国际兽医癫痫工作组共识建议：欧洲犬癫痫的药物治疗

Sofie F.M. Bhatti1*, Luisa De Risio2 , Karen Muñana3 , Jacques Penderis4 , Veronika M. Stein5 , Andrea Tipold5 , Mette Berendt6 , Robyn G. Farquhar7 , Andrea Fischer8 , Sam Long9 , Wolfgang Löscher10, Paul J.J. Mandigers11, Kaspar Matiasek12, Akos Pakozdy13, Edward E. Patterson14, Simon Platt15, Michael Podell16, Heidrun Potschka17, Clare Rusbridge18,19 and Holger A. Volk20 

Aims of AED treatment

抗癫痫药物治疗的目的

The ideal goal of AED therapy is to balance the ability to eliminate epileptic seizures with the quality of life of the patient. Seizure eradication is often not likely in dogs. More realistic goals are to decrease seizure frequency, duration, severity and the total number of epileptic seizures that occur over a short time span, with no or limited and acceptable AED adverse effects to maximize the dog’s and owner’s quality of life. Clinicians should approach treatment using the following paradigm [23, 76, 91, 92, 120]:

– Decide when to start AED treatment 

– Choose the most appropriate AED and dosage 

– Know if and when to monitor serum AED concentrations and adjust treatment accordingly 

– Know when to add or change to a different AED 

– Promote pet owner compliance

抗癫痫药物治疗的理想目标是在控制癫痫性抽搐发作和维持病患的生活质量之间取得平衡。

在犬，根除抽搐发作（Seizure eradication）通常是不可能的。

更现实的目标是减少抽搐发作的频率、持续时间、严重程度和在短时间内发生的癫痫性抽搐发作的总数，没有或很少的以及可接受的抗癫痫药物的相关副作用，以最大限度地提高犬和宠主的生活质量。

临床医生应采用以下治疗模式[23,76,91,92,120]:

-决定什么时候开始抗癫痫药物治疗 

-选择最合适的抗癫痫药物及剂量 

-知道是否以及什么时候监测血清抗癫痫药物浓度并相应调整治疗 

-知道什么时候添加或更换另一种的抗癫痫药物 

-督促宠物主人遵医嘱