关键词

临床研究 系统性红斑狼疮 PD-1 抗体反应 瑞武丽珠单抗 MOGAD 克立硼罗 布西珠单抗 RSV疫苗

 

#今日行业热点#

①New England Journal of Medicine：Selective Inhibition of NaV1.8 with VX-548 for Acute Pain

临床研究：VX-548选择性抑制NaV1.8对急性疼痛的影响

DOI: 10.1056/NEJMoa2209870

②Annals of the Rheumatic Diseases：Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets

综述：系统性红斑狼疮（SLE）发病风险、疾病机制和治疗靶点的研究

DOI: 10.1136/ard-2022-223741

③Gut：Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients

程序性细胞死亡蛋白1 (PD-1)异构体Δ42PD-1在HCC进展和纳武利尤单抗免疫检查点阻断(ICB)耐药中的作用

DOI: 10.1136/gutjnl-2022-327133

④Antiviral Research：Mpox virus mRNA-lipid nanoparticle vaccine candidates evoke antibody responses and drive protection against the Vaccinia virus challenge in mice

Mpox病毒mRNA-脂质纳米颗粒候选疫苗(mRNA-LNP)在小鼠中引起抗体反应并驱动对痘苗病毒攻击的保护

DOI: 10.1016/j.antiviral.2023.105668

⑤Journal of Neurology：Long-term efficacy and safety of ravulizumab in adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis: results from the phase 3 CHAMPION MG open-label extension

临床试验：瑞武丽珠单抗（Ravulizumab）用于抗乙酰胆碱受体抗体阳性全身型重症肌无力成人患者的长期疗效和安全性:CHAMPION MG开放标签3期扩展研究的结果

DOI: 10.1007/s00415-023-11699-x

⑥Journal of Neurology：Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): current understanding and challenges

综述：髓鞘少突胶质细胞糖蛋白抗体相关疾病( MOGAD)临床认识和当前挑战

DOI: 10.1007/s00415-023-11737-8

⑦小分子非激素磷酸二酯酶4（PDE-4）抑制剂克立硼罗获国家药监局批准新适应症，推测用于3个月及以上儿童和成人特应性皮炎

⑧小分子BRAF抑制剂ABM-1310获FDA授予孤儿药资格，用于BRAF V600突变的脑胶质母细胞瘤 (GBM)

⑨VEGF单抗布西珠单抗（brolucizumab）上市申请获CDE受理，拟用于糖尿病性黄斑水肿（DME）

⑩GSK在美对辉瑞提起诉讼，称辉瑞的RSV疫苗Abrysvo侵犯了GSK疫苗Arexvy的四项专利

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