了解SCI文章的实验设计、方法、结果以及图表等方面的常见修回意见，写作可提前避坑！
今天，请大家一起来看看基础医学SCI文章中实验设计、方法、结果以及图表等方面的常见修回意见，了解审稿人关注的点，尽量在写作中提前规避掉这些问题，可大大提高文章发表的速度哦。
实验设计
When testing a compound, drug or some other chemical or physical agents on cell lines, it is important for our readers to know whether similar (or different) results were found on:
解析：同一类型的癌症可能有多种细胞系，因为即使是同一种癌症，不同的细胞系中往往也会有不同的表现和机制。研究时最好选择多种细胞系进行实验。
DMSO is itself an anti-oxidant. It is imperative that appropriate vehicle controls be used. You have to refer to the data indicating whether or not the DMSO vehicle alone had an effect on cell death in any of your experiments.
解析：在设计实验的时候，一定要考虑所选用的对照是否合理，是否对本实验的细胞效应有影响。
方法
Although this study was fairly designed and performed, several methods are not clear enough. Moreover, authors should describe the principle of kits used to measure hydroxyl radicals and superoxide in the method.
解析：重要的研究方法叙述要详细。比如那些用试剂盒的方法或者之前参考文献的方法，引用之后还需要简单介绍一下。
It is very important to describe how to control the quality of aqueous extract of the shoot of ×× in each preparation or batch.
解析：对于中药提取物的实验，对于提取物成分的鉴定要有描述，比如液相色谱、指纹图谱之类的。
100 uM is a relatively high dose of the caspase inhibitors used compared to other published reports. You need to indicate why you used that dose. Appropriate vehicle controls are required. Please convert the r/min to g/min for centrifuge speed.
解析：用药物或试剂进行细胞处理时，最好给出所用剂量的依据（前人的研究），对照设置要全。试剂和仪器的单位要按照国际惯例，用SCI论文期刊中常用的单位。
For animal model establishment, mice were randomly divided into four groups while the number of mice in each group was not introduced. Specify type of rats and weights. What about handling and acclimation.
解析：对于动物模型实验建立后，将模型小鼠随机分组后，每组小鼠的数量要介绍清楚；动物的品系和体重，大鼠的饲养情况等。这些是动物实验中最基本的信息，需要在文章初稿中描述清楚。
Was the injection performed under sedation or anesthesia? When were the injections made? Please add the way of administration. For example, add i.p. or any other route of administration.
解析：针对动物的操作处理，包括麻醉方式、给药方式及频率以及指标检测等信息都要在手稿中交代清楚。请添加动物的喂药方式：是通过腹腔注射还是其它途径喂药？动物实验中处理动物的详细信息要交代清楚。模型构建方式最好是经典的方法，手稿中要引用相关的文献。
Authors described in method part, they treated the mice with 20 mg/kg of bleomycin, have them observed any death?
解析：动物在试剂处理后，有没有观察到死亡？即在实验中由于任何处理因素可能会引起实验动物死亡或者观察到实验动物死亡的都要在方法部分交代清楚，没有就描述没有，如果出现死亡，则要描述死亡的实验动物数以及出现死亡的原因。
Details were needed, such as the country information of chemiluminescence instrument. Beside the names, manufacturers’ states and countries of reagents should be given at the first time, and when the reagents appear again, just list the manufacturers’ names.
解析：对于实验中的观察指标的各种仪器，例如各种类型的显微镜（普通光学显微镜、荧光显微镜、激光共聚焦显微镜以及电子显微镜等）、分光光度剂、灰度扫描仪、血气分析仪等，其型号、厂家、原产地（城市，州，国家）以及所有试剂都要提供公司信息尽量展示在文章中。试剂或仪器第一次出现时要给出厂商的具体信息，之后再出现的时候只需要给出厂商就可以了。
Statistical Analysis: Did you perform a sample size calculation before the study to determine how many rats you needed in each group? Why use SEM and not SD? Please add the post-hoc test used in one-way ANOVA. I assume the Tukey post test was used.
解析：统计分析部分要说明在实验之前有无进行样本量估算来明确每组中大鼠的数目，为什么使用标准误SEM而不是SD即标准差。大多数情况审稿人不会追究实验前的样本量估算过程，我们在文章描述的过程中，只要如实描述实验中用到的样本量即可。如果前期我们确实没有做样本量估算，在回答审稿人问题的时候，引入相关文献并说明我们是参照之前报道的动物数目进行实验的也是可以的。针对标准差与标准误的问题，标准误反应的样本均数间的离散程度，也反映了样本均数与总体均数的差异，而标准误描述的数据分布的离散程度。一般在科技论文中需要展示的数据的离散程度即标准差而不是标准误。此外，在进行整体组间比较后，组与组之间的两两比较的多重检验也要表述清楚。
结果
If ×× is vehicle control, then it is unclear why ×× group has effect on ×× and whether there are any statistically significant differences between the ×× group and Extract treatment group. Also, in Table 3 and Table 4. Please check the data, result statements, and the Abstract.
解析：结果描述、图表、摘要里的结果要保持一致，不能出现不符甚至矛盾的情况。
You must not repeat the methods or background in your Results section – citations are not acceptable here – have deleted this reproduction of information.
解析：不要在结果部分重复方法以及研究背景，另外在实验结果中最好不要援引文献。结果部分只是展示我们的实验结果，没有必要也尽量不要援引文献。
Any words like “indicating” “suggesting” or “illustrating” were not very suitable to be in Results section because only the results of your research were needed, the analysis section should be put in Discussion.
解析：结果部分不应该出现如“indicating” “suggesting” 以及 “illustrating”等推测性的词语。结果部分还是主要客观地描述实验结果，尽量不要出现实验方法以及由实验结果引申出的实验推论。
The description of Figure 1 is too brief in Result section, please add more statements which could better illustrate the results of this study.
解析：主要结果的描述要详细，例如组织切片的结果，不能直接说模型组组织形态被破坏，干预组有明显的改善效果，要具体描述正常组织形态、病变组织形态。添加更多的语句会更好地说明文章的结果。
图表
There were no statistical significance in Figures.
解析：进行比较的结果展示中要标明统计学结果并在图注中给出关于统计差异的说明。
Arrows were needed in Figure 1C, Figure 2A, Figure 2B to make it more clear for pointing out important results.
解析：图1C，2A以及2B中需要用箭头指出更重要的结果。在一些定性展示的图片中，如HE染色中图片中组织特定部位的病变最好用箭头标注出来。
Scale bars are appropriate for histological images
解析：病理学图像分析中图中需要展示比例尺即Bar。也可以在图注中给出放大倍数（如×200）
There were too many figures in this manuscript. This reviewer suggest to reduce the numbers of figures or combine the figures. Some figures might be provided as supplementary materials.
解析：一篇文章的图表不宜太多，相关的结果图片最好能够整合，如果有很多，一些可以以补充材料的形式提交。
Figures need to be in improved resolution. In particular fig 3, 4 and 6. They can not be published in the present low quality.
解析：图片清晰度达不到发表标准，需要重新提供高清图片。
