活性氧Imidazole Ketone Erastin，CAS No. 1801530-11-9

产品名称：活性氧Imidazole Ketone Erastin，CAS No. 1801530-11-9

产地：西安

规格：1mg 5mg 10mg

纯度：99%

用途：仅用于科研

状态：固体/粉末

储藏条件：冷藏-20℃

温馨提示：仅用于科研，不能用于人体实验！

说明：提供使用说明，核磁图谱，包装，价格，产地，制备方法，应用，稳定性，溶解度，简单合成等各种信息　　

Imidazole ketone erastin is an inducer of ferroptosis.1 It inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 30 nM), indicating inhibition of the system xc- cystine/glutamate transporter.2 Imidazole ketone erastin increases production of lipid reactive oxygen species (ROS) in SUDHL6 diffuse large B cell lymphoma (DLBCL) cells in a concentration-dependent manner, as well as reduces glutathione (GSH) levels in these cells (IC50 = 34 nM).1 It inhibits the growth of HT-1080 fibrosarcoma cells (GI50 = 310 nM) as well as HRASG12V-overexpressing BJeLR cells (IC50 = 3 nM).2 Imidazole ketone erastin (23 and 40 mg/kg) reduces tumor growth in an SUDHL6 mouse xenograft model.1

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编辑：XAQYBIO HAO，2023年4月20日。