艾沃利单抗 ，Omburtamab，CAS:1895083-75-6， AntibodySystem Laboratories

货号：DHJ04002

产品链接：http://www.atagenix.com/product_detail-75194.html

别名：8H9, Mab 8H9, CAS: 1895083-75-6

简介：

Omburtamab 是一种 anti-CD276 (也被称为 B7-H3) 的单克隆抗体，CD276 是一种在人类实体肿瘤中表达的 B7/CD28 免疫球蛋白家族成员。Omburtamab 可以与肿瘤组织相结合，用于各种癌症的研究。

货号：DHJ04002

产品品牌：Antibodysystem

通用名：Omburtamab

纯度：>95% by SDS-PAGE.

浓度：1mg/ml

Formulationicon：0.01M PBS, pH 7.4.

别名：8H9, Mab 8H9

靶点;物种：Human CD276/B7-H3

种类：Mus musculus

受体鉴定：IgG1-kappa

CAS: 1895083-75-6

存储条件：

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

参考文献：

Phase 1 study of intraventricular 131I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies. PMID: 36371226
Antibodies to watch in 2020. PMID: 31847708
Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine. PMID: 31481583
IntraOmmaya compartmental radioimmunotherapy using 131I-omburtamab-pharmacokinetic modeling to optimize therapeutic index. PMID: 33047248
Biodistribution and Dosimetry of Intraventricularly Administered 124I-Omburtamab in Patients with Metastatic Leptomeningeal Tumors. PMID: 31405921
Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes. PMID: 33514401
Biodistribution and Radiation Dosimetry of Intraperitoneally Administered 124I-Omburtamab in Patients with Desmoplastic Small Round Cell Tumors. PMID: 34857661
B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase I Study. PMID: 33119478
Outcomes of intraventricular 131-I-omburtamab and external beam radiotherapy in patients with recurrent medulloblastoma and ependymoma. PMID: 36853490
Radioimmunoscintigraphy and pre-treatment dosimetry of 131I-omburtamab for planning treatment of leptomeningeal disease. PMID: 36759197
Antibodies to watch in 2019. PMID: 30516432
Targeted radioimmunotherapy for embryonal tumor with multilayered rosettes. PMID: 30879172
Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy. PMID: 33533945
Repeat convection-enhanced delivery for diffuse intrinsic pontine glioma. PMID: 32977309
Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody. PMID: 34601396
Evaluation of a patient-specific algorithm for predicting distribution for convection-enhanced drug delivery into the brainstem of patients with diffuse intrinsic pontine glioma. PMID: 33990084