酶标仪上在 37°C 下测量荧光强度。
58.DAXX-ATRX regulation of p53 chromatin binding and DNA damage response.
DAXX-ATRX对p53染色质结合和DNA损伤反应的调节。
59.BRAT1 links Integrator and defective RNA processing with neurodegeneration.
BRAT1将整合器和RNA处理缺陷与神经退行性联系起来。
60.Decomposing virulence to understand bacterial clearance in persistent infections.
分解毒力以了解持久性感染中的细菌清除。
61.The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma.
CCTG PA.7二期试验,吉西他滨和纳布-紫杉醇联合或不联合Durvalumab和Tremelimumab作为转移性胰腺导管腺癌的初始治疗。
62.Water-organizing motif continuity is critical for potent ice nucleation protein activity.
水组织图案的连续性对强效冰核蛋白的活性至关重要。
63.Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation.
参与快速内啡肽介导的内吞作用的分子成分之间的多价相互作用驱动蛋白质相分离。
64.Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage.
液体注入的微结构生物粘合剂阻止了不可压缩的出血。
65.AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death.
平滑肌中AMPK的缺失导致新生儿持续肺动脉高压和过早死亡。
66.Inducible expression of large gRNA arrays for multiplexed CRISPRai applications.
用于多重CRISPRai应用的大型gRNA阵列的诱导性表达。
67.Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
通道和屏障Claudins的纳米级隔离使细胞旁的离子通畅。
68.Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein.
α-synuclein的N端P1区淀粉样蛋白形成的单残基调节器。
69.Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila.
微型工程设备使行为的成年果蝇的腹侧神经索的长期成像成为可能。
70.An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila.
细胞生长和非典型融合之间的相互作用确定了果蝇模块化胶质壁龛的形态发生。
71.Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly.
设计的肽作为纳摩尔交叉淀粉样蛋白抑制剂,通过超分子纳米纤维共同组装发挥作用。
72.Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in the limb: from embryo to adult.
肢体中Hic1+间质祖先衍生物的细胞分类:从胚胎到成人。
73.Discrete subicular circuits control generalization of hippocampal seizures.
分离的亚细胞回路控制海马发作的泛化。
74.Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay.
少突胶质细胞分化改变了tRNA修饰和密码子优化介导的mRNA衰减。
75.Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide.
Tripterygium wilfordii细胞色素P450s在三苯氧胺的生物合成中催化甲基转移和环氧化作用。
76.Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8.
由LRRC33和整合素αVβ8指定的TGF-β1信号的特异性。
77.CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis.
CK2诱导的HHEX与YAP-TEAD4复合物的合作促进结直肠肿瘤的发生。
78.Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.
RNA结合蛋白ZFP36L1对神经内分泌可塑性的调节。
79.Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex.
胆碱能的前脑基底核Meynert通过调控前脑皮层调节慢性疼痛样行为。
80.Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids.
肝母细胞瘤的单细胞分析确定了使用患者特异性肿瘤球状体预测化疗敏感性的肿瘤特征。
81.Control cell migration by engineering integrin ligand assembly.
通过工程整合素配体组装控制细胞迁移。
82.Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence.
上皮-间质可塑性决定了雌激素受体阳性乳腺癌的休眠期,而上皮的重新转换则促使复发。
83.Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.
JAK抑制对缺乏IFN-γ途径的黑色素瘤的选择性抑制取决于T细胞和宿主TNF信号。
84.Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis.
催化创新是可卡因和透明胺生物合成中多酮体合成酶独立招募的基础。
85.Consistent predator-prey biomass scaling in complex food webs.
复杂食物网中一致的捕食者-猎物生物量比例。
86.Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
阐明克服卤虫酮抗性的疟原虫脯氨酰-tRNA合成酶抑制剂的途径。
87.A neural correlate of perceptual segmentation in macaque middle temporal cortical area.
猕猴中颞皮层区域感知分割的神经关联。
88.Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci.
关注编码序列的剪接QTL分析揭示了疾病易感位点的机制。
89.Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors.
合理设计敏感性增强的示踪剂,发现高效的APC-Asef抑制剂。
90.Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning.
纹状体多巴胺使哌醋甲酯对基于价值和基于惊奇的逆转学习的影响不一致。
91.Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.
Red1作为RNA靶向MTREC/PAXT复合物的保守支架的结构分析。
92.Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Omicron SARS-CoV-2突变稳定了尖峰向上的RBD构象并导致非RBM结合的单克隆抗体逃逸。
93.Genome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA.
无细胞DNA的低覆盖率全基因组测序中的全基因组突变特征。
94.Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus.
共价TCR-肽-MHC相互作用诱导T细胞激活并重定向胸腺中的T细胞命运。
95.scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory.
胃肿瘤的scRNA-seq显示复杂的细胞间相互作用与另一种T细胞衰竭轨迹。
96.Raptors avoid the confusion effect by targeting fixed points in dense aerial prey aggregations.
猛禽通过瞄准密集的空中猎物聚集区的固定点来避免混乱效应。
97.Nucleosome-directed replication origin licensing independent of a consensus DNA sequence.
独立于共识DNA序列的核糖体指导的复制起源许可。
98.Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing.
采用高分辨率核心基因组多焦点序列分型来描述脓肿分枝杆菌的种群结构和传播。
99.De novo protein design of photochemical reaction centers.
光化学反应中心的新蛋白质设计。
100.Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.
多门类外显子测序显示INHBE突变与有利的脂肪分布和保护糖尿病有关。
101.Linear and nonlinear correlation estimators unveil undescribed taxa interactions in microbiome data.
线性和非线性相关估计器揭示了微生物组数据中未描述的类群相互作用。
102.KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress.
KLF4招募SWI/SNF以增加染色质的可及性,并在层状剪切应力下重新规划内皮细胞增强器景观。
103.Duplicated ribosomal protein paralogs promote alternative translation and drug resistance.
重复的核糖体蛋白旁系物促进替代翻译和耐药性。
104.Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores.
利用多基因评分估计父母的认知和非认知技能对后代教育的影响。
105.Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals.
Bmal1的节律性转录稳定了哺乳动物的昼夜守时系统。
106.Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade.
多功能纳米粒子增强了放疗的原位接种效果并提高了对免疫检查点阻断的反应。
107.Rainfall and sea level drove the expansion of seasonally flooded habitats and associated bird populations across Amazonia.
降雨和海平面推动了整个亚马逊地区季节性洪水栖息地和相关鸟类种群的扩张。
108.A single WNT enhancer drives specification and regeneration of the Drosophila wing.
一个单一的WNT增强器驱动果蝇翅膀的规范和再生。
109.Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering.
普氏假单胞菌通过进化和代谢工程从葡萄糖和木糖中生产粘液酸。
110.Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
血浆代谢组的全基因组关联研究确定了与黑人心脏代谢疾病有关的代谢物。
111.The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.
日本COVID-19工作组465份COVID-19感染样本的全血转录调控图谱。
112.Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
溶酶体外分泌会从神经元中释放出致病的α-突触核苷酸物种,在突触核苷酸病模型中。
113.Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease.
人类小肠和乳糜泻中免疫细胞区的单细胞转录组分析。
114.Evolution of longitudinal division in multicellular bacteria of the Neisseriaceae family.
奈瑟尔科多细胞细菌的纵向分裂进化。
115.Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.
人类额叶皮层的全基因组关联研究确定了路易体病理学中不同的甲基化。
116.Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV.
COVID-19 mRNA疫苗第三剂对HIV感染者的免疫原性。
117.Global systematic review with meta-analysis reveals yield advantage of legume-based rotations and its drivers.
全球性的系统回顾与荟萃分析揭示了以豆科植物为基础的轮作的产量优势及其驱动因素。
118.Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
人类急性炎症的恢复是由白细胞和血小板群体的共同调控动态定义的。
119.Comparison of the 2021 COVID-19 roadmap projections against public health data in England.
2021年COVID-19路线图预测与英格兰公共卫生数据的比较。
120.Population-based tract-to-region connectome of the human brain and its hierarchical topology.
基于人群的人脑道-区域连接组及其分层拓扑结构。
121.Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19.
Bamlanivimab在非住院成人COVID-19的随机试验中的抗病毒和临床活性。
122.A nanopore interface for higher bandwidth DNA computing.
用于更高带宽DNA计算的纳米孔接口。
123.Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.
用光活化依赖性接近标记进行时空分辨的蛋白质网络分析。
124.Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma.
综合多组学揭示了支配基底细胞癌侵袭龛的细胞和分子相互作用。
125.Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation.
利用颅内刺激绘制人类杏仁核分区的有效连接图。
126.Global systematic review with meta-analysis shows that warming effects on terrestrial plant biomass allocation are influenced by precipitation and mycorrhizal association.
全球系统回顾与荟萃分析表明,气候变暖对陆地植物生物量分配的影响受到降水和菌根联合的影响。
127.Flavin-enabled reductive and oxidative epoxide ring opening reactions.
黄素促成的还原性和氧化性环氧化物开环反应。
128.Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading.
阿尔茨海默病发病较早,与大脑枢纽区域的tau病理有关,并促进了tau的扩散。
129.Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.
转座子激活的POU5F1B促进结直肠癌生长和转移。
130.Designing isolation guidelines for COVID-19 patients with rapid antigen tests.
用快速抗原检测为COVID-19患者设计隔离指南。
131.Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice.
IFNβ信号的时间限制性激活是小鼠对免疫检查点疗法反应的基础。
132.Modelling the medium-term dynamics of SARS-CoV-2 transmission in England in the Omicron era.
模拟Omicron时代SARS-CoV-2在英国传播的中期动态。
133.Permian hypercarnivore suggests dental complexity among early amniotes.
二叠纪超大型食肉动物表明早期羊齿动物中牙齿的复杂性。
134.Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.
晶体结构揭示了双特异性泛素/FAT10 E1酶Uba6的催化和调节机制。
135.In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM.
通过低温ET和低温EM研究嗜血杆菌穗状蛋白的原位结构和动力学。
136.SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells.
SARS CoV-2 mRNA疫苗使潜伏的HIV暴露于Nef特异性CD8+T细胞。
137.Increasing sensitivity of dryland vegetation greenness to precipitation due to rising atmospheric CO2.
大气中二氧化碳含量上升导致旱地植被绿度对降水的敏感性增加。
138.Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition.
免疫介导的肾小管萎缩促进急性肾脏损伤向慢性肾脏疾病过渡。
139.Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons.
铁蛋白介导的铁解毒作用促进优雅动物和小鼠神经元的低温生存。
140.Socially meaningful visual context either enhances or inhibits vocalisation processing in the macaque brain.
有社会意义的视觉背景增强或抑制猕猴大脑的发声处理。
141.Phylogenetically and catabolically diverse diazotrophs reside in deep-sea cold seep sediments.
深海冷泉沉积物中居住着系统发育和分解代谢不同的重氮生物。
142.Multiscale light-sheet organoid imaging framework.
多尺度光片类器官成像框架。
143.Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort.
基于人群的SARS-CoV-2感染后具有不同轨迹的体液和细胞免疫反应。
144.Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
大麻素诱导脂质纳米盘中α1-甘氨酸受体增效的结构基础。
145.On maternity and the stronger immune response in women.
关于产妇和妇女更强的免疫反应。
146.Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota.
口服Blautia wexlerae通过肠道微生物群的代谢重塑改善肥胖症和2型糖尿病。
147.Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
设计一个自主的VH结构域来调控细胞内的通路并审视eIF4F复合物。
148.BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19.
BNT162b2在异源或同源的ChAdOx1nCoV-19/BNT162b2疫苗接种COVID-19六个月后增强了免疫反应。
149.Inorganic nanosheets facilitate humoral immunity against medical implant infections by modulating immune co-stimulatory pathways.
无机纳米片通过调节免疫共刺激途径促进对医疗植入物感染的体液免疫。
150.Rubisco forms a lattice inside alpha-carboxysomes.
Rubisco在alpha-carboxysomes内形成一个晶格。
151.Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment.
通过肿瘤免疫微环境的多维分析预测胃癌免疫疗法的反应。
152.SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.
值得关注的SARS-CoV-2变体:尖峰蛋白突变分析和广泛中和的表位。
153.SARS-CoV-2 antibodies and breakthrough infections in the Virus Watch cohort.
病毒观察队列中的SARS-CoV-2抗体和突破性感染。
154.Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease.
阿尔茨海默病的血液和大脑表观基因组关联研究的跨组织分析。
155.Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.
mTORC1通过调节V-ATP酶的组装直接控制溶酶体的分解代谢活动。
156.Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein.
利用RBD-核壳融合蛋白促进对野生型和SARS-CoV-2变体的中和抗体依赖性免疫力。
157.Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning.
使用进化算法和深度学习对核酸酶中性网络的实验探索。
158.Intrinsic cell rheology drives junction maturation.
细胞内在流变学驱动结点成熟。
159.AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1.
AAA + ATPase Thorase通过mTOR复合物1的拆解抑制mTOR信号传导。
160.MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis.
弧菌的MARTX毒素诱导红细胞磷脂酰丝氨酸暴露,可促使血栓形成。
161.Halogenation of tyrosine perturbs large-scale protein self-organization.
酪氨酸的卤化扰乱了大规模的蛋白质自组织。
162.High impact of bacterial predation on cyanobacteria in soil biocrusts.
细菌捕食对土壤生物壳中蓝藻的高度影响。
163.Structural basis for proton coupled cystine transport by cystinosin.
胱氨酸酶质子耦合胱氨酸转运的结构基础。
164.GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements.
妊娠期肝内胆汁淤积症的GWAS元分析牵涉到多个肝脏基因和调节元件。
165.Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs.
脂质纳米盘中的通道色素ChRmine的低温EM结构。
166.The origin and evolution of open habitats in North America inferred by Bayesian deep learning models.
贝叶斯深度学习模型推断的北美开放栖息地的起源和演变。
167.Terrigenous dissolved organic matter persists in the energy-limited deep groundwaters of the Fennoscandian Shield.
芬诺斯坦地盾能量有限的深层地下水中持续存在土生的溶解性有机物。
168.A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer.
一种纳米工程局部经粘膜的顺铂输送系统在动物模型和口腔癌患者中诱发抗肿瘤反应。
169.A lymphatic-absorbed multi-targeted kinase inhibitor for myelofibrosis therapy.
一种淋巴吸收的多靶点激酶抑制剂用于骨髓纤维化治疗。
170.Trends in COVID-19 hospital outcomes in England before and after vaccine introduction, a cohort study.
疫苗引入前后英格兰COVID-19医院结果的趋势,一项队列研究。
171.Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis.
时空单细胞调控图谱揭示了牙齿形态发生过程中神经嵴系的多样化和细胞功能。
172.A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory.
内丘6b层神经元对海马的直接兴奋性投射有助于空间编码和记忆。
173.Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi.
铜饥饿诱导抗菌剂异氰酸酯集成到真菌的两个不同的生物合成途径中。
174.Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes.
IRF8对单核细胞中STING激活和先天免疫反应的转录非依赖性调节。
175.ABCA1 is an extracellular phospholipid translocase.
ABCA1是一种细胞外磷脂转运酶。
176.Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback.
通过光遗传学反馈对细菌共培养物组成的动态网络遗传控制。
177.The combination of genomic offset and niche modelling provides insights into climate change-driven vulnerability.
基因组偏移和生态位模型的结合提供了对气候变化驱动的脆弱性的见解。
178.Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.
单细胞空间分析揭示了胶质母细胞瘤中免疫调节性嘌呤信号的拓扑结构。
179.Neural circuit for social authentication in song learning.
歌曲学习中社会认证的神经回路。
180.A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice.
脑膜淋巴管在小鼠压力易感性的性别差异中的功能作用。
181.Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth.
早期治疗方案实现了出生时感染SIV的婴儿猕猴的持续病毒学缓解。
182.Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease.
人类和小鼠帕金森病模型中的初级纤毛和SHH信号传导障碍。
183.A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin.
一种TrkB激动剂原药通过抑制天冬酰胺内肽酶和增加骨保护素来防止骨质流失。
184.A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
一个新的基因组可以识别衰老细胞,并预测各组织中与衰老相关的途径。
185.Mannose ameliorates experimental colitis by protecting intestinal barrier integrity.
甘露糖通过保护肠道屏障的完整性改善了实验性结肠炎。
186.Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery.
病毒二类融合机制导致基因组传递的构象变化和膜重塑的可视化。
187.Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA.
新生 RNA 元素 HK022 putRNA 转录调控的结构基础。
188.Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.
对异柠檬酸脱氢酶1突变体抑制剂ivosidenib的耐药性可以通过替代的二聚体-界面结合抑制剂来克服。
189.Strigolactones are chemoattractants for host tropism in Orobanchaceae parasitic plants.
Strigolactones是Orobanchaceae寄生植物的宿主趋向性的化学吸引剂。
190.Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo.
哌嗪衍生的脂质纳米粒子在体内向免疫细胞传递mRNA。
191.Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses.
嵌合GPCRs模拟不同的信号通路并调节小胶质细胞反应。
192.Social incentivization of instrumental choice in mice requires amygdala-prelimbic cortex-nucleus accumbens connectivity.
小鼠工具性选择的社会激励需要杏仁核-前脑皮层-阿肯色的连接。
193.SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP.
SH3结构域对RhoGAP活性的调节: p120RasGAP和DLC1 RhoGAP之间的相互作用。
194.Expression plasticity regulates intraspecific variation in the acclimatization potential of a reef-building coral.
表达可塑性调控造礁珊瑚适应性潜力的种内变化。
195.A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness.
缓慢循环/静止细胞亚群参与胶质瘤的侵袭性
196.Circular EZH2-encoded EZH2-92aa mediates immune evasion in glioblastoma via inhibition of surface NKG2D ligands.
环形EZH2编码的EZH2-92aa通过抑制表面NKG2D配体介导胶质母细胞瘤的免疫规避。
197.Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.
UBA6的结构解释了其对泛素和FAT10的双重特异性。
198.Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform.
Spidroin的N端结构域形成了基于淀粉样纤维的水凝胶,并提供了一个蛋白质固定化的平台。
199.Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle.
可视化决定子弹型水泡口炎病毒颗粒组装的分子相互作用。
200.Precision dynamical mapping using topological data analysis reveals a hub-like transition state at rest.
利用拓扑学数据分析的精确动态图谱揭示了静止时的枢纽状过渡状态。
201.Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia.
Sirt2在发育过程中和新生儿缺氧模型中促进白质少突起。
202.Second-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland.
苏格兰第二剂量ChAdOx1和BNT162b2 COVID-19疫苗与血小板减少、血栓栓塞和出血性事件。
203.Distractibility and impulsivity neural states are distinct from selective attention and modulate the implementation of spatial attention.
分心性和冲动性神经状态与选择性注意不同,并能调节空间注意的实施。
204.Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport.
Sarbecovirus ORF6介导的核细胞质运输受阻的结构基础。
205.ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.
ELF5是严重COVID-19的潜在呼吸道上皮细胞特异性风险基因。
206.Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions.
区域连通性推动了SARS-CoV-2在中东地区旅行限制期间的双向传播。
207.PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.
PKD1和PKD2 mRNA顺式抑制驱动多囊肾病的进展。
208.Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges.
应对环境和群体遗传挑战的突变率和光谱的快速演变。
209.Adaptation to novel spatially-structured environments is driven by the capsule and alters virulence-associated traits.
对新的空间结构环境的适应是由胶囊驱动的,并改变了毒力相关的性状。
210.A method for Boolean analysis of protein interactions at a molecular level.
一种在分子水平上对蛋白质相互作用进行布尔分析的方法。
211.Vaccine effectiveness of CoronaVac against COVID-19 among children in Brazil during the Omicron period.
在Omicron时期,CoronaVac对巴西儿童的COVID-19的疫苗有效性。
212.Anionic nanoplastic exposure induces endothelial leakiness.
阴离子纳米塑料暴露诱导内皮渗漏。
213.XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair.
XPC-PARP复合物参与染色质重塑器ALC1以催化全球基因组DNA损伤修复。
214.Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer.
硫酸软骨素糖复合物的改造使不依赖AR的前列腺癌的进展。
215.Visual evoked feedforward–feedback traveling waves organize neural activity across the cortical hierarchy in mice.
视觉诱发的前馈行波组织了小鼠整个皮层的神经活动。
216.Extraction of accurate cytoskeletal actin velocity distributions from noisy measurements.
从噪声测量中提取准确的细胞骨架肌动蛋白速度分布。
217.Individuals with ventromedial frontal damage display unstable but transitive preferences during decision making.
额叶内侧损伤的个体在决策过程中显示出不稳定的但具有转折性的偏好。
218.Empirical evidence on the efficiency of backward contact tracing in COVID-19.
关于COVID-19中后向接触追踪效率的经验性证据。
219.Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area.
外侧延髓谷氨酸神经元对非快速眼动睡眠的控制,投射到视前区的谷氨酸神经元。
220.Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance.
一种CRISPR激活小鼠的产生,能够对侵袭性淋巴瘤进行建模并对venetoclax的耐药性进行询问。
221.Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms.
霉菌对锌中毒的抗性需要装配含P-ATP酶的膜金属流出平台。
222.Protection of COVID-19 vaccination and previous infection against Omicron BA.1, BA.2 and Delta SARS-CoV-2 infections.
COVID-19疫苗接种和先前感染对Omicron BA.1、BA.2和Delta SARS-CoV-2感染的保护。
223.Structural basis for receptor selectivity and inverse agonism in S1P5 receptors.
S1P5受体中受体选择性和反激动性的结构基础。
224.Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma.
单原子纳米酶的催化作用超过了自然发生的酶,作为脑创伤的持续缝合。
225.Accurate population proxies do not exist between 11.7 and 15 ka in North America.
北美洲11.7-15ka之间不存在准确的人口代用指标。
226.Reply to: Accurate population proxies do not exist between 11.7 and 15 ka in North America.
回复: 准确的人口代用指标在北美11.7和15 ka之间不存在。
227.Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
对人类兴奋性氨基酸转运体EAAT2的抑制机制的结构见解。
228.Biocatalytic routes to stereo-divergent iridoids.
生物催化的立体异构虹膜路线。
229.Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
环状RNA circTmem241通过启动Elk3转录驱动第三组先天淋巴细胞分化。
230.Clonal diversification and histogenesis of malignant germ cell tumours.
恶性生殖细胞肿瘤的克隆多样化和组织发生。
231.Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells.
超深度测序验证了CRISPR/Cas9基因组编辑在人类造血干细胞和祖细胞中的安全性。
232.Restructured membrane contacts rewire organelles for human cytomegalovirus infection.
重组的膜接触为人类巨细胞病毒感染的细胞器重新布线。
233.SARS-CoV-2 and other respiratory pathogens are detected in continuous air samples from congregate settings.
SARS-CoV-2和其他呼吸道病原体在聚集场所的连续空气样本中被检测出来。
234.PTEN inhibits AMPK to control collective migration.
PTEN抑制AMPK以控制集体迁移。
235.The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization.
阿尔茨海默病的原因和后果:来自孟德尔随机化的全表型证据。
236.Thermal adaptation best explains Bergmann’s and Allen’s Rules across ecologically diverse shorebirds.
热适应能最好地解释伯格曼规则和艾伦规则在不同生态环境下的海岸鸟。
237.Transcription-coupled and epigenome-encoded mechanisms direct H3K4 methylation.
转录耦合和表观基因组编码机制指导H3K4甲基化。
238.CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome.
CHIKV感染通过改变tRNA表观转录组来重新规划密码子的优化以利于病毒RNA的翻译。
239.Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens.
异源ChAdOx1-nCoV-19-priming和BNT162b2或mRNA-1273-boosting与同源COVID-19疫苗方案的免疫原性和反应原性的比较。
240.Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection.
三磷酸腺苷激活的原药系统用于按需灭活细菌和伤口消毒。
241.TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes.
TET酶通过增加RUNX2靶基因的染色质可及性调节骨骼发育。
242.Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers.
兆赫兹脉冲序列使X射线自由电子激光器的多击串联飞秒晶体学实验得以进行。
243.Science in the time of COVID-19: Reflections on the UK Events Research Programme.
COVID-19时代的科学: 对英国事件研究计划的反思。
244.mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1.
mTORC1通过SCYL1的磷酸化控制高尔基结构和囊泡的分泌。
245.Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus.
CDK4/6抑制剂靶向视网膜母细胞瘤/E2F抑制复合物,放大了肿瘤腺病毒的杀伤力。
246.PRC1-mediated epigenetic programming is required to generate the ovarian reserve.
PRC1介导的表观遗传编程是产生卵巢储备的必要条件。
247.Molecular basis of MHC I quality control in the peptide loading complex.
MHC I质量控制的分子基础在多肽装载复合物中的应用。
248.Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT.
DNAJB1中HTT特异性结合图案的鉴定,对HTT的抑制和分解至关重要。
249.Evidence for a HURP/EB free mixed-nucleotide zone in kinetochore-microtubules.
证据表明,在动点-微管中存在一个HURP/EB自由混合核苷酸区。
250.Molecular characterization of the missing electron pathways for butanol synthesis in Clostridium acetobutylicum.
乙酰丁酸梭菌中合成丁醇的缺失电子途径的分子特征。
251.Neuronal congruency effects in macaque prefrontal cortex.
猕猴前额叶皮层的神经元一致性效应。
252.Conserved subcortical processing in visuo-vestibular gaze control.
视觉-前庭凝视控制中保守的皮层下处理。
253.Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection.
Omicron BA.4/BA.5逃避由BA.1感染引起的中和免疫力。
254.Local molecular and global connectomic contributions to cross-disorder cortical abnormalities.
局部分子和全球连接组对跨障碍性皮质异常的贡献。
255.Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening.
脾脏巨噬细胞捕获的微生物通过T细胞死亡依赖的中性粒细胞寿命缩短引发败血症。
256.Repeated genetic adaptation to altitude in two tropical butterflies.
两种热带蝴蝶对海拔高度的重复遗传适应。
257.Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains.
绿色植物OTUB亚家族中保守的Met1特异性图案使水稻OTUB1能够水解Met1泛素链。
258.Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β.
人类拓扑异构酶3β的DNA和RNA催化作用的结构和生化基础。
259.Connecting omics signatures and revealing biological mechanisms with iLINCS.
用iLINCS连接omics特征并揭示生物机制。
260.MYC sensitises cells to apoptosis by driving energetic demand.
MYC通过驱动能量需求使细胞对凋亡敏感。
261.Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice.
Kiss1神经元中的Dicer消融会优先损害雌性小鼠的青春期和生育能力。
262.The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.
SWI/SNF染色质重塑因子DPF3通过调控TGF-β信号调节ccRCC的转移。
263.Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health.
循环蛋白质组的综合甲基组和表型组研究揭示了与大脑健康有关的标志物。
264.A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samples.
基于CRISPR的超灵敏检测法可检测临床样本中的阿托摩尔浓度的SARS-CoV-2抗体。

a UCAD 分析工作流程的示意图。 b 用于触发 CRISPR-Cas12a 侧链切割活性的 dsDNA 模板序列设计,以及将 dsDNA 模板拆分为用于 UCAD 的 TS 和 NTS 探针的策略。 c 两个 UCAD 探针通过亲和基序与同一抗 RBD 抗体的接近结合将双链结构域的 Tm 从 10 提高到 46°C,从而实现 TS 和 NTS 探针之间的稳定结合。 d, e 使用 UCAD 检测商业购买的认证抗 SARS-CoV-2 IgG/IgM 阳性和阴性血清样品中抗 RBD IgG (d) 和 IgM (e) 的动力学曲线。 f 通过绘制 CRISPR-Cas12a 反应第 40 分钟的荧光强度,建立了用于检测浓度范围为 1aM 至 1pM 的抗 SARS-CoV-2 刺突蛋白 RBD 人单克隆抗体(克隆:OTIH401)的校准曲线目标浓度的函数,还与没有 RPA 放大的 UCAD 进行了比较。每个浓度都有重复测量 (n = 2)。 g, h 使用 UCAD 和商用 ELISA 试剂盒检测经认证的抗 SARS-CoV-2 IgG/IgM 阳性血清中的抗 RBD IgG (g) 和 IgM (h),该血清稀释于阴性人血清中,稀释倍数为 1 至 100,000 . 每个浓度都有重复测量 (n = 2)。
265.Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex.
Raptor下调可拯救结节性硬化综合症小鼠模型的神经元表型。
266.Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses.
针对乙型流感病毒的五价广泛保护性核苷修饰的mRNA疫苗的开发。
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